Amino acid dipepetide frequency for Acidihalobacter prosperus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.476AlaAla: 16.476 ± 0.191	1.257AlaCys: 1.257 ± 0.039	6.566AlaAsp: 6.566 ± 0.084	7.273AlaGlu: 7.273 ± 0.125	3.737AlaPhe: 3.737 ± 0.064	10.945AlaGly: 10.945 ± 0.128	3.13AlaHis: 3.13 ± 0.062	5.51AlaIle: 5.51 ± 0.077	2.816AlaLys: 2.816 ± 0.062	15.302AlaLeu: 15.302 ± 0.16	3.201AlaMet: 3.201 ± 0.058	2.548AlaAsn: 2.548 ± 0.055	5.382AlaPro: 5.382 ± 0.095	4.575AlaGln: 4.575 ± 0.087	10.17AlaArg: 10.17 ± 0.15	5.894AlaSer: 5.894 ± 0.104	5.356AlaThr: 5.356 ± 0.078	8.606AlaVal: 8.606 ± 0.114	1.801AlaTrp: 1.801 ± 0.044	3.15AlaTyr: 3.15 ± 0.057	0.001AlaXaa: 0.001 ± 0.001
Cys	1.022CysAla: 1.022 ± 0.033	0.123CysCys: 0.123 ± 0.013	0.499CysAsp: 0.499 ± 0.025	0.493CysGlu: 0.493 ± 0.022	0.289CysPhe: 0.289 ± 0.018	0.966CysGly: 0.966 ± 0.034	0.285CysHis: 0.285 ± 0.015	0.337CysIle: 0.337 ± 0.018	0.157CysLys: 0.157 ± 0.012	0.925CysLeu: 0.925 ± 0.027	0.18CysMet: 0.18 ± 0.011	0.204CysAsn: 0.204 ± 0.015	0.539CysPro: 0.539 ± 0.025	0.253CysGln: 0.253 ± 0.016	0.769CysArg: 0.769 ± 0.032	0.405CysSer: 0.405 ± 0.023	0.411CysThr: 0.411 ± 0.021	0.667CysVal: 0.667 ± 0.027	0.108CysTrp: 0.108 ± 0.01	0.204CysTyr: 0.204 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.208AspAla: 7.208 ± 0.109	0.499AspCys: 0.499 ± 0.025	3.143AspAsp: 3.143 ± 0.063	3.735AspGlu: 3.735 ± 0.078	2.065AspPhe: 2.065 ± 0.044	4.689AspGly: 4.689 ± 0.086	1.271AspHis: 1.271 ± 0.04	2.766AspIle: 2.766 ± 0.053	1.389AspLys: 1.389 ± 0.042	5.698AspLeu: 5.698 ± 0.085	1.395AspMet: 1.395 ± 0.04	1.206AspAsn: 1.206 ± 0.038	3.127AspPro: 3.127 ± 0.062	1.669AspGln: 1.669 ± 0.043	4.082AspArg: 4.082 ± 0.072	2.183AspSer: 2.183 ± 0.052	2.698AspThr: 2.698 ± 0.055	3.708AspVal: 3.708 ± 0.068	0.976AspTrp: 0.976 ± 0.031	1.676AspTyr: 1.676 ± 0.042	0.005AspXaa: 0.005 ± 0.003
Glu	7.862GluAla: 7.862 ± 0.124	0.425GluCys: 0.425 ± 0.023	2.686GluAsp: 2.686 ± 0.058	2.523GluGlu: 2.523 ± 0.071	1.635GluPhe: 1.635 ± 0.044	4.025GluGly: 4.025 ± 0.069	1.657GluHis: 1.657 ± 0.037	3.08GluIle: 3.08 ± 0.06	1.48GluLys: 1.48 ± 0.045	5.746GluLeu: 5.746 ± 0.085	1.366GluMet: 1.366 ± 0.037	1.287GluAsn: 1.287 ± 0.039	2.526GluPro: 2.526 ± 0.052	2.529GluGln: 2.529 ± 0.06	5.649GluArg: 5.649 ± 0.087	2.748GluSer: 2.748 ± 0.063	3.227GluThr: 3.227 ± 0.059	3.987GluVal: 3.987 ± 0.069	0.765GluTrp: 0.765 ± 0.031	1.321GluTyr: 1.321 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.043PheAla: 4.043 ± 0.071	0.296PheCys: 0.296 ± 0.018	2.243PheAsp: 2.243 ± 0.049	2.03PheGlu: 2.03 ± 0.045	1.214PhePhe: 1.214 ± 0.042	3.202PheGly: 3.202 ± 0.062	0.757PheHis: 0.757 ± 0.034	1.472PheIle: 1.472 ± 0.04	0.911PheLys: 0.911 ± 0.029	2.996PheLeu: 2.996 ± 0.055	0.831PheMet: 0.831 ± 0.032	1.016PheAsn: 1.016 ± 0.034	1.435PhePro: 1.435 ± 0.038	0.871PheGln: 0.871 ± 0.03	2.028PheArg: 2.028 ± 0.045	1.924PheSer: 1.924 ± 0.048	1.665PheThr: 1.665 ± 0.045	2.64PheVal: 2.64 ± 0.053	0.53PheTrp: 0.53 ± 0.024	0.971PheTyr: 0.971 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.64GlyAla: 8.64 ± 0.119	0.907GlyCys: 0.907 ± 0.029	4.568GlyAsp: 4.568 ± 0.066	5.084GlyGlu: 5.084 ± 0.086	3.224GlyPhe: 3.224 ± 0.055	7.124GlyGly: 7.124 ± 0.102	2.39GlyHis: 2.39 ± 0.047	4.409GlyIle: 4.409 ± 0.072	2.67GlyLys: 2.67 ± 0.06	9.832GlyLeu: 9.832 ± 0.12	2.494GlyMet: 2.494 ± 0.06	2.081GlyAsn: 2.081 ± 0.054	3.083GlyPro: 3.083 ± 0.068	3.171GlyGln: 3.171 ± 0.059	6.75GlyArg: 6.75 ± 0.091	4.205GlySer: 4.205 ± 0.077	4.098GlyThr: 4.098 ± 0.075	6.376GlyVal: 6.376 ± 0.092	1.398GlyTrp: 1.398 ± 0.041	2.538GlyTyr: 2.538 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	3.325HisAla: 3.325 ± 0.054	0.308HisCys: 0.308 ± 0.017	1.453HisAsp: 1.453 ± 0.04	1.361HisGlu: 1.361 ± 0.04	0.993HisPhe: 0.993 ± 0.026	2.343HisGly: 2.343 ± 0.056	0.786HisHis: 0.786 ± 0.034	1.066HisIle: 1.066 ± 0.035	0.526HisLys: 0.526 ± 0.023	2.785HisLeu: 2.785 ± 0.055	0.55HisMet: 0.55 ± 0.026	0.595HisAsn: 0.595 ± 0.026	1.777HisPro: 1.777 ± 0.048	0.785HisGln: 0.785 ± 0.026	2.006HisArg: 2.006 ± 0.057	1.033HisSer: 1.033 ± 0.029	1.173HisThr: 1.173 ± 0.038	1.738HisVal: 1.738 ± 0.041	0.475HisTrp: 0.475 ± 0.022	0.827HisTyr: 0.827 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.059IleAla: 6.059 ± 0.079	0.377IleCys: 0.377 ± 0.02	3.418IleAsp: 3.418 ± 0.065	3.585IleGlu: 3.585 ± 0.076	1.292IlePhe: 1.292 ± 0.04	4.499IleGly: 4.499 ± 0.073	1.14IleHis: 1.14 ± 0.032	1.711IleIle: 1.711 ± 0.048	1.4IleLys: 1.4 ± 0.042	4.065IleLeu: 4.065 ± 0.069	0.862IleMet: 0.862 ± 0.031	1.414IleAsn: 1.414 ± 0.039	2.371IlePro: 2.371 ± 0.053	1.361IleGln: 1.361 ± 0.04	3.41IleArg: 3.41 ± 0.06	2.33IleSer: 2.33 ± 0.052	2.249IleThr: 2.249 ± 0.047	3.501IleVal: 3.501 ± 0.063	0.502IleTrp: 0.502 ± 0.024	1.161IleTyr: 1.161 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.115LysAla: 3.115 ± 0.065	0.139LysCys: 0.139 ± 0.012	1.201LysAsp: 1.201 ± 0.041	1.095LysGlu: 1.095 ± 0.044	0.596LysPhe: 0.596 ± 0.027	2.033LysGly: 2.033 ± 0.057	0.645LysHis: 0.645 ± 0.026	1.28LysIle: 1.28 ± 0.039	0.845LysLys: 0.845 ± 0.038	2.673LysLeu: 2.673 ± 0.059	0.531LysMet: 0.531 ± 0.026	0.667LysAsn: 0.667 ± 0.028	1.787LysPro: 1.787 ± 0.053	1.126LysGln: 1.126 ± 0.038	2.125LysArg: 2.125 ± 0.048	1.434LysSer: 1.434 ± 0.039	1.601LysThr: 1.601 ± 0.043	1.795LysVal: 1.795 ± 0.049	0.216LysTrp: 0.216 ± 0.016	0.542LysTyr: 0.542 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	15.11LeuAla: 15.11 ± 0.151	0.937LeuCys: 0.937 ± 0.033	6.822LeuAsp: 6.822 ± 0.1	5.98LeuGlu: 5.98 ± 0.104	3.75LeuPhe: 3.75 ± 0.074	9.554LeuGly: 9.554 ± 0.095	2.685LeuHis: 2.685 ± 0.052	5.314LeuIle: 5.314 ± 0.082	3.122LeuLys: 3.122 ± 0.061	12.328LeuLeu: 12.328 ± 0.154	2.563LeuMet: 2.563 ± 0.05	2.727LeuAsn: 2.727 ± 0.051	6.237LeuPro: 6.237 ± 0.092	3.509LeuGln: 3.509 ± 0.072	8.864LeuArg: 8.864 ± 0.124	6.624LeuSer: 6.624 ± 0.102	5.221LeuThr: 5.221 ± 0.068	7.393LeuVal: 7.393 ± 0.1	1.417LeuTrp: 1.417 ± 0.044	2.708LeuTyr: 2.708 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.801MetAla: 2.801 ± 0.053	0.123MetCys: 0.123 ± 0.01	1.184MetAsp: 1.184 ± 0.037	0.994MetGlu: 0.994 ± 0.035	0.587MetPhe: 0.587 ± 0.023	1.83MetGly: 1.83 ± 0.057	0.633MetHis: 0.633 ± 0.025	1.139MetIle: 1.139 ± 0.039	0.804MetLys: 0.804 ± 0.031	2.676MetLeu: 2.676 ± 0.064	0.533MetMet: 0.533 ± 0.026	0.862MetAsn: 0.862 ± 0.031	1.49MetPro: 1.49 ± 0.043	0.949MetGln: 0.949 ± 0.033	1.935MetArg: 1.935 ± 0.046	1.724MetSer: 1.724 ± 0.042	1.438MetThr: 1.438 ± 0.034	1.526MetVal: 1.526 ± 0.043	0.192MetTrp: 0.192 ± 0.015	0.393MetTyr: 0.393 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.852AsnAla: 2.852 ± 0.069	0.196AsnCys: 0.196 ± 0.015	1.267AsnAsp: 1.267 ± 0.039	1.137AsnGlu: 1.137 ± 0.035	0.782AsnPhe: 0.782 ± 0.032	2.142AsnGly: 2.142 ± 0.054	0.59AsnHis: 0.59 ± 0.023	1.195AsnIle: 1.195 ± 0.04	0.577AsnLys: 0.577 ± 0.025	2.774AsnLeu: 2.774 ± 0.053	0.527AsnMet: 0.527 ± 0.026	0.718AsnAsn: 0.718 ± 0.035	1.871AsnPro: 1.871 ± 0.045	0.887AsnGln: 0.887 ± 0.032	1.859AsnArg: 1.859 ± 0.044	1.057AsnSer: 1.057 ± 0.037	1.329AsnThr: 1.329 ± 0.048	1.739AsnVal: 1.739 ± 0.043	0.324AsnTrp: 0.324 ± 0.02	0.671AsnTyr: 0.671 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.615ProAla: 6.615 ± 0.106	0.351ProCys: 0.351 ± 0.019	3.307ProAsp: 3.307 ± 0.064	3.675ProGlu: 3.675 ± 0.071	1.619ProPhe: 1.619 ± 0.043	4.85ProGly: 4.85 ± 0.081	1.24ProHis: 1.24 ± 0.039	1.943ProIle: 1.943 ± 0.045	1.226ProLys: 1.226 ± 0.041	5.645ProLeu: 5.645 ± 0.083	1.267ProMet: 1.267 ± 0.035	1.234ProAsn: 1.234 ± 0.035	2.998ProPro: 2.998 ± 0.078	1.837ProGln: 1.837 ± 0.045	3.252ProArg: 3.252 ± 0.072	2.547ProSer: 2.547 ± 0.055	2.33ProThr: 2.33 ± 0.054	4.127ProVal: 4.127 ± 0.066	0.801ProTrp: 0.801 ± 0.033	1.376ProTyr: 1.376 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	5.256GlnAla: 5.256 ± 0.1	0.27GlnCys: 0.27 ± 0.016	1.515GlnAsp: 1.515 ± 0.045	1.424GlnGlu: 1.424 ± 0.041	1.006GlnPhe: 1.006 ± 0.033	2.955GlnGly: 2.955 ± 0.056	0.901GlnHis: 0.901 ± 0.027	1.808GlnIle: 1.808 ± 0.051	0.791GlnLys: 0.791 ± 0.033	3.654GlnLeu: 3.654 ± 0.076	0.798GlnMet: 0.798 ± 0.031	0.767GlnAsn: 0.767 ± 0.033	1.978GlnPro: 1.978 ± 0.04	1.568GlnGln: 1.568 ± 0.051	3.173GlnArg: 3.173 ± 0.062	1.786GlnSer: 1.786 ± 0.048	1.926GlnThr: 1.926 ± 0.049	2.64GlnVal: 2.64 ± 0.054	0.497GlnTrp: 0.497 ± 0.023	0.893GlnTyr: 0.893 ± 0.03	0.001GlnXaa: 0.001 ± 0.001
Arg	8.764ArgAla: 8.764 ± 0.111	0.675ArgCys: 0.675 ± 0.028	4.063ArgAsp: 4.063 ± 0.068	5.28ArgGlu: 5.28 ± 0.097	3.087ArgPhe: 3.087 ± 0.06	5.291ArgGly: 5.291 ± 0.083	2.506ArgHis: 2.506 ± 0.058	4.158ArgIle: 4.158 ± 0.07	1.945ArgLys: 1.945 ± 0.045	10.252ArgLeu: 10.252 ± 0.135	2.007ArgMet: 2.007 ± 0.043	1.777ArgAsn: 1.777 ± 0.041	3.781ArgPro: 3.781 ± 0.069	3.156ArgGln: 3.156 ± 0.064	7.123ArgArg: 7.123 ± 0.107	3.279ArgSer: 3.279 ± 0.067	3.171ArgThr: 3.171 ± 0.058	5.729ArgVal: 5.729 ± 0.094	1.211ArgTrp: 1.211 ± 0.038	2.463ArgTyr: 2.463 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	5.793SerAla: 5.793 ± 0.083	0.427SerCys: 0.427 ± 0.023	2.529SerAsp: 2.529 ± 0.049	2.72SerGlu: 2.72 ± 0.061	1.68SerPhe: 1.68 ± 0.041	5.135SerGly: 5.135 ± 0.08	1.203SerHis: 1.203 ± 0.035	2.252SerIle: 2.252 ± 0.043	1.176SerLys: 1.176 ± 0.037	5.925SerLeu: 5.925 ± 0.082	1.238SerMet: 1.238 ± 0.031	1.254SerAsn: 1.254 ± 0.043	2.813SerPro: 2.813 ± 0.059	1.779SerGln: 1.779 ± 0.045	3.74SerArg: 3.74 ± 0.063	2.576SerSer: 2.576 ± 0.057	2.447SerThr: 2.447 ± 0.059	3.546SerVal: 3.546 ± 0.058	0.641SerTrp: 0.641 ± 0.029	1.214SerTyr: 1.214 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.64ThrAla: 5.64 ± 0.075	0.408ThrCys: 0.408 ± 0.023	2.385ThrAsp: 2.385 ± 0.044	2.206ThrGlu: 2.206 ± 0.049	1.437ThrPhe: 1.437 ± 0.042	4.631ThrGly: 4.631 ± 0.076	1.353ThrHis: 1.353 ± 0.038	1.925ThrIle: 1.925 ± 0.049	0.85ThrLys: 0.85 ± 0.035	6.667ThrLeu: 6.667 ± 0.09	0.911ThrMet: 0.911 ± 0.033	0.998ThrAsn: 0.998 ± 0.036	3.374ThrPro: 3.374 ± 0.068	1.808ThrGln: 1.808 ± 0.048	3.785ThrArg: 3.785 ± 0.063	2.228ThrSer: 2.228 ± 0.051	2.354ThrThr: 2.354 ± 0.053	3.678ThrVal: 3.678 ± 0.065	0.583ThrTrp: 0.583 ± 0.025	1.152ThrTyr: 1.152 ± 0.038	0.001ThrXaa: 0.001 ± 0.001
Val	8.733ValAla: 8.733 ± 0.099	0.718ValCys: 0.718 ± 0.028	4.363ValAsp: 4.363 ± 0.077	4.15ValGlu: 4.15 ± 0.068	2.557ValPhe: 2.557 ± 0.052	5.581ValGly: 5.581 ± 0.087	1.664ValHis: 1.664 ± 0.041	3.755ValIle: 3.755 ± 0.072	1.904ValLys: 1.904 ± 0.054	7.606ValLeu: 7.606 ± 0.104	1.751ValMet: 1.751 ± 0.047	2.061ValAsn: 2.061 ± 0.046	3.561ValPro: 3.561 ± 0.074	2.109ValGln: 2.109 ± 0.041	5.213ValArg: 5.213 ± 0.073	4.131ValSer: 4.131 ± 0.065	3.749ValThr: 3.749 ± 0.073	5.816ValVal: 5.816 ± 0.095	0.911ValTrp: 0.911 ± 0.036	1.789ValTyr: 1.789 ± 0.048	0.001ValXaa: 0.001 ± 0.001
Trp	1.236TrpAla: 1.236 ± 0.04	0.138TrpCys: 0.138 ± 0.01	0.576TrpAsp: 0.576 ± 0.027	0.532TrpGlu: 0.532 ± 0.024	0.548TrpPhe: 0.548 ± 0.026	0.942TrpGly: 0.942 ± 0.036	0.409TrpHis: 0.409 ± 0.022	0.66TrpIle: 0.66 ± 0.027	0.29TrpLys: 0.29 ± 0.016	2.178TrpLeu: 2.178 ± 0.053	0.355TrpMet: 0.355 ± 0.019	0.367TrpAsn: 0.367 ± 0.02	0.731TrpPro: 0.731 ± 0.029	0.669TrpGln: 0.669 ± 0.028	1.309TrpArg: 1.309 ± 0.037	0.738TrpSer: 0.738 ± 0.028	0.631TrpThr: 0.631 ± 0.027	1.081TrpVal: 1.081 ± 0.034	0.262TrpTrp: 0.262 ± 0.018	0.365TrpTyr: 0.365 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.141TyrAla: 3.141 ± 0.062	0.262TyrCys: 0.262 ± 0.016	1.4TyrAsp: 1.4 ± 0.041	1.247TyrGlu: 1.247 ± 0.035	0.979TyrPhe: 0.979 ± 0.034	2.307TyrGly: 2.307 ± 0.054	0.659TyrHis: 0.659 ± 0.027	0.926TyrIle: 0.926 ± 0.033	0.566TyrLys: 0.566 ± 0.027	3.137TyrLeu: 3.137 ± 0.062	0.453TyrMet: 0.453 ± 0.024	0.714TyrAsn: 0.714 ± 0.034	1.378TyrPro: 1.378 ± 0.037	0.993TyrGln: 0.993 ± 0.034	2.475TyrArg: 2.475 ± 0.058	1.243TyrSer: 1.243 ± 0.038	1.301TyrThr: 1.301 ± 0.048	1.828TyrVal: 1.828 ± 0.046	0.408TyrTrp: 0.408 ± 0.02	0.811TyrTyr: 0.811 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3188 proteins (984843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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