Amino acid dipepetide frequency for Alteromonas sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.501AlaAla: 7.501 ± 0.118	1.011AlaCys: 1.011 ± 0.03	4.845AlaAsp: 4.845 ± 0.077	5.42AlaGlu: 5.42 ± 0.075	3.933AlaPhe: 3.933 ± 0.067	5.823AlaGly: 5.823 ± 0.081	1.872AlaHis: 1.872 ± 0.042	5.982AlaIle: 5.982 ± 0.074	4.742AlaLys: 4.742 ± 0.065	10.603AlaLeu: 10.603 ± 0.105	2.633AlaMet: 2.633 ± 0.047	3.832AlaAsn: 3.832 ± 0.049	2.968AlaPro: 2.968 ± 0.056	4.014AlaGln: 4.014 ± 0.067	3.971AlaArg: 3.971 ± 0.063	5.996AlaSer: 5.996 ± 0.08	4.592AlaThr: 4.592 ± 0.055	5.962AlaVal: 5.962 ± 0.081	0.988AlaTrp: 0.988 ± 0.032	2.678AlaTyr: 2.678 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.029	0.152CysCys: 0.152 ± 0.011	0.623CysAsp: 0.623 ± 0.024	0.629CysGlu: 0.629 ± 0.024	0.469CysPhe: 0.469 ± 0.019	0.746CysGly: 0.746 ± 0.025	0.3CysHis: 0.3 ± 0.016	0.678CysIle: 0.678 ± 0.024	0.439CysLys: 0.439 ± 0.018	0.997CysLeu: 0.997 ± 0.031	0.236CysMet: 0.236 ± 0.014	0.387CysAsn: 0.387 ± 0.018	0.407CysPro: 0.407 ± 0.019	0.458CysGln: 0.458 ± 0.018	0.479CysArg: 0.479 ± 0.021	0.643CysSer: 0.643 ± 0.024	0.449CysThr: 0.449 ± 0.018	0.665CysVal: 0.665 ± 0.027	0.129CysTrp: 0.129 ± 0.01	0.328CysTyr: 0.328 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.256AspAla: 5.256 ± 0.075	0.519AspCys: 0.519 ± 0.021	3.498AspAsp: 3.498 ± 0.068	3.769AspGlu: 3.769 ± 0.068	2.553AspPhe: 2.553 ± 0.049	3.774AspGly: 3.774 ± 0.069	1.031AspHis: 1.031 ± 0.029	4.338AspIle: 4.338 ± 0.064	3.312AspLys: 3.312 ± 0.056	4.947AspLeu: 4.947 ± 0.07	1.54AspMet: 1.54 ± 0.041	2.741AspAsn: 2.741 ± 0.046	2.094AspPro: 2.094 ± 0.05	1.816AspGln: 1.816 ± 0.04	2.247AspArg: 2.247 ± 0.047	3.356AspSer: 3.356 ± 0.059	3.168AspThr: 3.168 ± 0.05	4.257AspVal: 4.257 ± 0.059	0.886AspTrp: 0.886 ± 0.03	2.101AspTyr: 2.101 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.502GluAla: 5.502 ± 0.073	0.46GluCys: 0.46 ± 0.022	3.01GluAsp: 3.01 ± 0.055	3.774GluGlu: 3.774 ± 0.065	2.257GluPhe: 2.257 ± 0.041	3.711GluGly: 3.711 ± 0.053	1.607GluHis: 1.607 ± 0.033	3.484GluIle: 3.484 ± 0.065	3.853GluLys: 3.853 ± 0.067	6.152GluLeu: 6.152 ± 0.072	1.532GluMet: 1.532 ± 0.034	2.69GluAsn: 2.69 ± 0.048	2.003GluPro: 2.003 ± 0.046	3.894GluGln: 3.894 ± 0.061	3.442GluArg: 3.442 ± 0.062	3.954GluSer: 3.954 ± 0.064	3.102GluThr: 3.102 ± 0.051	4.022GluVal: 4.022 ± 0.06	0.796GluTrp: 0.796 ± 0.025	1.785GluTyr: 1.785 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.054	0.532PheCys: 0.532 ± 0.023	3.058PheAsp: 3.058 ± 0.053	2.675PheGlu: 2.675 ± 0.045	1.944PhePhe: 1.944 ± 0.044	3.089PheGly: 3.089 ± 0.055	0.868PheHis: 0.868 ± 0.029	2.81PheIle: 2.81 ± 0.047	1.848PheLys: 1.848 ± 0.041	3.486PheLeu: 3.486 ± 0.056	1.002PheMet: 1.002 ± 0.03	2.023PheAsn: 2.023 ± 0.048	1.512PhePro: 1.512 ± 0.035	1.196PheGln: 1.196 ± 0.031	1.643PheArg: 1.643 ± 0.04	3.62PheSer: 3.62 ± 0.057	2.627PheThr: 2.627 ± 0.048	2.999PheVal: 2.999 ± 0.057	0.566PheTrp: 0.566 ± 0.024	1.466PheTyr: 1.466 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.16GlyAla: 5.16 ± 0.074	0.825GlyCys: 0.825 ± 0.031	3.715GlyAsp: 3.715 ± 0.063	4.237GlyGlu: 4.237 ± 0.073	3.379GlyPhe: 3.379 ± 0.064	4.568GlyGly: 4.568 ± 0.083	1.518GlyHis: 1.518 ± 0.037	4.626GlyIle: 4.626 ± 0.067	3.884GlyLys: 3.884 ± 0.064	6.78GlyLeu: 6.78 ± 0.075	1.913GlyMet: 1.913 ± 0.039	2.706GlyAsn: 2.706 ± 0.044	1.704GlyPro: 1.704 ± 0.04	2.716GlyGln: 2.716 ± 0.046	2.988GlyArg: 2.988 ± 0.056	3.843GlySer: 3.843 ± 0.068	3.438GlyThr: 3.438 ± 0.061	5.0GlyVal: 5.0 ± 0.076	0.969GlyTrp: 0.969 ± 0.03	2.368GlyTyr: 2.368 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.925HisAla: 1.925 ± 0.039	0.335HisCys: 0.335 ± 0.018	1.167HisAsp: 1.167 ± 0.038	1.232HisGlu: 1.232 ± 0.035	1.197HisPhe: 1.197 ± 0.037	1.459HisGly: 1.459 ± 0.035	0.69HisHis: 0.69 ± 0.026	1.518HisIle: 1.518 ± 0.038	1.169HisLys: 1.169 ± 0.032	2.32HisLeu: 2.32 ± 0.048	0.536HisMet: 0.536 ± 0.019	0.947HisAsn: 0.947 ± 0.028	1.201HisPro: 1.201 ± 0.031	1.026HisGln: 1.026 ± 0.029	1.043HisArg: 1.043 ± 0.033	1.445HisSer: 1.445 ± 0.039	1.206HisThr: 1.206 ± 0.031	1.508HisVal: 1.508 ± 0.035	0.368HisTrp: 0.368 ± 0.016	0.997HisTyr: 0.997 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.359IleAla: 6.359 ± 0.086	0.645IleCys: 0.645 ± 0.022	4.311IleAsp: 4.311 ± 0.067	4.528IleGlu: 4.528 ± 0.062	2.079IlePhe: 2.079 ± 0.045	4.362IleGly: 4.362 ± 0.067	1.26IleHis: 1.26 ± 0.032	3.328IleIle: 3.328 ± 0.061	3.162IleLys: 3.162 ± 0.055	4.876IleLeu: 4.876 ± 0.074	1.3IleMet: 1.3 ± 0.038	3.133IleAsn: 3.133 ± 0.058	2.54IlePro: 2.54 ± 0.052	2.285IleGln: 2.285 ± 0.042	2.849IleArg: 2.849 ± 0.053	4.258IleSer: 4.258 ± 0.062	3.733IleThr: 3.733 ± 0.055	4.409IleVal: 4.409 ± 0.07	0.608IleTrp: 0.608 ± 0.023	1.57IleTyr: 1.57 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.919LysAla: 4.919 ± 0.081	0.332LysCys: 0.332 ± 0.016	2.639LysAsp: 2.639 ± 0.049	2.927LysGlu: 2.927 ± 0.054	1.391LysPhe: 1.391 ± 0.036	3.287LysGly: 3.287 ± 0.058	1.394LysHis: 1.394 ± 0.037	2.536LysIle: 2.536 ± 0.048	2.896LysLys: 2.896 ± 0.058	5.031LysLeu: 5.031 ± 0.069	1.227LysMet: 1.227 ± 0.032	2.019LysAsn: 2.019 ± 0.044	2.275LysPro: 2.275 ± 0.042	2.939LysGln: 2.939 ± 0.056	3.088LysArg: 3.088 ± 0.059	3.129LysSer: 3.129 ± 0.058	2.984LysThr: 2.984 ± 0.049	3.641LysVal: 3.641 ± 0.06	0.585LysTrp: 0.585 ± 0.022	1.313LysTyr: 1.313 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	9.768LeuAla: 9.768 ± 0.113	1.129LeuCys: 1.129 ± 0.031	5.698LeuAsp: 5.698 ± 0.081	5.597LeuGlu: 5.597 ± 0.081	4.507LeuPhe: 4.507 ± 0.064	6.413LeuGly: 6.413 ± 0.077	2.327LeuHis: 2.327 ± 0.052	6.052LeuIle: 6.052 ± 0.083	4.972LeuLys: 4.972 ± 0.078	10.683LeuLeu: 10.683 ± 0.14	2.508LeuMet: 2.508 ± 0.043	4.646LeuAsn: 4.646 ± 0.061	4.713LeuPro: 4.713 ± 0.061	3.95LeuGln: 3.95 ± 0.062	4.488LeuArg: 4.488 ± 0.071	8.429LeuSer: 8.429 ± 0.089	6.101LeuThr: 6.101 ± 0.083	6.923LeuVal: 6.923 ± 0.086	0.978LeuTrp: 0.978 ± 0.032	2.757LeuTyr: 2.757 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.483MetAla: 2.483 ± 0.054	0.206MetCys: 0.206 ± 0.012	1.202MetAsp: 1.202 ± 0.033	1.159MetGlu: 1.159 ± 0.032	0.858MetPhe: 0.858 ± 0.025	1.738MetGly: 1.738 ± 0.039	0.588MetHis: 0.588 ± 0.022	1.25MetIle: 1.25 ± 0.032	1.333MetLys: 1.333 ± 0.035	2.709MetLeu: 2.709 ± 0.055	0.669MetMet: 0.669 ± 0.025	1.038MetAsn: 1.038 ± 0.028	1.28MetPro: 1.28 ± 0.037	1.417MetGln: 1.417 ± 0.028	1.344MetArg: 1.344 ± 0.033	1.814MetSer: 1.814 ± 0.036	1.609MetThr: 1.609 ± 0.037	1.646MetVal: 1.646 ± 0.038	0.229MetTrp: 0.229 ± 0.013	0.533MetTyr: 0.533 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	4.131AsnAla: 4.131 ± 0.056	0.372AsnCys: 0.372 ± 0.016	2.428AsnAsp: 2.428 ± 0.044	2.55AsnGlu: 2.55 ± 0.049	1.477AsnPhe: 1.477 ± 0.031	3.018AsnGly: 3.018 ± 0.059	0.883AsnHis: 0.883 ± 0.027	2.763AsnIle: 2.763 ± 0.051	2.282AsnLys: 2.282 ± 0.041	3.884AsnLeu: 3.884 ± 0.062	1.047AsnMet: 1.047 ± 0.029	1.996AsnAsn: 1.996 ± 0.046	1.963AsnPro: 1.963 ± 0.037	1.996AsnGln: 1.996 ± 0.041	2.148AsnArg: 2.148 ± 0.044	2.312AsnSer: 2.312 ± 0.045	2.605AsnThr: 2.605 ± 0.049	2.953AsnVal: 2.953 ± 0.051	0.633AsnTrp: 0.633 ± 0.025	1.32AsnTyr: 1.32 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.066ProAla: 3.066 ± 0.054	0.318ProCys: 0.318 ± 0.016	2.69ProAsp: 2.69 ± 0.049	3.031ProGlu: 3.031 ± 0.052	1.855ProPhe: 1.855 ± 0.04	2.527ProGly: 2.527 ± 0.045	0.916ProHis: 0.916 ± 0.029	2.416ProIle: 2.416 ± 0.042	1.771ProLys: 1.771 ± 0.043	4.107ProLeu: 4.107 ± 0.054	0.925ProMet: 0.925 ± 0.024	1.781ProAsn: 1.781 ± 0.042	1.358ProPro: 1.358 ± 0.038	1.618ProGln: 1.618 ± 0.036	1.397ProArg: 1.397 ± 0.037	2.612ProSer: 2.612 ± 0.045	2.133ProThr: 2.133 ± 0.045	3.264ProVal: 3.264 ± 0.053	0.457ProTrp: 0.457 ± 0.021	1.227ProTyr: 1.227 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.452GlnAla: 4.452 ± 0.07	0.416GlnCys: 0.416 ± 0.018	2.031GlnAsp: 2.031 ± 0.039	2.367GlnGlu: 2.367 ± 0.056	1.805GlnPhe: 1.805 ± 0.036	2.887GlnGly: 2.887 ± 0.047	1.293GlnHis: 1.293 ± 0.032	2.569GlnIle: 2.569 ± 0.043	2.12GlnLys: 2.12 ± 0.043	4.73GlnLeu: 4.73 ± 0.079	1.05GlnMet: 1.05 ± 0.029	1.667GlnAsn: 1.667 ± 0.042	1.785GlnPro: 1.785 ± 0.037	2.944GlnGln: 2.944 ± 0.067	2.488GlnArg: 2.488 ± 0.05	3.016GlnSer: 3.016 ± 0.053	2.452GlnThr: 2.452 ± 0.046	3.075GlnVal: 3.075 ± 0.048	0.652GlnTrp: 0.652 ± 0.024	1.338GlnTyr: 1.338 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.855ArgAla: 3.855 ± 0.065	0.475ArgCys: 0.475 ± 0.023	2.528ArgAsp: 2.528 ± 0.041	2.998ArgGlu: 2.998 ± 0.056	2.498ArgPhe: 2.498 ± 0.046	2.675ArgGly: 2.675 ± 0.049	1.248ArgHis: 1.248 ± 0.036	3.098ArgIle: 3.098 ± 0.06	2.194ArgLys: 2.194 ± 0.044	5.215ArgLeu: 5.215 ± 0.076	1.19ArgMet: 1.19 ± 0.033	1.831ArgAsn: 1.831 ± 0.037	1.637ArgPro: 1.637 ± 0.034	2.367ArgGln: 2.367 ± 0.052	2.358ArgArg: 2.358 ± 0.051	2.526ArgSer: 2.526 ± 0.049	2.274ArgThr: 2.274 ± 0.045	3.364ArgVal: 3.364 ± 0.06	0.633ArgTrp: 0.633 ± 0.024	1.788ArgTyr: 1.788 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.96SerAla: 5.96 ± 0.079	0.577SerCys: 0.577 ± 0.024	3.986SerAsp: 3.986 ± 0.058	4.248SerGlu: 4.248 ± 0.056	2.835SerPhe: 2.835 ± 0.051	4.922SerGly: 4.922 ± 0.072	1.608SerHis: 1.608 ± 0.037	4.114SerIle: 4.114 ± 0.069	3.001SerLys: 3.001 ± 0.048	7.303SerLeu: 7.303 ± 0.084	1.724SerMet: 1.724 ± 0.037	2.601SerAsn: 2.601 ± 0.047	2.715SerPro: 2.715 ± 0.05	3.039SerGln: 3.039 ± 0.054	2.99SerArg: 2.99 ± 0.047	4.252SerSer: 4.252 ± 0.079	3.462SerThr: 3.462 ± 0.06	5.069SerVal: 5.069 ± 0.059	0.832SerTrp: 0.832 ± 0.028	1.827SerTyr: 1.827 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.68ThrAla: 4.68 ± 0.073	0.489ThrCys: 0.489 ± 0.021	3.082ThrAsp: 3.082 ± 0.056	3.162ThrGlu: 3.162 ± 0.048	2.457ThrPhe: 2.457 ± 0.05	4.01ThrGly: 4.01 ± 0.06	1.411ThrHis: 1.411 ± 0.038	3.208ThrIle: 3.208 ± 0.051	2.267ThrLys: 2.267 ± 0.046	6.881ThrLeu: 6.881 ± 0.079	1.151ThrMet: 1.151 ± 0.035	1.963ThrAsn: 1.963 ± 0.037	2.786ThrPro: 2.786 ± 0.055	2.614ThrGln: 2.614 ± 0.053	2.42ThrArg: 2.42 ± 0.047	3.496ThrSer: 3.496 ± 0.057	2.968ThrThr: 2.968 ± 0.066	3.997ThrVal: 3.997 ± 0.057	0.666ThrTrp: 0.666 ± 0.022	1.622ThrTyr: 1.622 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.341ValAla: 6.341 ± 0.079	0.743ValCys: 0.743 ± 0.026	4.348ValAsp: 4.348 ± 0.061	4.471ValGlu: 4.471 ± 0.066	3.177ValPhe: 3.177 ± 0.051	4.543ValGly: 4.543 ± 0.075	1.344ValHis: 1.344 ± 0.036	4.549ValIle: 4.549 ± 0.068	3.452ValLys: 3.452 ± 0.063	7.005ValLeu: 7.005 ± 0.078	1.921ValMet: 1.921 ± 0.042	3.274ValAsn: 3.274 ± 0.052	2.676ValPro: 2.676 ± 0.046	2.26ValGln: 2.26 ± 0.043	2.918ValArg: 2.918 ± 0.056	5.504ValSer: 5.504 ± 0.073	4.31ValThr: 4.31 ± 0.064	5.32ValVal: 5.32 ± 0.081	0.762ValTrp: 0.762 ± 0.025	1.922ValTyr: 1.922 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.803TrpAla: 0.803 ± 0.029	0.165TrpCys: 0.165 ± 0.011	0.616TrpAsp: 0.616 ± 0.024	0.581TrpGlu: 0.581 ± 0.023	0.609TrpPhe: 0.609 ± 0.024	0.733TrpGly: 0.733 ± 0.027	0.392TrpHis: 0.392 ± 0.016	0.627TrpIle: 0.627 ± 0.025	0.472TrpLys: 0.472 ± 0.023	1.718TrpLeu: 1.718 ± 0.042	0.36TrpMet: 0.36 ± 0.018	0.382TrpAsn: 0.382 ± 0.02	0.455TrpPro: 0.455 ± 0.022	0.921TrpGln: 0.921 ± 0.03	0.762TrpArg: 0.762 ± 0.022	0.797TrpSer: 0.797 ± 0.029	0.543TrpThr: 0.543 ± 0.024	0.868TrpVal: 0.868 ± 0.026	0.194TrpTrp: 0.194 ± 0.014	0.396TrpTyr: 0.396 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.626TyrAla: 2.626 ± 0.04	0.35TyrCys: 0.35 ± 0.019	1.731TyrAsp: 1.731 ± 0.041	1.673TyrGlu: 1.673 ± 0.04	1.427TyrPhe: 1.427 ± 0.036	2.053TyrGly: 2.053 ± 0.041	0.742TyrHis: 0.742 ± 0.023	1.65TyrIle: 1.65 ± 0.033	1.382TyrLys: 1.382 ± 0.041	3.213TyrLeu: 3.213 ± 0.048	0.638TyrMet: 0.638 ± 0.024	1.105TyrAsn: 1.105 ± 0.033	1.393TyrPro: 1.393 ± 0.036	1.669TyrGln: 1.669 ± 0.041	1.689TyrArg: 1.689 ± 0.038	2.061TyrSer: 2.061 ± 0.043	1.572TyrThr: 1.572 ± 0.038	1.898TyrVal: 1.898 ± 0.042	0.462TyrTrp: 0.462 ± 0.021	1.035TyrTyr: 1.035 ± 0.031	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3562 proteins (1208032 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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