Amino acid dipepetide frequency for Archaeal BJ1 virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.11AlaAla: 8.11 ± 0.978
0.365AlaCys: 0.365 ± 0.164
10.302AlaAsp: 10.302 ± 0.76
8.037AlaGlu: 8.037 ± 0.717
2.411AlaPhe: 2.411 ± 0.462
7.745AlaGly: 7.745 ± 0.803
1.534AlaHis: 1.534 ± 0.32
4.676AlaIle: 4.676 ± 0.623
2.338AlaLys: 2.338 ± 0.511
7.891AlaLeu: 7.891 ± 0.77
2.996AlaMet: 2.996 ± 0.507
2.557AlaAsn: 2.557 ± 0.508
2.777AlaPro: 2.777 ± 0.504
2.996AlaGln: 2.996 ± 0.429
6.138AlaArg: 6.138 ± 0.875
6.284AlaSer: 6.284 ± 0.704
6.868AlaThr: 6.868 ± 0.616
7.599AlaVal: 7.599 ± 0.831
1.607AlaTrp: 1.607 ± 0.347
2.703AlaTyr: 2.703 ± 0.498
0.0AlaXaa: 0.0 ± 0.0
Cys
0.365CysAla: 0.365 ± 0.176
0.0CysCys: 0.0 ± 0.0
0.804CysAsp: 0.804 ± 0.273
0.365CysGlu: 0.365 ± 0.151
0.073CysPhe: 0.073 ± 0.067
0.95CysGly: 0.95 ± 0.272
0.365CysHis: 0.365 ± 0.162
0.219CysIle: 0.219 ± 0.119
0.219CysLys: 0.219 ± 0.118
0.511CysLeu: 0.511 ± 0.239
0.0CysMet: 0.0 ± 0.0
0.073CysAsn: 0.073 ± 0.085
0.877CysPro: 0.877 ± 0.283
0.438CysGln: 0.438 ± 0.175
0.365CysArg: 0.365 ± 0.159
0.292CysSer: 0.292 ± 0.127
0.365CysThr: 0.365 ± 0.19
0.438CysVal: 0.438 ± 0.175
0.219CysTrp: 0.219 ± 0.128
0.438CysTyr: 0.438 ± 0.201
0.0CysXaa: 0.0 ± 0.0
Asp
11.618AspAla: 11.618 ± 0.898
0.365AspCys: 0.365 ± 0.15
10.449AspAsp: 10.449 ± 1.108
10.156AspGlu: 10.156 ± 0.899
2.046AspPhe: 2.046 ± 0.395
10.01AspGly: 10.01 ± 1.067
2.338AspHis: 2.338 ± 0.347
3.873AspIle: 3.873 ± 0.483
1.973AspLys: 1.973 ± 0.438
7.672AspLeu: 7.672 ± 0.836
1.169AspMet: 1.169 ± 0.323
1.681AspAsn: 1.681 ± 0.27
5.115AspPro: 5.115 ± 0.504
2.996AspGln: 2.996 ± 0.475
5.699AspArg: 5.699 ± 0.662
4.238AspSer: 4.238 ± 0.615
5.626AspThr: 5.626 ± 0.613
8.987AspVal: 8.987 ± 0.675
1.096AspTrp: 1.096 ± 0.236
2.777AspTyr: 2.777 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
7.307GluAla: 7.307 ± 0.846
0.804GluCys: 0.804 ± 0.283
5.334GluAsp: 5.334 ± 0.51
6.211GluGlu: 6.211 ± 0.774
2.703GluPhe: 2.703 ± 0.464
6.357GluGly: 6.357 ± 0.563
2.411GluHis: 2.411 ± 0.367
3.434GluIle: 3.434 ± 0.569
1.607GluLys: 1.607 ± 0.322
9.718GluLeu: 9.718 ± 0.757
1.827GluMet: 1.827 ± 0.351
2.557GluAsn: 2.557 ± 0.316
5.334GluPro: 5.334 ± 0.59
3.507GluGln: 3.507 ± 0.479
7.234GluArg: 7.234 ± 0.721
5.48GluSer: 5.48 ± 0.464
7.453GluThr: 7.453 ± 0.836
8.037GluVal: 8.037 ± 0.845
1.388GluTrp: 1.388 ± 0.3
2.703GluTyr: 2.703 ± 0.435
0.0GluXaa: 0.0 ± 0.0
Phe
2.338PheAla: 2.338 ± 0.443
0.219PheCys: 0.219 ± 0.13
3.069PheAsp: 3.069 ± 0.46
2.85PheGlu: 2.85 ± 0.484
0.511PhePhe: 0.511 ± 0.247
2.265PheGly: 2.265 ± 0.393
0.438PheHis: 0.438 ± 0.157
1.023PheIle: 1.023 ± 0.218
0.658PheLys: 0.658 ± 0.25
1.461PheLeu: 1.461 ± 0.283
0.073PheMet: 0.073 ± 0.078
0.95PheAsn: 0.95 ± 0.334
0.438PhePro: 0.438 ± 0.167
0.804PheGln: 0.804 ± 0.221
1.827PheArg: 1.827 ± 0.374
1.388PheSer: 1.388 ± 0.343
1.169PheThr: 1.169 ± 0.262
1.388PheVal: 1.388 ± 0.286
0.219PheTrp: 0.219 ± 0.124
0.511PheTyr: 0.511 ± 0.202
0.0PheXaa: 0.0 ± 0.0
Gly
7.526GlyAla: 7.526 ± 0.842
0.511GlyCys: 0.511 ± 0.203
9.499GlyAsp: 9.499 ± 0.903
7.964GlyGlu: 7.964 ± 1.012
1.973GlyPhe: 1.973 ± 0.29
10.741GlyGly: 10.741 ± 3.311
1.534GlyHis: 1.534 ± 0.326
2.85GlyIle: 2.85 ± 0.505
1.242GlyLys: 1.242 ± 0.3
5.042GlyLeu: 5.042 ± 0.607
0.877GlyMet: 0.877 ± 0.252
2.338GlyAsn: 2.338 ± 0.438
2.85GlyPro: 2.85 ± 0.331
2.411GlyGln: 2.411 ± 0.391
4.896GlyArg: 4.896 ± 0.611
5.334GlySer: 5.334 ± 0.929
4.457GlyThr: 4.457 ± 0.617
7.307GlyVal: 7.307 ± 0.699
1.461GlyTrp: 1.461 ± 0.304
2.265GlyTyr: 2.265 ± 0.452
0.0GlyXaa: 0.0 ± 0.0
His
1.827HisAla: 1.827 ± 0.329
0.292HisCys: 0.292 ± 0.138
1.9HisAsp: 1.9 ± 0.361
2.703HisGlu: 2.703 ± 0.408
0.365HisPhe: 0.365 ± 0.179
2.192HisGly: 2.192 ± 0.332
0.804HisHis: 0.804 ± 0.326
0.877HisIle: 0.877 ± 0.248
0.292HisLys: 0.292 ± 0.128
1.607HisLeu: 1.607 ± 0.42
0.292HisMet: 0.292 ± 0.143
0.658HisAsn: 0.658 ± 0.179
1.169HisPro: 1.169 ± 0.314
0.511HisGln: 0.511 ± 0.206
1.754HisArg: 1.754 ± 0.488
0.731HisSer: 0.731 ± 0.197
1.388HisThr: 1.388 ± 0.369
1.681HisVal: 1.681 ± 0.369
0.073HisTrp: 0.073 ± 0.077
0.658HisTyr: 0.658 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
4.311IleAla: 4.311 ± 0.495
0.146IleCys: 0.146 ± 0.105
4.603IleAsp: 4.603 ± 0.624
4.384IleGlu: 4.384 ± 0.59
0.804IlePhe: 0.804 ± 0.211
3.288IleGly: 3.288 ± 0.435
1.096IleHis: 1.096 ± 0.378
1.388IleIle: 1.388 ± 0.303
0.804IleLys: 0.804 ± 0.273
3.069IleLeu: 3.069 ± 0.565
0.292IleMet: 0.292 ± 0.143
0.804IleAsn: 0.804 ± 0.251
2.046IlePro: 2.046 ± 0.434
1.461IleGln: 1.461 ± 0.291
3.142IleArg: 3.142 ± 0.477
2.338IleSer: 2.338 ± 0.401
2.557IleThr: 2.557 ± 0.358
2.046IleVal: 2.046 ± 0.389
0.219IleTrp: 0.219 ± 0.109
0.95IleTyr: 0.95 ± 0.255
0.0IleXaa: 0.0 ± 0.0
Lys
2.046LysAla: 2.046 ± 0.49
0.292LysCys: 0.292 ± 0.133
1.388LysAsp: 1.388 ± 0.386
1.827LysGlu: 1.827 ± 0.362
0.731LysPhe: 0.731 ± 0.185
1.534LysGly: 1.534 ± 0.307
0.511LysHis: 0.511 ± 0.19
1.096LysIle: 1.096 ± 0.259
0.365LysLys: 0.365 ± 0.142
1.023LysLeu: 1.023 ± 0.32
0.292LysMet: 0.292 ± 0.141
0.365LysAsn: 0.365 ± 0.131
1.096LysPro: 1.096 ± 0.26
0.804LysGln: 0.804 ± 0.205
2.046LysArg: 2.046 ± 0.464
2.411LysSer: 2.411 ± 0.531
1.607LysThr: 1.607 ± 0.373
1.169LysVal: 1.169 ± 0.346
0.658LysTrp: 0.658 ± 0.242
0.438LysTyr: 0.438 ± 0.176
0.0LysXaa: 0.0 ± 0.0
Leu
8.037LeuAla: 8.037 ± 0.839
0.219LeuCys: 0.219 ± 0.13
7.964LeuAsp: 7.964 ± 0.683
6.722LeuGlu: 6.722 ± 0.739
1.681LeuPhe: 1.681 ± 0.374
5.334LeuGly: 5.334 ± 0.617
1.681LeuHis: 1.681 ± 0.358
2.046LeuIle: 2.046 ± 0.392
1.461LeuLys: 1.461 ± 0.317
4.457LeuLeu: 4.457 ± 0.823
1.096LeuMet: 1.096 ± 0.258
1.461LeuAsn: 1.461 ± 0.33
3.8LeuPro: 3.8 ± 0.572
1.973LeuGln: 1.973 ± 0.409
6.211LeuArg: 6.211 ± 0.763
5.992LeuSer: 5.992 ± 0.727
5.334LeuThr: 5.334 ± 0.645
6.503LeuVal: 6.503 ± 0.704
0.731LeuTrp: 0.731 ± 0.257
2.411LeuTyr: 2.411 ± 0.484
0.0LeuXaa: 0.0 ± 0.0
Met
1.315MetAla: 1.315 ± 0.331
0.073MetCys: 0.073 ± 0.067
1.461MetAsp: 1.461 ± 0.34
0.658MetGlu: 0.658 ± 0.207
0.292MetPhe: 0.292 ± 0.136
0.511MetGly: 0.511 ± 0.221
0.658MetHis: 0.658 ± 0.234
0.146MetIle: 0.146 ± 0.104
0.365MetLys: 0.365 ± 0.17
1.242MetLeu: 1.242 ± 0.319
0.292MetMet: 0.292 ± 0.132
0.292MetAsn: 0.292 ± 0.16
1.169MetPro: 1.169 ± 0.257
0.585MetGln: 0.585 ± 0.173
1.169MetArg: 1.169 ± 0.268
2.484MetSer: 2.484 ± 0.375
1.754MetThr: 1.754 ± 0.342
0.731MetVal: 0.731 ± 0.192
0.073MetTrp: 0.073 ± 0.08
0.292MetTyr: 0.292 ± 0.143
0.0MetXaa: 0.0 ± 0.0
Asn
3.361AsnAla: 3.361 ± 0.493
0.219AsnCys: 0.219 ± 0.167
1.681AsnAsp: 1.681 ± 0.287
2.192AsnGlu: 2.192 ± 0.402
0.511AsnPhe: 0.511 ± 0.192
2.63AsnGly: 2.63 ± 0.597
0.219AsnHis: 0.219 ± 0.131
0.877AsnIle: 0.877 ± 0.3
0.731AsnLys: 0.731 ± 0.225
1.461AsnLeu: 1.461 ± 0.293
0.292AsnMet: 0.292 ± 0.14
0.658AsnAsn: 0.658 ± 0.451
1.754AsnPro: 1.754 ± 0.337
1.023AsnGln: 1.023 ± 0.296
1.9AsnArg: 1.9 ± 0.443
1.169AsnSer: 1.169 ± 0.327
1.973AsnThr: 1.973 ± 0.375
2.046AsnVal: 2.046 ± 0.378
0.365AsnTrp: 0.365 ± 0.147
0.658AsnTyr: 0.658 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
5.699ProAla: 5.699 ± 0.581
0.438ProCys: 0.438 ± 0.169
5.553ProAsp: 5.553 ± 0.669
4.019ProGlu: 4.019 ± 0.542
0.731ProPhe: 0.731 ± 0.253
3.58ProGly: 3.58 ± 0.513
0.585ProHis: 0.585 ± 0.194
1.607ProIle: 1.607 ± 0.297
1.315ProLys: 1.315 ± 0.277
2.484ProLeu: 2.484 ± 0.427
0.731ProMet: 0.731 ± 0.213
1.388ProAsn: 1.388 ± 0.355
2.265ProPro: 2.265 ± 0.524
1.242ProGln: 1.242 ± 0.262
2.85ProArg: 2.85 ± 0.478
2.85ProSer: 2.85 ± 0.48
4.311ProThr: 4.311 ± 0.623
3.58ProVal: 3.58 ± 0.577
0.804ProTrp: 0.804 ± 0.243
1.315ProTyr: 1.315 ± 0.295
0.0ProXaa: 0.0 ± 0.0
Gln
2.63GlnAla: 2.63 ± 0.434
0.0GlnCys: 0.0 ± 0.0
1.827GlnAsp: 1.827 ± 0.438
2.557GlnGlu: 2.557 ± 0.441
1.9GlnPhe: 1.9 ± 0.439
2.119GlnGly: 2.119 ± 0.35
0.731GlnHis: 0.731 ± 0.219
1.9GlnIle: 1.9 ± 0.42
0.95GlnLys: 0.95 ± 0.276
2.923GlnLeu: 2.923 ± 0.508
0.511GlnMet: 0.511 ± 0.189
1.096GlnAsn: 1.096 ± 0.225
2.265GlnPro: 2.265 ± 0.488
1.242GlnGln: 1.242 ± 0.308
2.192GlnArg: 2.192 ± 0.33
2.046GlnSer: 2.046 ± 0.363
1.681GlnThr: 1.681 ± 0.322
1.534GlnVal: 1.534 ± 0.315
0.365GlnTrp: 0.365 ± 0.134
0.877GlnTyr: 0.877 ± 0.233
0.0GlnXaa: 0.0 ± 0.0
Arg
6.722ArgAla: 6.722 ± 0.781
1.096ArgCys: 1.096 ± 0.386
6.649ArgAsp: 6.649 ± 0.6
7.307ArgGlu: 7.307 ± 0.677
1.607ArgPhe: 1.607 ± 0.335
4.676ArgGly: 4.676 ± 0.468
1.681ArgHis: 1.681 ± 0.385
2.85ArgIle: 2.85 ± 0.504
1.827ArgLys: 1.827 ± 0.345
5.918ArgLeu: 5.918 ± 0.701
1.169ArgMet: 1.169 ± 0.289
1.534ArgAsn: 1.534 ± 0.357
2.046ArgPro: 2.046 ± 0.444
2.996ArgGln: 2.996 ± 0.448
6.211ArgArg: 6.211 ± 1.385
3.726ArgSer: 3.726 ± 0.439
3.58ArgThr: 3.58 ± 0.519
5.261ArgVal: 5.261 ± 0.932
1.388ArgTrp: 1.388 ± 0.376
2.265ArgTyr: 2.265 ± 0.457
0.0ArgXaa: 0.0 ± 0.0
Ser
5.845SerAla: 5.845 ± 0.754
0.658SerCys: 0.658 ± 0.247
5.845SerAsp: 5.845 ± 0.679
5.042SerGlu: 5.042 ± 0.548
1.315SerPhe: 1.315 ± 0.297
5.334SerGly: 5.334 ± 0.73
1.534SerHis: 1.534 ± 0.266
2.484SerIle: 2.484 ± 0.352
1.9SerLys: 1.9 ± 0.469
3.142SerLeu: 3.142 ± 0.567
1.169SerMet: 1.169 ± 0.264
2.411SerAsn: 2.411 ± 0.439
3.069SerPro: 3.069 ± 0.403
1.607SerGln: 1.607 ± 0.313
4.238SerArg: 4.238 ± 0.61
4.311SerSer: 4.311 ± 0.61
4.603SerThr: 4.603 ± 0.709
4.165SerVal: 4.165 ± 0.586
1.023SerTrp: 1.023 ± 0.267
1.9SerTyr: 1.9 ± 0.397
0.0SerXaa: 0.0 ± 0.0
Thr
5.407ThrAla: 5.407 ± 0.618
0.585ThrCys: 0.585 ± 0.227
6.795ThrAsp: 6.795 ± 0.671
5.845ThrGlu: 5.845 ± 0.638
1.681ThrPhe: 1.681 ± 0.279
5.334ThrGly: 5.334 ± 0.692
1.461ThrHis: 1.461 ± 0.307
3.726ThrIle: 3.726 ± 0.454
1.023ThrLys: 1.023 ± 0.305
6.43ThrLeu: 6.43 ± 0.647
0.731ThrMet: 0.731 ± 0.234
1.534ThrAsn: 1.534 ± 0.298
3.946ThrPro: 3.946 ± 0.479
1.607ThrGln: 1.607 ± 0.368
4.092ThrArg: 4.092 ± 0.52
3.288ThrSer: 3.288 ± 0.455
5.48ThrThr: 5.48 ± 0.669
5.918ThrVal: 5.918 ± 0.851
0.731ThrTrp: 0.731 ± 0.271
1.973ThrTyr: 1.973 ± 0.422
0.0ThrXaa: 0.0 ± 0.0
Val
8.257ValAla: 8.257 ± 0.883
0.511ValCys: 0.511 ± 0.226
10.156ValAsp: 10.156 ± 0.758
8.768ValGlu: 8.768 ± 0.978
1.607ValPhe: 1.607 ± 0.331
5.845ValGly: 5.845 ± 0.702
1.315ValHis: 1.315 ± 0.362
2.703ValIle: 2.703 ± 0.45
1.461ValLys: 1.461 ± 0.363
5.334ValLeu: 5.334 ± 0.694
1.023ValMet: 1.023 ± 0.272
1.9ValAsn: 1.9 ± 0.373
3.361ValPro: 3.361 ± 0.51
1.827ValGln: 1.827 ± 0.3
5.407ValArg: 5.407 ± 0.567
4.969ValSer: 4.969 ± 0.597
4.457ValThr: 4.457 ± 0.443
5.699ValVal: 5.699 ± 0.97
1.096ValTrp: 1.096 ± 0.283
2.119ValTyr: 2.119 ± 0.408
0.0ValXaa: 0.0 ± 0.0
Trp
0.95TrpAla: 0.95 ± 0.295
0.219TrpCys: 0.219 ± 0.115
1.023TrpAsp: 1.023 ± 0.272
1.096TrpGlu: 1.096 ± 0.254
0.219TrpPhe: 0.219 ± 0.129
0.731TrpGly: 0.731 ± 0.248
0.146TrpHis: 0.146 ± 0.093
0.804TrpIle: 0.804 ± 0.192
0.146TrpLys: 0.146 ± 0.084
1.827TrpLeu: 1.827 ± 0.348
0.292TrpMet: 0.292 ± 0.132
0.511TrpAsn: 0.511 ± 0.202
0.511TrpPro: 0.511 ± 0.212
0.511TrpGln: 0.511 ± 0.217
1.169TrpArg: 1.169 ± 0.279
1.242TrpSer: 1.242 ± 0.239
1.023TrpThr: 1.023 ± 0.263
1.023TrpVal: 1.023 ± 0.248
0.219TrpTrp: 0.219 ± 0.127
0.585TrpTyr: 0.585 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.265TyrAla: 2.265 ± 0.362
0.365TyrCys: 0.365 ± 0.151
3.653TyrAsp: 3.653 ± 0.57
2.703TyrGlu: 2.703 ± 0.398
0.438TyrPhe: 0.438 ± 0.204
1.9TyrGly: 1.9 ± 0.337
0.731TyrHis: 0.731 ± 0.207
1.169TyrIle: 1.169 ± 0.463
1.023TyrLys: 1.023 ± 0.285
1.9TyrLeu: 1.9 ± 0.33
0.365TyrMet: 0.365 ± 0.139
0.95TyrAsn: 0.95 ± 0.256
1.461TyrPro: 1.461 ± 0.296
0.804TyrGln: 0.804 ± 0.223
1.973TyrArg: 1.973 ± 0.354
1.023TyrSer: 1.023 ± 0.273
1.9TyrThr: 1.9 ± 0.447
2.703TyrVal: 2.703 ± 0.36
0.511TyrTrp: 0.511 ± 0.172
0.804TyrTyr: 0.804 ± 0.206
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (13687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski