Amino acid dipepetide frequency for Lentibacillus cibarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.507AlaAla: 6.507 ± 0.099	0.651AlaCys: 0.651 ± 0.027	4.138AlaAsp: 4.138 ± 0.08	4.796AlaGlu: 4.796 ± 0.089	3.469AlaPhe: 3.469 ± 0.064	5.614AlaGly: 5.614 ± 0.095	1.378AlaHis: 1.378 ± 0.049	6.198AlaIle: 6.198 ± 0.103	4.65AlaLys: 4.65 ± 0.075	7.076AlaLeu: 7.076 ± 0.108	2.296AlaMet: 2.296 ± 0.052	3.104AlaAsn: 3.104 ± 0.065	2.155AlaPro: 2.155 ± 0.054	2.247AlaGln: 2.247 ± 0.05	2.817AlaArg: 2.817 ± 0.062	4.523AlaSer: 4.523 ± 0.083	3.714AlaThr: 3.714 ± 0.07	5.707AlaVal: 5.707 ± 0.085	0.7AlaTrp: 0.7 ± 0.026	2.574AlaTyr: 2.574 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.421CysAla: 0.421 ± 0.024	0.085CysCys: 0.085 ± 0.013	0.414CysAsp: 0.414 ± 0.022	0.384CysGlu: 0.384 ± 0.021	0.259CysPhe: 0.259 ± 0.018	0.708CysGly: 0.708 ± 0.033	0.191CysHis: 0.191 ± 0.014	0.445CysIle: 0.445 ± 0.022	0.285CysLys: 0.285 ± 0.018	0.616CysLeu: 0.616 ± 0.028	0.199CysMet: 0.199 ± 0.017	0.286CysAsn: 0.286 ± 0.024	0.352CysPro: 0.352 ± 0.024	0.238CysGln: 0.238 ± 0.018	0.298CysArg: 0.298 ± 0.02	0.484CysSer: 0.484 ± 0.027	0.41CysThr: 0.41 ± 0.023	0.388CysVal: 0.388 ± 0.021	0.067CysTrp: 0.067 ± 0.008	0.247CysTyr: 0.247 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.066AspAla: 4.066 ± 0.075	0.355AspCys: 0.355 ± 0.022	3.68AspAsp: 3.68 ± 0.087	4.963AspGlu: 4.963 ± 0.095	2.293AspPhe: 2.293 ± 0.046	3.72AspGly: 3.72 ± 0.075	1.29AspHis: 1.29 ± 0.042	4.394AspIle: 4.394 ± 0.082	3.799AspLys: 3.799 ± 0.072	4.916AspLeu: 4.916 ± 0.079	1.799AspMet: 1.799 ± 0.042	2.312AspAsn: 2.312 ± 0.065	2.101AspPro: 2.101 ± 0.057	2.114AspGln: 2.114 ± 0.052	2.403AspArg: 2.403 ± 0.059	2.828AspSer: 2.828 ± 0.059	3.016AspThr: 3.016 ± 0.048	4.479AspVal: 4.479 ± 0.081	0.74AspTrp: 0.74 ± 0.029	2.414AspTyr: 2.414 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.53GluAla: 5.53 ± 0.093	0.303GluCys: 0.303 ± 0.02	3.787GluAsp: 3.787 ± 0.08	6.158GluGlu: 6.158 ± 0.113	2.122GluPhe: 2.122 ± 0.052	4.01GluGly: 4.01 ± 0.08	1.531GluHis: 1.531 ± 0.046	4.543GluIle: 4.543 ± 0.088	6.193GluLys: 6.193 ± 0.091	6.707GluLeu: 6.707 ± 0.107	2.443GluMet: 2.443 ± 0.05	3.601GluAsn: 3.601 ± 0.07	2.097GluPro: 2.097 ± 0.057	3.949GluGln: 3.949 ± 0.07	3.579GluArg: 3.579 ± 0.072	3.501GluSer: 3.501 ± 0.067	4.292GluThr: 4.292 ± 0.069	4.627GluVal: 4.627 ± 0.089	0.809GluTrp: 0.809 ± 0.027	1.898GluTyr: 1.898 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.138PheAla: 3.138 ± 0.066	0.286PheCys: 0.286 ± 0.019	2.413PheAsp: 2.413 ± 0.054	2.37PheGlu: 2.37 ± 0.05	2.136PhePhe: 2.136 ± 0.07	3.259PheGly: 3.259 ± 0.063	0.973PheHis: 0.973 ± 0.034	3.697PheIle: 3.697 ± 0.074	1.993PheLys: 1.993 ± 0.05	4.299PheLeu: 4.299 ± 0.088	1.299PheMet: 1.299 ± 0.039	1.701PheAsn: 1.701 ± 0.045	1.697PhePro: 1.697 ± 0.042	1.632PheGln: 1.632 ± 0.044	1.585PheArg: 1.585 ± 0.041	2.982PheSer: 2.982 ± 0.067	2.586PheThr: 2.586 ± 0.054	2.958PheVal: 2.958 ± 0.069	0.459PheTrp: 0.459 ± 0.026	1.639PheTyr: 1.639 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.993GlyAla: 4.993 ± 0.094	0.551GlyCys: 0.551 ± 0.028	3.678GlyAsp: 3.678 ± 0.065	4.462GlyGlu: 4.462 ± 0.077	3.345GlyPhe: 3.345 ± 0.068	4.93GlyGly: 4.93 ± 0.095	1.422GlyHis: 1.422 ± 0.041	5.791GlyIle: 5.791 ± 0.099	4.705GlyLys: 4.705 ± 0.076	6.517GlyLeu: 6.517 ± 0.116	2.345GlyMet: 2.345 ± 0.054	2.847GlyAsn: 2.847 ± 0.064	1.846GlyPro: 1.846 ± 0.057	2.104GlyGln: 2.104 ± 0.052	2.536GlyArg: 2.536 ± 0.058	4.121GlySer: 4.121 ± 0.072	4.301GlyThr: 4.301 ± 0.072	5.255GlyVal: 5.255 ± 0.091	0.849GlyTrp: 0.849 ± 0.039	2.789GlyTyr: 2.789 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.598HisAla: 1.598 ± 0.05	0.191HisCys: 0.191 ± 0.015	1.221HisAsp: 1.221 ± 0.039	1.455HisGlu: 1.455 ± 0.041	0.998HisPhe: 0.998 ± 0.034	1.513HisGly: 1.513 ± 0.044	0.706HisHis: 0.706 ± 0.032	1.536HisIle: 1.536 ± 0.04	1.056HisLys: 1.056 ± 0.035	2.063HisLeu: 2.063 ± 0.053	0.643HisMet: 0.643 ± 0.027	0.82HisAsn: 0.82 ± 0.035	1.194HisPro: 1.194 ± 0.037	0.91HisGln: 0.91 ± 0.029	0.957HisArg: 0.957 ± 0.038	1.076HisSer: 1.076 ± 0.036	1.161HisThr: 1.161 ± 0.038	1.606HisVal: 1.606 ± 0.039	0.222HisTrp: 0.222 ± 0.017	0.968HisTyr: 0.968 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.289IleAla: 6.289 ± 0.091	0.549IleCys: 0.549 ± 0.027	4.598IleAsp: 4.598 ± 0.082	4.561IleGlu: 4.561 ± 0.085	2.933IlePhe: 2.933 ± 0.074	5.897IleGly: 5.897 ± 0.111	1.606IleHis: 1.606 ± 0.044	5.395IleIle: 5.395 ± 0.103	3.864IleLys: 3.864 ± 0.072	6.248IleLeu: 6.248 ± 0.1	1.838IleMet: 1.838 ± 0.049	3.35IleAsn: 3.35 ± 0.076	3.578IlePro: 3.578 ± 0.127	2.674IleGln: 2.674 ± 0.052	3.132IleArg: 3.132 ± 0.066	4.677IleSer: 4.677 ± 0.082	4.646IleThr: 4.646 ± 0.086	5.347IleVal: 5.347 ± 0.087	0.648IleTrp: 0.648 ± 0.028	2.308IleTyr: 2.308 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.522LysAla: 4.522 ± 0.082	0.284LysCys: 0.284 ± 0.02	3.749LysAsp: 3.749 ± 0.068	5.882LysGlu: 5.882 ± 0.093	1.553LysPhe: 1.553 ± 0.046	4.195LysGly: 4.195 ± 0.072	1.421LysHis: 1.421 ± 0.04	3.649LysIle: 3.649 ± 0.063	5.108LysLys: 5.108 ± 0.096	5.372LysLeu: 5.372 ± 0.078	2.057LysMet: 2.057 ± 0.046	3.027LysAsn: 3.027 ± 0.056	2.272LysPro: 2.272 ± 0.056	3.782LysGln: 3.782 ± 0.078	3.445LysArg: 3.445 ± 0.07	3.173LysSer: 3.173 ± 0.064	3.596LysThr: 3.596 ± 0.068	3.866LysVal: 3.866 ± 0.067	0.768LysTrp: 0.768 ± 0.029	1.849LysTyr: 1.849 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.342LeuAla: 7.342 ± 0.097	0.561LeuCys: 0.561 ± 0.029	5.186LeuAsp: 5.186 ± 0.082	6.201LeuGlu: 6.201 ± 0.111	4.782LeuPhe: 4.782 ± 0.099	6.234LeuGly: 6.234 ± 0.106	2.005LeuHis: 2.005 ± 0.048	6.714LeuIle: 6.714 ± 0.112	5.735LeuLys: 5.735 ± 0.083	9.38LeuLeu: 9.38 ± 0.153	2.78LeuMet: 2.78 ± 0.092	4.022LeuAsn: 4.022 ± 0.07	3.895LeuPro: 3.895 ± 0.064	3.808LeuGln: 3.808 ± 0.078	3.651LeuArg: 3.651 ± 0.076	5.966LeuSer: 5.966 ± 0.098	5.712LeuThr: 5.712 ± 0.09	5.918LeuVal: 5.918 ± 0.1	0.775LeuTrp: 0.775 ± 0.031	2.949LeuTyr: 2.949 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.368MetAla: 2.368 ± 0.06	0.244MetCys: 0.244 ± 0.034	1.85MetAsp: 1.85 ± 0.044	2.295MetGlu: 2.295 ± 0.052	1.188MetPhe: 1.188 ± 0.048	1.973MetGly: 1.973 ± 0.055	0.554MetHis: 0.554 ± 0.027	2.093MetIle: 2.093 ± 0.05	2.273MetLys: 2.273 ± 0.049	2.912MetLeu: 2.912 ± 0.071	0.958MetMet: 0.958 ± 0.04	1.722MetAsn: 1.722 ± 0.044	1.116MetPro: 1.116 ± 0.04	1.228MetGln: 1.228 ± 0.034	1.246MetArg: 1.246 ± 0.038	1.794MetSer: 1.794 ± 0.056	1.834MetThr: 1.834 ± 0.045	1.892MetVal: 1.892 ± 0.052	0.195MetTrp: 0.195 ± 0.015	0.801MetTyr: 0.801 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.998AsnAla: 2.998 ± 0.052	0.285AsnCys: 0.285 ± 0.019	2.761AsnAsp: 2.761 ± 0.055	3.584AsnGlu: 3.584 ± 0.07	1.517AsnPhe: 1.517 ± 0.038	3.279AsnGly: 3.279 ± 0.065	1.142AsnHis: 1.142 ± 0.042	3.028AsnIle: 3.028 ± 0.071	2.913AsnLys: 2.913 ± 0.061	3.612AsnLeu: 3.612 ± 0.072	1.352AsnMet: 1.352 ± 0.039	2.071AsnAsn: 2.071 ± 0.059	2.043AsnPro: 2.043 ± 0.053	2.054AsnGln: 2.054 ± 0.053	2.194AsnArg: 2.194 ± 0.054	2.007AsnSer: 2.007 ± 0.05	2.348AsnThr: 2.348 ± 0.056	3.122AsnVal: 3.122 ± 0.065	0.542AsnTrp: 0.542 ± 0.026	1.519AsnTyr: 1.519 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.572ProAla: 2.572 ± 0.049	0.224ProCys: 0.224 ± 0.017	2.579ProAsp: 2.579 ± 0.057	3.154ProGlu: 3.154 ± 0.071	1.867ProPhe: 1.867 ± 0.046	2.516ProGly: 2.516 ± 0.056	0.788ProHis: 0.788 ± 0.029	2.702ProIle: 2.702 ± 0.059	1.99ProLys: 1.99 ± 0.046	3.526ProLeu: 3.526 ± 0.081	0.946ProMet: 0.946 ± 0.04	1.566ProAsn: 1.566 ± 0.039	1.083ProPro: 1.083 ± 0.035	1.095ProGln: 1.095 ± 0.038	1.125ProArg: 1.125 ± 0.036	2.437ProSer: 2.437 ± 0.07	1.842ProThr: 1.842 ± 0.045	3.165ProVal: 3.165 ± 0.066	0.354ProTrp: 0.354 ± 0.021	1.443ProTyr: 1.443 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.184GlnAla: 3.184 ± 0.072	0.184GlnCys: 0.184 ± 0.016	2.019GlnAsp: 2.019 ± 0.051	3.18GlnGlu: 3.18 ± 0.067	1.619GlnPhe: 1.619 ± 0.044	2.297GlnGly: 2.297 ± 0.068	0.936GlnHis: 0.936 ± 0.04	2.543GlnIle: 2.543 ± 0.052	2.697GlnLys: 2.697 ± 0.067	4.306GlnLeu: 4.306 ± 0.079	1.305GlnMet: 1.305 ± 0.037	1.666GlnAsn: 1.666 ± 0.049	1.334GlnPro: 1.334 ± 0.044	2.276GlnGln: 2.276 ± 0.075	1.667GlnArg: 1.667 ± 0.054	2.229GlnSer: 2.229 ± 0.052	2.403GlnThr: 2.403 ± 0.049	2.562GlnVal: 2.562 ± 0.057	0.429GlnTrp: 0.429 ± 0.022	1.27GlnTyr: 1.27 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.38ArgAla: 2.38 ± 0.051	0.269ArgCys: 0.269 ± 0.02	2.31ArgAsp: 2.31 ± 0.055	3.198ArgGlu: 3.198 ± 0.068	1.959ArgPhe: 1.959 ± 0.054	2.415ArgGly: 2.415 ± 0.053	0.999ArgHis: 0.999 ± 0.041	2.993ArgIle: 2.993 ± 0.054	3.217ArgLys: 3.217 ± 0.069	4.056ArgLeu: 4.056 ± 0.071	1.431ArgMet: 1.431 ± 0.039	2.088ArgAsn: 2.088 ± 0.049	1.402ArgPro: 1.402 ± 0.044	1.928ArgGln: 1.928 ± 0.047	1.944ArgArg: 1.944 ± 0.051	2.296ArgSer: 2.296 ± 0.052	2.207ArgThr: 2.207 ± 0.056	2.642ArgVal: 2.642 ± 0.061	0.419ArgTrp: 0.419 ± 0.026	1.564ArgTyr: 1.564 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.909SerAla: 3.909 ± 0.069	0.387SerCys: 0.387 ± 0.024	3.235SerAsp: 3.235 ± 0.064	3.838SerGlu: 3.838 ± 0.08	2.993SerPhe: 2.993 ± 0.073	4.595SerGly: 4.595 ± 0.079	1.176SerHis: 1.176 ± 0.04	4.72SerIle: 4.72 ± 0.084	3.287SerLys: 3.287 ± 0.057	5.561SerLeu: 5.561 ± 0.089	1.907SerMet: 1.907 ± 0.053	2.428SerAsn: 2.428 ± 0.061	2.078SerPro: 2.078 ± 0.054	1.973SerGln: 1.973 ± 0.047	2.399SerArg: 2.399 ± 0.057	3.626SerSer: 3.626 ± 0.078	2.889SerThr: 2.889 ± 0.058	4.368SerVal: 4.368 ± 0.078	0.584SerTrp: 0.584 ± 0.026	2.1SerTyr: 2.1 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.575ThrAla: 4.575 ± 0.075	0.379ThrCys: 0.379 ± 0.02	3.4ThrAsp: 3.4 ± 0.068	3.665ThrGlu: 3.665 ± 0.066	2.846ThrPhe: 2.846 ± 0.055	4.582ThrGly: 4.582 ± 0.072	1.076ThrHis: 1.076 ± 0.038	4.755ThrIle: 4.755 ± 0.085	3.151ThrLys: 3.151 ± 0.063	5.116ThrLeu: 5.116 ± 0.083	1.554ThrMet: 1.554 ± 0.042	2.638ThrAsn: 2.638 ± 0.06	2.295ThrPro: 2.295 ± 0.053	1.547ThrGln: 1.547 ± 0.04	1.887ThrArg: 1.887 ± 0.04	3.33ThrSer: 3.33 ± 0.061	3.159ThrThr: 3.159 ± 0.067	4.486ThrVal: 4.486 ± 0.077	0.566ThrTrp: 0.566 ± 0.03	1.998ThrTyr: 1.998 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	5.03ValAla: 5.03 ± 0.082	0.601ValCys: 0.601 ± 0.025	4.009ValAsp: 4.009 ± 0.078	4.48ValGlu: 4.48 ± 0.071	3.112ValPhe: 3.112 ± 0.066	4.533ValGly: 4.533 ± 0.082	1.555ValHis: 1.555 ± 0.038	5.782ValIle: 5.782 ± 0.094	4.121ValLys: 4.121 ± 0.07	6.912ValLeu: 6.912 ± 0.102	2.074ValMet: 2.074 ± 0.049	3.123ValAsn: 3.123 ± 0.06	2.784ValPro: 2.784 ± 0.052	2.514ValGln: 2.514 ± 0.053	2.753ValArg: 2.753 ± 0.051	4.563ValSer: 4.563 ± 0.077	4.427ValThr: 4.427 ± 0.074	5.106ValVal: 5.106 ± 0.096	0.647ValTrp: 0.647 ± 0.031	2.301ValTyr: 2.301 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.653TrpAla: 0.653 ± 0.026	0.069TrpCys: 0.069 ± 0.009	0.533TrpAsp: 0.533 ± 0.025	0.705TrpGlu: 0.705 ± 0.028	0.479TrpPhe: 0.479 ± 0.024	0.654TrpGly: 0.654 ± 0.027	0.216TrpHis: 0.216 ± 0.015	0.794TrpIle: 0.794 ± 0.032	0.694TrpLys: 0.694 ± 0.031	1.193TrpLeu: 1.193 ± 0.04	0.384TrpMet: 0.384 ± 0.023	0.541TrpAsn: 0.541 ± 0.025	0.26TrpPro: 0.26 ± 0.019	0.448TrpGln: 0.448 ± 0.027	0.402TrpArg: 0.402 ± 0.022	0.571TrpSer: 0.571 ± 0.023	0.525TrpThr: 0.525 ± 0.026	0.674TrpVal: 0.674 ± 0.03	0.132TrpTrp: 0.132 ± 0.013	0.366TrpTyr: 0.366 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.239TyrAla: 2.239 ± 0.057	0.316TyrCys: 0.316 ± 0.017	2.121TyrAsp: 2.121 ± 0.054	2.351TyrGlu: 2.351 ± 0.059	1.631TyrPhe: 1.631 ± 0.045	2.462TyrGly: 2.462 ± 0.049	0.927TyrHis: 0.927 ± 0.035	2.365TyrIle: 2.365 ± 0.053	1.838TyrLys: 1.838 ± 0.049	3.232TyrLeu: 3.232 ± 0.062	0.927TyrMet: 0.927 ± 0.035	1.459TyrAsn: 1.459 ± 0.045	1.394TyrPro: 1.394 ± 0.041	1.584TyrGln: 1.584 ± 0.049	1.696TyrArg: 1.696 ± 0.046	1.869TyrSer: 1.869 ± 0.051	1.937TyrThr: 1.937 ± 0.043	2.26TyrVal: 2.26 ± 0.053	0.387TyrTrp: 0.387 ± 0.022	1.368TyrTyr: 1.368 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3079 proteins (883714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---