Amino acid dipepetide frequency for Tobacco leaf curl Cuba virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.206AlaAla: 2.206 ± 1.022
0.735AlaCys: 0.735 ± 0.628
1.471AlaAsp: 1.471 ± 0.738
1.471AlaGlu: 1.471 ± 0.956
0.735AlaPhe: 0.735 ± 0.683
2.206AlaGly: 2.206 ± 1.264
3.676AlaHis: 3.676 ± 1.466
2.206AlaIle: 2.206 ± 1.018
6.618AlaLys: 6.618 ± 1.804
5.147AlaLeu: 5.147 ± 2.012
0.0AlaMet: 0.0 ± 0.0
2.941AlaAsn: 2.941 ± 1.398
2.941AlaPro: 2.941 ± 0.883
1.471AlaGln: 1.471 ± 0.702
4.412AlaArg: 4.412 ± 1.499
11.029AlaSer: 11.029 ± 4.439
2.941AlaThr: 2.941 ± 1.31
2.206AlaVal: 2.206 ± 1.036
0.0AlaTrp: 0.0 ± 0.0
0.735AlaTyr: 0.735 ± 0.736
0.0AlaXaa: 0.0 ± 0.0
Cys
0.735CysAla: 0.735 ± 0.683
0.0CysCys: 0.0 ± 0.0
0.735CysAsp: 0.735 ± 0.683
0.735CysGlu: 0.735 ± 0.628
0.0CysPhe: 0.0 ± 0.0
0.735CysGly: 0.735 ± 0.706
0.0CysHis: 0.0 ± 0.0
1.471CysIle: 1.471 ± 0.799
2.206CysLys: 2.206 ± 1.287
1.471CysLeu: 1.471 ± 0.942
0.735CysMet: 0.735 ± 0.683
0.735CysAsn: 0.735 ± 0.683
0.0CysPro: 0.0 ± 0.0
1.471CysGln: 1.471 ± 0.738
0.735CysArg: 0.735 ± 0.602
1.471CysSer: 1.471 ± 0.838
2.941CysThr: 2.941 ± 1.453
1.471CysVal: 1.471 ± 0.799
1.471CysTrp: 1.471 ± 1.302
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.471AspAla: 1.471 ± 0.799
0.735AspCys: 0.735 ± 0.706
1.471AspAsp: 1.471 ± 1.412
3.676AspGlu: 3.676 ± 0.967
2.206AspPhe: 2.206 ± 0.67
3.676AspGly: 3.676 ± 2.172
0.735AspHis: 0.735 ± 0.683
3.676AspIle: 3.676 ± 1.684
2.206AspLys: 2.206 ± 1.289
7.353AspLeu: 7.353 ± 1.325
0.0AspMet: 0.0 ± 0.0
2.206AspAsn: 2.206 ± 0.67
1.471AspPro: 1.471 ± 1.366
1.471AspGln: 1.471 ± 0.956
5.147AspArg: 5.147 ± 1.934
4.412AspSer: 4.412 ± 1.116
4.412AspThr: 4.412 ± 1.437
2.941AspVal: 2.941 ± 0.562
0.735AspTrp: 0.735 ± 0.602
1.471AspTyr: 1.471 ± 0.702
0.0AspXaa: 0.0 ± 0.0
Glu
2.941GluAla: 2.941 ± 1.398
0.735GluCys: 0.735 ± 0.683
1.471GluAsp: 1.471 ± 0.956
5.147GluGlu: 5.147 ± 2.821
0.0GluPhe: 0.0 ± 0.0
2.941GluGly: 2.941 ± 1.33
0.0GluHis: 0.0 ± 0.0
3.676GluIle: 3.676 ± 2.11
0.735GluLys: 0.735 ± 0.651
5.147GluLeu: 5.147 ± 1.141
1.471GluMet: 1.471 ± 0.738
5.882GluAsn: 5.882 ± 2.237
2.206GluPro: 2.206 ± 0.868
2.206GluGln: 2.206 ± 1.262
1.471GluArg: 1.471 ± 0.702
4.412GluSer: 4.412 ± 2.604
0.0GluThr: 0.0 ± 0.0
0.735GluVal: 0.735 ± 0.732
2.206GluTrp: 2.206 ± 0.922
2.206GluTyr: 2.206 ± 1.289
0.0GluXaa: 0.0 ± 0.0
Phe
1.471PheAla: 1.471 ± 0.979
0.735PheCys: 0.735 ± 0.628
2.941PheAsp: 2.941 ± 1.33
0.735PheGlu: 0.735 ± 0.602
2.206PhePhe: 2.206 ± 1.161
2.206PheGly: 2.206 ± 0.868
1.471PheHis: 1.471 ± 0.838
2.206PheIle: 2.206 ± 1.407
3.676PheLys: 3.676 ± 1.559
1.471PheLeu: 1.471 ± 1.204
0.0PheMet: 0.0 ± 0.0
2.941PheAsn: 2.941 ± 0.709
0.735PhePro: 0.735 ± 0.683
3.676PheGln: 3.676 ± 1.926
0.735PheArg: 0.735 ± 0.683
5.147PheSer: 5.147 ± 2.068
3.676PheThr: 3.676 ± 0.871
1.471PheVal: 1.471 ± 1.302
2.206PheTrp: 2.206 ± 1.387
1.471PheTyr: 1.471 ± 1.255
0.0PheXaa: 0.0 ± 0.0
Gly
2.941GlyAla: 2.941 ± 1.118
2.941GlyCys: 2.941 ± 1.014
1.471GlyAsp: 1.471 ± 0.838
3.676GlyGlu: 3.676 ± 1.544
1.471GlyPhe: 1.471 ± 0.966
2.206GlyGly: 2.206 ± 0.922
0.735GlyHis: 0.735 ± 0.706
1.471GlyIle: 1.471 ± 1.255
7.353GlyLys: 7.353 ± 2.13
1.471GlyLeu: 1.471 ± 0.702
0.735GlyMet: 0.735 ± 0.609
1.471GlyAsn: 1.471 ± 0.776
3.676GlyPro: 3.676 ± 1.279
2.941GlyGln: 2.941 ± 1.329
1.471GlyArg: 1.471 ± 1.204
6.618GlySer: 6.618 ± 1.874
5.147GlyThr: 5.147 ± 1.708
2.941GlyVal: 2.941 ± 1.69
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.735HisAla: 0.735 ± 0.628
1.471HisCys: 1.471 ± 0.858
2.206HisAsp: 2.206 ± 1.348
0.735HisGlu: 0.735 ± 0.651
2.206HisPhe: 2.206 ± 1.161
1.471HisGly: 1.471 ± 0.966
1.471HisHis: 1.471 ± 0.838
2.206HisIle: 2.206 ± 1.233
0.735HisLys: 0.735 ± 0.736
3.676HisLeu: 3.676 ± 1.651
0.735HisMet: 0.735 ± 0.732
2.206HisAsn: 2.206 ± 1.024
2.941HisPro: 2.941 ± 1.329
3.676HisGln: 3.676 ± 0.865
4.412HisArg: 4.412 ± 1.501
2.206HisSer: 2.206 ± 0.857
1.471HisThr: 1.471 ± 1.255
3.676HisVal: 3.676 ± 0.967
0.0HisTrp: 0.0 ± 0.0
0.735HisTyr: 0.735 ± 0.683
0.0HisXaa: 0.0 ± 0.0
Ile
1.471IleAla: 1.471 ± 0.838
0.735IleCys: 0.735 ± 0.602
5.147IleAsp: 5.147 ± 2.084
3.676IleGlu: 3.676 ± 1.89
1.471IlePhe: 1.471 ± 0.838
1.471IleGly: 1.471 ± 0.799
3.676IleHis: 3.676 ± 1.386
1.471IleIle: 1.471 ± 0.738
4.412IleLys: 4.412 ± 1.312
2.206IleLeu: 2.206 ± 1.348
0.735IleMet: 0.735 ± 0.628
2.206IleAsn: 2.206 ± 1.52
2.941IlePro: 2.941 ± 1.109
2.941IleGln: 2.941 ± 1.43
5.882IleArg: 5.882 ± 1.911
5.882IleSer: 5.882 ± 2.22
2.941IleThr: 2.941 ± 1.086
2.206IleVal: 2.206 ± 1.348
2.206IleTrp: 2.206 ± 1.099
3.676IleTyr: 3.676 ± 1.743
0.0IleXaa: 0.0 ± 0.0
Lys
2.206LysAla: 2.206 ± 1.419
0.0LysCys: 0.0 ± 0.0
4.412LysAsp: 4.412 ± 1.723
1.471LysGlu: 1.471 ± 1.204
2.941LysPhe: 2.941 ± 1.365
2.941LysGly: 2.941 ± 1.169
0.735LysHis: 0.735 ± 0.683
6.618LysIle: 6.618 ± 1.16
2.206LysLys: 2.206 ± 1.339
4.412LysLeu: 4.412 ± 1.497
1.471LysMet: 1.471 ± 0.656
2.941LysAsn: 2.941 ± 1.244
2.941LysPro: 2.941 ± 0.562
2.941LysGln: 2.941 ± 1.238
5.882LysArg: 5.882 ± 2.286
4.412LysSer: 4.412 ± 1.389
0.735LysThr: 0.735 ± 0.651
4.412LysVal: 4.412 ± 3.032
0.735LysTrp: 0.735 ± 0.683
1.471LysTyr: 1.471 ± 0.764
0.0LysXaa: 0.0 ± 0.0
Leu
0.0LeuAla: 0.0 ± 0.0
0.0LeuCys: 0.0 ± 0.0
3.676LeuAsp: 3.676 ± 1.225
2.206LeuGlu: 2.206 ± 1.201
1.471LeuPhe: 1.471 ± 0.966
5.147LeuGly: 5.147 ± 1.049
4.412LeuHis: 4.412 ± 2.049
2.206LeuIle: 2.206 ± 1.201
5.882LeuLys: 5.882 ± 1.406
2.941LeuLeu: 2.941 ± 1.217
1.471LeuMet: 1.471 ± 0.942
6.618LeuAsn: 6.618 ± 1.739
2.206LeuPro: 2.206 ± 1.562
3.676LeuGln: 3.676 ± 1.315
5.882LeuArg: 5.882 ± 1.338
5.147LeuSer: 5.147 ± 2.323
3.676LeuThr: 3.676 ± 1.502
6.618LeuVal: 6.618 ± 1.392
0.0LeuTrp: 0.0 ± 0.0
3.676LeuTyr: 3.676 ± 1.601
0.0LeuXaa: 0.0 ± 0.0
Met
2.206MetAla: 2.206 ± 1.252
0.735MetCys: 0.735 ± 0.628
3.676MetAsp: 3.676 ± 1.029
0.735MetGlu: 0.735 ± 0.683
1.471MetPhe: 1.471 ± 1.255
1.471MetGly: 1.471 ± 0.882
0.735MetHis: 0.735 ± 0.628
0.0MetIle: 0.0 ± 0.0
0.735MetLys: 0.735 ± 0.683
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.471MetAsn: 1.471 ± 1.255
2.206MetPro: 2.206 ± 1.022
0.735MetGln: 0.735 ± 0.602
0.735MetArg: 0.735 ± 0.706
3.676MetSer: 3.676 ± 1.815
2.206MetThr: 2.206 ± 1.126
0.735MetVal: 0.735 ± 0.651
0.0MetTrp: 0.0 ± 0.0
2.206MetTyr: 2.206 ± 0.839
0.0MetXaa: 0.0 ± 0.0
Asn
5.882AsnAla: 5.882 ± 1.47
2.206AsnCys: 2.206 ± 0.729
2.206AsnAsp: 2.206 ± 0.868
3.676AsnGlu: 3.676 ± 2.108
0.735AsnPhe: 0.735 ± 0.736
2.206AsnGly: 2.206 ± 1.099
3.676AsnHis: 3.676 ± 2.14
3.676AsnIle: 3.676 ± 0.901
3.676AsnLys: 3.676 ± 2.105
2.941AsnLeu: 2.941 ± 1.118
2.206AsnMet: 2.206 ± 1.132
2.206AsnAsn: 2.206 ± 0.974
2.206AsnPro: 2.206 ± 0.971
1.471AsnGln: 1.471 ± 0.942
3.676AsnArg: 3.676 ± 0.943
2.206AsnSer: 2.206 ± 0.937
3.676AsnThr: 3.676 ± 2.091
2.941AsnVal: 2.941 ± 0.886
0.0AsnTrp: 0.0 ± 0.0
3.676AsnTyr: 3.676 ± 1.208
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.735ProCys: 0.735 ± 0.628
2.206ProAsp: 2.206 ± 1.018
3.676ProGlu: 3.676 ± 2.075
1.471ProPhe: 1.471 ± 0.738
2.206ProGly: 2.206 ± 1.222
2.941ProHis: 2.941 ± 1.286
4.412ProIle: 4.412 ± 3.319
2.206ProLys: 2.206 ± 1.287
2.206ProLeu: 2.206 ± 1.317
2.206ProMet: 2.206 ± 1.883
2.206ProAsn: 2.206 ± 0.729
2.206ProPro: 2.206 ± 0.81
2.941ProGln: 2.941 ± 1.676
5.147ProArg: 5.147 ± 2.382
5.882ProSer: 5.882 ± 2.025
2.206ProThr: 2.206 ± 1.469
1.471ProVal: 1.471 ± 0.764
2.206ProTrp: 2.206 ± 0.738
1.471ProTyr: 1.471 ± 0.799
0.0ProXaa: 0.0 ± 0.0
Gln
5.147GlnAla: 5.147 ± 1.899
0.735GlnCys: 0.735 ± 0.602
2.941GlnAsp: 2.941 ± 1.409
1.471GlnGlu: 1.471 ± 0.799
2.206GlnPhe: 2.206 ± 1.289
0.735GlnGly: 0.735 ± 0.602
2.206GlnHis: 2.206 ± 1.405
2.206GlnIle: 2.206 ± 1.419
0.735GlnLys: 0.735 ± 0.602
6.618GlnLeu: 6.618 ± 2.252
0.735GlnMet: 0.735 ± 0.589
0.735GlnAsn: 0.735 ± 0.706
2.206GlnPro: 2.206 ± 1.428
0.735GlnGln: 0.735 ± 0.683
2.941GlnArg: 2.941 ± 1.109
3.676GlnSer: 3.676 ± 1.883
0.735GlnThr: 0.735 ± 0.602
2.941GlnVal: 2.941 ± 1.31
0.0GlnTrp: 0.0 ± 0.0
1.471GlnTyr: 1.471 ± 0.776
0.0GlnXaa: 0.0 ± 0.0
Arg
6.618ArgAla: 6.618 ± 1.426
2.206ArgCys: 2.206 ± 1.381
3.676ArgAsp: 3.676 ± 1.651
1.471ArgGlu: 1.471 ± 0.945
6.618ArgPhe: 6.618 ± 2.327
5.882ArgGly: 5.882 ± 1.39
2.206ArgHis: 2.206 ± 0.67
5.147ArgIle: 5.147 ± 1.703
3.676ArgLys: 3.676 ± 0.603
2.941ArgLeu: 2.941 ± 2.015
2.206ArgMet: 2.206 ± 0.935
2.206ArgAsn: 2.206 ± 1.287
4.412ArgPro: 4.412 ± 1.499
1.471ArgGln: 1.471 ± 0.858
8.088ArgArg: 8.088 ± 3.314
5.882ArgSer: 5.882 ± 1.299
5.882ArgThr: 5.882 ± 2.173
5.147ArgVal: 5.147 ± 1.309
0.0ArgTrp: 0.0 ± 0.0
2.206ArgTyr: 2.206 ± 1.287
0.0ArgXaa: 0.0 ± 0.0
Ser
6.618SerAla: 6.618 ± 2.147
1.471SerCys: 1.471 ± 0.702
3.676SerAsp: 3.676 ± 0.967
1.471SerGlu: 1.471 ± 0.799
3.676SerPhe: 3.676 ± 1.224
2.206SerGly: 2.206 ± 1.036
4.412SerHis: 4.412 ± 1.64
6.618SerIle: 6.618 ± 2.156
2.941SerLys: 2.941 ± 1.052
5.882SerLeu: 5.882 ± 1.791
2.941SerMet: 2.941 ± 1.471
3.676SerAsn: 3.676 ± 1.323
5.147SerPro: 5.147 ± 2.635
2.941SerGln: 2.941 ± 1.926
7.353SerArg: 7.353 ± 1.488
7.353SerSer: 7.353 ± 3.847
10.294SerThr: 10.294 ± 3.595
5.147SerVal: 5.147 ± 1.598
1.471SerTrp: 1.471 ± 1.366
4.412SerTyr: 4.412 ± 1.801
0.0SerXaa: 0.0 ± 0.0
Thr
7.353ThrAla: 7.353 ± 1.754
0.735ThrCys: 0.735 ± 0.732
2.941ThrAsp: 2.941 ± 1.547
2.941ThrGlu: 2.941 ± 1.48
2.941ThrPhe: 2.941 ± 2.604
3.676ThrGly: 3.676 ± 1.375
4.412ThrHis: 4.412 ± 1.789
0.735ThrIle: 0.735 ± 0.683
0.735ThrLys: 0.735 ± 0.602
3.676ThrLeu: 3.676 ± 1.532
1.471ThrMet: 1.471 ± 0.702
5.147ThrAsn: 5.147 ± 1.662
2.941ThrPro: 2.941 ± 1.244
0.0ThrGln: 0.0 ± 0.0
2.941ThrArg: 2.941 ± 1.625
5.882ThrSer: 5.882 ± 1.558
2.941ThrThr: 2.941 ± 1.163
4.412ThrVal: 4.412 ± 1.64
0.0ThrTrp: 0.0 ± 0.0
4.412ThrTyr: 4.412 ± 1.938
0.0ThrXaa: 0.0 ± 0.0
Val
1.471ValAla: 1.471 ± 0.838
1.471ValCys: 1.471 ± 0.702
3.676ValAsp: 3.676 ± 1.873
3.676ValGlu: 3.676 ± 1.682
2.206ValPhe: 2.206 ± 1.287
3.676ValGly: 3.676 ± 1.279
0.735ValHis: 0.735 ± 0.683
2.941ValIle: 2.941 ± 1.959
3.676ValLys: 3.676 ± 0.943
2.941ValLeu: 2.941 ± 1.163
2.941ValMet: 2.941 ± 1.823
5.882ValAsn: 5.882 ± 1.182
2.941ValPro: 2.941 ± 1.141
2.941ValGln: 2.941 ± 0.809
4.412ValArg: 4.412 ± 1.654
2.206ValSer: 2.206 ± 0.868
2.206ValThr: 2.206 ± 1.252
2.941ValVal: 2.941 ± 1.887
0.735ValTrp: 0.735 ± 0.736
5.882ValTyr: 5.882 ± 1.993
0.0ValXaa: 0.0 ± 0.0
Trp
1.471TrpAla: 1.471 ± 0.738
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.471TrpGlu: 1.471 ± 0.979
0.0TrpPhe: 0.0 ± 0.0
0.735TrpGly: 0.735 ± 0.602
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.471TrpLys: 1.471 ± 0.799
0.735TrpLeu: 0.735 ± 0.628
1.471TrpMet: 1.471 ± 0.776
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.471TrpArg: 1.471 ± 0.904
1.471TrpSer: 1.471 ± 0.942
1.471TrpThr: 1.471 ± 0.979
2.206TrpVal: 2.206 ± 0.922
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.206TyrAla: 2.206 ± 1.262
0.735TyrCys: 0.735 ± 0.651
1.471TyrAsp: 1.471 ± 0.776
1.471TyrGlu: 1.471 ± 1.255
5.147TyrPhe: 5.147 ± 0.85
2.941TyrGly: 2.941 ± 1.092
0.735TyrHis: 0.735 ± 0.736
4.412TyrIle: 4.412 ± 0.865
0.0TyrLys: 0.0 ± 0.0
3.676TyrLeu: 3.676 ± 2.926
1.471TyrMet: 1.471 ± 0.833
2.206TyrAsn: 2.206 ± 1.022
3.676TyrPro: 3.676 ± 1.746
1.471TyrGln: 1.471 ± 0.799
5.147TyrArg: 5.147 ± 2.044
0.735TyrSer: 0.735 ± 0.628
0.735TyrThr: 0.735 ± 0.736
2.941TyrVal: 2.941 ± 1.374
0.0TyrTrp: 0.0 ± 0.0
2.941TyrTyr: 2.941 ± 1.757
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski