Amino acid dipepetide frequency for Acaryochloris phage A-HIS1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.468AlaAla: 8.468 ± 1.326
0.522AlaCys: 0.522 ± 0.157
3.944AlaAsp: 3.944 ± 0.56
5.22AlaGlu: 5.22 ± 0.61
3.944AlaPhe: 3.944 ± 0.51
4.408AlaGly: 4.408 ± 0.846
1.682AlaHis: 1.682 ± 0.282
5.626AlaIle: 5.626 ± 0.69
4.582AlaLys: 4.582 ± 0.58
6.96AlaLeu: 6.96 ± 1.067
1.624AlaMet: 1.624 ± 0.344
4.93AlaAsn: 4.93 ± 0.756
1.914AlaPro: 1.914 ± 0.386
1.972AlaGln: 1.972 ± 0.306
3.77AlaArg: 3.77 ± 0.452
4.582AlaSer: 4.582 ± 0.535
4.64AlaThr: 4.64 ± 0.863
6.09AlaVal: 6.09 ± 0.628
0.928AlaTrp: 0.928 ± 0.232
2.784AlaTyr: 2.784 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.812CysAla: 0.812 ± 0.197
0.058CysCys: 0.058 ± 0.055
0.87CysAsp: 0.87 ± 0.236
0.928CysGlu: 0.928 ± 0.24
0.29CysPhe: 0.29 ± 0.144
0.87CysGly: 0.87 ± 0.311
0.174CysHis: 0.174 ± 0.093
0.638CysIle: 0.638 ± 0.193
0.348CysLys: 0.348 ± 0.136
0.986CysLeu: 0.986 ± 0.244
0.638CysMet: 0.638 ± 0.191
0.348CysAsn: 0.348 ± 0.154
0.638CysPro: 0.638 ± 0.166
0.29CysGln: 0.29 ± 0.126
0.406CysArg: 0.406 ± 0.149
0.522CysSer: 0.522 ± 0.142
0.174CysThr: 0.174 ± 0.097
0.638CysVal: 0.638 ± 0.187
0.058CysTrp: 0.058 ± 0.054
0.464CysTyr: 0.464 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
4.814AspAla: 4.814 ± 0.531
0.87AspCys: 0.87 ± 0.203
3.132AspAsp: 3.132 ± 0.545
3.886AspGlu: 3.886 ± 0.588
3.074AspPhe: 3.074 ± 0.413
4.176AspGly: 4.176 ± 0.562
1.508AspHis: 1.508 ± 0.349
3.828AspIle: 3.828 ± 0.62
1.624AspLys: 1.624 ± 0.342
5.684AspLeu: 5.684 ± 0.527
1.102AspMet: 1.102 ± 0.293
2.61AspAsn: 2.61 ± 0.41
3.886AspPro: 3.886 ± 0.591
1.276AspGln: 1.276 ± 0.29
3.364AspArg: 3.364 ± 0.423
3.596AspSer: 3.596 ± 0.522
2.726AspThr: 2.726 ± 0.442
3.654AspVal: 3.654 ± 0.481
0.696AspTrp: 0.696 ± 0.196
2.262AspTyr: 2.262 ± 0.307
0.0AspXaa: 0.0 ± 0.0
Glu
5.394GluAla: 5.394 ± 0.475
1.45GluCys: 1.45 ± 0.328
4.814GluAsp: 4.814 ± 0.597
3.306GluGlu: 3.306 ± 0.57
3.48GluPhe: 3.48 ± 0.412
3.306GluGly: 3.306 ± 0.361
0.986GluHis: 0.986 ± 0.273
7.192GluIle: 7.192 ± 0.655
3.596GluLys: 3.596 ± 0.454
5.452GluLeu: 5.452 ± 0.604
1.74GluMet: 1.74 ± 0.322
4.292GluAsn: 4.292 ± 0.405
2.32GluPro: 2.32 ± 0.371
1.566GluGln: 1.566 ± 0.276
4.06GluArg: 4.06 ± 0.539
4.002GluSer: 4.002 ± 0.492
6.148GluThr: 6.148 ± 0.528
4.234GluVal: 4.234 ± 0.481
0.638GluTrp: 0.638 ± 0.161
3.016GluTyr: 3.016 ± 0.463
0.0GluXaa: 0.0 ± 0.0
Phe
3.306PheAla: 3.306 ± 0.35
0.464PheCys: 0.464 ± 0.159
3.712PheAsp: 3.712 ± 0.524
4.524PheGlu: 4.524 ± 0.462
1.45PhePhe: 1.45 ± 0.247
3.596PheGly: 3.596 ± 0.39
0.58PheHis: 0.58 ± 0.175
1.914PheIle: 1.914 ± 0.37
1.276PheLys: 1.276 ± 0.311
4.176PheLeu: 4.176 ± 0.467
0.638PheMet: 0.638 ± 0.214
2.378PheAsn: 2.378 ± 0.416
1.798PhePro: 1.798 ± 0.404
0.812PheGln: 0.812 ± 0.21
2.378PheArg: 2.378 ± 0.37
3.074PheSer: 3.074 ± 0.353
3.654PheThr: 3.654 ± 0.445
3.248PheVal: 3.248 ± 0.331
0.638PheTrp: 0.638 ± 0.179
1.798PheTyr: 1.798 ± 0.356
0.0PheXaa: 0.0 ± 0.0
Gly
2.61GlyAla: 2.61 ± 0.513
0.696GlyCys: 0.696 ± 0.215
3.77GlyAsp: 3.77 ± 0.485
3.364GlyGlu: 3.364 ± 0.423
3.48GlyPhe: 3.48 ± 0.496
3.422GlyGly: 3.422 ± 0.607
1.16GlyHis: 1.16 ± 0.25
3.886GlyIle: 3.886 ± 0.457
2.842GlyLys: 2.842 ± 0.385
5.046GlyLeu: 5.046 ± 0.465
1.276GlyMet: 1.276 ± 0.29
3.364GlyAsn: 3.364 ± 0.574
1.798GlyPro: 1.798 ± 0.332
1.334GlyGln: 1.334 ± 0.254
3.654GlyArg: 3.654 ± 0.385
5.51GlySer: 5.51 ± 0.71
4.93GlyThr: 4.93 ± 0.777
4.06GlyVal: 4.06 ± 0.506
0.522GlyTrp: 0.522 ± 0.178
3.132GlyTyr: 3.132 ± 0.514
0.0GlyXaa: 0.0 ± 0.0
His
1.45HisAla: 1.45 ± 0.287
0.058HisCys: 0.058 ± 0.054
1.16HisAsp: 1.16 ± 0.26
2.03HisGlu: 2.03 ± 0.388
0.754HisPhe: 0.754 ± 0.207
1.044HisGly: 1.044 ± 0.242
0.29HisHis: 0.29 ± 0.135
0.986HisIle: 0.986 ± 0.263
1.218HisLys: 1.218 ± 0.304
1.624HisLeu: 1.624 ± 0.303
0.522HisMet: 0.522 ± 0.157
1.566HisAsn: 1.566 ± 0.332
0.638HisPro: 0.638 ± 0.202
0.116HisGln: 0.116 ± 0.085
1.044HisArg: 1.044 ± 0.263
1.16HisSer: 1.16 ± 0.308
0.812HisThr: 0.812 ± 0.22
1.334HisVal: 1.334 ± 0.327
0.29HisTrp: 0.29 ± 0.114
0.812HisTyr: 0.812 ± 0.266
0.0HisXaa: 0.0 ± 0.0
Ile
6.67IleAla: 6.67 ± 0.642
0.406IleCys: 0.406 ± 0.145
4.698IleAsp: 4.698 ± 0.473
5.974IleGlu: 5.974 ± 0.62
2.494IlePhe: 2.494 ± 0.403
3.132IleGly: 3.132 ± 0.42
0.928IleHis: 0.928 ± 0.26
3.48IleIle: 3.48 ± 0.481
2.494IleLys: 2.494 ± 0.382
5.8IleLeu: 5.8 ± 0.556
1.276IleMet: 1.276 ± 0.246
3.364IleAsn: 3.364 ± 0.435
3.422IlePro: 3.422 ± 0.471
1.392IleGln: 1.392 ± 0.274
3.77IleArg: 3.77 ± 0.517
4.35IleSer: 4.35 ± 0.436
4.698IleThr: 4.698 ± 0.581
5.452IleVal: 5.452 ± 0.642
0.58IleTrp: 0.58 ± 0.172
1.856IleTyr: 1.856 ± 0.301
0.0IleXaa: 0.0 ± 0.0
Lys
5.394LysAla: 5.394 ± 0.651
0.174LysCys: 0.174 ± 0.111
2.378LysAsp: 2.378 ± 0.405
3.596LysGlu: 3.596 ± 0.542
2.32LysPhe: 2.32 ± 0.356
2.436LysGly: 2.436 ± 0.394
1.508LysHis: 1.508 ± 0.285
3.248LysIle: 3.248 ± 0.422
3.364LysLys: 3.364 ± 0.674
3.712LysLeu: 3.712 ± 0.475
0.812LysMet: 0.812 ± 0.226
3.19LysAsn: 3.19 ± 0.383
1.798LysPro: 1.798 ± 0.411
1.044LysGln: 1.044 ± 0.248
4.698LysArg: 4.698 ± 0.742
3.074LysSer: 3.074 ± 0.484
4.582LysThr: 4.582 ± 0.641
2.842LysVal: 2.842 ± 0.336
0.348LysTrp: 0.348 ± 0.154
2.378LysTyr: 2.378 ± 0.511
0.0LysXaa: 0.0 ± 0.0
Leu
6.148LeuAla: 6.148 ± 0.482
1.16LeuCys: 1.16 ± 0.254
4.756LeuAsp: 4.756 ± 0.524
6.96LeuGlu: 6.96 ± 0.64
2.842LeuPhe: 2.842 ± 0.437
4.988LeuGly: 4.988 ± 0.614
1.334LeuHis: 1.334 ± 0.34
5.104LeuIle: 5.104 ± 0.499
4.292LeuLys: 4.292 ± 0.621
6.09LeuLeu: 6.09 ± 0.54
2.32LeuMet: 2.32 ± 0.393
3.712LeuAsn: 3.712 ± 0.591
4.408LeuPro: 4.408 ± 0.466
2.378LeuGln: 2.378 ± 0.416
5.916LeuArg: 5.916 ± 0.592
8.41LeuSer: 8.41 ± 0.688
7.308LeuThr: 7.308 ± 0.502
4.06LeuVal: 4.06 ± 0.475
0.928LeuTrp: 0.928 ± 0.224
2.842LeuTyr: 2.842 ± 0.446
0.0LeuXaa: 0.0 ± 0.0
Met
1.624MetAla: 1.624 ± 0.322
0.232MetCys: 0.232 ± 0.12
0.58MetAsp: 0.58 ± 0.189
0.754MetGlu: 0.754 ± 0.177
0.696MetPhe: 0.696 ± 0.21
0.58MetGly: 0.58 ± 0.19
0.348MetHis: 0.348 ± 0.131
2.146MetIle: 2.146 ± 0.316
2.088MetLys: 2.088 ± 0.411
2.204MetLeu: 2.204 ± 0.365
0.058MetMet: 0.058 ± 0.057
1.45MetAsn: 1.45 ± 0.289
0.812MetPro: 0.812 ± 0.227
0.58MetGln: 0.58 ± 0.224
1.218MetArg: 1.218 ± 0.24
0.986MetSer: 0.986 ± 0.207
1.798MetThr: 1.798 ± 0.259
0.87MetVal: 0.87 ± 0.219
0.174MetTrp: 0.174 ± 0.095
0.638MetTyr: 0.638 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
5.452AsnAla: 5.452 ± 0.608
0.464AsnCys: 0.464 ± 0.171
3.074AsnAsp: 3.074 ± 0.499
3.886AsnGlu: 3.886 ± 0.491
1.624AsnPhe: 1.624 ± 0.286
6.09AsnGly: 6.09 ± 0.582
1.044AsnHis: 1.044 ± 0.263
3.364AsnIle: 3.364 ± 0.572
1.798AsnLys: 1.798 ± 0.413
4.93AsnLeu: 4.93 ± 0.588
0.58AsnMet: 0.58 ± 0.152
2.436AsnAsn: 2.436 ± 0.49
2.784AsnPro: 2.784 ± 0.4
1.218AsnGln: 1.218 ± 0.319
2.9AsnArg: 2.9 ± 0.428
2.784AsnSer: 2.784 ± 0.378
3.538AsnThr: 3.538 ± 0.596
4.234AsnVal: 4.234 ± 0.464
0.174AsnTrp: 0.174 ± 0.106
1.856AsnTyr: 1.856 ± 0.33
0.0AsnXaa: 0.0 ± 0.0
Pro
2.436ProAla: 2.436 ± 0.403
0.232ProCys: 0.232 ± 0.104
2.32ProAsp: 2.32 ± 0.371
3.77ProGlu: 3.77 ± 0.495
1.856ProPhe: 1.856 ± 0.38
2.378ProGly: 2.378 ± 0.513
1.044ProHis: 1.044 ± 0.29
2.436ProIle: 2.436 ± 0.378
3.074ProLys: 3.074 ± 0.473
3.48ProLeu: 3.48 ± 0.419
0.696ProMet: 0.696 ± 0.207
2.494ProAsn: 2.494 ± 0.385
1.914ProPro: 1.914 ± 0.567
0.812ProGln: 0.812 ± 0.178
2.088ProArg: 2.088 ± 0.344
3.306ProSer: 3.306 ± 0.408
3.19ProThr: 3.19 ± 0.579
2.668ProVal: 2.668 ± 0.317
0.348ProTrp: 0.348 ± 0.145
1.508ProTyr: 1.508 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
1.798GlnAla: 1.798 ± 0.353
0.232GlnCys: 0.232 ± 0.113
0.638GlnAsp: 0.638 ± 0.198
1.16GlnGlu: 1.16 ± 0.234
0.87GlnPhe: 0.87 ± 0.268
1.508GlnGly: 1.508 ± 0.277
0.29GlnHis: 0.29 ± 0.136
2.436GlnIle: 2.436 ± 0.357
1.566GlnLys: 1.566 ± 0.323
2.436GlnLeu: 2.436 ± 0.338
0.522GlnMet: 0.522 ± 0.157
1.16GlnAsn: 1.16 ± 0.258
0.87GlnPro: 0.87 ± 0.221
0.812GlnGln: 0.812 ± 0.221
1.624GlnArg: 1.624 ± 0.295
2.668GlnSer: 2.668 ± 0.466
1.624GlnThr: 1.624 ± 0.404
1.218GlnVal: 1.218 ± 0.251
0.58GlnTrp: 0.58 ± 0.154
0.638GlnTyr: 0.638 ± 0.194
0.0GlnXaa: 0.0 ± 0.0
Arg
2.958ArgAla: 2.958 ± 0.514
0.522ArgCys: 0.522 ± 0.167
3.132ArgAsp: 3.132 ± 0.509
3.944ArgGlu: 3.944 ± 0.513
2.958ArgPhe: 2.958 ± 0.463
2.552ArgGly: 2.552 ± 0.43
1.566ArgHis: 1.566 ± 0.391
3.654ArgIle: 3.654 ± 0.499
4.988ArgLys: 4.988 ± 0.731
5.104ArgLeu: 5.104 ± 0.556
1.682ArgMet: 1.682 ± 0.304
4.002ArgAsn: 4.002 ± 0.418
2.204ArgPro: 2.204 ± 0.385
1.798ArgGln: 1.798 ± 0.259
3.828ArgArg: 3.828 ± 0.778
3.364ArgSer: 3.364 ± 0.528
3.654ArgThr: 3.654 ± 0.613
3.538ArgVal: 3.538 ± 0.469
0.696ArgTrp: 0.696 ± 0.225
2.842ArgTyr: 2.842 ± 0.433
0.0ArgXaa: 0.0 ± 0.0
Ser
4.408SerAla: 4.408 ± 0.654
0.986SerCys: 0.986 ± 0.289
3.828SerAsp: 3.828 ± 0.469
4.408SerGlu: 4.408 ± 0.527
2.726SerPhe: 2.726 ± 0.359
4.756SerGly: 4.756 ± 0.576
1.392SerHis: 1.392 ± 0.294
3.77SerIle: 3.77 ± 0.495
4.234SerLys: 4.234 ± 0.633
6.206SerLeu: 6.206 ± 0.679
1.276SerMet: 1.276 ± 0.274
3.016SerAsn: 3.016 ± 0.467
2.552SerPro: 2.552 ± 0.42
2.61SerGln: 2.61 ± 0.394
4.002SerArg: 4.002 ± 0.476
3.538SerSer: 3.538 ± 0.473
3.712SerThr: 3.712 ± 0.46
4.814SerVal: 4.814 ± 0.421
1.508SerTrp: 1.508 ± 0.246
2.61SerTyr: 2.61 ± 0.381
0.0SerXaa: 0.0 ± 0.0
Thr
6.206ThrAla: 6.206 ± 0.873
0.406ThrCys: 0.406 ± 0.141
4.292ThrAsp: 4.292 ± 0.479
4.988ThrGlu: 4.988 ± 0.643
4.93ThrPhe: 4.93 ± 0.576
3.48ThrGly: 3.48 ± 0.527
1.102ThrHis: 1.102 ± 0.271
4.814ThrIle: 4.814 ± 0.559
3.886ThrLys: 3.886 ± 0.496
7.482ThrLeu: 7.482 ± 0.741
0.986ThrMet: 0.986 ± 0.228
3.074ThrAsn: 3.074 ± 0.468
3.538ThrPro: 3.538 ± 0.483
2.03ThrGln: 2.03 ± 0.294
3.016ThrArg: 3.016 ± 0.45
3.538ThrSer: 3.538 ± 0.448
5.278ThrThr: 5.278 ± 0.773
5.974ThrVal: 5.974 ± 0.704
0.522ThrTrp: 0.522 ± 0.155
2.262ThrTyr: 2.262 ± 0.386
0.0ThrXaa: 0.0 ± 0.0
Val
4.64ValAla: 4.64 ± 0.735
0.638ValCys: 0.638 ± 0.198
3.422ValAsp: 3.422 ± 0.473
4.002ValGlu: 4.002 ± 0.445
3.596ValPhe: 3.596 ± 0.398
3.654ValGly: 3.654 ± 0.518
0.812ValHis: 0.812 ± 0.279
4.524ValIle: 4.524 ± 0.513
3.654ValLys: 3.654 ± 0.437
4.466ValLeu: 4.466 ± 0.46
1.334ValMet: 1.334 ± 0.224
4.234ValAsn: 4.234 ± 0.531
2.494ValPro: 2.494 ± 0.41
1.624ValGln: 1.624 ± 0.363
3.77ValArg: 3.77 ± 0.515
5.626ValSer: 5.626 ± 0.559
5.974ValThr: 5.974 ± 0.605
3.77ValVal: 3.77 ± 0.466
0.754ValTrp: 0.754 ± 0.205
2.9ValTyr: 2.9 ± 0.478
0.0ValXaa: 0.0 ± 0.0
Trp
0.812TrpAla: 0.812 ± 0.199
0.232TrpCys: 0.232 ± 0.107
0.406TrpAsp: 0.406 ± 0.149
0.638TrpGlu: 0.638 ± 0.185
0.58TrpPhe: 0.58 ± 0.161
0.29TrpGly: 0.29 ± 0.107
0.232TrpHis: 0.232 ± 0.118
0.986TrpIle: 0.986 ± 0.246
0.754TrpLys: 0.754 ± 0.175
0.928TrpLeu: 0.928 ± 0.24
0.232TrpMet: 0.232 ± 0.096
0.696TrpAsn: 0.696 ± 0.186
0.348TrpPro: 0.348 ± 0.146
0.406TrpGln: 0.406 ± 0.175
0.58TrpArg: 0.58 ± 0.154
0.696TrpSer: 0.696 ± 0.195
1.044TrpThr: 1.044 ± 0.216
0.464TrpVal: 0.464 ± 0.16
0.116TrpTrp: 0.116 ± 0.076
0.406TrpTyr: 0.406 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.19TyrAla: 3.19 ± 0.477
0.348TyrCys: 0.348 ± 0.138
2.842TyrAsp: 2.842 ± 0.378
3.654TyrGlu: 3.654 ± 0.564
1.45TyrPhe: 1.45 ± 0.306
3.19TyrGly: 3.19 ± 0.528
0.928TyrHis: 0.928 ± 0.201
2.204TyrIle: 2.204 ± 0.429
1.218TyrLys: 1.218 ± 0.217
3.248TyrLeu: 3.248 ± 0.464
0.464TyrMet: 0.464 ± 0.187
1.914TyrAsn: 1.914 ± 0.291
1.914TyrPro: 1.914 ± 0.344
0.58TyrGln: 0.58 ± 0.179
2.9TyrArg: 2.9 ± 0.464
1.566TyrSer: 1.566 ± 0.226
2.32TyrThr: 2.32 ± 0.35
2.726TyrVal: 2.726 ± 0.34
0.348TyrTrp: 0.348 ± 0.185
1.624TyrTyr: 1.624 ± 0.427
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (17243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski