Amino acid dipepetide frequency for Candidatus Borkfalkia ceftriaxoniphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.922AlaAla: 9.922 ± 0.164	1.406AlaCys: 1.406 ± 0.042	5.418AlaAsp: 5.418 ± 0.097	6.993AlaGlu: 6.993 ± 0.113	4.296AlaPhe: 4.296 ± 0.091	6.741AlaGly: 6.741 ± 0.114	1.207AlaHis: 1.207 ± 0.044	4.626AlaIle: 4.626 ± 0.103	5.339AlaLys: 5.339 ± 0.101	8.856AlaLeu: 8.856 ± 0.143	2.15AlaMet: 2.15 ± 0.052	2.95AlaAsn: 2.95 ± 0.064	2.616AlaPro: 2.616 ± 0.069	2.615AlaGln: 2.615 ± 0.055	4.105AlaArg: 4.105 ± 0.085	4.217AlaSer: 4.217 ± 0.087	3.469AlaThr: 3.469 ± 0.086	7.405AlaVal: 7.405 ± 0.107	0.617AlaTrp: 0.617 ± 0.031	3.265AlaTyr: 3.265 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	1.718CysAla: 1.718 ± 0.055	0.318CysCys: 0.318 ± 0.022	1.065CysAsp: 1.065 ± 0.038	1.192CysGlu: 1.192 ± 0.041	0.782CysPhe: 0.782 ± 0.033	1.986CysGly: 1.986 ± 0.059	0.259CysHis: 0.259 ± 0.02	0.89CysIle: 0.89 ± 0.034	0.925CysLys: 0.925 ± 0.039	1.322CysLeu: 1.322 ± 0.04	0.38CysMet: 0.38 ± 0.023	0.525CysAsn: 0.525 ± 0.027	0.648CysPro: 0.648 ± 0.033	0.261CysGln: 0.261 ± 0.02	0.816CysArg: 0.816 ± 0.031	0.893CysSer: 0.893 ± 0.04	0.728CysThr: 0.728 ± 0.031	1.195CysVal: 1.195 ± 0.037	0.121CysTrp: 0.121 ± 0.013	0.626CysTyr: 0.626 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	4.962AspAla: 4.962 ± 0.09	1.079AspCys: 1.079 ± 0.036	2.851AspAsp: 2.851 ± 0.074	4.658AspGlu: 4.658 ± 0.091	3.35AspPhe: 3.35 ± 0.068	5.132AspGly: 5.132 ± 0.116	0.627AspHis: 0.627 ± 0.029	3.916AspIle: 3.916 ± 0.077	3.716AspLys: 3.716 ± 0.072	4.898AspLeu: 4.898 ± 0.079	1.527AspMet: 1.527 ± 0.049	2.208AspAsn: 2.208 ± 0.063	1.645AspPro: 1.645 ± 0.05	0.808AspGln: 0.808 ± 0.034	2.352AspArg: 2.352 ± 0.06	2.909AspSer: 2.909 ± 0.063	2.939AspThr: 2.939 ± 0.068	3.95AspVal: 3.95 ± 0.078	0.694AspTrp: 0.694 ± 0.03	2.846AspTyr: 2.846 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	4.562GluAla: 4.562 ± 0.09	0.995GluCys: 0.995 ± 0.037	3.547GluAsp: 3.547 ± 0.07	5.745GluGlu: 5.745 ± 0.111	2.912GluPhe: 2.912 ± 0.062	4.957GluGly: 4.957 ± 0.085	1.0GluHis: 1.0 ± 0.036	5.471GluIle: 5.471 ± 0.089	6.633GluLys: 6.633 ± 0.098	5.636GluLeu: 5.636 ± 0.095	1.895GluMet: 1.895 ± 0.048	4.692GluAsn: 4.692 ± 0.08	1.879GluPro: 1.879 ± 0.048	2.126GluGln: 2.126 ± 0.059	4.074GluArg: 4.074 ± 0.093	3.716GluSer: 3.716 ± 0.07	3.964GluThr: 3.964 ± 0.069	3.637GluVal: 3.637 ± 0.076	0.67GluTrp: 0.67 ± 0.032	3.141GluTyr: 3.141 ± 0.057	0.001GluXaa: 0.001 ± 0.001
Phe	4.502PheAla: 4.502 ± 0.092	0.968PheCys: 0.968 ± 0.042	3.045PheAsp: 3.045 ± 0.075	3.176PheGlu: 3.176 ± 0.073	2.318PhePhe: 2.318 ± 0.063	3.855PheGly: 3.855 ± 0.084	0.647PheHis: 0.647 ± 0.028	2.856PheIle: 2.856 ± 0.072	2.311PheLys: 2.311 ± 0.056	4.116PheLeu: 4.116 ± 0.077	1.169PheMet: 1.169 ± 0.044	1.882PheAsn: 1.882 ± 0.051	1.584PhePro: 1.584 ± 0.049	1.094PheGln: 1.094 ± 0.036	2.109PheArg: 2.109 ± 0.058	3.768PheSer: 3.768 ± 0.075	2.987PheThr: 2.987 ± 0.075	3.364PheVal: 3.364 ± 0.071	0.488PheTrp: 0.488 ± 0.026	2.086PheTyr: 2.086 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	6.596GlyAla: 6.596 ± 0.116	1.39GlyCys: 1.39 ± 0.048	4.116GlyAsp: 4.116 ± 0.077	5.953GlyGlu: 5.953 ± 0.098	3.359GlyPhe: 3.359 ± 0.063	6.265GlyGly: 6.265 ± 0.145	0.983GlyHis: 0.983 ± 0.036	4.937GlyIle: 4.937 ± 0.078	6.041GlyLys: 6.041 ± 0.085	5.656GlyLeu: 5.656 ± 0.086	2.071GlyMet: 2.071 ± 0.049	3.263GlyAsn: 3.263 ± 0.08	1.091GlyPro: 1.091 ± 0.042	1.76GlyGln: 1.76 ± 0.042	3.244GlyArg: 3.244 ± 0.066	3.846GlySer: 3.846 ± 0.087	3.993GlyThr: 3.993 ± 0.073	5.937GlyVal: 5.937 ± 0.076	0.889GlyTrp: 0.889 ± 0.034	3.418GlyTyr: 3.418 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.156HisAla: 1.156 ± 0.04	0.274HisCys: 0.274 ± 0.018	0.682HisAsp: 0.682 ± 0.029	0.809HisGlu: 0.809 ± 0.032	0.787HisPhe: 0.787 ± 0.035	1.123HisGly: 1.123 ± 0.038	0.201HisHis: 0.201 ± 0.015	1.03HisIle: 1.03 ± 0.038	0.749HisLys: 0.749 ± 0.032	1.148HisLeu: 1.148 ± 0.043	0.344HisMet: 0.344 ± 0.02	0.569HisAsn: 0.569 ± 0.031	0.691HisPro: 0.691 ± 0.03	0.283HisGln: 0.283 ± 0.017	0.663HisArg: 0.663 ± 0.03	0.861HisSer: 0.861 ± 0.036	0.794HisThr: 0.794 ± 0.033	0.89HisVal: 0.89 ± 0.032	0.136HisTrp: 0.136 ± 0.013	0.656HisTyr: 0.656 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.962IleAla: 5.962 ± 0.099	1.088IleCys: 1.088 ± 0.038	3.609IleAsp: 3.609 ± 0.074	4.152IleGlu: 4.152 ± 0.082	2.909IlePhe: 2.909 ± 0.065	4.493IleGly: 4.493 ± 0.101	0.812IleHis: 0.812 ± 0.033	3.385IleIle: 3.385 ± 0.087	3.094IleLys: 3.094 ± 0.069	6.185IleLeu: 6.185 ± 0.096	1.44IleMet: 1.44 ± 0.041	2.25IleAsn: 2.25 ± 0.055	2.618IlePro: 2.618 ± 0.056	1.407IleGln: 1.407 ± 0.043	3.228IleArg: 3.228 ± 0.078	4.364IleSer: 4.364 ± 0.086	3.346IleThr: 3.346 ± 0.081	5.115IleVal: 5.115 ± 0.097	0.458IleTrp: 0.458 ± 0.024	2.338IleTyr: 2.338 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.668LysAla: 4.668 ± 0.092	0.77LysCys: 0.77 ± 0.037	3.745LysAsp: 3.745 ± 0.083	4.936LysGlu: 4.936 ± 0.088	2.476LysPhe: 2.476 ± 0.046	4.101LysGly: 4.101 ± 0.068	0.903LysHis: 0.903 ± 0.032	5.312LysIle: 5.312 ± 0.086	5.743LysLys: 5.743 ± 0.112	5.44LysLeu: 5.44 ± 0.091	1.925LysMet: 1.925 ± 0.049	3.91LysAsn: 3.91 ± 0.079	1.896LysPro: 1.896 ± 0.046	1.937LysGln: 1.937 ± 0.051	3.101LysArg: 3.101 ± 0.071	3.603LysSer: 3.603 ± 0.063	4.037LysThr: 4.037 ± 0.073	3.902LysVal: 3.902 ± 0.075	0.462LysTrp: 0.462 ± 0.024	2.957LysTyr: 2.957 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	7.583LeuAla: 7.583 ± 0.11	1.907LeuCys: 1.907 ± 0.05	4.712LeuAsp: 4.712 ± 0.074	5.121LeuGlu: 5.121 ± 0.104	4.658LeuPhe: 4.658 ± 0.087	5.796LeuGly: 5.796 ± 0.08	1.351LeuHis: 1.351 ± 0.036	5.145LeuIle: 5.145 ± 0.098	6.21LeuLys: 6.21 ± 0.093	7.994LeuLeu: 7.994 ± 0.125	2.129LeuMet: 2.129 ± 0.056	3.906LeuAsn: 3.906 ± 0.078	3.682LeuPro: 3.682 ± 0.07	2.572LeuGln: 2.572 ± 0.057	4.3LeuArg: 4.3 ± 0.092	7.123LeuSer: 7.123 ± 0.098	5.117LeuThr: 5.117 ± 0.095	5.665LeuVal: 5.665 ± 0.108	0.791LeuTrp: 0.791 ± 0.031	3.777LeuTyr: 3.777 ± 0.093	0.0LeuXaa: 0.0 ± 0.0
Met	1.72MetAla: 1.72 ± 0.055	0.332MetCys: 0.332 ± 0.02	1.274MetAsp: 1.274 ± 0.042	1.528MetGlu: 1.528 ± 0.045	1.054MetPhe: 1.054 ± 0.038	1.582MetGly: 1.582 ± 0.046	0.41MetHis: 0.41 ± 0.025	1.631MetIle: 1.631 ± 0.048	2.041MetLys: 2.041 ± 0.047	2.402MetLeu: 2.402 ± 0.054	0.665MetMet: 0.665 ± 0.031	1.304MetAsn: 1.304 ± 0.037	1.1MetPro: 1.1 ± 0.032	1.052MetGln: 1.052 ± 0.038	1.561MetArg: 1.561 ± 0.043	1.514MetSer: 1.514 ± 0.053	1.451MetThr: 1.451 ± 0.038	1.381MetVal: 1.381 ± 0.045	0.189MetTrp: 0.189 ± 0.017	0.818MetTyr: 0.818 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.015AsnAla: 4.015 ± 0.083	0.728AsnCys: 0.728 ± 0.037	2.339AsnAsp: 2.339 ± 0.053	2.778AsnGlu: 2.778 ± 0.063	2.149AsnPhe: 2.149 ± 0.059	4.004AsnGly: 4.004 ± 0.083	0.545AsnHis: 0.545 ± 0.026	3.043AsnIle: 3.043 ± 0.069	2.403AsnLys: 2.403 ± 0.059	3.733AsnLeu: 3.733 ± 0.069	1.127AsnMet: 1.127 ± 0.038	1.767AsnAsn: 1.767 ± 0.052	1.667AsnPro: 1.667 ± 0.046	0.978AsnGln: 0.978 ± 0.036	1.812AsnArg: 1.812 ± 0.052	2.315AsnSer: 2.315 ± 0.061	2.253AsnThr: 2.253 ± 0.054	3.345AsnVal: 3.345 ± 0.078	0.47AsnTrp: 0.47 ± 0.023	2.073AsnTyr: 2.073 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	3.281ProAla: 3.281 ± 0.071	0.519ProCys: 0.519 ± 0.028	2.404ProAsp: 2.404 ± 0.063	2.884ProGlu: 2.884 ± 0.057	1.707ProPhe: 1.707 ± 0.05	1.433ProGly: 1.433 ± 0.044	0.559ProHis: 0.559 ± 0.026	1.531ProIle: 1.531 ± 0.054	1.716ProLys: 1.716 ± 0.043	3.069ProLeu: 3.069 ± 0.066	0.783ProMet: 0.783 ± 0.034	1.214ProAsn: 1.214 ± 0.038	1.013ProPro: 1.013 ± 0.039	1.11ProGln: 1.11 ± 0.039	1.235ProArg: 1.235 ± 0.038	2.019ProSer: 2.019 ± 0.046	1.533ProThr: 1.533 ± 0.053	3.08ProVal: 3.08 ± 0.071	0.297ProTrp: 0.297 ± 0.022	1.488ProTyr: 1.488 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.127GlnAla: 2.127 ± 0.051	0.286GlnCys: 0.286 ± 0.022	1.201GlnAsp: 1.201 ± 0.042	1.621GlnGlu: 1.621 ± 0.041	1.104GlnPhe: 1.104 ± 0.04	1.794GlnGly: 1.794 ± 0.049	0.32GlnHis: 0.32 ± 0.02	2.031GlnIle: 2.031 ± 0.053	2.456GlnLys: 2.456 ± 0.062	2.015GlnLeu: 2.015 ± 0.051	0.728GlnMet: 0.728 ± 0.025	1.555GlnAsn: 1.555 ± 0.045	0.921GlnPro: 0.921 ± 0.04	0.695GlnGln: 0.695 ± 0.036	1.147GlnArg: 1.147 ± 0.039	1.633GlnSer: 1.633 ± 0.05	1.531GlnThr: 1.531 ± 0.039	1.404GlnVal: 1.404 ± 0.045	0.296GlnTrp: 0.296 ± 0.022	1.21GlnTyr: 1.21 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.473ArgAla: 4.473 ± 0.098	0.7ArgCys: 0.7 ± 0.034	2.509ArgAsp: 2.509 ± 0.062	3.963ArgGlu: 3.963 ± 0.079	2.257ArgPhe: 2.257 ± 0.059	3.344ArgGly: 3.344 ± 0.074	0.704ArgHis: 0.704 ± 0.032	3.063ArgIle: 3.063 ± 0.065	3.214ArgLys: 3.214 ± 0.074	4.458ArgLeu: 4.458 ± 0.091	1.225ArgMet: 1.225 ± 0.038	1.893ArgAsn: 1.893 ± 0.045	1.386ArgPro: 1.386 ± 0.049	1.312ArgGln: 1.312 ± 0.039	2.583ArgArg: 2.583 ± 0.073	2.407ArgSer: 2.407 ± 0.056	2.25ArgThr: 2.25 ± 0.052	3.218ArgVal: 3.218 ± 0.071	0.384ArgTrp: 0.384 ± 0.024	2.116ArgTyr: 2.116 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	5.868SerAla: 5.868 ± 0.089	0.856SerCys: 0.856 ± 0.036	4.05SerAsp: 4.05 ± 0.084	4.523SerGlu: 4.523 ± 0.079	3.07SerPhe: 3.07 ± 0.073	5.208SerGly: 5.208 ± 0.097	0.778SerHis: 0.778 ± 0.033	3.199SerIle: 3.199 ± 0.073	3.184SerLys: 3.184 ± 0.063	5.542SerLeu: 5.542 ± 0.097	1.389SerMet: 1.389 ± 0.042	1.997SerAsn: 1.997 ± 0.058	1.947SerPro: 1.947 ± 0.055	1.454SerGln: 1.454 ± 0.043	2.583SerArg: 2.583 ± 0.058	3.408SerSer: 3.408 ± 0.091	2.555SerThr: 2.555 ± 0.056	5.354SerVal: 5.354 ± 0.087	0.507SerTrp: 0.507 ± 0.026	2.533SerTyr: 2.533 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	5.081ThrAla: 5.081 ± 0.096	0.671ThrCys: 0.671 ± 0.033	3.66ThrAsp: 3.66 ± 0.078	3.686ThrGlu: 3.686 ± 0.069	2.597ThrPhe: 2.597 ± 0.066	4.27ThrGly: 4.27 ± 0.098	0.759ThrHis: 0.759 ± 0.032	2.99ThrIle: 2.99 ± 0.075	2.484ThrLys: 2.484 ± 0.062	5.369ThrLeu: 5.369 ± 0.09	1.193ThrMet: 1.193 ± 0.046	1.92ThrAsn: 1.92 ± 0.055	2.063ThrPro: 2.063 ± 0.059	1.305ThrGln: 1.305 ± 0.045	1.956ThrArg: 1.956 ± 0.054	2.777ThrSer: 2.777 ± 0.067	2.321ThrThr: 2.321 ± 0.057	5.047ThrVal: 5.047 ± 0.092	0.425ThrTrp: 0.425 ± 0.027	2.224ThrTyr: 2.224 ± 0.069	0.0ThrXaa: 0.0 ± 0.0
Val	5.599ValAla: 5.599 ± 0.106	1.518ValCys: 1.518 ± 0.045	3.481ValAsp: 3.481 ± 0.073	4.142ValGlu: 4.142 ± 0.069	3.76ValPhe: 3.76 ± 0.072	4.738ValGly: 4.738 ± 0.08	1.007ValHis: 1.007 ± 0.039	4.12ValIle: 4.12 ± 0.079	4.599ValLys: 4.599 ± 0.086	7.052ValLeu: 7.052 ± 0.112	1.686ValMet: 1.686 ± 0.054	3.247ValAsn: 3.247 ± 0.074	2.671ValPro: 2.671 ± 0.062	1.854ValGln: 1.854 ± 0.05	3.935ValArg: 3.935 ± 0.087	5.367ValSer: 5.367 ± 0.09	4.43ValThr: 4.43 ± 0.113	4.915ValVal: 4.915 ± 0.104	0.677ValTrp: 0.677 ± 0.028	3.258ValTyr: 3.258 ± 0.073	0.0ValXaa: 0.0 ± 0.0
Trp	0.606TrpAla: 0.606 ± 0.03	0.157TrpCys: 0.157 ± 0.014	0.501TrpAsp: 0.501 ± 0.024	0.578TrpGlu: 0.578 ± 0.028	0.491TrpPhe: 0.491 ± 0.024	0.711TrpGly: 0.711 ± 0.029	0.189TrpHis: 0.189 ± 0.017	0.522TrpIle: 0.522 ± 0.026	0.597TrpLys: 0.597 ± 0.028	0.838TrpLeu: 0.838 ± 0.036	0.262TrpMet: 0.262 ± 0.02	0.532TrpAsn: 0.532 ± 0.025	0.206TrpPro: 0.206 ± 0.016	0.397TrpGln: 0.397 ± 0.023	0.366TrpArg: 0.366 ± 0.02	0.514TrpSer: 0.514 ± 0.025	0.535TrpThr: 0.535 ± 0.026	0.486TrpVal: 0.486 ± 0.028	0.137TrpTrp: 0.137 ± 0.012	0.447TrpTyr: 0.447 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.814TyrAla: 3.814 ± 0.082	0.687TyrCys: 0.687 ± 0.031	2.859TyrAsp: 2.859 ± 0.07	2.814TyrGlu: 2.814 ± 0.07	2.289TyrPhe: 2.289 ± 0.063	3.274TyrGly: 3.274 ± 0.074	0.587TyrHis: 0.587 ± 0.024	2.554TyrIle: 2.554 ± 0.056	2.37TyrLys: 2.37 ± 0.058	3.809TyrLeu: 3.809 ± 0.074	0.924TyrMet: 0.924 ± 0.03	1.96TyrAsn: 1.96 ± 0.045	1.547TyrPro: 1.547 ± 0.043	1.052TyrGln: 1.052 ± 0.033	2.287TyrArg: 2.287 ± 0.062	2.751TyrSer: 2.751 ± 0.064	2.563TyrThr: 2.563 ± 0.076	2.769TyrVal: 2.769 ± 0.058	0.365TyrTrp: 0.365 ± 0.027	2.047TyrTyr: 2.047 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2214 proteins (794369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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