Amino acid dipepetide frequency for Blastococcus sp. TF02-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.701AlaAla: 23.701 ± 0.25
0.958AlaCys: 0.958 ± 0.028
9.44AlaAsp: 9.44 ± 0.106
9.155AlaGlu: 9.155 ± 0.09
3.375AlaPhe: 3.375 ± 0.055
14.642AlaGly: 14.642 ± 0.139
2.543AlaHis: 2.543 ± 0.048
3.72AlaIle: 3.72 ± 0.059
1.875AlaLys: 1.875 ± 0.05
15.095AlaLeu: 15.095 ± 0.151
2.482AlaMet: 2.482 ± 0.046
1.723AlaAsn: 1.723 ± 0.039
7.518AlaPro: 7.518 ± 0.115
3.799AlaGln: 3.799 ± 0.062
10.848AlaArg: 10.848 ± 0.104
5.739AlaSer: 5.739 ± 0.073
7.548AlaThr: 7.548 ± 0.106
14.156AlaVal: 14.156 ± 0.148
1.961AlaTrp: 1.961 ± 0.045
2.209AlaTyr: 2.209 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.027
0.081CysCys: 0.081 ± 0.009
0.433CysAsp: 0.433 ± 0.02
0.304CysGlu: 0.304 ± 0.015
0.185CysPhe: 0.185 ± 0.012
0.856CysGly: 0.856 ± 0.031
0.156CysHis: 0.156 ± 0.012
0.185CysIle: 0.185 ± 0.011
0.074CysLys: 0.074 ± 0.008
0.616CysLeu: 0.616 ± 0.024
0.096CysMet: 0.096 ± 0.009
0.096CysAsn: 0.096 ± 0.01
0.482CysPro: 0.482 ± 0.02
0.14CysGln: 0.14 ± 0.011
0.57CysArg: 0.57 ± 0.024
0.375CysSer: 0.375 ± 0.018
0.482CysThr: 0.482 ± 0.022
0.55CysVal: 0.55 ± 0.021
0.104CysTrp: 0.104 ± 0.009
0.121CysTyr: 0.121 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.641AspAla: 8.641 ± 0.087
0.366AspCys: 0.366 ± 0.019
4.626AspAsp: 4.626 ± 0.076
4.351AspGlu: 4.351 ± 0.07
1.389AspPhe: 1.389 ± 0.032
6.879AspGly: 6.879 ± 0.096
1.145AspHis: 1.145 ± 0.03
1.536AspIle: 1.536 ± 0.04
0.776AspLys: 0.776 ± 0.028
6.985AspLeu: 6.985 ± 0.081
0.788AspMet: 0.788 ± 0.028
0.747AspAsn: 0.747 ± 0.027
4.711AspPro: 4.711 ± 0.076
1.59AspGln: 1.59 ± 0.043
5.46AspArg: 5.46 ± 0.07
2.332AspSer: 2.332 ± 0.044
2.806AspThr: 2.806 ± 0.048
6.602AspVal: 6.602 ± 0.076
0.932AspTrp: 0.932 ± 0.032
1.021AspTyr: 1.021 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
7.25GluAla: 7.25 ± 0.086
0.297GluCys: 0.297 ± 0.016
3.13GluAsp: 3.13 ± 0.054
3.417GluGlu: 3.417 ± 0.067
1.464GluPhe: 1.464 ± 0.034
4.283GluGly: 4.283 ± 0.055
1.492GluHis: 1.492 ± 0.035
2.065GluIle: 2.065 ± 0.04
1.027GluLys: 1.027 ± 0.033
7.246GluLeu: 7.246 ± 0.075
0.838GluMet: 0.838 ± 0.03
0.881GluAsn: 0.881 ± 0.025
3.462GluPro: 3.462 ± 0.051
2.504GluGln: 2.504 ± 0.045
5.287GluArg: 5.287 ± 0.086
2.481GluSer: 2.481 ± 0.048
2.666GluThr: 2.666 ± 0.051
5.427GluVal: 5.427 ± 0.073
0.772GluTrp: 0.772 ± 0.03
0.91GluTyr: 0.91 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.59PheAla: 3.59 ± 0.062
0.221PheCys: 0.221 ± 0.014
1.908PheAsp: 1.908 ± 0.038
1.301PheGlu: 1.301 ± 0.033
0.855PhePhe: 0.855 ± 0.029
2.885PheGly: 2.885 ± 0.051
0.471PheHis: 0.471 ± 0.018
0.632PheIle: 0.632 ± 0.025
0.341PheLys: 0.341 ± 0.017
2.515PheLeu: 2.515 ± 0.054
0.309PheMet: 0.309 ± 0.016
0.405PheAsn: 0.405 ± 0.019
1.32PhePro: 1.32 ± 0.035
0.61PheGln: 0.61 ± 0.023
1.688PheArg: 1.688 ± 0.039
1.343PheSer: 1.343 ± 0.032
1.77PheThr: 1.77 ± 0.042
2.454PheVal: 2.454 ± 0.051
0.42PheTrp: 0.42 ± 0.019
0.527PheTyr: 0.527 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
11.862GlyAla: 11.862 ± 0.133
0.779GlyCys: 0.779 ± 0.028
5.62GlyAsp: 5.62 ± 0.071
5.324GlyGlu: 5.324 ± 0.072
2.71GlyPhe: 2.71 ± 0.051
8.889GlyGly: 8.889 ± 0.112
1.922GlyHis: 1.922 ± 0.04
3.304GlyIle: 3.304 ± 0.054
1.657GlyLys: 1.657 ± 0.037
9.949GlyLeu: 9.949 ± 0.111
2.05GlyMet: 2.05 ± 0.04
1.584GlyAsn: 1.584 ± 0.045
5.165GlyPro: 5.165 ± 0.068
2.684GlyGln: 2.684 ± 0.052
8.293GlyArg: 8.293 ± 0.101
5.453GlySer: 5.453 ± 0.07
6.153GlyThr: 6.153 ± 0.082
8.38GlyVal: 8.38 ± 0.09
1.812GlyTrp: 1.812 ± 0.037
2.151GlyTyr: 2.151 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.362HisAla: 2.362 ± 0.05
0.181HisCys: 0.181 ± 0.012
1.249HisAsp: 1.249 ± 0.032
1.096HisGlu: 1.096 ± 0.032
0.478HisPhe: 0.478 ± 0.022
1.993HisGly: 1.993 ± 0.041
0.54HisHis: 0.54 ± 0.027
0.437HisIle: 0.437 ± 0.018
0.209HisLys: 0.209 ± 0.014
2.243HisLeu: 2.243 ± 0.039
0.269HisMet: 0.269 ± 0.016
0.258HisAsn: 0.258 ± 0.015
1.638HisPro: 1.638 ± 0.04
0.478HisGln: 0.478 ± 0.021
1.888HisArg: 1.888 ± 0.041
0.835HisSer: 0.835 ± 0.029
0.907HisThr: 0.907 ± 0.028
1.757HisVal: 1.757 ± 0.044
0.3HisTrp: 0.3 ± 0.016
0.368HisTyr: 0.368 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.638IleAla: 4.638 ± 0.069
0.241IleCys: 0.241 ± 0.015
2.279IleAsp: 2.279 ± 0.044
1.892IleGlu: 1.892 ± 0.04
0.59IlePhe: 0.59 ± 0.024
3.474IleGly: 3.474 ± 0.062
0.398IleHis: 0.398 ± 0.019
0.743IleIle: 0.743 ± 0.031
0.446IleLys: 0.446 ± 0.022
1.915IleLeu: 1.915 ± 0.046
0.352IleMet: 0.352 ± 0.018
0.627IleAsn: 0.627 ± 0.025
1.559IlePro: 1.559 ± 0.037
0.656IleGln: 0.656 ± 0.024
2.067IleArg: 2.067 ± 0.042
1.625IleSer: 1.625 ± 0.038
1.902IleThr: 1.902 ± 0.045
2.594IleVal: 2.594 ± 0.053
0.331IleTrp: 0.331 ± 0.016
0.468IleTyr: 0.468 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.992LysAla: 1.992 ± 0.048
0.071LysCys: 0.071 ± 0.009
0.87LysAsp: 0.87 ± 0.03
0.727LysGlu: 0.727 ± 0.029
0.314LysPhe: 0.314 ± 0.016
1.103LysGly: 1.103 ± 0.032
0.3LysHis: 0.3 ± 0.018
0.531LysIle: 0.531 ± 0.024
0.483LysLys: 0.483 ± 0.029
1.363LysLeu: 1.363 ± 0.039
0.264LysMet: 0.264 ± 0.016
0.324LysAsn: 0.324 ± 0.018
0.883LysPro: 0.883 ± 0.027
0.477LysGln: 0.477 ± 0.02
1.123LysArg: 1.123 ± 0.035
0.711LysSer: 0.711 ± 0.027
0.868LysThr: 0.868 ± 0.031
1.334LysVal: 1.334 ± 0.041
0.185LysTrp: 0.185 ± 0.012
0.291LysTyr: 0.291 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
16.876LeuAla: 16.876 ± 0.168
0.651LeuCys: 0.651 ± 0.024
7.114LeuAsp: 7.114 ± 0.093
5.095LeuGlu: 5.095 ± 0.069
2.442LeuPhe: 2.442 ± 0.053
9.978LeuGly: 9.978 ± 0.102
1.989LeuHis: 1.989 ± 0.031
2.703LeuIle: 2.703 ± 0.06
1.303LeuLys: 1.303 ± 0.043
11.91LeuLeu: 11.91 ± 0.135
1.429LeuMet: 1.429 ± 0.037
1.352LeuAsn: 1.352 ± 0.037
6.916LeuPro: 6.916 ± 0.078
2.636LeuGln: 2.636 ± 0.048
8.549LeuArg: 8.549 ± 0.103
5.178LeuSer: 5.178 ± 0.073
6.796LeuThr: 6.796 ± 0.068
10.833LeuVal: 10.833 ± 0.112
1.152LeuTrp: 1.152 ± 0.037
1.49LeuTyr: 1.49 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.257MetAla: 2.257 ± 0.042
0.124MetCys: 0.124 ± 0.009
0.863MetAsp: 0.863 ± 0.026
0.636MetGlu: 0.636 ± 0.026
0.376MetPhe: 0.376 ± 0.019
1.257MetGly: 1.257 ± 0.037
0.322MetHis: 0.322 ± 0.015
0.54MetIle: 0.54 ± 0.023
0.309MetLys: 0.309 ± 0.017
1.536MetLeu: 1.536 ± 0.042
0.229MetMet: 0.229 ± 0.017
0.327MetAsn: 0.327 ± 0.018
1.106MetPro: 1.106 ± 0.03
0.451MetGln: 0.451 ± 0.02
1.301MetArg: 1.301 ± 0.035
1.284MetSer: 1.284 ± 0.032
1.616MetThr: 1.616 ± 0.035
1.279MetVal: 1.279 ± 0.031
0.178MetTrp: 0.178 ± 0.012
0.231MetTyr: 0.231 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
1.927AsnAla: 1.927 ± 0.043
0.13AsnCys: 0.13 ± 0.011
0.755AsnAsp: 0.755 ± 0.024
0.703AsnGlu: 0.703 ± 0.025
0.4AsnPhe: 0.4 ± 0.021
1.512AsnGly: 1.512 ± 0.043
0.298AsnHis: 0.298 ± 0.015
0.502AsnIle: 0.502 ± 0.021
0.238AsnLys: 0.238 ± 0.013
1.521AsnLeu: 1.521 ± 0.04
0.245AsnMet: 0.245 ± 0.015
0.305AsnAsn: 0.305 ± 0.016
1.208AsnPro: 1.208 ± 0.034
0.418AsnGln: 0.418 ± 0.021
1.14AsnArg: 1.14 ± 0.035
0.731AsnSer: 0.731 ± 0.027
0.821AsnThr: 0.821 ± 0.026
1.291AsnVal: 1.291 ± 0.033
0.217AsnTrp: 0.217 ± 0.014
0.319AsnTyr: 0.319 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
9.389ProAla: 9.389 ± 0.121
0.306ProCys: 0.306 ± 0.017
4.79ProAsp: 4.79 ± 0.064
4.427ProGlu: 4.427 ± 0.063
1.514ProPhe: 1.514 ± 0.038
6.802ProGly: 6.802 ± 0.087
1.173ProHis: 1.173 ± 0.032
1.434ProIle: 1.434 ± 0.035
0.756ProLys: 0.756 ± 0.029
5.467ProLeu: 5.467 ± 0.072
1.028ProMet: 1.028 ± 0.028
0.736ProAsn: 0.736 ± 0.024
3.787ProPro: 3.787 ± 0.085
1.429ProGln: 1.429 ± 0.038
4.138ProArg: 4.138 ± 0.061
3.132ProSer: 3.132 ± 0.052
3.566ProThr: 3.566 ± 0.065
6.029ProVal: 6.029 ± 0.076
0.943ProTrp: 0.943 ± 0.031
0.975ProTyr: 0.975 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
3.788GlnAla: 3.788 ± 0.06
0.146GlnCys: 0.146 ± 0.011
1.236GlnAsp: 1.236 ± 0.034
1.419GlnGlu: 1.419 ± 0.033
0.715GlnPhe: 0.715 ± 0.025
2.029GlnGly: 2.029 ± 0.042
0.61GlnHis: 0.61 ± 0.023
0.958GlnIle: 0.958 ± 0.028
0.441GlnLys: 0.441 ± 0.02
3.424GlnLeu: 3.424 ± 0.065
0.473GlnMet: 0.473 ± 0.022
0.424GlnAsn: 0.424 ± 0.018
1.68GlnPro: 1.68 ± 0.041
1.217GlnGln: 1.217 ± 0.037
2.576GlnArg: 2.576 ± 0.055
1.119GlnSer: 1.119 ± 0.031
1.318GlnThr: 1.318 ± 0.037
2.766GlnVal: 2.766 ± 0.045
0.404GlnTrp: 0.404 ± 0.017
0.514GlnTyr: 0.514 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
10.537ArgAla: 10.537 ± 0.118
0.545ArgCys: 0.545 ± 0.023
4.519ArgAsp: 4.519 ± 0.06
4.475ArgGlu: 4.475 ± 0.069
2.266ArgPhe: 2.266 ± 0.043
6.11ArgGly: 6.11 ± 0.081
1.689ArgHis: 1.689 ± 0.035
2.8ArgIle: 2.8 ± 0.05
1.109ArgLys: 1.109 ± 0.033
8.856ArgLeu: 8.856 ± 0.109
1.772ArgMet: 1.772 ± 0.038
1.223ArgAsn: 1.223 ± 0.034
5.451ArgPro: 5.451 ± 0.075
2.335ArgGln: 2.335 ± 0.045
8.599ArgArg: 8.599 ± 0.115
4.405ArgSer: 4.405 ± 0.059
5.198ArgThr: 5.198 ± 0.067
6.532ArgVal: 6.532 ± 0.072
1.535ArgTrp: 1.535 ± 0.04
1.715ArgTyr: 1.715 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.695SerAla: 6.695 ± 0.073
0.339SerCys: 0.339 ± 0.018
2.697SerAsp: 2.697 ± 0.047
2.33SerGlu: 2.33 ± 0.043
1.461SerPhe: 1.461 ± 0.042
5.554SerGly: 5.554 ± 0.067
0.812SerHis: 0.812 ± 0.026
1.487SerIle: 1.487 ± 0.039
0.65SerLys: 0.65 ± 0.023
4.675SerLeu: 4.675 ± 0.07
1.033SerMet: 1.033 ± 0.031
0.737SerAsn: 0.737 ± 0.025
3.223SerPro: 3.223 ± 0.059
1.138SerGln: 1.138 ± 0.037
3.662SerArg: 3.662 ± 0.061
3.093SerSer: 3.093 ± 0.058
3.25SerThr: 3.25 ± 0.058
4.418SerVal: 4.418 ± 0.06
0.884SerTrp: 0.884 ± 0.028
1.045SerTyr: 1.045 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
8.763ThrAla: 8.763 ± 0.102
0.376ThrCys: 0.376 ± 0.019
3.738ThrAsp: 3.738 ± 0.057
3.053ThrGlu: 3.053 ± 0.049
1.552ThrPhe: 1.552 ± 0.043
6.53ThrGly: 6.53 ± 0.093
0.985ThrHis: 0.985 ± 0.032
1.731ThrIle: 1.731 ± 0.044
0.8ThrLys: 0.8 ± 0.032
5.566ThrLeu: 5.566 ± 0.069
0.888ThrMet: 0.888 ± 0.025
0.909ThrAsn: 0.909 ± 0.028
3.982ThrPro: 3.982 ± 0.058
1.269ThrGln: 1.269 ± 0.034
3.972ThrArg: 3.972 ± 0.055
3.147ThrSer: 3.147 ± 0.068
4.151ThrThr: 4.151 ± 0.077
6.406ThrVal: 6.406 ± 0.076
0.916ThrTrp: 0.916 ± 0.029
1.151ThrTyr: 1.151 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
13.33ValAla: 13.33 ± 0.121
0.696ValCys: 0.696 ± 0.022
6.275ValAsp: 6.275 ± 0.064
5.519ValGlu: 5.519 ± 0.072
2.423ValPhe: 2.423 ± 0.042
8.051ValGly: 8.051 ± 0.086
2.047ValHis: 2.047 ± 0.041
2.666ValIle: 2.666 ± 0.053
1.235ValLys: 1.235 ± 0.036
11.712ValLeu: 11.712 ± 0.135
1.252ValMet: 1.252 ± 0.031
1.441ValAsn: 1.441 ± 0.037
5.966ValPro: 5.966 ± 0.073
2.439ValGln: 2.439 ± 0.044
7.541ValArg: 7.541 ± 0.088
4.358ValSer: 4.358 ± 0.055
6.074ValThr: 6.074 ± 0.089
11.136ValVal: 11.136 ± 0.114
1.144ValTrp: 1.144 ± 0.03
1.456ValTyr: 1.456 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.723TrpAla: 1.723 ± 0.042
0.125TrpCys: 0.125 ± 0.011
0.776TrpAsp: 0.776 ± 0.026
0.681TrpGlu: 0.681 ± 0.022
0.522TrpPhe: 0.522 ± 0.021
1.027TrpGly: 1.027 ± 0.027
0.327TrpHis: 0.327 ± 0.018
0.436TrpIle: 0.436 ± 0.019
0.211TrpLys: 0.211 ± 0.014
1.823TrpLeu: 1.823 ± 0.048
0.247TrpMet: 0.247 ± 0.013
0.287TrpAsn: 0.287 ± 0.018
0.864TrpPro: 0.864 ± 0.029
0.54TrpGln: 0.54 ± 0.023
1.379TrpArg: 1.379 ± 0.032
0.996TrpSer: 0.996 ± 0.028
1.031TrpThr: 1.031 ± 0.032
1.19TrpVal: 1.19 ± 0.031
0.366TrpTrp: 0.366 ± 0.019
0.297TrpTyr: 0.297 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.282TyrAla: 2.282 ± 0.048
0.16TyrCys: 0.16 ± 0.011
1.365TyrAsp: 1.365 ± 0.048
0.993TyrGlu: 0.993 ± 0.033
0.533TyrPhe: 0.533 ± 0.025
1.887TyrGly: 1.887 ± 0.042
0.266TyrHis: 0.266 ± 0.015
0.386TyrIle: 0.386 ± 0.02
0.273TyrLys: 0.273 ± 0.017
1.972TyrLeu: 1.972 ± 0.042
0.18TyrMet: 0.18 ± 0.015
0.297TyrAsn: 0.297 ± 0.016
0.9TyrPro: 0.9 ± 0.029
0.447TyrGln: 0.447 ± 0.018
1.592TyrArg: 1.592 ± 0.036
0.847TyrSer: 0.847 ± 0.027
0.962TyrThr: 0.962 ± 0.034
1.628TyrVal: 1.628 ± 0.036
0.289TyrTrp: 0.289 ± 0.016
0.353TyrTyr: 0.353 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3851 proteins (1224882 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski