Amino acid dipepetide frequency for Candidatus Aquiluna sp. UB-MaderosW2red

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.777AlaAla: 11.777 ± 0.193
0.525AlaCys: 0.525 ± 0.034
4.87AlaAsp: 4.87 ± 0.095
6.06AlaGlu: 6.06 ± 0.134
3.802AlaPhe: 3.802 ± 0.09
9.17AlaGly: 9.17 ± 0.158
1.626AlaHis: 1.626 ± 0.065
7.304AlaIle: 7.304 ± 0.136
5.598AlaLys: 5.598 ± 0.145
11.875AlaLeu: 11.875 ± 0.177
2.664AlaMet: 2.664 ± 0.089
3.628AlaAsn: 3.628 ± 0.1
3.843AlaPro: 3.843 ± 0.104
4.089AlaGln: 4.089 ± 0.098
5.233AlaArg: 5.233 ± 0.113
6.722AlaSer: 6.722 ± 0.138
5.978AlaThr: 5.978 ± 0.221
7.815AlaVal: 7.815 ± 0.142
1.091AlaTrp: 1.091 ± 0.043
1.938AlaTyr: 1.938 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.562CysAla: 0.562 ± 0.031
0.029CysCys: 0.029 ± 0.007
0.371CysAsp: 0.371 ± 0.029
0.379CysGlu: 0.379 ± 0.029
0.195CysPhe: 0.195 ± 0.019
0.595CysGly: 0.595 ± 0.04
0.092CysHis: 0.092 ± 0.014
0.236CysIle: 0.236 ± 0.022
0.195CysLys: 0.195 ± 0.022
0.453CysLeu: 0.453 ± 0.032
0.074CysMet: 0.074 ± 0.012
0.183CysAsn: 0.183 ± 0.021
0.273CysPro: 0.273 ± 0.025
0.176CysGln: 0.176 ± 0.019
0.256CysArg: 0.256 ± 0.024
0.412CysSer: 0.412 ± 0.028
0.295CysThr: 0.295 ± 0.022
0.408CysVal: 0.408 ± 0.031
0.059CysTrp: 0.059 ± 0.011
0.113CysTyr: 0.113 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.026AspAla: 5.026 ± 0.096
0.316AspCys: 0.316 ± 0.025
2.126AspAsp: 2.126 ± 0.073
3.265AspGlu: 3.265 ± 0.088
2.362AspPhe: 2.362 ± 0.072
3.992AspGly: 3.992 ± 0.102
0.857AspHis: 0.857 ± 0.05
2.793AspIle: 2.793 ± 0.092
1.989AspLys: 1.989 ± 0.073
6.252AspLeu: 6.252 ± 0.106
0.958AspMet: 0.958 ± 0.051
1.333AspAsn: 1.333 ± 0.056
2.971AspPro: 2.971 ± 0.072
2.108AspGln: 2.108 ± 0.071
2.692AspArg: 2.692 ± 0.087
3.755AspSer: 3.755 ± 0.089
2.245AspThr: 2.245 ± 0.063
3.777AspVal: 3.777 ± 0.084
0.839AspTrp: 0.839 ± 0.044
1.456AspTyr: 1.456 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.4GluAla: 6.4 ± 0.154
0.25GluCys: 0.25 ± 0.024
2.707GluAsp: 2.707 ± 0.087
3.121GluGlu: 3.121 ± 0.102
2.649GluPhe: 2.649 ± 0.072
3.718GluGly: 3.718 ± 0.087
1.15GluHis: 1.15 ± 0.056
4.647GluIle: 4.647 ± 0.115
2.668GluLys: 2.668 ± 0.089
8.51GluLeu: 8.51 ± 0.171
1.234GluMet: 1.234 ± 0.051
2.147GluAsn: 2.147 ± 0.067
2.596GluPro: 2.596 ± 0.081
2.286GluGln: 2.286 ± 0.08
3.615GluArg: 3.615 ± 0.1
4.05GluSer: 4.05 ± 0.106
3.193GluThr: 3.193 ± 0.077
5.186GluVal: 5.186 ± 0.119
0.57GluTrp: 0.57 ± 0.037
1.479GluTyr: 1.479 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.234PheAla: 4.234 ± 0.1
0.254PheCys: 0.254 ± 0.022
2.61PheAsp: 2.61 ± 0.069
2.783PheGlu: 2.783 ± 0.066
1.622PhePhe: 1.622 ± 0.059
4.267PheGly: 4.267 ± 0.1
0.548PheHis: 0.548 ± 0.036
2.192PheIle: 2.192 ± 0.076
1.298PheLys: 1.298 ± 0.051
3.66PheLeu: 3.66 ± 0.103
0.746PheMet: 0.746 ± 0.037
1.196PheAsn: 1.196 ± 0.053
1.499PhePro: 1.499 ± 0.055
1.189PheGln: 1.189 ± 0.053
1.837PheArg: 1.837 ± 0.069
2.926PheSer: 2.926 ± 0.08
2.247PheThr: 2.247 ± 0.093
2.971PheVal: 2.971 ± 0.074
0.519PheTrp: 0.519 ± 0.035
0.91PheTyr: 0.91 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
7.897GlyAla: 7.897 ± 0.147
0.556GlyCys: 0.556 ± 0.035
3.88GlyAsp: 3.88 ± 0.118
4.747GlyGlu: 4.747 ± 0.1
4.017GlyPhe: 4.017 ± 0.101
6.291GlyGly: 6.291 ± 0.222
1.509GlyHis: 1.509 ± 0.058
5.563GlyIle: 5.563 ± 0.101
3.976GlyLys: 3.976 ± 0.073
8.945GlyLeu: 8.945 ± 0.15
2.057GlyMet: 2.057 ± 0.069
2.608GlyAsn: 2.608 ± 0.108
2.863GlyPro: 2.863 ± 0.086
2.926GlyGln: 2.926 ± 0.093
3.802GlyArg: 3.802 ± 0.087
6.006GlySer: 6.006 ± 0.185
4.316GlyThr: 4.316 ± 0.169
6.843GlyVal: 6.843 ± 0.113
1.136GlyTrp: 1.136 ± 0.055
2.256GlyTyr: 2.256 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.538HisAla: 1.538 ± 0.062
0.111HisCys: 0.111 ± 0.015
0.861HisAsp: 0.861 ± 0.046
1.093HisGlu: 1.093 ± 0.045
0.611HisPhe: 0.611 ± 0.031
1.458HisGly: 1.458 ± 0.051
0.394HisHis: 0.394 ± 0.03
0.865HisIle: 0.865 ± 0.043
0.699HisLys: 0.699 ± 0.039
1.817HisLeu: 1.817 ± 0.067
0.299HisMet: 0.299 ± 0.026
0.527HisAsn: 0.527 ± 0.031
1.118HisPro: 1.118 ± 0.057
0.685HisGln: 0.685 ± 0.039
0.978HisArg: 0.978 ± 0.043
1.148HisSer: 1.148 ± 0.053
0.75HisThr: 0.75 ± 0.046
1.14HisVal: 1.14 ± 0.043
0.203HisTrp: 0.203 ± 0.02
0.441HisTyr: 0.441 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
7.581IleAla: 7.581 ± 0.152
0.424IleCys: 0.424 ± 0.03
3.767IleAsp: 3.767 ± 0.096
4.44IleGlu: 4.44 ± 0.104
2.215IlePhe: 2.215 ± 0.082
5.656IleGly: 5.656 ± 0.113
0.945IleHis: 0.945 ± 0.045
3.25IleIle: 3.25 ± 0.092
2.332IleLys: 2.332 ± 0.076
5.559IleLeu: 5.559 ± 0.109
0.982IleMet: 0.982 ± 0.046
1.848IleAsn: 1.848 ± 0.058
2.961IlePro: 2.961 ± 0.091
1.948IleGln: 1.948 ± 0.061
3.306IleArg: 3.306 ± 0.079
5.143IleSer: 5.143 ± 0.114
3.749IleThr: 3.749 ± 0.142
4.113IleVal: 4.113 ± 0.082
0.88IleTrp: 0.88 ± 0.043
1.349IleTyr: 1.349 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.413LysAla: 4.413 ± 0.107
0.156LysCys: 0.156 ± 0.018
2.397LysAsp: 2.397 ± 0.088
2.551LysGlu: 2.551 ± 0.08
1.458LysPhe: 1.458 ± 0.062
2.859LysGly: 2.859 ± 0.078
0.798LysHis: 0.798 ± 0.039
2.674LysIle: 2.674 ± 0.071
2.354LysLys: 2.354 ± 0.084
4.778LysLeu: 4.778 ± 0.105
1.038LysMet: 1.038 ± 0.044
1.69LysAsn: 1.69 ± 0.059
2.161LysPro: 2.161 ± 0.07
1.394LysGln: 1.394 ± 0.059
2.725LysArg: 2.725 ± 0.081
2.908LysSer: 2.908 ± 0.08
2.867LysThr: 2.867 ± 0.072
3.488LysVal: 3.488 ± 0.085
0.455LysTrp: 0.455 ± 0.026
0.956LysTyr: 0.956 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
13.089LeuAla: 13.089 ± 0.175
0.537LeuCys: 0.537 ± 0.039
5.777LeuAsp: 5.777 ± 0.108
7.39LeuGlu: 7.39 ± 0.163
3.71LeuPhe: 3.71 ± 0.101
9.584LeuGly: 9.584 ± 0.163
1.499LeuHis: 1.499 ± 0.05
7.038LeuIle: 7.038 ± 0.143
4.339LeuLys: 4.339 ± 0.108
10.515LeuLeu: 10.515 ± 0.207
2.284LeuMet: 2.284 ± 0.079
3.334LeuAsn: 3.334 ± 0.073
4.723LeuPro: 4.723 ± 0.102
3.035LeuGln: 3.035 ± 0.068
5.91LeuArg: 5.91 ± 0.128
7.803LeuSer: 7.803 ± 0.158
5.826LeuThr: 5.826 ± 0.125
8.631LeuVal: 8.631 ± 0.147
1.155LeuTrp: 1.155 ± 0.051
1.862LeuTyr: 1.862 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.594MetAla: 2.594 ± 0.085
0.105MetCys: 0.105 ± 0.014
1.019MetAsp: 1.019 ± 0.046
0.992MetGlu: 0.992 ± 0.046
0.705MetPhe: 0.705 ± 0.041
1.653MetGly: 1.653 ± 0.062
0.39MetHis: 0.39 ± 0.028
1.212MetIle: 1.212 ± 0.054
0.966MetLys: 0.966 ± 0.045
2.241MetLeu: 2.241 ± 0.086
0.406MetMet: 0.406 ± 0.028
0.804MetAsn: 0.804 ± 0.041
1.099MetPro: 1.099 ± 0.052
0.82MetGln: 0.82 ± 0.043
1.298MetArg: 1.298 ± 0.054
1.673MetSer: 1.673 ± 0.06
1.405MetThr: 1.405 ± 0.059
1.647MetVal: 1.647 ± 0.058
0.18MetTrp: 0.18 ± 0.019
0.285MetTyr: 0.285 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.059AsnAla: 3.059 ± 0.085
0.236AsnCys: 0.236 ± 0.025
1.548AsnAsp: 1.548 ± 0.046
1.604AsnGlu: 1.604 ± 0.053
1.427AsnPhe: 1.427 ± 0.064
2.418AsnGly: 2.418 ± 0.091
0.648AsnHis: 0.648 ± 0.036
1.749AsnIle: 1.749 ± 0.068
1.255AsnLys: 1.255 ± 0.053
3.935AsnLeu: 3.935 ± 0.098
0.693AsnMet: 0.693 ± 0.038
1.068AsnAsn: 1.068 ± 0.055
2.295AsnPro: 2.295 ± 0.07
1.706AsnGln: 1.706 ± 0.063
1.78AsnArg: 1.78 ± 0.071
2.25AsnSer: 2.25 ± 0.08
1.688AsnThr: 1.688 ± 0.074
2.11AsnVal: 2.11 ± 0.075
0.588AsnTrp: 0.588 ± 0.033
0.937AsnTyr: 0.937 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
4.292ProAla: 4.292 ± 0.102
0.174ProCys: 0.174 ± 0.017
2.397ProAsp: 2.397 ± 0.083
3.705ProGlu: 3.705 ± 0.109
1.597ProPhe: 1.597 ± 0.054
3.746ProGly: 3.746 ± 0.094
0.753ProHis: 0.753 ± 0.035
2.807ProIle: 2.807 ± 0.08
2.528ProLys: 2.528 ± 0.082
4.154ProLeu: 4.154 ± 0.101
0.913ProMet: 0.913 ± 0.043
1.747ProAsn: 1.747 ± 0.061
1.177ProPro: 1.177 ± 0.052
1.524ProGln: 1.524 ± 0.059
1.913ProArg: 1.913 ± 0.068
2.951ProSer: 2.951 ± 0.08
2.781ProThr: 2.781 ± 0.108
3.402ProVal: 3.402 ± 0.094
0.611ProTrp: 0.611 ± 0.036
0.974ProTyr: 0.974 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.952GlnAla: 3.952 ± 0.101
0.133GlnCys: 0.133 ± 0.014
1.848GlnAsp: 1.848 ± 0.059
2.348GlnGlu: 2.348 ± 0.08
1.04GlnPhe: 1.04 ± 0.045
2.715GlnGly: 2.715 ± 0.074
0.582GlnHis: 0.582 ± 0.035
2.52GlnIle: 2.52 ± 0.075
1.698GlnLys: 1.698 ± 0.055
4.157GlnLeu: 4.157 ± 0.098
0.816GlnMet: 0.816 ± 0.045
1.335GlnAsn: 1.335 ± 0.061
1.374GlnPro: 1.374 ± 0.057
1.337GlnGln: 1.337 ± 0.053
2.01GlnArg: 2.01 ± 0.08
2.213GlnSer: 2.213 ± 0.073
1.649GlnThr: 1.649 ± 0.06
2.854GlnVal: 2.854 ± 0.074
0.418GlnTrp: 0.418 ± 0.028
0.685GlnTyr: 0.685 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
5.067ArgAla: 5.067 ± 0.094
0.263ArgCys: 0.263 ± 0.024
2.74ArgAsp: 2.74 ± 0.071
3.509ArgGlu: 3.509 ± 0.106
2.371ArgPhe: 2.371 ± 0.069
3.58ArgGly: 3.58 ± 0.089
0.98ArgHis: 0.98 ± 0.051
3.414ArgIle: 3.414 ± 0.085
2.399ArgLys: 2.399 ± 0.077
5.549ArgLeu: 5.549 ± 0.108
1.265ArgMet: 1.265 ± 0.047
1.78ArgAsn: 1.78 ± 0.057
2.19ArgPro: 2.19 ± 0.064
1.819ArgGln: 1.819 ± 0.062
2.904ArgArg: 2.904 ± 0.094
3.379ArgSer: 3.379 ± 0.081
2.617ArgThr: 2.617 ± 0.073
4.232ArgVal: 4.232 ± 0.107
0.693ArgTrp: 0.693 ± 0.045
1.36ArgTyr: 1.36 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
7.073SerAla: 7.073 ± 0.163
0.371SerCys: 0.371 ± 0.031
3.609SerAsp: 3.609 ± 0.089
4.581SerGlu: 4.581 ± 0.119
2.939SerPhe: 2.939 ± 0.063
6.841SerGly: 6.841 ± 0.223
1.124SerHis: 1.124 ± 0.05
4.007SerIle: 4.007 ± 0.105
3.197SerLys: 3.197 ± 0.074
7.07SerLeu: 7.07 ± 0.128
1.643SerMet: 1.643 ± 0.054
2.342SerAsn: 2.342 ± 0.088
2.959SerPro: 2.959 ± 0.088
2.785SerGln: 2.785 ± 0.09
3.453SerArg: 3.453 ± 0.077
5.127SerSer: 5.127 ± 0.162
3.461SerThr: 3.461 ± 0.138
5.042SerVal: 5.042 ± 0.118
0.976SerTrp: 0.976 ± 0.054
1.759SerTyr: 1.759 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
5.377ThrAla: 5.377 ± 0.188
0.281ThrCys: 0.281 ± 0.022
2.805ThrAsp: 2.805 ± 0.08
3.096ThrGlu: 3.096 ± 0.08
1.983ThrPhe: 1.983 ± 0.098
4.971ThrGly: 4.971 ± 0.181
1.05ThrHis: 1.05 ± 0.041
3.269ThrIle: 3.269 ± 0.125
2.614ThrLys: 2.614 ± 0.076
5.785ThrLeu: 5.785 ± 0.128
1.04ThrMet: 1.04 ± 0.044
1.997ThrAsn: 1.997 ± 0.1
3.041ThrPro: 3.041 ± 0.095
2.059ThrGln: 2.059 ± 0.071
2.614ThrArg: 2.614 ± 0.072
3.671ThrSer: 3.671 ± 0.153
3.105ThrThr: 3.105 ± 0.144
4.013ThrVal: 4.013 ± 0.139
0.597ThrTrp: 0.597 ± 0.035
1.161ThrTyr: 1.161 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
8.416ValAla: 8.416 ± 0.133
0.39ValCys: 0.39 ± 0.025
3.976ValAsp: 3.976 ± 0.098
4.444ValGlu: 4.444 ± 0.097
3.154ValPhe: 3.154 ± 0.079
5.941ValGly: 5.941 ± 0.124
1.154ValHis: 1.154 ± 0.051
5.243ValIle: 5.243 ± 0.112
2.865ValLys: 2.865 ± 0.08
8.418ValLeu: 8.418 ± 0.139
1.794ValMet: 1.794 ± 0.066
2.358ValAsn: 2.358 ± 0.071
3.377ValPro: 3.377 ± 0.094
2.106ValGln: 2.106 ± 0.066
3.738ValArg: 3.738 ± 0.08
5.781ValSer: 5.781 ± 0.114
4.762ValThr: 4.762 ± 0.176
6.627ValVal: 6.627 ± 0.124
0.855ValTrp: 0.855 ± 0.042
1.456ValTyr: 1.456 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.183TrpAla: 1.183 ± 0.044
0.072TrpCys: 0.072 ± 0.012
0.615TrpAsp: 0.615 ± 0.037
0.65TrpGlu: 0.65 ± 0.04
0.625TrpPhe: 0.625 ± 0.036
0.89TrpGly: 0.89 ± 0.037
0.226TrpHis: 0.226 ± 0.022
0.738TrpIle: 0.738 ± 0.033
0.392TrpLys: 0.392 ± 0.026
1.686TrpLeu: 1.686 ± 0.06
0.263TrpMet: 0.263 ± 0.023
0.449TrpAsn: 0.449 ± 0.03
0.517TrpPro: 0.517 ± 0.032
0.574TrpGln: 0.574 ± 0.031
0.671TrpArg: 0.671 ± 0.038
0.853TrpSer: 0.853 ± 0.043
0.515TrpThr: 0.515 ± 0.038
0.997TrpVal: 0.997 ± 0.048
0.252TrpTrp: 0.252 ± 0.023
0.252TrpTyr: 0.252 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.079TyrAla: 2.079 ± 0.068
0.172TyrCys: 0.172 ± 0.017
1.189TyrAsp: 1.189 ± 0.048
1.417TyrGlu: 1.417 ± 0.054
1.023TyrPhe: 1.023 ± 0.044
1.848TyrGly: 1.848 ± 0.068
0.41TyrHis: 0.41 ± 0.025
0.931TyrIle: 0.931 ± 0.047
0.759TyrLys: 0.759 ± 0.038
2.684TyrLeu: 2.684 ± 0.078
0.322TyrMet: 0.322 ± 0.027
0.619TyrAsn: 0.619 ± 0.038
1.107TyrPro: 1.107 ± 0.045
1.12TyrGln: 1.12 ± 0.05
1.378TyrArg: 1.378 ± 0.056
1.587TyrSer: 1.587 ± 0.053
1.079TyrThr: 1.079 ± 0.06
1.561TyrVal: 1.561 ± 0.061
0.345TyrTrp: 0.345 ± 0.027
0.47TyrTyr: 0.47 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1613 proteins (512337 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski