Amino acid dipepetide frequency for Aeromonas phage PS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.99AlaAla: 10.99 ± 0.941
0.5AlaCys: 0.5 ± 0.233
5.828AlaAsp: 5.828 ± 0.611
6.411AlaGlu: 6.411 ± 1.195
3.996AlaPhe: 3.996 ± 0.615
6.827AlaGly: 6.827 ± 0.591
1.582AlaHis: 1.582 ± 0.47
5.578AlaIle: 5.578 ± 0.8
5.828AlaLys: 5.828 ± 0.94
8.825AlaLeu: 8.825 ± 1.011
1.998AlaMet: 1.998 ± 0.355
3.83AlaAsn: 3.83 ± 0.558
4.662AlaPro: 4.662 ± 0.866
4.912AlaGln: 4.912 ± 0.69
4.08AlaArg: 4.08 ± 0.75
5.828AlaSer: 5.828 ± 0.745
4.246AlaThr: 4.246 ± 0.613
7.576AlaVal: 7.576 ± 0.792
1.082AlaTrp: 1.082 ± 0.313
3.497AlaTyr: 3.497 ± 0.483
0.0AlaXaa: 0.0 ± 0.0
Cys
0.666CysAla: 0.666 ± 0.26
0.167CysCys: 0.167 ± 0.119
0.749CysAsp: 0.749 ± 0.257
0.083CysGlu: 0.083 ± 0.081
0.333CysPhe: 0.333 ± 0.186
0.5CysGly: 0.5 ± 0.176
0.666CysHis: 0.666 ± 0.285
0.666CysIle: 0.666 ± 0.28
0.999CysLys: 0.999 ± 0.287
0.749CysLeu: 0.749 ± 0.242
0.25CysMet: 0.25 ± 0.129
0.416CysAsn: 0.416 ± 0.215
0.5CysPro: 0.5 ± 0.216
0.167CysGln: 0.167 ± 0.109
0.583CysArg: 0.583 ± 0.233
0.999CysSer: 0.999 ± 0.347
1.332CysThr: 1.332 ± 0.318
1.166CysVal: 1.166 ± 0.295
0.083CysTrp: 0.083 ± 0.089
0.916CysTyr: 0.916 ± 0.356
0.0CysXaa: 0.0 ± 0.0
Asp
6.661AspAla: 6.661 ± 0.643
0.916AspCys: 0.916 ± 0.273
3.663AspAsp: 3.663 ± 0.481
4.08AspGlu: 4.08 ± 0.585
2.165AspPhe: 2.165 ± 0.381
4.08AspGly: 4.08 ± 0.657
0.583AspHis: 0.583 ± 0.222
2.747AspIle: 2.747 ± 0.454
4.413AspLys: 4.413 ± 0.595
4.329AspLeu: 4.329 ± 0.477
2.081AspMet: 2.081 ± 0.332
2.997AspAsn: 2.997 ± 0.453
2.165AspPro: 2.165 ± 0.345
1.249AspGln: 1.249 ± 0.345
1.582AspArg: 1.582 ± 0.39
3.081AspSer: 3.081 ± 0.335
3.747AspThr: 3.747 ± 0.599
4.08AspVal: 4.08 ± 0.471
1.249AspTrp: 1.249 ± 0.268
2.081AspTyr: 2.081 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
7.743GluAla: 7.743 ± 0.899
0.666GluCys: 0.666 ± 0.226
2.581GluAsp: 2.581 ± 0.375
4.163GluGlu: 4.163 ± 0.64
3.747GluPhe: 3.747 ± 0.521
3.913GluGly: 3.913 ± 0.475
0.916GluHis: 0.916 ± 0.253
1.748GluIle: 1.748 ± 0.41
2.664GluLys: 2.664 ± 0.612
6.577GluLeu: 6.577 ± 0.796
1.499GluMet: 1.499 ± 0.349
1.915GluAsn: 1.915 ± 0.395
1.665GluPro: 1.665 ± 0.376
4.163GluGln: 4.163 ± 0.627
3.164GluArg: 3.164 ± 0.537
2.248GluSer: 2.248 ± 0.466
2.664GluThr: 2.664 ± 0.385
4.829GluVal: 4.829 ± 0.613
0.749GluTrp: 0.749 ± 0.294
2.498GluTyr: 2.498 ± 0.404
0.0GluXaa: 0.0 ± 0.0
Phe
2.581PheAla: 2.581 ± 0.448
0.333PheCys: 0.333 ± 0.181
1.915PheAsp: 1.915 ± 0.547
1.665PheGlu: 1.665 ± 0.403
1.082PhePhe: 1.082 ± 0.281
2.664PheGly: 2.664 ± 0.557
0.583PheHis: 0.583 ± 0.192
1.582PheIle: 1.582 ± 0.262
1.998PheLys: 1.998 ± 0.463
2.831PheLeu: 2.831 ± 0.524
0.999PheMet: 0.999 ± 0.24
1.582PheAsn: 1.582 ± 0.442
1.748PhePro: 1.748 ± 0.33
1.582PheGln: 1.582 ± 0.399
1.249PheArg: 1.249 ± 0.326
2.248PheSer: 2.248 ± 0.396
2.498PheThr: 2.498 ± 0.376
2.165PheVal: 2.165 ± 0.507
0.333PheTrp: 0.333 ± 0.153
1.082PheTyr: 1.082 ± 0.309
0.0PheXaa: 0.0 ± 0.0
Gly
6.411GlyAla: 6.411 ± 0.912
1.249GlyCys: 1.249 ± 0.397
2.581GlyAsp: 2.581 ± 0.424
3.58GlyGlu: 3.58 ± 0.443
1.915GlyPhe: 1.915 ± 0.38
5.328GlyGly: 5.328 ± 1.029
0.999GlyHis: 0.999 ± 0.229
4.246GlyIle: 4.246 ± 0.796
5.079GlyLys: 5.079 ± 0.713
5.911GlyLeu: 5.911 ± 0.647
2.081GlyMet: 2.081 ± 0.404
3.081GlyAsn: 3.081 ± 0.551
1.166GlyPro: 1.166 ± 0.308
1.915GlyGln: 1.915 ± 0.474
4.163GlyArg: 4.163 ± 0.607
5.745GlySer: 5.745 ± 1.011
5.745GlyThr: 5.745 ± 0.733
7.16GlyVal: 7.16 ± 0.959
0.999GlyTrp: 0.999 ± 0.408
3.081GlyTyr: 3.081 ± 0.724
0.0GlyXaa: 0.0 ± 0.0
His
0.749HisAla: 0.749 ± 0.278
0.333HisCys: 0.333 ± 0.159
0.916HisAsp: 0.916 ± 0.317
1.249HisGlu: 1.249 ± 0.36
0.5HisPhe: 0.5 ± 0.19
1.332HisGly: 1.332 ± 0.33
0.583HisHis: 0.583 ± 0.191
0.999HisIle: 0.999 ± 0.262
1.082HisLys: 1.082 ± 0.255
1.998HisLeu: 1.998 ± 0.436
0.25HisMet: 0.25 ± 0.128
0.333HisAsn: 0.333 ± 0.16
0.999HisPro: 0.999 ± 0.259
0.749HisGln: 0.749 ± 0.195
0.999HisArg: 0.999 ± 0.313
1.249HisSer: 1.249 ± 0.315
0.999HisThr: 0.999 ± 0.351
1.332HisVal: 1.332 ± 0.341
0.583HisTrp: 0.583 ± 0.264
0.666HisTyr: 0.666 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
3.83IleAla: 3.83 ± 0.603
0.167IleCys: 0.167 ± 0.106
3.663IleAsp: 3.663 ± 0.515
2.831IleGlu: 2.831 ± 0.464
0.333IlePhe: 0.333 ± 0.183
4.08IleGly: 4.08 ± 0.716
0.749IleHis: 0.749 ± 0.2
1.665IleIle: 1.665 ± 0.387
3.58IleLys: 3.58 ± 0.543
3.247IleLeu: 3.247 ± 0.436
1.166IleMet: 1.166 ± 0.349
2.248IleAsn: 2.248 ± 0.523
2.914IlePro: 2.914 ± 0.463
2.081IleGln: 2.081 ± 0.349
2.498IleArg: 2.498 ± 0.415
4.08IleSer: 4.08 ± 0.572
2.664IleThr: 2.664 ± 0.439
2.747IleVal: 2.747 ± 0.517
0.333IleTrp: 0.333 ± 0.154
1.332IleTyr: 1.332 ± 0.302
0.0IleXaa: 0.0 ± 0.0
Lys
5.828LysAla: 5.828 ± 0.721
0.416LysCys: 0.416 ± 0.185
3.913LysAsp: 3.913 ± 0.663
4.746LysGlu: 4.746 ± 0.758
1.249LysPhe: 1.249 ± 0.338
3.663LysGly: 3.663 ± 0.656
1.499LysHis: 1.499 ± 0.462
1.582LysIle: 1.582 ± 0.37
2.331LysLys: 2.331 ± 0.67
4.912LysLeu: 4.912 ± 0.485
1.915LysMet: 1.915 ± 0.428
1.998LysAsn: 1.998 ± 0.362
2.581LysPro: 2.581 ± 0.539
3.414LysGln: 3.414 ± 0.492
3.33LysArg: 3.33 ± 0.531
2.581LysSer: 2.581 ± 0.42
2.331LysThr: 2.331 ± 0.58
3.33LysVal: 3.33 ± 0.648
0.749LysTrp: 0.749 ± 0.324
2.248LysTyr: 2.248 ± 0.455
0.0LysXaa: 0.0 ± 0.0
Leu
6.994LeuAla: 6.994 ± 0.863
1.665LeuCys: 1.665 ± 0.397
5.911LeuAsp: 5.911 ± 0.66
5.828LeuGlu: 5.828 ± 0.592
2.914LeuPhe: 2.914 ± 0.548
6.494LeuGly: 6.494 ± 1.212
1.582LeuHis: 1.582 ± 0.352
4.413LeuIle: 4.413 ± 0.609
4.662LeuLys: 4.662 ± 0.596
7.743LeuLeu: 7.743 ± 0.666
2.331LeuMet: 2.331 ± 0.446
4.496LeuAsn: 4.496 ± 0.628
3.081LeuPro: 3.081 ± 0.495
3.58LeuGln: 3.58 ± 0.539
4.912LeuArg: 4.912 ± 0.566
5.495LeuSer: 5.495 ± 0.534
3.996LeuThr: 3.996 ± 0.604
6.744LeuVal: 6.744 ± 0.696
0.916LeuTrp: 0.916 ± 0.287
2.498LeuTyr: 2.498 ± 0.388
0.0LeuXaa: 0.0 ± 0.0
Met
2.248MetAla: 2.248 ± 0.56
0.333MetCys: 0.333 ± 0.155
1.665MetAsp: 1.665 ± 0.404
1.082MetGlu: 1.082 ± 0.301
0.583MetPhe: 0.583 ± 0.231
1.499MetGly: 1.499 ± 0.335
0.749MetHis: 0.749 ± 0.276
0.749MetIle: 0.749 ± 0.253
1.249MetLys: 1.249 ± 0.331
2.331MetLeu: 2.331 ± 0.474
0.583MetMet: 0.583 ± 0.221
0.833MetAsn: 0.833 ± 0.217
1.082MetPro: 1.082 ± 0.28
1.499MetGln: 1.499 ± 0.445
2.248MetArg: 2.248 ± 0.481
2.498MetSer: 2.498 ± 0.475
1.249MetThr: 1.249 ± 0.292
2.331MetVal: 2.331 ± 0.445
0.583MetTrp: 0.583 ± 0.194
1.582MetTyr: 1.582 ± 0.284
0.0MetXaa: 0.0 ± 0.0
Asn
4.829AsnAla: 4.829 ± 0.539
0.5AsnCys: 0.5 ± 0.245
1.665AsnAsp: 1.665 ± 0.364
1.998AsnGlu: 1.998 ± 0.42
1.499AsnPhe: 1.499 ± 0.377
2.914AsnGly: 2.914 ± 0.474
0.833AsnHis: 0.833 ± 0.242
2.081AsnIle: 2.081 ± 0.268
1.332AsnLys: 1.332 ± 0.32
3.164AsnLeu: 3.164 ± 0.549
1.499AsnMet: 1.499 ± 0.322
1.665AsnAsn: 1.665 ± 0.364
2.248AsnPro: 2.248 ± 0.406
1.499AsnGln: 1.499 ± 0.367
2.081AsnArg: 2.081 ± 0.503
2.581AsnSer: 2.581 ± 0.56
3.497AsnThr: 3.497 ± 0.719
2.997AsnVal: 2.997 ± 0.672
0.749AsnTrp: 0.749 ± 0.25
1.499AsnTyr: 1.499 ± 0.328
0.0AsnXaa: 0.0 ± 0.0
Pro
4.496ProAla: 4.496 ± 1.122
0.5ProCys: 0.5 ± 0.198
2.498ProAsp: 2.498 ± 0.483
2.747ProGlu: 2.747 ± 0.541
0.999ProPhe: 0.999 ± 0.35
2.414ProGly: 2.414 ± 0.454
0.333ProHis: 0.333 ± 0.154
2.165ProIle: 2.165 ± 0.524
2.248ProLys: 2.248 ± 0.406
2.498ProLeu: 2.498 ± 0.372
0.749ProMet: 0.749 ± 0.283
1.499ProAsn: 1.499 ± 0.306
0.833ProPro: 0.833 ± 0.288
1.915ProGln: 1.915 ± 0.389
1.748ProArg: 1.748 ± 0.372
2.831ProSer: 2.831 ± 0.452
3.164ProThr: 3.164 ± 0.538
5.245ProVal: 5.245 ± 1.009
0.333ProTrp: 0.333 ± 0.175
1.832ProTyr: 1.832 ± 0.39
0.0ProXaa: 0.0 ± 0.0
Gln
4.746GlnAla: 4.746 ± 0.834
0.083GlnCys: 0.083 ± 0.075
2.331GlnAsp: 2.331 ± 0.396
2.831GlnGlu: 2.831 ± 0.393
1.665GlnPhe: 1.665 ± 0.331
3.164GlnGly: 3.164 ± 0.505
1.082GlnHis: 1.082 ± 0.3
2.081GlnIle: 2.081 ± 0.443
2.165GlnLys: 2.165 ± 0.477
3.747GlnLeu: 3.747 ± 0.626
1.332GlnMet: 1.332 ± 0.398
1.582GlnAsn: 1.582 ± 0.452
1.665GlnPro: 1.665 ± 0.436
2.914GlnGln: 2.914 ± 0.477
2.747GlnArg: 2.747 ± 0.336
2.664GlnSer: 2.664 ± 0.456
1.499GlnThr: 1.499 ± 0.34
2.997GlnVal: 2.997 ± 0.433
0.916GlnTrp: 0.916 ± 0.271
2.414GlnTyr: 2.414 ± 0.449
0.0GlnXaa: 0.0 ± 0.0
Arg
4.496ArgAla: 4.496 ± 0.63
0.916ArgCys: 0.916 ± 0.306
2.747ArgAsp: 2.747 ± 0.432
3.414ArgGlu: 3.414 ± 0.628
1.748ArgPhe: 1.748 ± 0.398
3.414ArgGly: 3.414 ± 0.484
0.749ArgHis: 0.749 ± 0.293
2.914ArgIle: 2.914 ± 0.604
1.748ArgLys: 1.748 ± 0.381
3.58ArgLeu: 3.58 ± 0.599
1.665ArgMet: 1.665 ± 0.384
2.081ArgAsn: 2.081 ± 0.48
1.249ArgPro: 1.249 ± 0.25
2.165ArgGln: 2.165 ± 0.394
3.164ArgArg: 3.164 ± 0.624
4.163ArgSer: 4.163 ± 0.634
3.913ArgThr: 3.913 ± 0.462
3.83ArgVal: 3.83 ± 0.394
0.749ArgTrp: 0.749 ± 0.293
1.998ArgTyr: 1.998 ± 0.462
0.0ArgXaa: 0.0 ± 0.0
Ser
6.994SerAla: 6.994 ± 0.885
0.25SerCys: 0.25 ± 0.149
4.163SerAsp: 4.163 ± 0.516
3.081SerGlu: 3.081 ± 0.485
2.248SerPhe: 2.248 ± 0.523
5.245SerGly: 5.245 ± 0.818
0.583SerHis: 0.583 ± 0.225
2.664SerIle: 2.664 ± 0.463
3.83SerLys: 3.83 ± 0.58
6.411SerLeu: 6.411 ± 0.713
1.665SerMet: 1.665 ± 0.475
3.081SerAsn: 3.081 ± 0.561
2.414SerPro: 2.414 ± 0.34
1.332SerGln: 1.332 ± 0.392
2.498SerArg: 2.498 ± 0.418
3.33SerSer: 3.33 ± 0.849
7.327SerThr: 7.327 ± 0.94
3.663SerVal: 3.663 ± 0.538
0.916SerTrp: 0.916 ± 0.284
2.498SerTyr: 2.498 ± 0.491
0.0SerXaa: 0.0 ± 0.0
Thr
7.243ThrAla: 7.243 ± 0.721
0.833ThrCys: 0.833 ± 0.242
3.83ThrAsp: 3.83 ± 0.471
3.58ThrGlu: 3.58 ± 0.583
1.915ThrPhe: 1.915 ± 0.418
5.745ThrGly: 5.745 ± 0.982
0.749ThrHis: 0.749 ± 0.172
3.081ThrIle: 3.081 ± 0.485
3.247ThrLys: 3.247 ± 0.397
4.496ThrLeu: 4.496 ± 0.681
1.082ThrMet: 1.082 ± 0.276
2.081ThrAsn: 2.081 ± 0.362
3.081ThrPro: 3.081 ± 0.667
2.581ThrGln: 2.581 ± 0.462
3.497ThrArg: 3.497 ± 0.518
3.58ThrSer: 3.58 ± 0.406
2.831ThrThr: 2.831 ± 0.485
5.745ThrVal: 5.745 ± 0.943
0.666ThrTrp: 0.666 ± 0.163
2.414ThrTyr: 2.414 ± 0.418
0.0ThrXaa: 0.0 ± 0.0
Val
6.577ValAla: 6.577 ± 0.739
0.749ValCys: 0.749 ± 0.262
4.579ValAsp: 4.579 ± 0.528
4.746ValGlu: 4.746 ± 0.718
1.998ValPhe: 1.998 ± 0.364
5.995ValGly: 5.995 ± 0.838
1.915ValHis: 1.915 ± 0.474
2.997ValIle: 2.997 ± 0.447
3.663ValLys: 3.663 ± 0.554
7.077ValLeu: 7.077 ± 0.913
2.414ValMet: 2.414 ± 0.378
2.831ValAsn: 2.831 ± 0.509
5.328ValPro: 5.328 ± 1.026
4.163ValGln: 4.163 ± 0.549
3.497ValArg: 3.497 ± 0.577
4.329ValSer: 4.329 ± 0.476
4.912ValThr: 4.912 ± 0.681
6.244ValVal: 6.244 ± 0.635
1.415ValTrp: 1.415 ± 0.381
2.581ValTyr: 2.581 ± 0.406
0.0ValXaa: 0.0 ± 0.0
Trp
0.833TrpAla: 0.833 ± 0.308
0.25TrpCys: 0.25 ± 0.134
1.082TrpAsp: 1.082 ± 0.394
0.5TrpGlu: 0.5 ± 0.223
0.666TrpPhe: 0.666 ± 0.238
0.749TrpGly: 0.749 ± 0.221
0.583TrpHis: 0.583 ± 0.233
0.5TrpIle: 0.5 ± 0.243
0.749TrpLys: 0.749 ± 0.246
1.998TrpLeu: 1.998 ± 0.492
0.25TrpMet: 0.25 ± 0.123
0.25TrpAsn: 0.25 ± 0.146
0.5TrpPro: 0.5 ± 0.166
0.5TrpGln: 0.5 ± 0.165
0.749TrpArg: 0.749 ± 0.277
0.833TrpSer: 0.833 ± 0.335
1.166TrpThr: 1.166 ± 0.276
1.166TrpVal: 1.166 ± 0.29
0.167TrpTrp: 0.167 ± 0.137
0.5TrpTyr: 0.5 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.164TyrAla: 3.164 ± 0.519
1.166TyrCys: 1.166 ± 0.315
1.665TyrAsp: 1.665 ± 0.35
1.499TyrGlu: 1.499 ± 0.399
1.166TyrPhe: 1.166 ± 0.282
2.414TyrGly: 2.414 ± 0.599
0.583TyrHis: 0.583 ± 0.265
1.748TyrIle: 1.748 ± 0.342
1.832TyrLys: 1.832 ± 0.331
3.83TyrLeu: 3.83 ± 0.498
1.082TyrMet: 1.082 ± 0.274
2.331TyrAsn: 2.331 ± 0.487
1.166TyrPro: 1.166 ± 0.238
2.248TyrGln: 2.248 ± 0.4
1.915TyrArg: 1.915 ± 0.369
3.83TyrSer: 3.83 ± 0.563
2.498TyrThr: 2.498 ± 0.451
2.664TyrVal: 2.664 ± 0.446
0.416TyrTrp: 0.416 ± 0.213
1.582TyrTyr: 1.582 ± 0.329
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (12012 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski