Amino acid dipepetide frequency for Citreimonas salinaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.273AlaAla: 18.273 ± 0.193	1.131AlaCys: 1.131 ± 0.031	7.337AlaAsp: 7.337 ± 0.083	8.659AlaGlu: 8.659 ± 0.101	4.604AlaPhe: 4.604 ± 0.072	11.156AlaGly: 11.156 ± 0.106	2.479AlaHis: 2.479 ± 0.043	6.072AlaIle: 6.072 ± 0.08	3.049AlaLys: 3.049 ± 0.057	15.233AlaLeu: 15.233 ± 0.134	3.971AlaMet: 3.971 ± 0.063	2.316AlaAsn: 2.316 ± 0.042	6.356AlaPro: 6.356 ± 0.072	4.6AlaGln: 4.6 ± 0.075	10.707AlaArg: 10.707 ± 0.123	5.553AlaSer: 5.553 ± 0.077	6.242AlaThr: 6.242 ± 0.078	8.953AlaVal: 8.953 ± 0.096	1.665AlaTrp: 1.665 ± 0.039	2.376AlaTyr: 2.376 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.156CysAla: 1.156 ± 0.032	0.116CysCys: 0.116 ± 0.011	0.622CysAsp: 0.622 ± 0.025	0.427CysGlu: 0.427 ± 0.017	0.295CysPhe: 0.295 ± 0.016	0.883CysGly: 0.883 ± 0.028	0.29CysHis: 0.29 ± 0.018	0.398CysIle: 0.398 ± 0.019	0.167CysLys: 0.167 ± 0.012	0.825CysLeu: 0.825 ± 0.03	0.165CysMet: 0.165 ± 0.012	0.191CysAsn: 0.191 ± 0.012	0.504CysPro: 0.504 ± 0.023	0.213CysGln: 0.213 ± 0.011	0.589CysArg: 0.589 ± 0.026	0.433CysSer: 0.433 ± 0.017	0.422CysThr: 0.422 ± 0.021	0.621CysVal: 0.621 ± 0.022	0.115CysTrp: 0.115 ± 0.011	0.187CysTyr: 0.187 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.431AspAla: 8.431 ± 0.094	0.522AspCys: 0.522 ± 0.023	3.799AspAsp: 3.799 ± 0.06	4.108AspGlu: 4.108 ± 0.07	2.237AspPhe: 2.237 ± 0.037	5.768AspGly: 5.768 ± 0.08	1.392AspHis: 1.392 ± 0.035	2.826AspIle: 2.826 ± 0.046	1.441AspLys: 1.441 ± 0.039	6.419AspLeu: 6.419 ± 0.078	1.658AspMet: 1.658 ± 0.034	1.128AspAsn: 1.128 ± 0.027	3.969AspPro: 3.969 ± 0.063	1.691AspGln: 1.691 ± 0.047	5.179AspArg: 5.179 ± 0.067	2.25AspSer: 2.25 ± 0.044	3.207AspThr: 3.207 ± 0.054	4.301AspVal: 4.301 ± 0.061	1.241AspTrp: 1.241 ± 0.032	1.421AspTyr: 1.421 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.712GluAla: 8.712 ± 0.106	0.372GluCys: 0.372 ± 0.02	3.604GluAsp: 3.604 ± 0.052	3.518GluGlu: 3.518 ± 0.061	1.614GluPhe: 1.614 ± 0.035	5.15GluGly: 5.15 ± 0.073	1.263GluHis: 1.263 ± 0.034	3.568GluIle: 3.568 ± 0.056	1.855GluLys: 1.855 ± 0.042	4.794GluLeu: 4.794 ± 0.074	1.776GluMet: 1.776 ± 0.04	1.55GluAsn: 1.55 ± 0.04	2.857GluPro: 2.857 ± 0.048	1.919GluGln: 1.919 ± 0.043	4.947GluArg: 4.947 ± 0.077	2.419GluSer: 2.419 ± 0.044	4.007GluThr: 4.007 ± 0.068	4.078GluVal: 4.078 ± 0.059	0.75GluTrp: 0.75 ± 0.024	1.062GluTyr: 1.062 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.531PheAla: 4.531 ± 0.075	0.418PheCys: 0.418 ± 0.018	2.93PheAsp: 2.93 ± 0.048	2.19PheGlu: 2.19 ± 0.042	1.327PhePhe: 1.327 ± 0.043	3.522PheGly: 3.522 ± 0.059	0.761PheHis: 0.761 ± 0.024	1.484PheIle: 1.484 ± 0.037	0.688PheLys: 0.688 ± 0.027	3.313PheLeu: 3.313 ± 0.063	0.806PheMet: 0.806 ± 0.025	0.875PheAsn: 0.875 ± 0.03	1.549PhePro: 1.549 ± 0.034	0.895PheGln: 0.895 ± 0.027	2.3PheArg: 2.3 ± 0.047	1.906PheSer: 1.906 ± 0.041	1.918PheThr: 1.918 ± 0.042	2.761PheVal: 2.761 ± 0.051	0.58PheTrp: 0.58 ± 0.022	0.834PheTyr: 0.834 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.543GlyAla: 10.543 ± 0.118	0.846GlyCys: 0.846 ± 0.03	4.999GlyAsp: 4.999 ± 0.071	4.706GlyGlu: 4.706 ± 0.077	3.601GlyPhe: 3.601 ± 0.047	7.606GlyGly: 7.606 ± 0.132	2.067GlyHis: 2.067 ± 0.042	4.349GlyIle: 4.349 ± 0.058	2.599GlyLys: 2.599 ± 0.05	9.321GlyLeu: 9.321 ± 0.096	2.678GlyMet: 2.678 ± 0.047	1.899GlyAsn: 1.899 ± 0.053	3.903GlyPro: 3.903 ± 0.056	2.943GlyGln: 2.943 ± 0.045	6.58GlyArg: 6.58 ± 0.079	4.207GlySer: 4.207 ± 0.056	4.833GlyThr: 4.833 ± 0.065	6.417GlyVal: 6.417 ± 0.08	1.547GlyTrp: 1.547 ± 0.039	2.206GlyTyr: 2.206 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.687HisAla: 2.687 ± 0.049	0.214HisCys: 0.214 ± 0.013	1.488HisAsp: 1.488 ± 0.04	1.203HisGlu: 1.203 ± 0.033	0.839HisPhe: 0.839 ± 0.024	2.105HisGly: 2.105 ± 0.045	0.587HisHis: 0.587 ± 0.023	0.824HisIle: 0.824 ± 0.028	0.442HisLys: 0.442 ± 0.02	2.011HisLeu: 2.011 ± 0.047	0.54HisMet: 0.54 ± 0.021	0.399HisAsn: 0.399 ± 0.017	1.408HisPro: 1.408 ± 0.039	0.532HisGln: 0.532 ± 0.02	1.508HisArg: 1.508 ± 0.036	0.862HisSer: 0.862 ± 0.024	0.787HisThr: 0.787 ± 0.025	1.736HisVal: 1.736 ± 0.036	0.341HisTrp: 0.341 ± 0.019	0.572HisTyr: 0.572 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.045IleAla: 7.045 ± 0.084	0.487IleCys: 0.487 ± 0.021	3.508IleAsp: 3.508 ± 0.053	3.521IleGlu: 3.521 ± 0.053	1.641IlePhe: 1.641 ± 0.048	4.513IleGly: 4.513 ± 0.069	0.911IleHis: 0.911 ± 0.03	1.83IleIle: 1.83 ± 0.045	1.104IleLys: 1.104 ± 0.031	4.502IleLeu: 4.502 ± 0.06	0.947IleMet: 0.947 ± 0.03	1.107IleAsn: 1.107 ± 0.029	2.223IlePro: 2.223 ± 0.044	0.996IleGln: 0.996 ± 0.031	3.25IleArg: 3.25 ± 0.051	2.408IleSer: 2.408 ± 0.046	2.459IleThr: 2.459 ± 0.043	3.919IleVal: 3.919 ± 0.062	0.626IleTrp: 0.626 ± 0.022	1.075IleTyr: 1.075 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.416LysAla: 3.416 ± 0.065	0.163LysCys: 0.163 ± 0.012	1.413LysAsp: 1.413 ± 0.037	1.228LysGlu: 1.228 ± 0.036	0.696LysPhe: 0.696 ± 0.023	2.225LysGly: 2.225 ± 0.048	0.548LysHis: 0.548 ± 0.021	1.317LysIle: 1.317 ± 0.032	0.958LysLys: 0.958 ± 0.034	2.379LysLeu: 2.379 ± 0.043	0.684LysMet: 0.684 ± 0.026	0.62LysAsn: 0.62 ± 0.023	1.614LysPro: 1.614 ± 0.037	0.735LysGln: 0.735 ± 0.024	2.107LysArg: 2.107 ± 0.04	1.388LysSer: 1.388 ± 0.036	1.629LysThr: 1.629 ± 0.041	1.894LysVal: 1.894 ± 0.045	0.307LysTrp: 0.307 ± 0.014	0.512LysTyr: 0.512 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.416LeuAla: 13.416 ± 0.12	0.954LeuCys: 0.954 ± 0.028	6.535LeuAsp: 6.535 ± 0.085	5.262LeuGlu: 5.262 ± 0.067	3.491LeuPhe: 3.491 ± 0.061	8.741LeuGly: 8.741 ± 0.099	1.995LeuHis: 1.995 ± 0.037	4.668LeuIle: 4.668 ± 0.067	2.663LeuLys: 2.663 ± 0.049	9.225LeuLeu: 9.225 ± 0.107	2.606LeuMet: 2.606 ± 0.045	2.362LeuAsn: 2.362 ± 0.041	5.631LeuPro: 5.631 ± 0.08	2.651LeuGln: 2.651 ± 0.048	8.025LeuArg: 8.025 ± 0.091	6.427LeuSer: 6.427 ± 0.076	5.56LeuThr: 5.56 ± 0.074	7.326LeuVal: 7.326 ± 0.079	1.386LeuTrp: 1.386 ± 0.035	1.853LeuTyr: 1.853 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.418MetAla: 3.418 ± 0.051	0.172MetCys: 0.172 ± 0.012	1.388MetAsp: 1.388 ± 0.038	1.284MetGlu: 1.284 ± 0.031	0.757MetPhe: 0.757 ± 0.028	2.231MetGly: 2.231 ± 0.046	0.513MetHis: 0.513 ± 0.023	1.466MetIle: 1.466 ± 0.032	0.955MetLys: 0.955 ± 0.03	2.67MetLeu: 2.67 ± 0.045	0.762MetMet: 0.762 ± 0.026	0.763MetAsn: 0.763 ± 0.025	1.607MetPro: 1.607 ± 0.038	0.948MetGln: 0.948 ± 0.029	2.105MetArg: 2.105 ± 0.042	1.585MetSer: 1.585 ± 0.036	2.082MetThr: 2.082 ± 0.036	1.812MetVal: 1.812 ± 0.04	0.239MetTrp: 0.239 ± 0.014	0.31MetTyr: 0.31 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.955AsnAla: 2.955 ± 0.054	0.22AsnCys: 0.22 ± 0.013	1.269AsnAsp: 1.269 ± 0.036	1.14AsnGlu: 1.14 ± 0.031	0.788AsnPhe: 0.788 ± 0.024	1.968AsnGly: 1.968 ± 0.046	0.454AsnHis: 0.454 ± 0.022	1.054AsnIle: 1.054 ± 0.03	0.468AsnLys: 0.468 ± 0.019	2.258AsnLeu: 2.258 ± 0.04	0.57AsnMet: 0.57 ± 0.022	0.496AsnAsn: 0.496 ± 0.023	1.7AsnPro: 1.7 ± 0.033	0.609AsnGln: 0.609 ± 0.023	1.697AsnArg: 1.697 ± 0.041	0.952AsnSer: 0.952 ± 0.027	1.082AsnThr: 1.082 ± 0.032	1.678AsnVal: 1.678 ± 0.042	0.36AsnTrp: 0.36 ± 0.015	0.549AsnTyr: 0.549 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.52ProAla: 6.52 ± 0.083	0.365ProCys: 0.365 ± 0.018	4.329ProAsp: 4.329 ± 0.069	4.255ProGlu: 4.255 ± 0.064	1.964ProPhe: 1.964 ± 0.041	4.835ProGly: 4.835 ± 0.06	1.101ProHis: 1.101 ± 0.03	2.073ProIle: 2.073 ± 0.038	1.33ProLys: 1.33 ± 0.037	4.691ProLeu: 4.691 ± 0.067	1.298ProMet: 1.298 ± 0.034	1.157ProAsn: 1.157 ± 0.033	2.557ProPro: 2.557 ± 0.055	1.676ProGln: 1.676 ± 0.042	3.371ProArg: 3.371 ± 0.05	2.431ProSer: 2.431 ± 0.049	2.287ProThr: 2.287 ± 0.044	4.476ProVal: 4.476 ± 0.06	0.732ProTrp: 0.732 ± 0.026	1.13ProTyr: 1.13 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.271GlnAla: 4.271 ± 0.056	0.187GlnCys: 0.187 ± 0.012	1.736GlnAsp: 1.736 ± 0.042	1.515GlnGlu: 1.515 ± 0.036	0.928GlnPhe: 0.928 ± 0.023	2.566GlnGly: 2.566 ± 0.047	0.56GlnHis: 0.56 ± 0.024	1.736GlnIle: 1.736 ± 0.034	0.873GlnLys: 0.873 ± 0.028	2.538GlnLeu: 2.538 ± 0.049	0.973GlnMet: 0.973 ± 0.03	0.755GlnAsn: 0.755 ± 0.021	1.628GlnPro: 1.628 ± 0.037	1.03GlnGln: 1.03 ± 0.036	2.134GlnArg: 2.134 ± 0.044	1.562GlnSer: 1.562 ± 0.037	1.709GlnThr: 1.709 ± 0.033	2.355GlnVal: 2.355 ± 0.043	0.377GlnTrp: 0.377 ± 0.016	0.481GlnTyr: 0.481 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.831ArgAla: 9.831 ± 0.111	0.566ArgCys: 0.566 ± 0.023	5.075ArgAsp: 5.075 ± 0.068	4.317ArgGlu: 4.317 ± 0.06	2.836ArgPhe: 2.836 ± 0.047	5.392ArgGly: 5.392 ± 0.065	1.848ArgHis: 1.848 ± 0.04	4.034ArgIle: 4.034 ± 0.053	2.217ArgLys: 2.217 ± 0.049	8.307ArgLeu: 8.307 ± 0.09	2.219ArgMet: 2.219 ± 0.044	1.795ArgAsn: 1.795 ± 0.035	3.846ArgPro: 3.846 ± 0.056	2.376ArgGln: 2.376 ± 0.043	6.325ArgArg: 6.325 ± 0.089	3.483ArgSer: 3.483 ± 0.059	3.549ArgThr: 3.549 ± 0.049	5.276ArgVal: 5.276 ± 0.079	0.981ArgTrp: 0.981 ± 0.029	1.61ArgTyr: 1.61 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.802SerAla: 5.802 ± 0.073	0.436SerCys: 0.436 ± 0.018	3.135SerAsp: 3.135 ± 0.05	2.8SerGlu: 2.8 ± 0.05	1.958SerPhe: 1.958 ± 0.042	5.218SerGly: 5.218 ± 0.08	1.013SerHis: 1.013 ± 0.029	2.273SerIle: 2.273 ± 0.051	1.248SerLys: 1.248 ± 0.033	4.65SerLeu: 4.65 ± 0.057	1.297SerMet: 1.297 ± 0.031	1.116SerAsn: 1.116 ± 0.031	2.406SerPro: 2.406 ± 0.048	1.426SerGln: 1.426 ± 0.035	3.508SerArg: 3.508 ± 0.059	2.364SerSer: 2.364 ± 0.053	2.399SerThr: 2.399 ± 0.044	3.775SerVal: 3.775 ± 0.064	0.677SerTrp: 0.677 ± 0.023	1.133SerTyr: 1.133 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.296ThrAla: 6.296 ± 0.078	0.464ThrCys: 0.464 ± 0.023	3.142ThrAsp: 3.142 ± 0.058	3.106ThrGlu: 3.106 ± 0.042	1.925ThrPhe: 1.925 ± 0.038	5.43ThrGly: 5.43 ± 0.063	1.106ThrHis: 1.106 ± 0.029	2.643ThrIle: 2.643 ± 0.051	1.149ThrLys: 1.149 ± 0.035	6.105ThrLeu: 6.105 ± 0.082	1.283ThrMet: 1.283 ± 0.033	1.126ThrAsn: 1.126 ± 0.029	3.213ThrPro: 3.213 ± 0.05	1.461ThrGln: 1.461 ± 0.036	3.802ThrArg: 3.802 ± 0.056	2.424ThrSer: 2.424 ± 0.044	2.678ThrThr: 2.678 ± 0.053	4.191ThrVal: 4.191 ± 0.061	0.736ThrTrp: 0.736 ± 0.021	1.152ThrTyr: 1.152 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.52ValAla: 9.52 ± 0.109	0.641ValCys: 0.641 ± 0.022	4.291ValAsp: 4.291 ± 0.059	4.693ValGlu: 4.693 ± 0.069	2.728ValPhe: 2.728 ± 0.053	5.469ValGly: 5.469 ± 0.076	1.341ValHis: 1.341 ± 0.03	3.944ValIle: 3.944 ± 0.061	1.786ValLys: 1.786 ± 0.041	7.802ValLeu: 7.802 ± 0.093	2.022ValMet: 2.022 ± 0.041	1.75ValAsn: 1.75 ± 0.042	3.833ValPro: 3.833 ± 0.054	2.096ValGln: 2.096 ± 0.041	4.846ValArg: 4.846 ± 0.069	4.09ValSer: 4.09 ± 0.058	4.744ValThr: 4.744 ± 0.068	5.932ValVal: 5.932 ± 0.084	1.011ValTrp: 1.011 ± 0.025	1.416ValTyr: 1.416 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.383TrpAla: 1.383 ± 0.034	0.139TrpCys: 0.139 ± 0.01	0.815TrpAsp: 0.815 ± 0.027	0.666TrpGlu: 0.666 ± 0.023	0.56TrpPhe: 0.56 ± 0.022	1.027TrpGly: 1.027 ± 0.03	0.364TrpHis: 0.364 ± 0.018	0.735TrpIle: 0.735 ± 0.022	0.397TrpLys: 0.397 ± 0.019	1.719TrpLeu: 1.719 ± 0.042	0.405TrpMet: 0.405 ± 0.019	0.387TrpAsn: 0.387 ± 0.021	0.751TrpPro: 0.751 ± 0.024	0.555TrpGln: 0.555 ± 0.021	1.297TrpArg: 1.297 ± 0.031	0.854TrpSer: 0.854 ± 0.029	0.802TrpThr: 0.802 ± 0.027	0.912TrpVal: 0.912 ± 0.031	0.234TrpTrp: 0.234 ± 0.015	0.25TrpTyr: 0.25 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.043	0.207TyrCys: 0.207 ± 0.014	1.574TyrAsp: 1.574 ± 0.037	1.216TyrGlu: 1.216 ± 0.032	0.802TyrPhe: 0.802 ± 0.031	2.042TyrGly: 2.042 ± 0.038	0.491TyrHis: 0.491 ± 0.021	0.776TyrIle: 0.776 ± 0.026	0.444TyrLys: 0.444 ± 0.022	2.013TyrLeu: 2.013 ± 0.041	0.406TyrMet: 0.406 ± 0.017	0.475TyrAsn: 0.475 ± 0.02	1.025TyrPro: 1.025 ± 0.033	0.562TyrGln: 0.562 ± 0.022	1.606TyrArg: 1.606 ± 0.034	1.037TyrSer: 1.037 ± 0.03	1.042TyrThr: 1.042 ± 0.03	1.539TyrVal: 1.539 ± 0.038	0.347TyrTrp: 0.347 ± 0.017	0.528TyrTyr: 0.528 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4109 proteins (1253694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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