Amino acid dipepetide frequency for Citrobacter phage CVT22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.989AlaAla: 7.989 ± 0.894
0.671AlaCys: 0.671 ± 0.216
4.901AlaAsp: 4.901 ± 0.569
5.438AlaGlu: 5.438 ± 0.537
2.954AlaPhe: 2.954 ± 0.409
6.042AlaGly: 6.042 ± 0.901
1.477AlaHis: 1.477 ± 0.311
5.371AlaIle: 5.371 ± 0.578
5.84AlaLys: 5.84 ± 0.517
6.579AlaLeu: 6.579 ± 0.697
2.081AlaMet: 2.081 ± 0.463
3.894AlaAsn: 3.894 ± 0.527
2.752AlaPro: 2.752 ± 0.557
4.028AlaGln: 4.028 ± 0.643
2.282AlaArg: 2.282 ± 0.502
6.176AlaSer: 6.176 ± 0.775
5.303AlaThr: 5.303 ± 0.805
5.035AlaVal: 5.035 ± 0.454
1.678AlaTrp: 1.678 ± 0.367
3.088AlaTyr: 3.088 ± 0.396
0.0AlaXaa: 0.0 ± 0.0
Cys
0.47CysAla: 0.47 ± 0.168
0.269CysCys: 0.269 ± 0.127
0.537CysAsp: 0.537 ± 0.258
0.738CysGlu: 0.738 ± 0.22
0.671CysPhe: 0.671 ± 0.222
0.806CysGly: 0.806 ± 0.253
0.269CysHis: 0.269 ± 0.115
0.738CysIle: 0.738 ± 0.234
0.604CysLys: 0.604 ± 0.222
0.604CysLeu: 0.604 ± 0.176
0.201CysMet: 0.201 ± 0.109
0.269CysAsn: 0.269 ± 0.121
0.067CysPro: 0.067 ± 0.063
0.403CysGln: 0.403 ± 0.147
0.738CysArg: 0.738 ± 0.239
0.738CysSer: 0.738 ± 0.237
0.738CysThr: 0.738 ± 0.203
0.738CysVal: 0.738 ± 0.226
0.201CysTrp: 0.201 ± 0.123
0.269CysTyr: 0.269 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
5.639AspAla: 5.639 ± 0.743
0.47AspCys: 0.47 ± 0.176
3.088AspAsp: 3.088 ± 0.446
3.289AspGlu: 3.289 ± 0.485
2.148AspPhe: 2.148 ± 0.448
5.572AspGly: 5.572 ± 0.616
0.604AspHis: 0.604 ± 0.169
3.894AspIle: 3.894 ± 0.425
4.296AspLys: 4.296 ± 0.555
5.438AspLeu: 5.438 ± 0.632
1.141AspMet: 1.141 ± 0.263
3.357AspAsn: 3.357 ± 0.548
2.148AspPro: 2.148 ± 0.481
1.208AspGln: 1.208 ± 0.291
2.35AspArg: 2.35 ± 0.363
3.021AspSer: 3.021 ± 0.544
3.625AspThr: 3.625 ± 0.553
5.84AspVal: 5.84 ± 0.498
1.141AspTrp: 1.141 ± 0.296
3.088AspTyr: 3.088 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
5.84GluAla: 5.84 ± 0.68
1.074GluCys: 1.074 ± 0.328
4.498GluAsp: 4.498 ± 0.528
6.042GluGlu: 6.042 ± 0.867
2.35GluPhe: 2.35 ± 0.4
4.968GluGly: 4.968 ± 0.712
1.343GluHis: 1.343 ± 0.312
3.558GluIle: 3.558 ± 0.465
3.558GluLys: 3.558 ± 0.521
6.243GluLeu: 6.243 ± 0.718
3.021GluMet: 3.021 ± 0.419
4.095GluAsn: 4.095 ± 0.45
1.678GluPro: 1.678 ± 0.334
3.289GluGln: 3.289 ± 0.457
2.618GluArg: 2.618 ± 0.501
3.357GluSer: 3.357 ± 0.362
2.551GluThr: 2.551 ± 0.445
4.162GluVal: 4.162 ± 0.565
1.88GluTrp: 1.88 ± 0.33
3.289GluTyr: 3.289 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
2.752PheAla: 2.752 ± 0.455
0.738PheCys: 0.738 ± 0.186
2.148PheAsp: 2.148 ± 0.341
2.417PheGlu: 2.417 ± 0.413
1.276PhePhe: 1.276 ± 0.25
3.357PheGly: 3.357 ± 0.414
0.806PheHis: 0.806 ± 0.21
2.685PheIle: 2.685 ± 0.43
2.887PheLys: 2.887 ± 0.427
2.35PheLeu: 2.35 ± 0.372
1.074PheMet: 1.074 ± 0.271
2.417PheAsn: 2.417 ± 0.35
1.208PhePro: 1.208 ± 0.283
1.41PheGln: 1.41 ± 0.308
1.477PheArg: 1.477 ± 0.287
2.887PheSer: 2.887 ± 0.392
2.685PheThr: 2.685 ± 0.449
1.745PheVal: 1.745 ± 0.329
0.537PheTrp: 0.537 ± 0.208
1.88PheTyr: 1.88 ± 0.373
0.0PheXaa: 0.0 ± 0.0
Gly
5.639GlyAla: 5.639 ± 0.675
1.007GlyCys: 1.007 ± 0.326
5.035GlyAsp: 5.035 ± 0.517
4.565GlyGlu: 4.565 ± 0.612
3.759GlyPhe: 3.759 ± 0.385
4.565GlyGly: 4.565 ± 0.716
1.276GlyHis: 1.276 ± 0.327
4.095GlyIle: 4.095 ± 0.511
6.378GlyLys: 6.378 ± 0.76
4.498GlyLeu: 4.498 ± 0.464
2.282GlyMet: 2.282 ± 0.281
3.625GlyAsn: 3.625 ± 0.538
1.208GlyPro: 1.208 ± 0.307
1.477GlyGln: 1.477 ± 0.348
2.82GlyArg: 2.82 ± 0.445
4.968GlySer: 4.968 ± 0.572
4.095GlyThr: 4.095 ± 0.538
6.915GlyVal: 6.915 ± 0.821
1.611GlyTrp: 1.611 ± 0.395
2.82GlyTyr: 2.82 ± 0.359
0.0GlyXaa: 0.0 ± 0.0
His
1.141HisAla: 1.141 ± 0.315
0.269HisCys: 0.269 ± 0.12
0.94HisAsp: 0.94 ± 0.256
1.208HisGlu: 1.208 ± 0.325
1.276HisPhe: 1.276 ± 0.291
1.074HisGly: 1.074 ± 0.242
0.269HisHis: 0.269 ± 0.115
1.007HisIle: 1.007 ± 0.25
0.94HisLys: 0.94 ± 0.224
1.678HisLeu: 1.678 ± 0.399
0.604HisMet: 0.604 ± 0.181
1.41HisAsn: 1.41 ± 0.269
1.343HisPro: 1.343 ± 0.403
0.537HisGln: 0.537 ± 0.192
0.738HisArg: 0.738 ± 0.209
0.94HisSer: 0.94 ± 0.258
0.94HisThr: 0.94 ± 0.203
1.074HisVal: 1.074 ± 0.224
0.671HisTrp: 0.671 ± 0.198
0.806HisTyr: 0.806 ± 0.214
0.0HisXaa: 0.0 ± 0.0
Ile
4.632IleAla: 4.632 ± 0.565
0.738IleCys: 0.738 ± 0.225
4.095IleAsp: 4.095 ± 0.532
3.558IleGlu: 3.558 ± 0.515
2.014IlePhe: 2.014 ± 0.399
4.498IleGly: 4.498 ± 0.466
1.141IleHis: 1.141 ± 0.365
3.289IleIle: 3.289 ± 0.614
4.565IleLys: 4.565 ± 0.526
3.759IleLeu: 3.759 ± 0.516
1.611IleMet: 1.611 ± 0.309
3.424IleAsn: 3.424 ± 0.572
2.551IlePro: 2.551 ± 0.381
1.678IleGln: 1.678 ± 0.313
2.752IleArg: 2.752 ± 0.429
2.417IleSer: 2.417 ± 0.396
3.625IleThr: 3.625 ± 0.539
3.692IleVal: 3.692 ± 0.504
0.94IleTrp: 0.94 ± 0.253
1.544IleTyr: 1.544 ± 0.382
0.0IleXaa: 0.0 ± 0.0
Lys
7.385LysAla: 7.385 ± 0.854
0.537LysCys: 0.537 ± 0.176
5.773LysAsp: 5.773 ± 0.684
5.236LysGlu: 5.236 ± 0.685
1.947LysPhe: 1.947 ± 0.285
6.847LysGly: 6.847 ± 0.905
1.41LysHis: 1.41 ± 0.275
3.491LysIle: 3.491 ± 0.495
4.632LysLys: 4.632 ± 0.765
4.632LysLeu: 4.632 ± 0.472
2.887LysMet: 2.887 ± 0.427
2.215LysAsn: 2.215 ± 0.392
2.282LysPro: 2.282 ± 0.351
3.491LysGln: 3.491 ± 0.457
3.759LysArg: 3.759 ± 0.599
3.558LysSer: 3.558 ± 0.42
2.82LysThr: 2.82 ± 0.505
4.901LysVal: 4.901 ± 0.53
1.007LysTrp: 1.007 ± 0.227
2.887LysTyr: 2.887 ± 0.464
0.0LysXaa: 0.0 ± 0.0
Leu
5.706LeuAla: 5.706 ± 0.631
0.671LeuCys: 0.671 ± 0.221
4.968LeuAsp: 4.968 ± 0.478
6.378LeuGlu: 6.378 ± 0.601
3.222LeuPhe: 3.222 ± 0.532
5.438LeuGly: 5.438 ± 0.579
1.813LeuHis: 1.813 ± 0.335
3.424LeuIle: 3.424 ± 0.475
5.438LeuLys: 5.438 ± 0.545
5.236LeuLeu: 5.236 ± 0.631
2.081LeuMet: 2.081 ± 0.392
4.095LeuAsn: 4.095 ± 0.437
2.752LeuPro: 2.752 ± 0.469
2.685LeuGln: 2.685 ± 0.448
3.759LeuArg: 3.759 ± 0.475
3.357LeuSer: 3.357 ± 0.411
4.364LeuThr: 4.364 ± 0.471
5.706LeuVal: 5.706 ± 0.639
0.94LeuTrp: 0.94 ± 0.251
3.155LeuTyr: 3.155 ± 0.432
0.0LeuXaa: 0.0 ± 0.0
Met
2.148MetAla: 2.148 ± 0.348
0.537MetCys: 0.537 ± 0.191
1.544MetAsp: 1.544 ± 0.417
2.417MetGlu: 2.417 ± 0.453
1.343MetPhe: 1.343 ± 0.262
1.41MetGly: 1.41 ± 0.25
0.806MetHis: 0.806 ± 0.246
1.276MetIle: 1.276 ± 0.258
2.484MetLys: 2.484 ± 0.475
2.148MetLeu: 2.148 ± 0.375
0.806MetMet: 0.806 ± 0.202
2.014MetAsn: 2.014 ± 0.387
0.738MetPro: 0.738 ± 0.213
1.007MetGln: 1.007 ± 0.269
1.544MetArg: 1.544 ± 0.337
2.35MetSer: 2.35 ± 0.345
1.208MetThr: 1.208 ± 0.274
1.947MetVal: 1.947 ± 0.386
0.403MetTrp: 0.403 ± 0.158
0.94MetTyr: 0.94 ± 0.225
0.0MetXaa: 0.0 ± 0.0
Asn
4.901AsnAla: 4.901 ± 0.538
0.47AsnCys: 0.47 ± 0.185
3.021AsnAsp: 3.021 ± 0.494
3.961AsnGlu: 3.961 ± 0.455
1.813AsnPhe: 1.813 ± 0.388
3.222AsnGly: 3.222 ± 0.549
0.738AsnHis: 0.738 ± 0.21
3.021AsnIle: 3.021 ± 0.481
4.229AsnLys: 4.229 ± 0.517
4.431AsnLeu: 4.431 ± 0.56
0.873AsnMet: 0.873 ± 0.235
2.282AsnAsn: 2.282 ± 0.359
2.282AsnPro: 2.282 ± 0.355
2.081AsnGln: 2.081 ± 0.36
1.745AsnArg: 1.745 ± 0.356
3.625AsnSer: 3.625 ± 0.574
2.887AsnThr: 2.887 ± 0.559
4.162AsnVal: 4.162 ± 0.552
0.604AsnTrp: 0.604 ± 0.213
1.813AsnTyr: 1.813 ± 0.299
0.0AsnXaa: 0.0 ± 0.0
Pro
1.813ProAla: 1.813 ± 0.276
0.269ProCys: 0.269 ± 0.133
2.282ProAsp: 2.282 ± 0.367
2.954ProGlu: 2.954 ± 0.414
1.41ProPhe: 1.41 ± 0.282
1.141ProGly: 1.141 ± 0.293
1.007ProHis: 1.007 ± 0.286
2.148ProIle: 2.148 ± 0.345
2.551ProLys: 2.551 ± 0.315
2.35ProLeu: 2.35 ± 0.415
0.604ProMet: 0.604 ± 0.176
1.678ProAsn: 1.678 ± 0.31
1.141ProPro: 1.141 ± 0.246
1.343ProGln: 1.343 ± 0.274
1.611ProArg: 1.611 ± 0.287
2.752ProSer: 2.752 ± 0.473
1.813ProThr: 1.813 ± 0.289
3.088ProVal: 3.088 ± 0.542
0.336ProTrp: 0.336 ± 0.133
1.141ProTyr: 1.141 ± 0.264
0.0ProXaa: 0.0 ± 0.0
Gln
3.827GlnAla: 3.827 ± 0.468
0.336GlnCys: 0.336 ± 0.133
1.678GlnAsp: 1.678 ± 0.345
3.625GlnGlu: 3.625 ± 0.446
1.611GlnPhe: 1.611 ± 0.296
2.618GlnGly: 2.618 ± 0.386
0.336GlnHis: 0.336 ± 0.13
2.484GlnIle: 2.484 ± 0.388
2.014GlnLys: 2.014 ± 0.403
2.484GlnLeu: 2.484 ± 0.368
1.276GlnMet: 1.276 ± 0.335
0.94GlnAsn: 0.94 ± 0.239
1.41GlnPro: 1.41 ± 0.308
1.41GlnGln: 1.41 ± 0.388
2.618GlnArg: 2.618 ± 0.364
2.014GlnSer: 2.014 ± 0.412
1.611GlnThr: 1.611 ± 0.343
2.081GlnVal: 2.081 ± 0.346
0.537GlnTrp: 0.537 ± 0.19
1.611GlnTyr: 1.611 ± 0.324
0.0GlnXaa: 0.0 ± 0.0
Arg
2.82ArgAla: 2.82 ± 0.35
0.403ArgCys: 0.403 ± 0.159
2.417ArgAsp: 2.417 ± 0.439
3.021ArgGlu: 3.021 ± 0.373
1.88ArgPhe: 1.88 ± 0.35
2.551ArgGly: 2.551 ± 0.423
0.738ArgHis: 0.738 ± 0.215
2.618ArgIle: 2.618 ± 0.393
3.894ArgLys: 3.894 ± 0.675
3.357ArgLeu: 3.357 ± 0.4
1.88ArgMet: 1.88 ± 0.376
2.685ArgAsn: 2.685 ± 0.518
1.276ArgPro: 1.276 ± 0.339
1.813ArgGln: 1.813 ± 0.378
2.081ArgArg: 2.081 ± 0.433
2.551ArgSer: 2.551 ± 0.363
2.685ArgThr: 2.685 ± 0.38
2.82ArgVal: 2.82 ± 0.492
0.94ArgTrp: 0.94 ± 0.225
1.745ArgTyr: 1.745 ± 0.295
0.0ArgXaa: 0.0 ± 0.0
Ser
5.102SerAla: 5.102 ± 0.739
0.47SerCys: 0.47 ± 0.199
3.692SerAsp: 3.692 ± 0.504
3.357SerGlu: 3.357 ± 0.406
2.014SerPhe: 2.014 ± 0.488
4.229SerGly: 4.229 ± 0.535
1.276SerHis: 1.276 ± 0.307
3.155SerIle: 3.155 ± 0.356
3.827SerLys: 3.827 ± 0.513
5.639SerLeu: 5.639 ± 0.602
1.745SerMet: 1.745 ± 0.354
3.222SerAsn: 3.222 ± 0.441
3.088SerPro: 3.088 ± 0.552
2.215SerGln: 2.215 ± 0.333
2.35SerArg: 2.35 ± 0.385
4.095SerSer: 4.095 ± 0.538
3.692SerThr: 3.692 ± 0.58
4.632SerVal: 4.632 ± 0.585
1.007SerTrp: 1.007 ± 0.238
2.148SerTyr: 2.148 ± 0.419
0.0SerXaa: 0.0 ± 0.0
Thr
4.968ThrAla: 4.968 ± 0.645
0.403ThrCys: 0.403 ± 0.199
2.752ThrAsp: 2.752 ± 0.492
2.954ThrGlu: 2.954 ± 0.384
2.35ThrPhe: 2.35 ± 0.38
4.901ThrGly: 4.901 ± 0.887
1.208ThrHis: 1.208 ± 0.3
3.424ThrIle: 3.424 ± 0.481
3.827ThrLys: 3.827 ± 0.646
3.894ThrLeu: 3.894 ± 0.532
1.074ThrMet: 1.074 ± 0.286
2.551ThrAsn: 2.551 ± 0.363
1.678ThrPro: 1.678 ± 0.325
2.215ThrGln: 2.215 ± 0.339
2.685ThrArg: 2.685 ± 0.453
3.692ThrSer: 3.692 ± 0.69
4.565ThrThr: 4.565 ± 0.617
4.431ThrVal: 4.431 ± 0.591
0.671ThrTrp: 0.671 ± 0.195
2.148ThrTyr: 2.148 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
6.31ValAla: 6.31 ± 0.718
0.336ValCys: 0.336 ± 0.157
4.565ValAsp: 4.565 ± 0.557
5.371ValGlu: 5.371 ± 0.622
2.551ValPhe: 2.551 ± 0.396
4.431ValGly: 4.431 ± 0.458
1.208ValHis: 1.208 ± 0.342
3.625ValIle: 3.625 ± 0.518
5.236ValLys: 5.236 ± 0.569
5.572ValLeu: 5.572 ± 0.593
1.947ValMet: 1.947 ± 0.424
4.095ValAsn: 4.095 ± 0.382
2.148ValPro: 2.148 ± 0.381
2.685ValGln: 2.685 ± 0.376
3.155ValArg: 3.155 ± 0.358
5.773ValSer: 5.773 ± 0.661
3.692ValThr: 3.692 ± 0.658
6.579ValVal: 6.579 ± 0.818
0.806ValTrp: 0.806 ± 0.234
2.618ValTyr: 2.618 ± 0.385
0.0ValXaa: 0.0 ± 0.0
Trp
1.544TrpAla: 1.544 ± 0.316
0.067TrpCys: 0.067 ± 0.057
0.806TrpAsp: 0.806 ± 0.218
1.074TrpGlu: 1.074 ± 0.222
0.738TrpPhe: 0.738 ± 0.255
1.141TrpGly: 1.141 ± 0.245
0.134TrpHis: 0.134 ± 0.094
1.007TrpIle: 1.007 ± 0.242
1.41TrpLys: 1.41 ± 0.259
1.074TrpLeu: 1.074 ± 0.308
0.738TrpMet: 0.738 ± 0.265
1.276TrpAsn: 1.276 ± 0.287
0.47TrpPro: 0.47 ± 0.19
0.336TrpGln: 0.336 ± 0.132
1.477TrpArg: 1.477 ± 0.319
1.141TrpSer: 1.141 ± 0.359
0.738TrpThr: 0.738 ± 0.195
0.738TrpVal: 0.738 ± 0.195
0.403TrpTrp: 0.403 ± 0.142
0.738TrpTyr: 0.738 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.954TyrAla: 2.954 ± 0.471
0.336TyrCys: 0.336 ± 0.151
2.618TyrAsp: 2.618 ± 0.434
1.813TyrGlu: 1.813 ± 0.315
1.41TyrPhe: 1.41 ± 0.354
3.827TyrGly: 3.827 ± 0.463
1.007TyrHis: 1.007 ± 0.227
2.215TyrIle: 2.215 ± 0.41
3.088TyrLys: 3.088 ± 0.472
3.289TyrLeu: 3.289 ± 0.49
1.074TyrMet: 1.074 ± 0.242
2.618TyrAsn: 2.618 ± 0.364
1.208TyrPro: 1.208 ± 0.293
1.208TyrGln: 1.208 ± 0.258
1.611TyrArg: 1.611 ± 0.275
1.544TyrSer: 1.544 ± 0.322
2.752TyrThr: 2.752 ± 0.437
2.417TyrVal: 2.417 ± 0.346
0.738TyrTrp: 0.738 ± 0.231
1.745TyrTyr: 1.745 ± 0.406
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (14897 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski