Amino acid dipepetide frequency for Chlorogloea sp. CCALA 695

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.736AlaAla: 7.736 ± 0.097
0.86AlaCys: 0.86 ± 0.025
3.909AlaAsp: 3.909 ± 0.058
5.121AlaGlu: 5.121 ± 0.06
2.933AlaPhe: 2.933 ± 0.041
5.37AlaGly: 5.37 ± 0.065
1.322AlaHis: 1.322 ± 0.036
7.496AlaIle: 7.496 ± 0.088
4.546AlaLys: 4.546 ± 0.06
9.159AlaLeu: 9.159 ± 0.093
1.761AlaMet: 1.761 ± 0.04
3.587AlaAsn: 3.587 ± 0.063
3.166AlaPro: 3.166 ± 0.056
4.634AlaGln: 4.634 ± 0.074
3.635AlaArg: 3.635 ± 0.053
4.991AlaSer: 4.991 ± 0.063
5.154AlaThr: 5.154 ± 0.067
5.658AlaVal: 5.658 ± 0.068
1.051AlaTrp: 1.051 ± 0.029
2.377AlaTyr: 2.377 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.689CysAla: 0.689 ± 0.023
0.192CysCys: 0.192 ± 0.014
0.641CysAsp: 0.641 ± 0.024
0.499CysGlu: 0.499 ± 0.018
0.437CysPhe: 0.437 ± 0.018
0.841CysGly: 0.841 ± 0.022
0.293CysHis: 0.293 ± 0.016
0.6CysIle: 0.6 ± 0.02
0.426CysLys: 0.426 ± 0.017
1.143CysLeu: 1.143 ± 0.031
0.141CysMet: 0.141 ± 0.009
0.41CysAsn: 0.41 ± 0.017
0.581CysPro: 0.581 ± 0.019
0.58CysGln: 0.58 ± 0.023
0.536CysArg: 0.536 ± 0.018
0.674CysSer: 0.674 ± 0.02
0.548CysThr: 0.548 ± 0.019
0.545CysVal: 0.545 ± 0.021
0.153CysTrp: 0.153 ± 0.011
0.351CysTyr: 0.351 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.524AspAla: 3.524 ± 0.061
0.53AspCys: 0.53 ± 0.02
2.106AspAsp: 2.106 ± 0.047
2.921AspGlu: 2.921 ± 0.052
2.244AspPhe: 2.244 ± 0.039
3.191AspGly: 3.191 ± 0.06
0.596AspHis: 0.596 ± 0.022
3.31AspIle: 3.31 ± 0.053
2.424AspLys: 2.424 ± 0.045
5.716AspLeu: 5.716 ± 0.081
0.737AspMet: 0.737 ± 0.022
2.027AspAsn: 2.027 ± 0.037
2.251AspPro: 2.251 ± 0.045
1.387AspGln: 1.387 ± 0.031
3.755AspArg: 3.755 ± 0.059
3.065AspSer: 3.065 ± 0.048
2.454AspThr: 2.454 ± 0.042
2.933AspVal: 2.933 ± 0.043
0.911AspTrp: 0.911 ± 0.026
1.916AspTyr: 1.916 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
5.31GluAla: 5.31 ± 0.067
0.499GluCys: 0.499 ± 0.025
2.705GluAsp: 2.705 ± 0.047
3.578GluGlu: 3.578 ± 0.062
2.304GluPhe: 2.304 ± 0.043
2.949GluGly: 2.949 ± 0.048
0.948GluHis: 0.948 ± 0.027
4.707GluIle: 4.707 ± 0.054
3.4GluLys: 3.4 ± 0.061
7.033GluLeu: 7.033 ± 0.082
1.247GluMet: 1.247 ± 0.032
2.548GluAsn: 2.548 ± 0.04
2.308GluPro: 2.308 ± 0.045
3.928GluGln: 3.928 ± 0.061
3.524GluArg: 3.524 ± 0.05
3.484GluSer: 3.484 ± 0.053
3.422GluThr: 3.422 ± 0.05
4.477GluVal: 4.477 ± 0.062
0.728GluTrp: 0.728 ± 0.023
1.73GluTyr: 1.73 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.267PheAla: 3.267 ± 0.052
0.563PheCys: 0.563 ± 0.022
2.169PheAsp: 2.169 ± 0.04
2.167PheGlu: 2.167 ± 0.039
1.544PhePhe: 1.544 ± 0.041
2.748PheGly: 2.748 ± 0.045
0.674PheHis: 0.674 ± 0.023
2.326PheIle: 2.326 ± 0.046
1.723PheLys: 1.723 ± 0.039
3.876PheLeu: 3.876 ± 0.062
0.638PheMet: 0.638 ± 0.022
1.836PheAsn: 1.836 ± 0.042
1.706PhePro: 1.706 ± 0.038
1.605PheGln: 1.605 ± 0.032
1.718PheArg: 1.718 ± 0.037
2.794PheSer: 2.794 ± 0.05
2.342PheThr: 2.342 ± 0.048
2.421PheVal: 2.421 ± 0.041
0.671PheTrp: 0.671 ± 0.026
1.315PheTyr: 1.315 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
5.073GlyAla: 5.073 ± 0.083
0.814GlyCys: 0.814 ± 0.024
3.371GlyAsp: 3.371 ± 0.049
3.971GlyGlu: 3.971 ± 0.053
2.877GlyPhe: 2.877 ± 0.05
4.59GlyGly: 4.59 ± 0.071
1.114GlyHis: 1.114 ± 0.029
4.963GlyIle: 4.963 ± 0.054
4.096GlyLys: 4.096 ± 0.064
6.932GlyLeu: 6.932 ± 0.087
1.488GlyMet: 1.488 ± 0.033
2.745GlyAsn: 2.745 ± 0.051
0.981GlyPro: 0.981 ± 0.027
2.929GlyGln: 2.929 ± 0.045
3.157GlyArg: 3.157 ± 0.047
3.999GlySer: 3.999 ± 0.059
3.743GlyThr: 3.743 ± 0.065
4.793GlyVal: 4.793 ± 0.056
1.1GlyTrp: 1.1 ± 0.03
2.304GlyTyr: 2.304 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
0.993HisAla: 0.993 ± 0.028
0.264HisCys: 0.264 ± 0.013
0.734HisAsp: 0.734 ± 0.024
0.844HisGlu: 0.844 ± 0.023
0.745HisPhe: 0.745 ± 0.022
1.003HisGly: 1.003 ± 0.028
0.548HisHis: 0.548 ± 0.025
1.064HisIle: 1.064 ± 0.031
0.741HisLys: 0.741 ± 0.025
2.118HisLeu: 2.118 ± 0.048
0.25HisMet: 0.25 ± 0.013
0.711HisAsn: 0.711 ± 0.026
1.219HisPro: 1.219 ± 0.035
1.087HisGln: 1.087 ± 0.031
1.068HisArg: 1.068 ± 0.026
1.212HisSer: 1.212 ± 0.03
0.865HisThr: 0.865 ± 0.026
0.754HisVal: 0.754 ± 0.024
0.356HisTrp: 0.356 ± 0.016
0.658HisTyr: 0.658 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.778IleAla: 7.778 ± 0.082
0.753IleCys: 0.753 ± 0.025
3.934IleAsp: 3.934 ± 0.052
4.657IleGlu: 4.657 ± 0.061
2.433IlePhe: 2.433 ± 0.047
4.604IleGly: 4.604 ± 0.06
1.129IleHis: 1.129 ± 0.028
3.708IleIle: 3.708 ± 0.046
3.224IleLys: 3.224 ± 0.056
6.219IleLeu: 6.219 ± 0.069
0.864IleMet: 0.864 ± 0.026
3.1IleAsn: 3.1 ± 0.055
3.481IlePro: 3.481 ± 0.052
2.555IleGln: 2.555 ± 0.042
3.007IleArg: 3.007 ± 0.041
4.793IleSer: 4.793 ± 0.064
3.696IleThr: 3.696 ± 0.056
4.668IleVal: 4.668 ± 0.055
0.766IleTrp: 0.766 ± 0.021
1.978IleTyr: 1.978 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.468LysAla: 4.468 ± 0.061
0.39LysCys: 0.39 ± 0.016
2.248LysAsp: 2.248 ± 0.038
3.054LysGlu: 3.054 ± 0.047
1.769LysPhe: 1.769 ± 0.038
2.775LysGly: 2.775 ± 0.054
0.833LysHis: 0.833 ± 0.027
3.462LysIle: 3.462 ± 0.06
2.423LysLys: 2.423 ± 0.044
5.872LysLeu: 5.872 ± 0.068
0.984LysMet: 0.984 ± 0.029
2.19LysAsn: 2.19 ± 0.046
2.565LysPro: 2.565 ± 0.048
3.091LysGln: 3.091 ± 0.043
2.555LysArg: 2.555 ± 0.047
3.41LysSer: 3.41 ± 0.055
3.1LysThr: 3.1 ± 0.046
3.653LysVal: 3.653 ± 0.055
0.53LysTrp: 0.53 ± 0.021
1.413LysTyr: 1.413 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
9.967LeuAla: 9.967 ± 0.087
1.006LeuCys: 1.006 ± 0.026
5.226LeuAsp: 5.226 ± 0.062
7.341LeuGlu: 7.341 ± 0.084
3.733LeuPhe: 3.733 ± 0.064
7.678LeuGly: 7.678 ± 0.088
1.916LeuHis: 1.916 ± 0.043
6.883LeuIle: 6.883 ± 0.072
5.815LeuLys: 5.815 ± 0.066
11.807LeuLeu: 11.807 ± 0.115
1.982LeuMet: 1.982 ± 0.037
4.58LeuAsn: 4.58 ± 0.055
5.88LeuPro: 5.88 ± 0.069
5.803LeuGln: 5.803 ± 0.081
5.333LeuArg: 5.333 ± 0.061
7.569LeuSer: 7.569 ± 0.091
6.508LeuThr: 6.508 ± 0.071
7.518LeuVal: 7.518 ± 0.085
1.41LeuTrp: 1.41 ± 0.035
2.652LeuTyr: 2.652 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
1.641MetAla: 1.641 ± 0.033
0.124MetCys: 0.124 ± 0.009
0.748MetAsp: 0.748 ± 0.023
0.94MetGlu: 0.94 ± 0.029
0.579MetPhe: 0.579 ± 0.022
1.333MetGly: 1.333 ± 0.035
0.262MetHis: 0.262 ± 0.014
0.951MetIle: 0.951 ± 0.027
0.897MetLys: 0.897 ± 0.024
1.935MetLeu: 1.935 ± 0.038
0.402MetMet: 0.402 ± 0.017
0.833MetAsn: 0.833 ± 0.023
1.011MetPro: 1.011 ± 0.027
1.1MetGln: 1.1 ± 0.029
0.989MetArg: 0.989 ± 0.027
1.278MetSer: 1.278 ± 0.035
1.263MetThr: 1.263 ± 0.029
1.24MetVal: 1.24 ± 0.027
0.163MetTrp: 0.163 ± 0.012
0.366MetTyr: 0.366 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.167AsnAla: 3.167 ± 0.048
0.54AsnCys: 0.54 ± 0.022
1.729AsnAsp: 1.729 ± 0.04
1.877AsnGlu: 1.877 ± 0.037
1.77AsnPhe: 1.77 ± 0.035
2.556AsnGly: 2.556 ± 0.045
0.788AsnHis: 0.788 ± 0.024
2.795AsnIle: 2.795 ± 0.045
2.0AsnLys: 2.0 ± 0.044
5.479AsnLeu: 5.479 ± 0.08
0.692AsnMet: 0.692 ± 0.022
2.139AsnAsn: 2.139 ± 0.05
2.739AsnPro: 2.739 ± 0.048
2.541AsnGln: 2.541 ± 0.046
2.413AsnArg: 2.413 ± 0.037
3.169AsnSer: 3.169 ± 0.057
2.284AsnThr: 2.284 ± 0.047
2.35AsnVal: 2.35 ± 0.047
0.728AsnTrp: 0.728 ± 0.026
1.652AsnTyr: 1.652 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.215ProAla: 3.215 ± 0.051
0.364ProCys: 0.364 ± 0.015
2.634ProAsp: 2.634 ± 0.044
3.406ProGlu: 3.406 ± 0.052
1.653ProPhe: 1.653 ± 0.037
2.961ProGly: 2.961 ± 0.052
0.83ProHis: 0.83 ± 0.027
3.131ProIle: 3.131 ± 0.055
2.272ProLys: 2.272 ± 0.044
4.773ProLeu: 4.773 ± 0.062
0.764ProMet: 0.764 ± 0.023
2.244ProAsn: 2.244 ± 0.048
2.254ProPro: 2.254 ± 0.056
2.719ProGln: 2.719 ± 0.05
1.737ProArg: 1.737 ± 0.039
3.07ProSer: 3.07 ± 0.057
2.901ProThr: 2.901 ± 0.048
3.358ProVal: 3.358 ± 0.055
0.596ProTrp: 0.596 ± 0.022
1.321ProTyr: 1.321 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.71GlnAla: 4.71 ± 0.069
0.385GlnCys: 0.385 ± 0.018
1.979GlnAsp: 1.979 ± 0.04
3.359GlnGlu: 3.359 ± 0.049
1.756GlnPhe: 1.756 ± 0.036
3.084GlnGly: 3.084 ± 0.052
0.897GlnHis: 0.897 ± 0.03
3.825GlnIle: 3.825 ± 0.051
3.02GlnLys: 3.02 ± 0.05
6.509GlnLeu: 6.509 ± 0.096
1.043GlnMet: 1.043 ± 0.024
2.097GlnAsn: 2.097 ± 0.037
2.479GlnPro: 2.479 ± 0.05
3.722GlnGln: 3.722 ± 0.073
2.618GlnArg: 2.618 ± 0.048
3.205GlnSer: 3.205 ± 0.049
3.019GlnThr: 3.019 ± 0.045
4.069GlnVal: 4.069 ± 0.058
0.743GlnTrp: 0.743 ± 0.023
1.242GlnTyr: 1.242 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
3.504ArgAla: 3.504 ± 0.057
0.555ArgCys: 0.555 ± 0.02
2.466ArgAsp: 2.466 ± 0.044
2.991ArgGlu: 2.991 ± 0.048
2.104ArgPhe: 2.104 ± 0.042
2.93ArgGly: 2.93 ± 0.044
1.006ArgHis: 1.006 ± 0.028
3.178ArgIle: 3.178 ± 0.048
2.296ArgLys: 2.296 ± 0.047
6.009ArgLeu: 6.009 ± 0.073
0.927ArgMet: 0.927 ± 0.027
2.08ArgAsn: 2.08 ± 0.038
2.097ArgPro: 2.097 ± 0.037
3.337ArgGln: 3.337 ± 0.054
2.996ArgArg: 2.996 ± 0.048
3.461ArgSer: 3.461 ± 0.053
2.775ArgThr: 2.775 ± 0.045
3.366ArgVal: 3.366 ± 0.044
0.747ArgTrp: 0.747 ± 0.023
1.872ArgTyr: 1.872 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.082SerAla: 5.082 ± 0.07
0.683SerCys: 0.683 ± 0.023
3.179SerAsp: 3.179 ± 0.053
3.513SerGlu: 3.513 ± 0.047
2.598SerPhe: 2.598 ± 0.052
4.519SerGly: 4.519 ± 0.059
1.175SerHis: 1.175 ± 0.031
4.11SerIle: 4.11 ± 0.057
3.173SerLys: 3.173 ± 0.053
7.528SerLeu: 7.528 ± 0.078
1.179SerMet: 1.179 ± 0.026
3.091SerAsn: 3.091 ± 0.05
3.579SerPro: 3.579 ± 0.046
3.639SerGln: 3.639 ± 0.061
3.241SerArg: 3.241 ± 0.043
4.844SerSer: 4.844 ± 0.069
3.707SerThr: 3.707 ± 0.062
4.238SerVal: 4.238 ± 0.058
0.972SerTrp: 0.972 ± 0.025
1.905SerTyr: 1.905 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
4.958ThrAla: 4.958 ± 0.056
0.518ThrCys: 0.518 ± 0.019
2.753ThrAsp: 2.753 ± 0.049
3.369ThrGlu: 3.369 ± 0.049
2.062ThrPhe: 2.062 ± 0.037
4.405ThrGly: 4.405 ± 0.056
0.962ThrHis: 0.962 ± 0.025
3.995ThrIle: 3.995 ± 0.063
2.69ThrLys: 2.69 ± 0.05
6.118ThrLeu: 6.118 ± 0.07
0.875ThrMet: 0.875 ± 0.023
2.507ThrAsn: 2.507 ± 0.047
3.4ThrPro: 3.4 ± 0.054
2.88ThrGln: 2.88 ± 0.047
2.439ThrArg: 2.439 ± 0.042
3.623ThrSer: 3.623 ± 0.052
3.672ThrThr: 3.672 ± 0.066
3.996ThrVal: 3.996 ± 0.06
0.693ThrTrp: 0.693 ± 0.025
1.686ThrTyr: 1.686 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.258ValAla: 6.258 ± 0.076
0.675ValCys: 0.675 ± 0.025
3.42ValAsp: 3.42 ± 0.048
4.717ValGlu: 4.717 ± 0.058
2.661ValPhe: 2.661 ± 0.05
4.608ValGly: 4.608 ± 0.061
0.984ValHis: 0.984 ± 0.027
4.331ValIle: 4.331 ± 0.054
3.613ValLys: 3.613 ± 0.057
6.744ValLeu: 6.744 ± 0.072
1.37ValMet: 1.37 ± 0.031
2.85ValAsn: 2.85 ± 0.05
2.784ValPro: 2.784 ± 0.05
3.047ValGln: 3.047 ± 0.052
3.26ValArg: 3.26 ± 0.047
4.504ValSer: 4.504 ± 0.062
4.015ValThr: 4.015 ± 0.047
5.098ValVal: 5.098 ± 0.067
0.863ValTrp: 0.863 ± 0.03
1.808ValTyr: 1.808 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.964TrpAla: 0.964 ± 0.028
0.157TrpCys: 0.157 ± 0.01
0.593TrpAsp: 0.593 ± 0.024
0.834TrpGlu: 0.834 ± 0.026
0.584TrpPhe: 0.584 ± 0.023
0.89TrpGly: 0.89 ± 0.024
0.325TrpHis: 0.325 ± 0.016
0.808TrpIle: 0.808 ± 0.028
0.619TrpLys: 0.619 ± 0.024
1.96TrpLeu: 1.96 ± 0.046
0.309TrpMet: 0.309 ± 0.013
0.584TrpAsn: 0.584 ± 0.024
0.147TrpPro: 0.147 ± 0.011
1.321TrpGln: 1.321 ± 0.031
0.827TrpArg: 0.827 ± 0.028
0.863TrpSer: 0.863 ± 0.025
0.613TrpThr: 0.613 ± 0.022
0.892TrpVal: 0.892 ± 0.025
0.241TrpTrp: 0.241 ± 0.014
0.421TrpTyr: 0.421 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.161TyrAla: 2.161 ± 0.043
0.409TyrCys: 0.409 ± 0.017
1.452TyrAsp: 1.452 ± 0.032
1.67TyrGlu: 1.67 ± 0.033
1.317TyrPhe: 1.317 ± 0.031
2.005TyrGly: 2.005 ± 0.043
0.633TyrHis: 0.633 ± 0.021
1.702TyrIle: 1.702 ± 0.033
1.388TyrLys: 1.388 ± 0.031
3.676TyrLeu: 3.676 ± 0.051
0.402TyrMet: 0.402 ± 0.018
1.248TyrAsn: 1.248 ± 0.036
1.573TyrPro: 1.573 ± 0.033
1.857TyrGln: 1.857 ± 0.033
1.892TyrArg: 1.892 ± 0.033
1.95TyrSer: 1.95 ± 0.032
1.518TyrThr: 1.518 ± 0.034
1.584TyrVal: 1.584 ± 0.039
0.53TyrTrp: 0.53 ± 0.02
1.101TyrTyr: 1.101 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4747 proteins (1414214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski