Amino acid dipepetide frequency for Salmonella phage vB_SenM-S16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.06AlaAla: 5.06 ± 0.373
0.413AlaCys: 0.413 ± 0.084
3.643AlaAsp: 3.643 ± 0.259
4.706AlaGlu: 4.706 ± 0.395
2.146AlaPhe: 2.146 ± 0.216
4.312AlaGly: 4.312 ± 0.41
0.925AlaHis: 0.925 ± 0.123
4.194AlaIle: 4.194 ± 0.292
5.139AlaLys: 5.139 ± 0.329
5.69AlaLeu: 5.69 ± 0.402
1.536AlaMet: 1.536 ± 0.166
3.17AlaAsn: 3.17 ± 0.22
2.245AlaPro: 2.245 ± 0.214
2.008AlaGln: 2.008 ± 0.227
2.737AlaArg: 2.737 ± 0.25
4.017AlaSer: 4.017 ± 0.283
3.643AlaThr: 3.643 ± 0.441
4.647AlaVal: 4.647 ± 0.352
1.122AlaTrp: 1.122 ± 0.14
2.501AlaTyr: 2.501 ± 0.226
0.0AlaXaa: 0.0 ± 0.0
Cys
0.591CysAla: 0.591 ± 0.128
0.138CysCys: 0.138 ± 0.065
0.61CysAsp: 0.61 ± 0.107
0.965CysGlu: 0.965 ± 0.156
0.512CysPhe: 0.512 ± 0.098
0.866CysGly: 0.866 ± 0.138
0.276CysHis: 0.276 ± 0.072
0.65CysIle: 0.65 ± 0.11
0.906CysLys: 0.906 ± 0.135
0.827CysLeu: 0.827 ± 0.154
0.276CysMet: 0.276 ± 0.086
0.433CysAsn: 0.433 ± 0.09
0.61CysPro: 0.61 ± 0.121
0.335CysGln: 0.335 ± 0.085
0.689CysArg: 0.689 ± 0.115
0.827CysSer: 0.827 ± 0.117
0.591CysThr: 0.591 ± 0.104
0.551CysVal: 0.551 ± 0.117
0.158CysTrp: 0.158 ± 0.048
0.512CysTyr: 0.512 ± 0.105
0.0CysXaa: 0.0 ± 0.0
Asp
4.233AspAla: 4.233 ± 0.313
0.63AspCys: 0.63 ± 0.101
3.938AspAsp: 3.938 ± 0.288
4.607AspGlu: 4.607 ± 0.321
3.249AspPhe: 3.249 ± 0.263
4.548AspGly: 4.548 ± 0.333
0.729AspHis: 0.729 ± 0.127
5.001AspIle: 5.001 ± 0.301
4.489AspLys: 4.489 ± 0.305
4.942AspLeu: 4.942 ± 0.274
1.91AspMet: 1.91 ± 0.179
3.327AspAsn: 3.327 ± 0.295
2.166AspPro: 2.166 ± 0.195
1.26AspGln: 1.26 ± 0.153
2.166AspArg: 2.166 ± 0.229
3.702AspSer: 3.702 ± 0.301
3.524AspThr: 3.524 ± 0.3
3.564AspVal: 3.564 ± 0.239
1.24AspTrp: 1.24 ± 0.191
2.914AspTyr: 2.914 ± 0.252
0.0AspXaa: 0.0 ± 0.0
Glu
5.1GluAla: 5.1 ± 0.358
0.807GluCys: 0.807 ± 0.127
4.745GluAsp: 4.745 ± 0.265
5.257GluGlu: 5.257 ± 0.363
3.327GluPhe: 3.327 ± 0.25
3.643GluGly: 3.643 ± 0.269
1.299GluHis: 1.299 ± 0.172
6.379GluIle: 6.379 ± 0.352
5.237GluLys: 5.237 ± 0.311
7.128GluLeu: 7.128 ± 0.448
2.343GluMet: 2.343 ± 0.211
3.958GluAsn: 3.958 ± 0.283
1.693GluPro: 1.693 ± 0.207
2.363GluGln: 2.363 ± 0.237
2.717GluArg: 2.717 ± 0.232
3.367GluSer: 3.367 ± 0.262
3.977GluThr: 3.977 ± 0.277
4.883GluVal: 4.883 ± 0.298
1.004GluTrp: 1.004 ± 0.136
2.934GluTyr: 2.934 ± 0.234
0.0GluXaa: 0.0 ± 0.0
Phe
2.717PheAla: 2.717 ± 0.25
0.63PheCys: 0.63 ± 0.111
3.327PheAsp: 3.327 ± 0.24
3.485PheGlu: 3.485 ± 0.296
1.221PhePhe: 1.221 ± 0.18
2.717PheGly: 2.717 ± 0.229
0.709PheHis: 0.709 ± 0.132
3.327PheIle: 3.327 ± 0.264
3.879PheLys: 3.879 ± 0.324
2.56PheLeu: 2.56 ± 0.22
1.378PheMet: 1.378 ± 0.165
2.697PheAsn: 2.697 ± 0.199
1.142PhePro: 1.142 ± 0.172
1.398PheGln: 1.398 ± 0.16
1.693PheArg: 1.693 ± 0.175
2.835PheSer: 2.835 ± 0.223
2.599PheThr: 2.599 ± 0.219
2.757PheVal: 2.757 ± 0.213
0.591PheTrp: 0.591 ± 0.1
1.615PheTyr: 1.615 ± 0.168
0.0PheXaa: 0.0 ± 0.0
Gly
3.78GlyAla: 3.78 ± 0.3
0.551GlyCys: 0.551 ± 0.1
4.036GlyAsp: 4.036 ± 0.366
3.958GlyGlu: 3.958 ± 0.274
3.012GlyPhe: 3.012 ± 0.279
3.879GlyGly: 3.879 ± 0.53
1.063GlyHis: 1.063 ± 0.155
4.312GlyIle: 4.312 ± 0.287
4.509GlyLys: 4.509 ± 0.298
4.883GlyLeu: 4.883 ± 0.296
1.87GlyMet: 1.87 ± 0.228
3.367GlyAsn: 3.367 ± 0.31
1.516GlyPro: 1.516 ± 0.171
2.067GlyGln: 2.067 ± 0.22
2.678GlyArg: 2.678 ± 0.207
3.898GlySer: 3.898 ± 0.258
3.859GlyThr: 3.859 ± 0.291
4.076GlyVal: 4.076 ± 0.293
1.24GlyTrp: 1.24 ± 0.161
2.737GlyTyr: 2.737 ± 0.196
0.0GlyXaa: 0.0 ± 0.0
His
1.063HisAla: 1.063 ± 0.145
0.236HisCys: 0.236 ± 0.074
0.925HisAsp: 0.925 ± 0.124
1.162HisGlu: 1.162 ± 0.144
1.063HisPhe: 1.063 ± 0.154
1.122HisGly: 1.122 ± 0.143
0.453HisHis: 0.453 ± 0.098
1.634HisIle: 1.634 ± 0.183
1.418HisLys: 1.418 ± 0.197
1.437HisLeu: 1.437 ± 0.167
0.473HisMet: 0.473 ± 0.096
0.709HisAsn: 0.709 ± 0.118
0.807HisPro: 0.807 ± 0.119
0.571HisGln: 0.571 ± 0.129
0.65HisArg: 0.65 ± 0.13
0.945HisSer: 0.945 ± 0.129
0.925HisThr: 0.925 ± 0.125
1.221HisVal: 1.221 ± 0.177
0.335HisTrp: 0.335 ± 0.075
0.61HisTyr: 0.61 ± 0.099
0.0HisXaa: 0.0 ± 0.0
Ile
4.43IleAla: 4.43 ± 0.318
0.827IleCys: 0.827 ± 0.124
4.981IleAsp: 4.981 ± 0.369
5.218IleGlu: 5.218 ± 0.369
2.481IlePhe: 2.481 ± 0.226
4.036IleGly: 4.036 ± 0.281
1.418IleHis: 1.418 ± 0.178
5.119IleIle: 5.119 ± 0.277
6.478IleLys: 6.478 ± 0.5
4.45IleLeu: 4.45 ± 0.286
2.107IleMet: 2.107 ± 0.194
5.139IleAsn: 5.139 ± 0.362
2.993IlePro: 2.993 ± 0.256
2.323IleGln: 2.323 ± 0.218
3.702IleArg: 3.702 ± 0.26
5.139IleSer: 5.139 ± 0.315
4.135IleThr: 4.135 ± 0.267
4.785IleVal: 4.785 ± 0.298
0.925IleTrp: 0.925 ± 0.17
2.658IleTyr: 2.658 ± 0.236
0.0IleXaa: 0.0 ± 0.0
Lys
5.611LysAla: 5.611 ± 0.367
0.709LysCys: 0.709 ± 0.125
4.588LysAsp: 4.588 ± 0.338
5.296LysGlu: 5.296 ± 0.372
3.406LysPhe: 3.406 ± 0.293
4.174LysGly: 4.174 ± 0.292
1.87LysHis: 1.87 ± 0.194
6.379LysIle: 6.379 ± 0.341
5.08LysLys: 5.08 ± 0.333
5.986LysLeu: 5.986 ± 0.341
2.658LysMet: 2.658 ± 0.231
4.154LysAsn: 4.154 ± 0.34
2.245LysPro: 2.245 ± 0.228
2.697LysGln: 2.697 ± 0.242
3.465LysArg: 3.465 ± 0.291
5.06LysSer: 5.06 ± 0.291
4.725LysThr: 4.725 ± 0.307
4.332LysVal: 4.332 ± 0.281
1.319LysTrp: 1.319 ± 0.147
3.505LysTyr: 3.505 ± 0.255
0.0LysXaa: 0.0 ± 0.0
Leu
5.001LeuAla: 5.001 ± 0.352
0.886LeuCys: 0.886 ± 0.139
5.001LeuAsp: 5.001 ± 0.293
5.316LeuGlu: 5.316 ± 0.374
3.288LeuPhe: 3.288 ± 0.265
3.8LeuGly: 3.8 ± 0.254
1.339LeuHis: 1.339 ± 0.142
5.159LeuIle: 5.159 ± 0.356
6.064LeuLys: 6.064 ± 0.359
4.942LeuLeu: 4.942 ± 0.41
2.363LeuMet: 2.363 ± 0.218
5.08LeuAsn: 5.08 ± 0.3
2.934LeuPro: 2.934 ± 0.221
2.343LeuGln: 2.343 ± 0.219
3.741LeuArg: 3.741 ± 0.281
5.237LeuSer: 5.237 ± 0.389
4.391LeuThr: 4.391 ± 0.363
4.706LeuVal: 4.706 ± 0.266
0.925LeuTrp: 0.925 ± 0.168
2.934LeuTyr: 2.934 ± 0.215
0.0LeuXaa: 0.0 ± 0.0
Met
1.989MetAla: 1.989 ± 0.189
0.335MetCys: 0.335 ± 0.084
1.536MetAsp: 1.536 ± 0.208
2.087MetGlu: 2.087 ± 0.185
1.221MetPhe: 1.221 ± 0.153
1.26MetGly: 1.26 ± 0.152
0.374MetHis: 0.374 ± 0.078
2.087MetIle: 2.087 ± 0.224
3.052MetLys: 3.052 ± 0.272
2.087MetLeu: 2.087 ± 0.158
0.788MetMet: 0.788 ± 0.133
1.831MetAsn: 1.831 ± 0.196
0.61MetPro: 0.61 ± 0.117
1.162MetGln: 1.162 ± 0.144
1.339MetArg: 1.339 ± 0.163
2.382MetSer: 2.382 ± 0.224
1.969MetThr: 1.969 ± 0.169
1.398MetVal: 1.398 ± 0.152
0.335MetTrp: 0.335 ± 0.075
1.004MetTyr: 1.004 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
3.229AsnAla: 3.229 ± 0.228
0.729AsnCys: 0.729 ± 0.133
3.268AsnAsp: 3.268 ± 0.271
4.194AsnGlu: 4.194 ± 0.287
2.717AsnPhe: 2.717 ± 0.204
4.194AsnGly: 4.194 ± 0.307
1.221AsnHis: 1.221 ± 0.164
4.017AsnIle: 4.017 ± 0.259
4.529AsnLys: 4.529 ± 0.321
4.076AsnLeu: 4.076 ± 0.279
1.615AsnMet: 1.615 ± 0.199
3.347AsnAsn: 3.347 ± 0.314
2.658AsnPro: 2.658 ± 0.263
2.048AsnGln: 2.048 ± 0.171
2.894AsnArg: 2.894 ± 0.214
4.017AsnSer: 4.017 ± 0.294
2.816AsnThr: 2.816 ± 0.208
3.209AsnVal: 3.209 ± 0.252
0.729AsnTrp: 0.729 ± 0.111
2.402AsnTyr: 2.402 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
2.126ProAla: 2.126 ± 0.21
0.473ProCys: 0.473 ± 0.111
2.402ProAsp: 2.402 ± 0.228
3.17ProGlu: 3.17 ± 0.304
1.398ProPhe: 1.398 ± 0.17
2.678ProGly: 2.678 ± 0.279
0.709ProHis: 0.709 ± 0.122
2.186ProIle: 2.186 ± 0.254
1.949ProLys: 1.949 ± 0.182
2.146ProLeu: 2.146 ± 0.179
0.669ProMet: 0.669 ± 0.132
1.989ProAsn: 1.989 ± 0.199
0.984ProPro: 0.984 ± 0.175
0.729ProGln: 0.729 ± 0.111
1.299ProArg: 1.299 ± 0.173
2.304ProSer: 2.304 ± 0.189
1.87ProThr: 1.87 ± 0.212
2.776ProVal: 2.776 ± 0.225
0.591ProTrp: 0.591 ± 0.127
1.418ProTyr: 1.418 ± 0.17
0.0ProXaa: 0.0 ± 0.0
Gln
1.851GlnAla: 1.851 ± 0.229
0.354GlnCys: 0.354 ± 0.087
1.615GlnAsp: 1.615 ± 0.192
2.225GlnGlu: 2.225 ± 0.191
1.674GlnPhe: 1.674 ± 0.187
2.126GlnGly: 2.126 ± 0.196
0.551GlnHis: 0.551 ± 0.13
2.501GlnIle: 2.501 ± 0.245
2.264GlnLys: 2.264 ± 0.217
2.776GlnLeu: 2.776 ± 0.208
1.044GlnMet: 1.044 ± 0.165
1.398GlnAsn: 1.398 ± 0.181
1.063GlnPro: 1.063 ± 0.16
1.004GlnGln: 1.004 ± 0.135
1.811GlnArg: 1.811 ± 0.172
1.949GlnSer: 1.949 ± 0.204
2.008GlnThr: 2.008 ± 0.196
2.245GlnVal: 2.245 ± 0.203
0.571GlnTrp: 0.571 ± 0.117
1.595GlnTyr: 1.595 ± 0.182
0.0GlnXaa: 0.0 ± 0.0
Arg
2.875ArgAla: 2.875 ± 0.239
0.65ArgCys: 0.65 ± 0.112
2.697ArgAsp: 2.697 ± 0.245
3.209ArgGlu: 3.209 ± 0.243
1.772ArgPhe: 1.772 ± 0.173
2.638ArgGly: 2.638 ± 0.215
0.669ArgHis: 0.669 ± 0.101
3.524ArgIle: 3.524 ± 0.249
3.387ArgLys: 3.387 ± 0.263
3.209ArgLeu: 3.209 ± 0.254
1.083ArgMet: 1.083 ± 0.145
2.579ArgAsn: 2.579 ± 0.209
1.181ArgPro: 1.181 ± 0.163
1.713ArgGln: 1.713 ± 0.169
2.422ArgArg: 2.422 ± 0.215
2.461ArgSer: 2.461 ± 0.209
2.501ArgThr: 2.501 ± 0.223
2.973ArgVal: 2.973 ± 0.247
0.807ArgTrp: 0.807 ± 0.144
1.91ArgTyr: 1.91 ± 0.214
0.0ArgXaa: 0.0 ± 0.0
Ser
3.82SerAla: 3.82 ± 0.277
0.748SerCys: 0.748 ± 0.111
3.8SerAsp: 3.8 ± 0.263
3.879SerGlu: 3.879 ± 0.239
3.052SerPhe: 3.052 ± 0.235
4.765SerGly: 4.765 ± 0.346
0.945SerHis: 0.945 ± 0.133
4.548SerIle: 4.548 ± 0.349
5.198SerLys: 5.198 ± 0.365
4.804SerLeu: 4.804 ± 0.302
1.792SerMet: 1.792 ± 0.164
3.623SerAsn: 3.623 ± 0.298
2.284SerPro: 2.284 ± 0.205
2.225SerGln: 2.225 ± 0.234
2.993SerArg: 2.993 ± 0.225
4.785SerSer: 4.785 ± 0.345
3.859SerThr: 3.859 ± 0.321
4.41SerVal: 4.41 ± 0.331
0.866SerTrp: 0.866 ± 0.131
2.835SerTyr: 2.835 ± 0.271
0.0SerXaa: 0.0 ± 0.0
Thr
3.623ThrAla: 3.623 ± 0.332
0.551ThrCys: 0.551 ± 0.101
2.973ThrAsp: 2.973 ± 0.283
4.273ThrGlu: 4.273 ± 0.276
2.441ThrPhe: 2.441 ± 0.25
3.879ThrGly: 3.879 ± 0.258
1.083ThrHis: 1.083 ± 0.134
4.095ThrIle: 4.095 ± 0.273
3.643ThrLys: 3.643 ± 0.242
4.194ThrLeu: 4.194 ± 0.278
1.516ThrMet: 1.516 ± 0.2
3.387ThrAsn: 3.387 ± 0.268
2.816ThrPro: 2.816 ± 0.253
1.792ThrGln: 1.792 ± 0.232
2.599ThrArg: 2.599 ± 0.223
4.036ThrSer: 4.036 ± 0.327
3.111ThrThr: 3.111 ± 0.339
4.253ThrVal: 4.253 ± 0.334
0.669ThrTrp: 0.669 ± 0.106
2.363ThrTyr: 2.363 ± 0.182
0.0ThrXaa: 0.0 ± 0.0
Val
3.702ValAla: 3.702 ± 0.274
0.729ValCys: 0.729 ± 0.116
4.174ValAsp: 4.174 ± 0.312
5.257ValGlu: 5.257 ± 0.338
2.914ValPhe: 2.914 ± 0.222
3.327ValGly: 3.327 ± 0.27
1.044ValHis: 1.044 ± 0.141
4.568ValIle: 4.568 ± 0.364
5.808ValLys: 5.808 ± 0.346
4.706ValLeu: 4.706 ± 0.297
1.674ValMet: 1.674 ± 0.164
3.741ValAsn: 3.741 ± 0.299
2.107ValPro: 2.107 ± 0.219
2.481ValGln: 2.481 ± 0.244
2.481ValArg: 2.481 ± 0.215
4.45ValSer: 4.45 ± 0.302
3.839ValThr: 3.839 ± 0.327
4.45ValVal: 4.45 ± 0.288
0.748ValTrp: 0.748 ± 0.133
2.914ValTyr: 2.914 ± 0.237
0.0ValXaa: 0.0 ± 0.0
Trp
0.61TrpAla: 0.61 ± 0.109
0.276TrpCys: 0.276 ± 0.072
1.063TrpAsp: 1.063 ± 0.131
1.083TrpGlu: 1.083 ± 0.148
0.512TrpPhe: 0.512 ± 0.111
0.65TrpGly: 0.65 ± 0.117
0.315TrpHis: 0.315 ± 0.093
0.866TrpIle: 0.866 ± 0.143
1.299TrpLys: 1.299 ± 0.182
1.437TrpLeu: 1.437 ± 0.179
0.571TrpMet: 0.571 ± 0.095
1.142TrpAsn: 1.142 ± 0.157
0.354TrpPro: 0.354 ± 0.091
0.551TrpGln: 0.551 ± 0.098
0.63TrpArg: 0.63 ± 0.095
0.906TrpSer: 0.906 ± 0.124
0.669TrpThr: 0.669 ± 0.13
1.063TrpVal: 1.063 ± 0.153
0.335TrpTrp: 0.335 ± 0.079
0.827TrpTyr: 0.827 ± 0.111
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.441TyrAla: 2.441 ± 0.222
0.65TyrCys: 0.65 ± 0.128
2.816TyrAsp: 2.816 ± 0.22
2.816TyrGlu: 2.816 ± 0.251
1.87TyrPhe: 1.87 ± 0.204
2.678TyrGly: 2.678 ± 0.238
0.768TyrHis: 0.768 ± 0.118
2.796TyrIle: 2.796 ± 0.251
2.934TyrLys: 2.934 ± 0.24
3.17TyrLeu: 3.17 ± 0.216
1.162TyrMet: 1.162 ± 0.144
2.855TyrAsn: 2.855 ± 0.233
1.457TyrPro: 1.457 ± 0.145
1.555TyrGln: 1.555 ± 0.169
1.555TyrArg: 1.555 ± 0.165
2.914TyrSer: 2.914 ± 0.247
2.284TyrThr: 2.284 ± 0.22
2.816TyrVal: 2.816 ± 0.227
0.65TyrTrp: 0.65 ± 0.103
1.654TyrTyr: 1.654 ± 0.219
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 268 proteins (50790 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski