Amino acid dipepetide frequency for Smittium culicis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.881AlaAla: 3.881 ± 0.056	0.635AlaCys: 0.635 ± 0.014	2.919AlaAsp: 2.919 ± 0.037	3.178AlaGlu: 3.178 ± 0.037	2.074AlaPhe: 2.074 ± 0.026	2.561AlaGly: 2.561 ± 0.03	0.96AlaHis: 0.96 ± 0.016	3.881AlaIle: 3.881 ± 0.033	3.716AlaLys: 3.716 ± 0.032	4.703AlaLeu: 4.703 ± 0.042	1.009AlaMet: 1.009 ± 0.018	3.264AlaAsn: 3.264 ± 0.032	2.453AlaPro: 2.453 ± 0.036	2.008AlaGln: 2.008 ± 0.033	2.203AlaArg: 2.203 ± 0.027	5.522AlaSer: 5.522 ± 0.044	2.916AlaThr: 2.916 ± 0.035	3.029AlaVal: 3.029 ± 0.033	0.38AlaTrp: 0.38 ± 0.009	1.607AlaTyr: 1.607 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.605CysAla: 0.605 ± 0.013	0.226CysCys: 0.226 ± 0.009	0.663CysAsp: 0.663 ± 0.013	0.59CysGlu: 0.59 ± 0.011	0.559CysPhe: 0.559 ± 0.013	0.806CysGly: 0.806 ± 0.016	0.223CysHis: 0.223 ± 0.009	0.822CysIle: 0.822 ± 0.016	0.8CysLys: 0.8 ± 0.017	1.114CysLeu: 1.114 ± 0.02	0.22CysMet: 0.22 ± 0.007	0.664CysAsn: 0.664 ± 0.014	0.614CysPro: 0.614 ± 0.014	0.348CysGln: 0.348 ± 0.01	0.51CysArg: 0.51 ± 0.015	1.16CysSer: 1.16 ± 0.02	0.607CysThr: 0.607 ± 0.012	0.641CysVal: 0.641 ± 0.013	0.125CysTrp: 0.125 ± 0.005	0.454CysTyr: 0.454 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	2.623AspAla: 2.623 ± 0.028	0.651AspCys: 0.651 ± 0.014	3.443AspAsp: 3.443 ± 0.042	3.47AspGlu: 3.47 ± 0.042	3.098AspPhe: 3.098 ± 0.029	2.508AspGly: 2.508 ± 0.033	1.083AspHis: 1.083 ± 0.016	4.493AspIle: 4.493 ± 0.04	3.615AspLys: 3.615 ± 0.032	5.492AspLeu: 5.492 ± 0.041	1.099AspMet: 1.099 ± 0.017	3.626AspAsn: 3.626 ± 0.035	2.668AspPro: 2.668 ± 0.027	2.05AspGln: 2.05 ± 0.022	2.008AspArg: 2.008 ± 0.028	7.217AspSer: 7.217 ± 0.066	3.105AspThr: 3.105 ± 0.03	2.655AspVal: 2.655 ± 0.028	0.464AspTrp: 0.464 ± 0.011	2.217AspTyr: 2.217 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	3.001GluAla: 3.001 ± 0.034	0.637GluCys: 0.637 ± 0.014	2.912GluAsp: 2.912 ± 0.034	3.38GluGlu: 3.38 ± 0.061	2.738GluPhe: 2.738 ± 0.03	1.973GluGly: 1.973 ± 0.026	0.963GluHis: 0.963 ± 0.017	4.869GluIle: 4.869 ± 0.041	4.781GluLys: 4.781 ± 0.05	5.427GluLeu: 5.427 ± 0.045	1.255GluMet: 1.255 ± 0.019	4.835GluAsn: 4.835 ± 0.043	2.105GluPro: 2.105 ± 0.03	1.862GluGln: 1.862 ± 0.028	2.18GluArg: 2.18 ± 0.03	6.044GluSer: 6.044 ± 0.056	3.149GluThr: 3.149 ± 0.034	2.412GluVal: 2.412 ± 0.026	0.503GluTrp: 0.503 ± 0.013	2.161GluTyr: 2.161 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	2.149PheAla: 2.149 ± 0.023	0.621PheCys: 0.621 ± 0.012	3.097PheAsp: 3.097 ± 0.027	2.666PheGlu: 2.666 ± 0.028	2.059PhePhe: 2.059 ± 0.031	2.768PheGly: 2.768 ± 0.041	0.751PheHis: 0.751 ± 0.012	3.12PheIle: 3.12 ± 0.03	3.052PheLys: 3.052 ± 0.029	3.664PheLeu: 3.664 ± 0.036	0.885PheMet: 0.885 ± 0.014	3.246PheAsn: 3.246 ± 0.032	1.766PhePro: 1.766 ± 0.022	1.295PheGln: 1.295 ± 0.02	1.573PheArg: 1.573 ± 0.018	5.145PheSer: 5.145 ± 0.045	2.199PheThr: 2.199 ± 0.025	2.313PheVal: 2.313 ± 0.027	0.365PheTrp: 0.365 ± 0.009	1.627PheTyr: 1.627 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	2.492GlyAla: 2.492 ± 0.032	0.721GlyCys: 0.721 ± 0.015	2.353GlyAsp: 2.353 ± 0.031	2.201GlyGlu: 2.201 ± 0.028	2.321GlyPhe: 2.321 ± 0.026	2.919GlyGly: 2.919 ± 0.054	1.01GlyHis: 1.01 ± 0.019	3.664GlyIle: 3.664 ± 0.036	3.168GlyLys: 3.168 ± 0.034	4.163GlyLeu: 4.163 ± 0.035	1.023GlyMet: 1.023 ± 0.018	3.15GlyAsn: 3.15 ± 0.036	1.63GlyPro: 1.63 ± 0.026	1.436GlyGln: 1.436 ± 0.022	1.894GlyArg: 1.894 ± 0.026	4.876GlySer: 4.876 ± 0.04	2.477GlyThr: 2.477 ± 0.028	2.703GlyVal: 2.703 ± 0.029	0.45GlyTrp: 0.45 ± 0.014	1.985GlyTyr: 1.985 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	0.905HisAla: 0.905 ± 0.021	0.235HisCys: 0.235 ± 0.008	0.912HisAsp: 0.912 ± 0.015	0.926HisGlu: 0.926 ± 0.016	0.874HisPhe: 0.874 ± 0.015	0.883HisGly: 0.883 ± 0.019	0.461HisHis: 0.461 ± 0.012	1.372HisIle: 1.372 ± 0.02	1.258HisLys: 1.258 ± 0.019	1.732HisLeu: 1.732 ± 0.023	0.321HisMet: 0.321 ± 0.008	1.316HisAsn: 1.316 ± 0.02	0.99HisPro: 0.99 ± 0.018	0.745HisGln: 0.745 ± 0.016	0.907HisArg: 0.907 ± 0.023	2.048HisSer: 2.048 ± 0.029	0.994HisThr: 0.994 ± 0.018	0.873HisVal: 0.873 ± 0.018	0.178HisTrp: 0.178 ± 0.006	0.625HisTyr: 0.625 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.587IleAla: 3.587 ± 0.035	0.917IleCys: 0.917 ± 0.016	4.867IleAsp: 4.867 ± 0.037	4.453IleGlu: 4.453 ± 0.04	3.092IlePhe: 3.092 ± 0.029	3.304IleGly: 3.304 ± 0.037	1.391IleHis: 1.391 ± 0.021	4.484IleIle: 4.484 ± 0.041	5.47IleLys: 5.47 ± 0.044	5.948IleLeu: 5.948 ± 0.041	1.236IleMet: 1.236 ± 0.018	5.518IleAsn: 5.518 ± 0.041	3.837IlePro: 3.837 ± 0.032	2.574IleGln: 2.574 ± 0.025	2.704IleArg: 2.704 ± 0.026	8.823IleSer: 8.823 ± 0.071	3.582IleThr: 3.582 ± 0.039	3.56IleVal: 3.56 ± 0.034	0.489IleTrp: 0.489 ± 0.011	2.355IleTyr: 2.355 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.827LysAla: 3.827 ± 0.036	0.736LysCys: 0.736 ± 0.018	3.835LysAsp: 3.835 ± 0.037	3.82LysGlu: 3.82 ± 0.043	3.058LysPhe: 3.058 ± 0.032	2.594LysGly: 2.594 ± 0.025	1.337LysHis: 1.337 ± 0.02	5.868LysIle: 5.868 ± 0.039	7.198LysLys: 7.198 ± 0.068	6.551LysLeu: 6.551 ± 0.051	1.347LysMet: 1.347 ± 0.018	6.556LysAsn: 6.556 ± 0.059	3.438LysPro: 3.438 ± 0.041	2.307LysGln: 2.307 ± 0.026	3.221LysArg: 3.221 ± 0.035	8.323LysSer: 8.323 ± 0.069	3.985LysThr: 3.985 ± 0.032	3.605LysVal: 3.605 ± 0.032	0.577LysTrp: 0.577 ± 0.013	2.592LysTyr: 2.592 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	5.114LeuAla: 5.114 ± 0.044	1.096LeuCys: 1.096 ± 0.016	5.33LeuAsp: 5.33 ± 0.041	5.419LeuGlu: 5.419 ± 0.052	3.955LeuPhe: 3.955 ± 0.039	4.199LeuGly: 4.199 ± 0.034	1.534LeuHis: 1.534 ± 0.018	5.676LeuIle: 5.676 ± 0.055	6.587LeuLys: 6.587 ± 0.053	7.625LeuLeu: 7.625 ± 0.063	1.591LeuMet: 1.591 ± 0.02	6.411LeuAsn: 6.411 ± 0.055	4.127LeuPro: 4.127 ± 0.041	3.071LeuGln: 3.071 ± 0.031	3.235LeuArg: 3.235 ± 0.032	9.318LeuSer: 9.318 ± 0.058	4.332LeuThr: 4.332 ± 0.035	4.998LeuVal: 4.998 ± 0.045	0.622LeuTrp: 0.622 ± 0.011	2.783LeuTyr: 2.783 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.212MetAla: 1.212 ± 0.017	0.224MetCys: 0.224 ± 0.007	1.12MetAsp: 1.12 ± 0.017	1.119MetGlu: 1.119 ± 0.017	0.831MetPhe: 0.831 ± 0.014	0.914MetGly: 0.914 ± 0.017	0.318MetHis: 0.318 ± 0.009	1.185MetIle: 1.185 ± 0.017	1.228MetLys: 1.228 ± 0.017	1.524MetLeu: 1.524 ± 0.02	0.368MetMet: 0.368 ± 0.011	1.231MetAsn: 1.231 ± 0.017	0.806MetPro: 0.806 ± 0.015	0.643MetGln: 0.643 ± 0.014	0.773MetArg: 0.773 ± 0.015	1.761MetSer: 1.761 ± 0.021	0.925MetThr: 0.925 ± 0.016	1.043MetVal: 1.043 ± 0.015	0.141MetTrp: 0.141 ± 0.005	0.704MetTyr: 0.704 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.124AsnAla: 3.124 ± 0.024	0.784AsnCys: 0.784 ± 0.016	4.276AsnAsp: 4.276 ± 0.037	3.967AsnGlu: 3.967 ± 0.036	3.34AsnPhe: 3.34 ± 0.036	3.107AsnGly: 3.107 ± 0.034	1.465AsnHis: 1.465 ± 0.022	5.421AsnIle: 5.421 ± 0.047	5.446AsnLys: 5.446 ± 0.048	6.408AsnLeu: 6.408 ± 0.054	1.22AsnMet: 1.22 ± 0.017	6.568AsnAsn: 6.568 ± 0.077	3.597AsnPro: 3.597 ± 0.041	2.988AsnGln: 2.988 ± 0.037	2.666AsnArg: 2.666 ± 0.029	10.545AsnSer: 10.545 ± 0.089	4.212AsnThr: 4.212 ± 0.056	3.112AsnVal: 3.112 ± 0.026	0.502AsnTrp: 0.502 ± 0.011	2.691AsnTyr: 2.691 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.536ProAla: 2.536 ± 0.031	0.392ProCys: 0.392 ± 0.013	2.396ProAsp: 2.396 ± 0.026	3.052ProGlu: 3.052 ± 0.03	1.745ProPhe: 1.745 ± 0.023	2.061ProGly: 2.061 ± 0.026	0.867ProHis: 0.867 ± 0.019	3.577ProIle: 3.577 ± 0.037	3.679ProLys: 3.679 ± 0.037	3.699ProLeu: 3.699 ± 0.032	0.682ProMet: 0.682 ± 0.012	3.519ProAsn: 3.519 ± 0.037	2.575ProPro: 2.575 ± 0.06	1.832ProGln: 1.832 ± 0.025	1.692ProArg: 1.692 ± 0.026	5.289ProSer: 5.289 ± 0.057	3.021ProThr: 3.021 ± 0.045	2.591ProVal: 2.591 ± 0.033	0.281ProTrp: 0.281 ± 0.009	1.28ProTyr: 1.28 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.009GlnAla: 2.009 ± 0.04	0.325GlnCys: 0.325 ± 0.009	1.741GlnAsp: 1.741 ± 0.023	1.87GlnGlu: 1.87 ± 0.027	1.434GlnPhe: 1.434 ± 0.017	1.435GlnGly: 1.435 ± 0.029	0.678GlnHis: 0.678 ± 0.013	2.669GlnIle: 2.669 ± 0.028	2.736GlnLys: 2.736 ± 0.026	3.239GlnLeu: 3.239 ± 0.036	0.7GlnMet: 0.7 ± 0.014	3.235GlnAsn: 3.235 ± 0.04	1.666GlnPro: 1.666 ± 0.026	1.837GlnGln: 1.837 ± 0.075	1.393GlnArg: 1.393 ± 0.019	3.425GlnSer: 3.425 ± 0.036	2.034GlnThr: 2.034 ± 0.026	1.761GlnVal: 1.761 ± 0.023	0.237GlnTrp: 0.237 ± 0.008	1.14GlnTyr: 1.14 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	2.191ArgAla: 2.191 ± 0.025	0.49ArgCys: 0.49 ± 0.013	2.032ArgAsp: 2.032 ± 0.03	1.947ArgGlu: 1.947 ± 0.025	1.814ArgPhe: 1.814 ± 0.023	1.811ArgGly: 1.811 ± 0.026	0.814ArgHis: 0.814 ± 0.023	2.894ArgIle: 2.894 ± 0.03	3.197ArgLys: 3.197 ± 0.03	3.49ArgLeu: 3.49 ± 0.033	0.878ArgMet: 0.878 ± 0.015	2.787ArgAsn: 2.787 ± 0.031	1.759ArgPro: 1.759 ± 0.028	1.378ArgGln: 1.378 ± 0.02	2.194ArgArg: 2.194 ± 0.034	3.756ArgSer: 3.756 ± 0.038	1.914ArgThr: 1.914 ± 0.029	2.119ArgVal: 2.119 ± 0.026	0.355ArgTrp: 0.355 ± 0.01	1.375ArgTyr: 1.375 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	5.745SerAla: 5.745 ± 0.051	1.07SerCys: 1.07 ± 0.019	6.854SerAsp: 6.854 ± 0.064	6.589SerGlu: 6.589 ± 0.049	4.852SerPhe: 4.852 ± 0.042	5.148SerGly: 5.148 ± 0.044	1.995SerHis: 1.995 ± 0.026	8.192SerIle: 8.192 ± 0.068	8.86SerLys: 8.86 ± 0.067	9.387SerLeu: 9.387 ± 0.076	1.723SerMet: 1.723 ± 0.021	9.373SerAsn: 9.373 ± 0.098	5.077SerPro: 5.077 ± 0.056	4.176SerGln: 4.176 ± 0.039	4.256SerArg: 4.256 ± 0.04	15.62SerSer: 15.62 ± 0.164	6.916SerThr: 6.916 ± 0.078	5.247SerVal: 5.247 ± 0.044	0.701SerTrp: 0.701 ± 0.015	3.283SerTyr: 3.283 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	3.064ThrAla: 3.064 ± 0.037	0.622ThrCys: 0.622 ± 0.015	3.078ThrAsp: 3.078 ± 0.033	3.307ThrGlu: 3.307 ± 0.048	2.242ThrPhe: 2.242 ± 0.026	2.729ThrGly: 2.729 ± 0.03	0.978ThrHis: 0.978 ± 0.016	3.87ThrIle: 3.87 ± 0.036	3.774ThrLys: 3.774 ± 0.034	4.474ThrLeu: 4.474 ± 0.031	0.835ThrMet: 0.835 ± 0.014	3.905ThrAsn: 3.905 ± 0.041	3.163ThrPro: 3.163 ± 0.04	1.925ThrGln: 1.925 ± 0.025	2.101ThrArg: 2.101 ± 0.03	6.263ThrSer: 6.263 ± 0.071	3.563ThrThr: 3.563 ± 0.08	2.911ThrVal: 2.911 ± 0.046	0.446ThrTrp: 0.446 ± 0.01	1.484ThrTyr: 1.484 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	2.875ValAla: 2.875 ± 0.036	0.757ValCys: 0.757 ± 0.014	3.275ValAsp: 3.275 ± 0.032	2.995ValGlu: 2.995 ± 0.034	2.293ValPhe: 2.293 ± 0.026	2.715ValGly: 2.715 ± 0.033	0.942ValHis: 0.942 ± 0.018	3.287ValIle: 3.287 ± 0.034	3.26ValLys: 3.26 ± 0.032	4.546ValLeu: 4.546 ± 0.039	0.894ValMet: 0.894 ± 0.016	3.175ValAsn: 3.175 ± 0.031	2.6ValPro: 2.6 ± 0.028	1.601ValGln: 1.601 ± 0.025	1.961ValArg: 1.961 ± 0.027	5.317ValSer: 5.317 ± 0.042	2.643ValThr: 2.643 ± 0.042	3.035ValVal: 3.035 ± 0.043	0.447ValTrp: 0.447 ± 0.011	1.914ValTyr: 1.914 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.435TrpAla: 0.435 ± 0.01	0.128TrpCys: 0.128 ± 0.005	0.515TrpAsp: 0.515 ± 0.014	0.476TrpGlu: 0.476 ± 0.011	0.37TrpPhe: 0.37 ± 0.01	0.372TrpGly: 0.372 ± 0.01	0.125TrpHis: 0.125 ± 0.006	0.6TrpIle: 0.6 ± 0.012	0.568TrpLys: 0.568 ± 0.011	0.668TrpLeu: 0.668 ± 0.014	0.167TrpMet: 0.167 ± 0.006	0.503TrpAsn: 0.503 ± 0.011	0.295TrpPro: 0.295 ± 0.009	0.2TrpGln: 0.2 ± 0.007	0.341TrpArg: 0.341 ± 0.009	0.712TrpSer: 0.712 ± 0.013	0.373TrpThr: 0.373 ± 0.016	0.451TrpVal: 0.451 ± 0.011	0.107TrpTrp: 0.107 ± 0.006	0.247TrpTyr: 0.247 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.524TyrAla: 1.524 ± 0.019	0.484TyrCys: 0.484 ± 0.012	1.967TyrAsp: 1.967 ± 0.024	1.765TyrGlu: 1.765 ± 0.021	1.613TyrPhe: 1.613 ± 0.023	1.827TyrGly: 1.827 ± 0.024	0.661TyrHis: 0.661 ± 0.014	2.247TyrIle: 2.247 ± 0.027	2.378TyrLys: 2.378 ± 0.025	3.171TyrLeu: 3.171 ± 0.034	0.617TyrMet: 0.617 ± 0.014	2.557TyrAsn: 2.557 ± 0.031	1.602TyrPro: 1.602 ± 0.021	1.288TyrGln: 1.288 ± 0.019	1.383TyrArg: 1.383 ± 0.019	3.899TyrSer: 3.899 ± 0.033	1.789TyrThr: 1.789 ± 0.022	1.469TyrVal: 1.469 ± 0.022	0.284TyrTrp: 0.284 ± 0.008	1.353TyrTyr: 1.353 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.154XaaXaa: 0.154 ± 0.061

Statistics based on 10832 proteins (4382278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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