Amino acid dipepetide frequency for Streptococcus satellite phage Javan86

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.393AlaCys: 0.393 ± 0.424
3.928AlaAsp: 3.928 ± 0.928
5.106AlaGlu: 5.106 ± 1.443
3.535AlaPhe: 3.535 ± 1.065
4.713AlaGly: 4.713 ± 1.182
0.393AlaHis: 0.393 ± 0.397
3.535AlaIle: 3.535 ± 0.967
4.321AlaLys: 4.321 ± 1.732
6.284AlaLeu: 6.284 ± 2.202
2.749AlaMet: 2.749 ± 1.503
2.749AlaAsn: 2.749 ± 0.795
0.786AlaPro: 0.786 ± 0.491
1.571AlaGln: 1.571 ± 0.999
2.357AlaArg: 2.357 ± 0.984
3.142AlaSer: 3.142 ± 0.981
2.749AlaThr: 2.749 ± 0.738
3.535AlaVal: 3.535 ± 0.829
0.786AlaTrp: 0.786 ± 0.67
3.142AlaTyr: 3.142 ± 1.114
0.0AlaXaa: 0.0 ± 0.0
Cys
0.393CysAla: 0.393 ± 0.397
0.0CysCys: 0.0 ± 0.0
0.393CysAsp: 0.393 ± 0.412
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.786CysGly: 0.786 ± 0.635
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.964CysLeu: 1.964 ± 1.149
0.393CysMet: 0.393 ± 0.311
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.393CysGln: 0.393 ± 0.335
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.786CysTyr: 0.786 ± 0.66
0.0CysXaa: 0.0 ± 0.0
Asp
2.357AspAla: 2.357 ± 0.965
0.786AspCys: 0.786 ± 0.522
3.928AspAsp: 3.928 ± 1.519
3.142AspGlu: 3.142 ± 1.052
2.749AspPhe: 2.749 ± 0.947
4.713AspGly: 4.713 ± 1.856
0.393AspHis: 0.393 ± 0.417
5.499AspIle: 5.499 ± 1.315
5.892AspLys: 5.892 ± 1.787
5.499AspLeu: 5.499 ± 1.449
0.393AspMet: 0.393 ± 0.373
3.928AspAsn: 3.928 ± 1.164
1.178AspPro: 1.178 ± 0.622
1.964AspGln: 1.964 ± 0.812
2.357AspArg: 2.357 ± 0.958
4.713AspSer: 4.713 ± 1.089
3.142AspThr: 3.142 ± 1.276
0.786AspVal: 0.786 ± 0.494
0.393AspTrp: 0.393 ± 0.335
3.142AspTyr: 3.142 ± 0.935
0.0AspXaa: 0.0 ± 0.0
Glu
5.499GluAla: 5.499 ± 1.034
1.571GluCys: 1.571 ± 1.184
4.713GluAsp: 4.713 ± 1.658
9.427GluGlu: 9.427 ± 2.572
2.357GluPhe: 2.357 ± 1.125
3.142GluGly: 3.142 ± 1.315
1.178GluHis: 1.178 ± 0.487
4.713GluIle: 4.713 ± 1.585
6.677GluLys: 6.677 ± 1.32
13.747GluLeu: 13.747 ± 2.092
3.535GluMet: 3.535 ± 1.11
3.928GluAsn: 3.928 ± 1.651
1.571GluPro: 1.571 ± 0.688
5.106GluGln: 5.106 ± 1.277
5.892GluArg: 5.892 ± 1.536
1.964GluSer: 1.964 ± 0.916
5.106GluThr: 5.106 ± 1.493
3.535GluVal: 3.535 ± 0.954
1.571GluTrp: 1.571 ± 0.708
1.178GluTyr: 1.178 ± 0.458
0.0GluXaa: 0.0 ± 0.0
Phe
1.178PheAla: 1.178 ± 0.668
0.0PheCys: 0.0 ± 0.0
0.393PheAsp: 0.393 ± 0.335
1.964PheGlu: 1.964 ± 0.623
3.535PhePhe: 3.535 ± 1.041
1.964PheGly: 1.964 ± 0.873
0.393PheHis: 0.393 ± 0.311
1.178PheIle: 1.178 ± 0.617
3.535PheLys: 3.535 ± 0.907
4.713PheLeu: 4.713 ± 1.051
0.786PheMet: 0.786 ± 0.633
1.571PheAsn: 1.571 ± 0.889
1.571PhePro: 1.571 ± 1.015
1.178PheGln: 1.178 ± 0.559
2.749PheArg: 2.749 ± 0.923
4.321PheSer: 4.321 ± 1.128
1.571PheThr: 1.571 ± 0.804
1.571PheVal: 1.571 ± 0.514
0.0PheTrp: 0.0 ± 0.0
2.749PheTyr: 2.749 ± 1.185
0.0PheXaa: 0.0 ± 0.0
Gly
2.357GlyAla: 2.357 ± 0.974
0.393GlyCys: 0.393 ± 0.335
1.964GlyAsp: 1.964 ± 1.053
3.928GlyGlu: 3.928 ± 1.247
0.786GlyPhe: 0.786 ± 0.449
0.393GlyGly: 0.393 ± 0.396
0.786GlyHis: 0.786 ± 0.512
4.713GlyIle: 4.713 ± 1.377
6.284GlyLys: 6.284 ± 1.802
5.106GlyLeu: 5.106 ± 1.278
2.749GlyMet: 2.749 ± 1.171
2.357GlyAsn: 2.357 ± 0.806
0.0GlyPro: 0.0 ± 0.0
1.178GlyGln: 1.178 ± 0.709
3.535GlyArg: 3.535 ± 0.897
1.571GlySer: 1.571 ± 0.627
2.749GlyThr: 2.749 ± 1.229
2.749GlyVal: 2.749 ± 0.9
1.571GlyTrp: 1.571 ± 0.746
4.321GlyTyr: 4.321 ± 1.321
0.0GlyXaa: 0.0 ± 0.0
His
1.571HisAla: 1.571 ± 0.982
0.0HisCys: 0.0 ± 0.0
0.393HisAsp: 0.393 ± 0.397
0.0HisGlu: 0.0 ± 0.0
0.393HisPhe: 0.393 ± 0.412
0.0HisGly: 0.0 ± 0.0
0.393HisHis: 0.393 ± 0.397
0.786HisIle: 0.786 ± 0.618
0.786HisLys: 0.786 ± 0.466
2.749HisLeu: 2.749 ± 1.212
0.0HisMet: 0.0 ± 0.0
1.178HisAsn: 1.178 ± 0.848
0.393HisPro: 0.393 ± 0.424
0.393HisGln: 0.393 ± 0.335
0.393HisArg: 0.393 ± 0.311
1.571HisSer: 1.571 ± 0.607
1.571HisThr: 1.571 ± 0.753
0.0HisVal: 0.0 ± 0.0
0.393HisTrp: 0.393 ± 0.417
1.178HisTyr: 1.178 ± 0.48
0.0HisXaa: 0.0 ± 0.0
Ile
5.499IleAla: 5.499 ± 1.593
0.393IleCys: 0.393 ± 0.396
3.535IleAsp: 3.535 ± 1.347
5.499IleGlu: 5.499 ± 1.707
0.393IlePhe: 0.393 ± 0.419
2.357IleGly: 2.357 ± 0.994
0.393IleHis: 0.393 ± 0.311
4.713IleIle: 4.713 ± 1.048
4.321IleLys: 4.321 ± 1.496
3.535IleLeu: 3.535 ± 0.892
0.393IleMet: 0.393 ± 0.384
3.142IleAsn: 3.142 ± 1.146
2.357IlePro: 2.357 ± 0.934
3.535IleGln: 3.535 ± 1.274
3.535IleArg: 3.535 ± 1.327
6.284IleSer: 6.284 ± 1.837
7.07IleThr: 7.07 ± 1.468
3.535IleVal: 3.535 ± 1.287
0.393IleTrp: 0.393 ± 0.335
1.571IleTyr: 1.571 ± 0.822
0.0IleXaa: 0.0 ± 0.0
Lys
5.499LysAla: 5.499 ± 1.418
0.0LysCys: 0.0 ± 0.0
3.928LysAsp: 3.928 ± 1.608
12.176LysGlu: 12.176 ± 1.885
1.964LysPhe: 1.964 ± 0.666
3.535LysGly: 3.535 ± 1.638
3.142LysHis: 3.142 ± 0.749
5.892LysIle: 5.892 ± 1.806
5.106LysLys: 5.106 ± 1.049
7.07LysLeu: 7.07 ± 1.108
2.749LysMet: 2.749 ± 1.14
4.321LysAsn: 4.321 ± 1.208
4.321LysPro: 4.321 ± 1.153
6.677LysGln: 6.677 ± 1.517
4.713LysArg: 4.713 ± 1.118
3.535LysSer: 3.535 ± 1.01
5.892LysThr: 5.892 ± 1.629
2.749LysVal: 2.749 ± 0.8
0.0LysTrp: 0.0 ± 0.0
3.928LysTyr: 3.928 ± 1.144
0.0LysXaa: 0.0 ± 0.0
Leu
6.677LeuAla: 6.677 ± 1.366
0.0LeuCys: 0.0 ± 0.0
9.034LeuAsp: 9.034 ± 1.387
12.176LeuGlu: 12.176 ± 1.889
3.535LeuPhe: 3.535 ± 1.383
7.463LeuGly: 7.463 ± 1.862
0.393LeuHis: 0.393 ± 0.335
3.535LeuIle: 3.535 ± 0.883
8.248LeuLys: 8.248 ± 1.513
9.819LeuLeu: 9.819 ± 2.744
2.749LeuMet: 2.749 ± 0.952
7.463LeuAsn: 7.463 ± 1.685
3.928LeuPro: 3.928 ± 0.899
3.535LeuGln: 3.535 ± 1.338
5.892LeuArg: 5.892 ± 1.416
7.463LeuSer: 7.463 ± 1.295
4.713LeuThr: 4.713 ± 1.212
3.928LeuVal: 3.928 ± 1.276
0.393LeuTrp: 0.393 ± 0.311
4.321LeuTyr: 4.321 ± 1.136
0.0LeuXaa: 0.0 ± 0.0
Met
2.357MetAla: 2.357 ± 1.06
0.0MetCys: 0.0 ± 0.0
1.571MetAsp: 1.571 ± 0.899
1.964MetGlu: 1.964 ± 0.869
1.178MetPhe: 1.178 ± 0.677
0.393MetGly: 0.393 ± 0.402
0.0MetHis: 0.0 ± 0.0
0.786MetIle: 0.786 ± 0.491
2.749MetLys: 2.749 ± 0.792
1.964MetLeu: 1.964 ± 0.923
0.786MetMet: 0.786 ± 0.618
2.357MetAsn: 2.357 ± 0.975
0.786MetPro: 0.786 ± 0.482
0.786MetGln: 0.786 ± 0.494
1.571MetArg: 1.571 ± 0.806
1.571MetSer: 1.571 ± 0.787
5.106MetThr: 5.106 ± 1.589
2.749MetVal: 2.749 ± 1.195
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.749AsnAla: 2.749 ± 1.203
0.0AsnCys: 0.0 ± 0.0
3.535AsnAsp: 3.535 ± 1.094
1.964AsnGlu: 1.964 ± 0.738
2.749AsnPhe: 2.749 ± 0.969
3.535AsnGly: 3.535 ± 1.213
0.393AsnHis: 0.393 ± 0.311
3.928AsnIle: 3.928 ± 0.854
5.106AsnLys: 5.106 ± 1.454
5.106AsnLeu: 5.106 ± 1.492
1.964AsnMet: 1.964 ± 1.076
4.321AsnAsn: 4.321 ± 1.165
3.142AsnPro: 3.142 ± 1.055
1.964AsnGln: 1.964 ± 1.129
2.749AsnArg: 2.749 ± 1.404
3.535AsnSer: 3.535 ± 0.99
3.928AsnThr: 3.928 ± 1.678
0.393AsnVal: 0.393 ± 0.424
0.786AsnTrp: 0.786 ± 0.769
3.928AsnTyr: 3.928 ± 1.218
0.0AsnXaa: 0.0 ± 0.0
Pro
1.571ProAla: 1.571 ± 0.573
0.393ProCys: 0.393 ± 0.311
1.178ProAsp: 1.178 ± 0.478
4.321ProGlu: 4.321 ± 1.373
1.571ProPhe: 1.571 ± 0.952
0.0ProGly: 0.0 ± 0.0
0.393ProHis: 0.393 ± 0.335
3.535ProIle: 3.535 ± 0.923
2.749ProLys: 2.749 ± 1.05
1.964ProLeu: 1.964 ± 0.593
1.178ProMet: 1.178 ± 0.617
0.786ProAsn: 0.786 ± 0.405
0.393ProPro: 0.393 ± 0.392
0.393ProGln: 0.393 ± 0.311
0.786ProArg: 0.786 ± 0.427
0.393ProSer: 0.393 ± 0.397
1.571ProThr: 1.571 ± 0.737
1.964ProVal: 1.964 ± 0.818
0.393ProTrp: 0.393 ± 0.462
1.178ProTyr: 1.178 ± 0.72
0.0ProXaa: 0.0 ± 0.0
Gln
4.713GlnAla: 4.713 ± 1.659
0.0GlnCys: 0.0 ± 0.0
0.393GlnAsp: 0.393 ± 0.392
3.535GlnGlu: 3.535 ± 1.236
2.749GlnPhe: 2.749 ± 0.89
0.786GlnGly: 0.786 ± 0.465
0.786GlnHis: 0.786 ± 0.499
2.749GlnIle: 2.749 ± 1.033
4.713GlnLys: 4.713 ± 1.017
5.499GlnLeu: 5.499 ± 1.333
0.786GlnMet: 0.786 ± 0.551
0.786GlnAsn: 0.786 ± 0.666
0.786GlnPro: 0.786 ± 0.46
1.964GlnGln: 1.964 ± 0.87
4.713GlnArg: 4.713 ± 1.168
1.178GlnSer: 1.178 ± 0.751
1.964GlnThr: 1.964 ± 0.754
3.535GlnVal: 3.535 ± 0.824
0.393GlnTrp: 0.393 ± 0.335
2.749GlnTyr: 2.749 ± 0.747
0.0GlnXaa: 0.0 ± 0.0
Arg
3.535ArgAla: 3.535 ± 0.961
0.0ArgCys: 0.0 ± 0.0
1.964ArgAsp: 1.964 ± 1.121
3.535ArgGlu: 3.535 ± 1.706
1.571ArgPhe: 1.571 ± 0.809
2.357ArgGly: 2.357 ± 0.944
0.786ArgHis: 0.786 ± 0.623
1.964ArgIle: 1.964 ± 0.801
5.499ArgLys: 5.499 ± 1.692
7.07ArgLeu: 7.07 ± 1.183
0.786ArgMet: 0.786 ± 0.419
3.928ArgAsn: 3.928 ± 1.368
1.178ArgPro: 1.178 ± 0.531
3.535ArgGln: 3.535 ± 0.983
3.142ArgArg: 3.142 ± 1.202
1.571ArgSer: 1.571 ± 0.773
1.964ArgThr: 1.964 ± 0.992
6.284ArgVal: 6.284 ± 1.658
0.786ArgTrp: 0.786 ± 0.512
3.142ArgTyr: 3.142 ± 1.147
0.0ArgXaa: 0.0 ± 0.0
Ser
0.393SerAla: 0.393 ± 0.397
0.393SerCys: 0.393 ± 0.412
4.713SerAsp: 4.713 ± 1.141
4.713SerGlu: 4.713 ± 1.175
2.357SerPhe: 2.357 ± 0.769
1.964SerGly: 1.964 ± 0.642
1.178SerHis: 1.178 ± 0.607
5.106SerIle: 5.106 ± 0.866
5.892SerLys: 5.892 ± 1.137
5.499SerLeu: 5.499 ± 1.444
2.749SerMet: 2.749 ± 1.027
2.357SerAsn: 2.357 ± 0.959
1.178SerPro: 1.178 ± 0.458
3.142SerGln: 3.142 ± 1.071
2.357SerArg: 2.357 ± 0.833
3.142SerSer: 3.142 ± 0.972
3.142SerThr: 3.142 ± 0.921
1.571SerVal: 1.571 ± 0.545
0.393SerTrp: 0.393 ± 0.335
5.106SerTyr: 5.106 ± 1.237
0.0SerXaa: 0.0 ± 0.0
Thr
1.571ThrAla: 1.571 ± 0.652
0.0ThrCys: 0.0 ± 0.0
5.892ThrAsp: 5.892 ± 2.332
4.321ThrGlu: 4.321 ± 0.873
3.142ThrPhe: 3.142 ± 0.874
5.499ThrGly: 5.499 ± 1.265
1.178ThrHis: 1.178 ± 0.51
4.713ThrIle: 4.713 ± 1.354
4.713ThrLys: 4.713 ± 1.406
5.499ThrLeu: 5.499 ± 1.595
1.571ThrMet: 1.571 ± 0.77
4.321ThrAsn: 4.321 ± 1.247
0.786ThrPro: 0.786 ± 0.466
2.749ThrGln: 2.749 ± 0.9
2.749ThrArg: 2.749 ± 1.251
1.571ThrSer: 1.571 ± 0.803
4.713ThrThr: 4.713 ± 1.937
4.713ThrVal: 4.713 ± 1.451
0.0ThrTrp: 0.0 ± 0.0
2.749ThrTyr: 2.749 ± 0.739
0.0ThrXaa: 0.0 ± 0.0
Val
5.499ValAla: 5.499 ± 1.406
0.0ValCys: 0.0 ± 0.0
2.357ValAsp: 2.357 ± 0.844
2.357ValGlu: 2.357 ± 1.032
1.178ValPhe: 1.178 ± 0.478
1.571ValGly: 1.571 ± 0.756
1.178ValHis: 1.178 ± 0.605
2.357ValIle: 2.357 ± 0.944
3.142ValLys: 3.142 ± 0.838
5.499ValLeu: 5.499 ± 1.588
0.786ValMet: 0.786 ± 0.439
2.357ValAsn: 2.357 ± 0.678
1.178ValPro: 1.178 ± 0.702
1.571ValGln: 1.571 ± 0.755
1.964ValArg: 1.964 ± 0.785
5.499ValSer: 5.499 ± 1.513
4.321ValThr: 4.321 ± 1.079
1.571ValVal: 1.571 ± 0.931
0.393ValTrp: 0.393 ± 0.384
2.749ValTyr: 2.749 ± 1.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.393TrpAla: 0.393 ± 0.384
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.749TrpGlu: 2.749 ± 0.924
0.0TrpPhe: 0.0 ± 0.0
1.178TrpGly: 1.178 ± 0.755
0.0TrpHis: 0.0 ± 0.0
0.393TrpIle: 0.393 ± 0.486
0.786TrpLys: 0.786 ± 0.642
1.178TrpLeu: 1.178 ± 0.539
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.393TrpArg: 0.393 ± 0.417
0.393TrpSer: 0.393 ± 0.311
0.0TrpThr: 0.0 ± 0.0
1.178TrpVal: 1.178 ± 0.721
0.0TrpTrp: 0.0 ± 0.0
0.786TrpTyr: 0.786 ± 0.529
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.964TyrAla: 1.964 ± 0.629
0.786TyrCys: 0.786 ± 0.515
3.142TyrAsp: 3.142 ± 1.086
3.535TyrGlu: 3.535 ± 1.102
1.178TyrPhe: 1.178 ± 0.799
3.142TyrGly: 3.142 ± 0.816
0.786TyrHis: 0.786 ± 0.508
2.357TyrIle: 2.357 ± 0.752
6.677TyrLys: 6.677 ± 1.467
5.892TyrLeu: 5.892 ± 0.818
1.178TyrMet: 1.178 ± 0.794
3.928TyrAsn: 3.928 ± 0.978
1.178TyrPro: 1.178 ± 0.593
3.142TyrGln: 3.142 ± 1.191
2.749TyrArg: 2.749 ± 1.036
3.928TyrSer: 3.928 ± 0.802
1.178TyrThr: 1.178 ± 0.688
1.178TyrVal: 1.178 ± 0.668
0.786TyrTrp: 0.786 ± 0.969
4.321TyrTyr: 4.321 ± 1.496
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski