Amino acid dipepetide frequency for Lachnospiraceae bacterium YSD2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.468AlaAla: 6.468 ± 0.113	1.163AlaCys: 1.163 ± 0.036	5.01AlaAsp: 5.01 ± 0.082	5.797AlaGlu: 5.797 ± 0.091	3.364AlaPhe: 3.364 ± 0.065	6.046AlaGly: 6.046 ± 0.087	1.154AlaHis: 1.154 ± 0.031	5.571AlaIle: 5.571 ± 0.09	4.972AlaLys: 4.972 ± 0.078	7.14AlaLeu: 7.14 ± 0.086	2.269AlaMet: 2.269 ± 0.049	2.624AlaAsn: 2.624 ± 0.052	2.26AlaPro: 2.26 ± 0.06	1.72AlaGln: 1.72 ± 0.044	2.996AlaArg: 2.996 ± 0.053	4.459AlaSer: 4.459 ± 0.083	3.888AlaThr: 3.888 ± 0.071	6.159AlaVal: 6.159 ± 0.091	0.583AlaTrp: 0.583 ± 0.028	2.996AlaTyr: 2.996 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.008CysAla: 1.008 ± 0.033	0.221CysCys: 0.221 ± 0.015	0.955CysAsp: 0.955 ± 0.032	0.948CysGlu: 0.948 ± 0.031	0.689CysPhe: 0.689 ± 0.027	1.401CysGly: 1.401 ± 0.037	0.265CysHis: 0.265 ± 0.017	0.988CysIle: 0.988 ± 0.031	0.982CysLys: 0.982 ± 0.035	1.159CysLeu: 1.159 ± 0.031	0.395CysMet: 0.395 ± 0.02	0.618CysAsn: 0.618 ± 0.028	0.553CysPro: 0.553 ± 0.026	0.197CysGln: 0.197 ± 0.014	0.501CysArg: 0.501 ± 0.026	0.729CysSer: 0.729 ± 0.025	0.668CysThr: 0.668 ± 0.023	1.117CysVal: 1.117 ± 0.034	0.118CysTrp: 0.118 ± 0.012	0.595CysTyr: 0.595 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.87AspAla: 4.87 ± 0.074	0.831AspCys: 0.831 ± 0.031	3.77AspAsp: 3.77 ± 0.071	5.378AspGlu: 5.378 ± 0.081	2.992AspPhe: 2.992 ± 0.058	4.607AspGly: 4.607 ± 0.078	0.814AspHis: 0.814 ± 0.033	4.965AspIle: 4.965 ± 0.08	4.947AspLys: 4.947 ± 0.085	4.505AspLeu: 4.505 ± 0.073	1.854AspMet: 1.854 ± 0.043	2.844AspAsn: 2.844 ± 0.06	1.737AspPro: 1.737 ± 0.043	0.814AspGln: 0.814 ± 0.032	2.352AspArg: 2.352 ± 0.056	3.671AspSer: 3.671 ± 0.059	3.36AspThr: 3.36 ± 0.061	4.422AspVal: 4.422 ± 0.072	0.656AspTrp: 0.656 ± 0.025	3.345AspTyr: 3.345 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	6.257GluAla: 6.257 ± 0.106	0.875GluCys: 0.875 ± 0.029	4.54GluAsp: 4.54 ± 0.072	6.846GluGlu: 6.846 ± 0.134	2.925GluPhe: 2.925 ± 0.052	4.639GluGly: 4.639 ± 0.062	1.177GluHis: 1.177 ± 0.039	5.563GluIle: 5.563 ± 0.079	5.964GluLys: 5.964 ± 0.097	6.483GluLeu: 6.483 ± 0.088	2.223GluMet: 2.223 ± 0.05	3.599GluAsn: 3.599 ± 0.068	2.108GluPro: 2.108 ± 0.074	1.903GluGln: 1.903 ± 0.045	3.375GluArg: 3.375 ± 0.068	3.965GluSer: 3.965 ± 0.07	3.931GluThr: 3.931 ± 0.062	4.817GluVal: 4.817 ± 0.08	0.689GluTrp: 0.689 ± 0.029	3.674GluTyr: 3.674 ± 0.071	0.0GluXaa: 0.0 ± 0.0
Phe	3.368PheAla: 3.368 ± 0.055	0.745PheCys: 0.745 ± 0.035	3.151PheAsp: 3.151 ± 0.061	3.008PheGlu: 3.008 ± 0.06	2.311PhePhe: 2.311 ± 0.064	3.087PheGly: 3.087 ± 0.065	0.629PheHis: 0.629 ± 0.025	3.139PheIle: 3.139 ± 0.073	3.177PheLys: 3.177 ± 0.058	3.77PheLeu: 3.77 ± 0.079	1.322PheMet: 1.322 ± 0.039	1.972PheAsn: 1.972 ± 0.05	1.333PhePro: 1.333 ± 0.039	0.767PheGln: 0.767 ± 0.027	1.544PheArg: 1.544 ± 0.04	2.901PheSer: 2.901 ± 0.06	2.522PheThr: 2.522 ± 0.053	3.377PheVal: 3.377 ± 0.071	0.449PheTrp: 0.449 ± 0.022	1.889PheTyr: 1.889 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.943GlyAla: 4.943 ± 0.07	1.138GlyCys: 1.138 ± 0.035	4.03GlyAsp: 4.03 ± 0.07	4.909GlyGlu: 4.909 ± 0.071	3.256GlyPhe: 3.256 ± 0.059	4.77GlyGly: 4.77 ± 0.08	1.204GlyHis: 1.204 ± 0.038	5.713GlyIle: 5.713 ± 0.077	5.325GlyLys: 5.325 ± 0.079	5.873GlyLeu: 5.873 ± 0.084	2.195GlyMet: 2.195 ± 0.042	3.268GlyAsn: 3.268 ± 0.064	1.375GlyPro: 1.375 ± 0.041	1.578GlyGln: 1.578 ± 0.042	2.815GlyArg: 2.815 ± 0.043	3.882GlySer: 3.882 ± 0.083	4.163GlyThr: 4.163 ± 0.078	5.113GlyVal: 5.113 ± 0.065	0.645GlyTrp: 0.645 ± 0.026	3.476GlyTyr: 3.476 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.996HisAla: 0.996 ± 0.033	0.262HisCys: 0.262 ± 0.016	1.011HisAsp: 1.011 ± 0.034	1.1HisGlu: 1.1 ± 0.036	0.793HisPhe: 0.793 ± 0.035	1.179HisGly: 1.179 ± 0.037	0.337HisHis: 0.337 ± 0.028	1.151HisIle: 1.151 ± 0.033	0.993HisLys: 0.993 ± 0.03	1.22HisLeu: 1.22 ± 0.033	0.448HisMet: 0.448 ± 0.021	0.695HisAsn: 0.695 ± 0.025	0.699HisPro: 0.699 ± 0.031	0.344HisGln: 0.344 ± 0.018	0.678HisArg: 0.678 ± 0.025	0.924HisSer: 0.924 ± 0.029	0.807HisThr: 0.807 ± 0.032	1.043HisVal: 1.043 ± 0.031	0.161HisTrp: 0.161 ± 0.014	0.71HisTyr: 0.71 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.881IleAla: 5.881 ± 0.075	1.2IleCys: 1.2 ± 0.041	4.772IleAsp: 4.772 ± 0.076	5.074IleGlu: 5.074 ± 0.08	2.954IlePhe: 2.954 ± 0.064	4.929IleGly: 4.929 ± 0.089	1.109IleHis: 1.109 ± 0.034	5.439IleIle: 5.439 ± 0.095	5.302IleLys: 5.302 ± 0.073	6.333IleLeu: 6.333 ± 0.103	1.963IleMet: 1.963 ± 0.047	3.351IleAsn: 3.351 ± 0.053	2.862IlePro: 2.862 ± 0.05	1.521IleGln: 1.521 ± 0.039	2.951IleArg: 2.951 ± 0.055	4.808IleSer: 4.808 ± 0.069	4.363IleThr: 4.363 ± 0.083	5.42IleVal: 5.42 ± 0.084	0.589IleTrp: 0.589 ± 0.024	2.894IleTyr: 2.894 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.888LysAla: 5.888 ± 0.09	0.856LysCys: 0.856 ± 0.032	4.684LysAsp: 4.684 ± 0.071	6.641LysGlu: 6.641 ± 0.091	2.344LysPhe: 2.344 ± 0.051	4.481LysGly: 4.481 ± 0.068	1.02LysHis: 1.02 ± 0.03	4.898LysIle: 4.898 ± 0.075	6.253LysLys: 6.253 ± 0.114	6.024LysLeu: 6.024 ± 0.087	2.213LysMet: 2.213 ± 0.048	3.888LysAsn: 3.888 ± 0.069	2.225LysPro: 2.225 ± 0.05	1.672LysGln: 1.672 ± 0.046	3.258LysArg: 3.258 ± 0.065	3.847LysSer: 3.847 ± 0.071	3.897LysThr: 3.897 ± 0.056	4.808LysVal: 4.808 ± 0.071	0.698LysTrp: 0.698 ± 0.028	3.284LysTyr: 3.284 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.327LeuAla: 6.327 ± 0.081	1.347LeuCys: 1.347 ± 0.039	4.899LeuAsp: 4.899 ± 0.078	5.521LeuGlu: 5.521 ± 0.086	4.038LeuPhe: 4.038 ± 0.077	5.51LeuGly: 5.51 ± 0.083	1.296LeuHis: 1.296 ± 0.04	5.991LeuIle: 5.991 ± 0.102	6.857LeuLys: 6.857 ± 0.091	7.694LeuLeu: 7.694 ± 0.111	2.509LeuMet: 2.509 ± 0.062	4.063LeuAsn: 4.063 ± 0.068	3.055LeuPro: 3.055 ± 0.065	1.951LeuGln: 1.951 ± 0.046	3.521LeuArg: 3.521 ± 0.063	6.443LeuSer: 6.443 ± 0.082	5.001LeuThr: 5.001 ± 0.072	5.534LeuVal: 5.534 ± 0.082	0.761LeuTrp: 0.761 ± 0.028	3.56LeuTyr: 3.56 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.3MetAla: 2.3 ± 0.053	0.397MetCys: 0.397 ± 0.019	1.816MetAsp: 1.816 ± 0.044	1.901MetGlu: 1.901 ± 0.043	1.128MetPhe: 1.128 ± 0.039	2.014MetGly: 2.014 ± 0.046	0.488MetHis: 0.488 ± 0.024	2.046MetIle: 2.046 ± 0.046	2.252MetLys: 2.252 ± 0.048	2.559MetLeu: 2.559 ± 0.056	0.791MetMet: 0.791 ± 0.03	1.507MetAsn: 1.507 ± 0.042	1.095MetPro: 1.095 ± 0.037	0.802MetGln: 0.802 ± 0.033	1.206MetArg: 1.206 ± 0.036	1.902MetSer: 1.902 ± 0.041	1.63MetThr: 1.63 ± 0.039	1.922MetVal: 1.922 ± 0.04	0.234MetTrp: 0.234 ± 0.016	1.075MetTyr: 1.075 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.357AsnAla: 3.357 ± 0.063	0.61AsnCys: 0.61 ± 0.024	2.53AsnAsp: 2.53 ± 0.053	2.864AsnGlu: 2.864 ± 0.058	1.815AsnPhe: 1.815 ± 0.045	3.557AsnGly: 3.557 ± 0.088	0.762AsnHis: 0.762 ± 0.036	3.502AsnIle: 3.502 ± 0.066	2.952AsnLys: 2.952 ± 0.057	3.937AsnLeu: 3.937 ± 0.064	1.384AsnMet: 1.384 ± 0.038	2.129AsnAsn: 2.129 ± 0.047	1.97AsnPro: 1.97 ± 0.045	1.035AsnGln: 1.035 ± 0.037	1.89AsnArg: 1.89 ± 0.047	2.643AsnSer: 2.643 ± 0.059	2.439AsnThr: 2.439 ± 0.057	3.512AsnVal: 3.512 ± 0.061	0.434AsnTrp: 0.434 ± 0.022	1.992AsnTyr: 1.992 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.494ProAla: 2.494 ± 0.062	0.414ProCys: 0.414 ± 0.02	2.282ProAsp: 2.282 ± 0.055	3.249ProGlu: 3.249 ± 0.082	1.57ProPhe: 1.57 ± 0.041	2.24ProGly: 2.24 ± 0.056	0.497ProHis: 0.497 ± 0.021	2.192ProIle: 2.192 ± 0.053	1.949ProLys: 1.949 ± 0.046	2.523ProLeu: 2.523 ± 0.05	0.874ProMet: 0.874 ± 0.034	1.219ProAsn: 1.219 ± 0.04	0.608ProPro: 0.608 ± 0.025	0.761ProGln: 0.761 ± 0.031	0.907ProArg: 0.907 ± 0.028	1.703ProSer: 1.703 ± 0.041	1.648ProThr: 1.648 ± 0.047	2.757ProVal: 2.757 ± 0.051	0.323ProTrp: 0.323 ± 0.02	1.363ProTyr: 1.363 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.82GlnAla: 1.82 ± 0.048	0.292GlnCys: 0.292 ± 0.016	1.207GlnAsp: 1.207 ± 0.039	1.548GlnGlu: 1.548 ± 0.044	0.92GlnPhe: 0.92 ± 0.034	1.521GlnGly: 1.521 ± 0.04	0.331GlnHis: 0.331 ± 0.018	1.735GlnIle: 1.735 ± 0.046	1.869GlnLys: 1.869 ± 0.047	1.735GlnLeu: 1.735 ± 0.039	0.745GlnMet: 0.745 ± 0.025	1.041GlnAsn: 1.041 ± 0.033	0.647GlnPro: 0.647 ± 0.025	0.597GlnGln: 0.597 ± 0.025	0.954GlnArg: 0.954 ± 0.036	1.215GlnSer: 1.215 ± 0.036	1.204GlnThr: 1.204 ± 0.038	1.373GlnVal: 1.373 ± 0.037	0.215GlnTrp: 0.215 ± 0.017	1.038GlnTyr: 1.038 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.667ArgAla: 2.667 ± 0.06	0.431ArgCys: 0.431 ± 0.023	2.443ArgAsp: 2.443 ± 0.054	3.463ArgGlu: 3.463 ± 0.07	1.964ArgPhe: 1.964 ± 0.044	2.394ArgGly: 2.394 ± 0.053	0.718ArgHis: 0.718 ± 0.029	3.321ArgIle: 3.321 ± 0.062	3.095ArgLys: 3.095 ± 0.06	3.598ArgLeu: 3.598 ± 0.068	1.32ArgMet: 1.32 ± 0.045	1.938ArgAsn: 1.938 ± 0.038	1.202ArgPro: 1.202 ± 0.037	1.057ArgGln: 1.057 ± 0.03	1.829ArgArg: 1.829 ± 0.053	1.921ArgSer: 1.921 ± 0.042	1.988ArgThr: 1.988 ± 0.049	2.774ArgVal: 2.774 ± 0.054	0.341ArgTrp: 0.341 ± 0.019	1.747ArgTyr: 1.747 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.362SerAla: 4.362 ± 0.077	0.667SerCys: 0.667 ± 0.025	3.982SerAsp: 3.982 ± 0.071	4.502SerGlu: 4.502 ± 0.082	3.343SerPhe: 3.343 ± 0.059	4.73SerGly: 4.73 ± 0.078	0.931SerHis: 0.931 ± 0.029	4.161SerIle: 4.161 ± 0.068	3.849SerLys: 3.849 ± 0.068	5.365SerLeu: 5.365 ± 0.08	1.695SerMet: 1.695 ± 0.042	2.472SerAsn: 2.472 ± 0.047	1.572SerPro: 1.572 ± 0.04	1.418SerGln: 1.418 ± 0.043	2.352SerArg: 2.352 ± 0.049	3.443SerSer: 3.443 ± 0.079	3.003SerThr: 3.003 ± 0.056	4.887SerVal: 4.887 ± 0.076	0.516SerTrp: 0.516 ± 0.03	2.597SerTyr: 2.597 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.41ThrAla: 4.41 ± 0.069	0.668ThrCys: 0.668 ± 0.025	3.727ThrAsp: 3.727 ± 0.076	4.044ThrGlu: 4.044 ± 0.076	2.36ThrPhe: 2.36 ± 0.049	4.342ThrGly: 4.342 ± 0.07	0.875ThrHis: 0.875 ± 0.029	4.17ThrIle: 4.17 ± 0.073	3.266ThrLys: 3.266 ± 0.061	4.833ThrLeu: 4.833 ± 0.082	1.373ThrMet: 1.373 ± 0.04	2.071ThrAsn: 2.071 ± 0.044	2.11ThrPro: 2.11 ± 0.054	1.158ThrGln: 1.158 ± 0.034	1.889ThrArg: 1.889 ± 0.043	2.977ThrSer: 2.977 ± 0.061	2.885ThrThr: 2.885 ± 0.074	4.786ThrVal: 4.786 ± 0.085	0.474ThrTrp: 0.474 ± 0.019	2.412ThrTyr: 2.412 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	5.502ValAla: 5.502 ± 0.09	1.237ValCys: 1.237 ± 0.038	4.192ValAsp: 4.192 ± 0.073	4.792ValGlu: 4.792 ± 0.08	3.315ValPhe: 3.315 ± 0.071	4.511ValGly: 4.511 ± 0.08	1.031ValHis: 1.031 ± 0.029	5.417ValIle: 5.417 ± 0.083	5.341ValLys: 5.341 ± 0.077	6.579ValLeu: 6.579 ± 0.098	2.035ValMet: 2.035 ± 0.053	3.316ValAsn: 3.316 ± 0.066	2.516ValPro: 2.516 ± 0.044	1.41ValGln: 1.41 ± 0.041	2.893ValArg: 2.893 ± 0.056	5.218ValSer: 5.218 ± 0.075	4.518ValThr: 4.518 ± 0.102	5.228ValVal: 5.228 ± 0.079	0.644ValTrp: 0.644 ± 0.03	2.985ValTyr: 2.985 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.595TrpAla: 0.595 ± 0.026	0.15TrpCys: 0.15 ± 0.013	0.564TrpAsp: 0.564 ± 0.028	0.632TrpGlu: 0.632 ± 0.026	0.406TrpPhe: 0.406 ± 0.021	0.668TrpGly: 0.668 ± 0.026	0.204TrpHis: 0.204 ± 0.017	0.648TrpIle: 0.648 ± 0.026	0.599TrpLys: 0.599 ± 0.022	0.837TrpLeu: 0.837 ± 0.032	0.297TrpMet: 0.297 ± 0.017	0.541TrpAsn: 0.541 ± 0.022	0.239TrpPro: 0.239 ± 0.016	0.313TrpGln: 0.313 ± 0.02	0.315TrpArg: 0.315 ± 0.016	0.457TrpSer: 0.457 ± 0.021	0.441TrpThr: 0.441 ± 0.021	0.552TrpVal: 0.552 ± 0.024	0.13TrpTrp: 0.13 ± 0.011	0.462TrpTyr: 0.462 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.125TyrAla: 3.125 ± 0.063	0.606TyrCys: 0.606 ± 0.025	3.167TyrAsp: 3.167 ± 0.076	3.334TyrGlu: 3.334 ± 0.061	1.97TyrPhe: 1.97 ± 0.046	3.044TyrGly: 3.044 ± 0.063	0.708TyrHis: 0.708 ± 0.028	3.107TyrIle: 3.107 ± 0.055	2.935TyrLys: 2.935 ± 0.063	3.711TyrLeu: 3.711 ± 0.061	1.161TyrMet: 1.161 ± 0.031	2.159TyrAsn: 2.159 ± 0.046	1.409TyrPro: 1.409 ± 0.038	0.989TyrGln: 0.989 ± 0.027	1.985TyrArg: 1.985 ± 0.043	2.737TyrSer: 2.737 ± 0.051	2.476TyrThr: 2.476 ± 0.059	3.079TyrVal: 3.079 ± 0.063	0.388TyrTrp: 0.388 ± 0.018	2.139TyrTyr: 2.139 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2888 proteins (989764 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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