Amino acid dipepetide frequency for Deinococcus sp. K2S05-167

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.716AlaAla: 14.716 ± 0.157
0.842AlaCys: 0.842 ± 0.029
5.609AlaAsp: 5.609 ± 0.076
6.403AlaGlu: 6.403 ± 0.095
3.885AlaPhe: 3.885 ± 0.06
10.339AlaGly: 10.339 ± 0.103
2.642AlaHis: 2.642 ± 0.06
3.614AlaIle: 3.614 ± 0.057
2.861AlaLys: 2.861 ± 0.063
14.624AlaLeu: 14.624 ± 0.165
2.262AlaMet: 2.262 ± 0.047
2.391AlaAsn: 2.391 ± 0.053
5.645AlaPro: 5.645 ± 0.09
6.158AlaGln: 6.158 ± 0.091
8.894AlaArg: 8.894 ± 0.092
5.769AlaSer: 5.769 ± 0.084
5.387AlaThr: 5.387 ± 0.082
7.863AlaVal: 7.863 ± 0.091
1.671AlaTrp: 1.671 ± 0.041
2.773AlaTyr: 2.773 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.726CysAla: 0.726 ± 0.027
0.08CysCys: 0.08 ± 0.009
0.313CysAsp: 0.313 ± 0.015
0.301CysGlu: 0.301 ± 0.016
0.192CysPhe: 0.192 ± 0.014
0.677CysGly: 0.677 ± 0.028
0.172CysHis: 0.172 ± 0.013
0.215CysIle: 0.215 ± 0.014
0.164CysLys: 0.164 ± 0.012
0.565CysLeu: 0.565 ± 0.023
0.104CysMet: 0.104 ± 0.009
0.166CysAsn: 0.166 ± 0.013
0.493CysPro: 0.493 ± 0.019
0.256CysGln: 0.256 ± 0.015
0.452CysArg: 0.452 ± 0.019
0.376CysSer: 0.376 ± 0.018
0.401CysThr: 0.401 ± 0.02
0.444CysVal: 0.444 ± 0.022
0.1CysTrp: 0.1 ± 0.009
0.129CysTyr: 0.129 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.073AspAla: 6.073 ± 0.088
0.261AspCys: 0.261 ± 0.013
2.547AspAsp: 2.547 ± 0.057
3.095AspGlu: 3.095 ± 0.063
1.934AspPhe: 1.934 ± 0.04
4.212AspGly: 4.212 ± 0.069
1.104AspHis: 1.104 ± 0.033
2.166AspIle: 2.166 ± 0.042
1.221AspLys: 1.221 ± 0.036
6.428AspLeu: 6.428 ± 0.077
1.044AspMet: 1.044 ± 0.026
1.062AspAsn: 1.062 ± 0.032
3.124AspPro: 3.124 ± 0.05
1.707AspGln: 1.707 ± 0.045
2.905AspArg: 2.905 ± 0.056
2.204AspSer: 2.204 ± 0.039
2.902AspThr: 2.902 ± 0.048
4.258AspVal: 4.258 ± 0.058
0.891AspTrp: 0.891 ± 0.029
1.203AspTyr: 1.203 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.964GluAla: 6.964 ± 0.093
0.291GluCys: 0.291 ± 0.017
2.471GluAsp: 2.471 ± 0.052
3.342GluGlu: 3.342 ± 0.063
2.022GluPhe: 2.022 ± 0.043
4.372GluGly: 4.372 ± 0.068
1.488GluHis: 1.488 ± 0.037
2.289GluIle: 2.289 ± 0.045
2.238GluLys: 2.238 ± 0.045
6.775GluLeu: 6.775 ± 0.086
1.12GluMet: 1.12 ± 0.031
1.531GluAsn: 1.531 ± 0.033
2.293GluPro: 2.293 ± 0.04
3.008GluGln: 3.008 ± 0.054
4.931GluArg: 4.931 ± 0.068
2.215GluSer: 2.215 ± 0.051
2.908GluThr: 2.908 ± 0.05
4.826GluVal: 4.826 ± 0.068
0.872GluTrp: 0.872 ± 0.028
1.424GluTyr: 1.424 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.337PheAla: 3.337 ± 0.051
0.223PheCys: 0.223 ± 0.013
1.964PheAsp: 1.964 ± 0.043
1.826PheGlu: 1.826 ± 0.043
1.041PhePhe: 1.041 ± 0.033
3.047PheGly: 3.047 ± 0.054
0.677PheHis: 0.677 ± 0.021
1.435PheIle: 1.435 ± 0.037
1.094PheLys: 1.094 ± 0.033
3.379PheLeu: 3.379 ± 0.048
0.744PheMet: 0.744 ± 0.025
0.975PheAsn: 0.975 ± 0.032
1.771PhePro: 1.771 ± 0.042
1.31PheGln: 1.31 ± 0.038
1.957PheArg: 1.957 ± 0.041
1.989PheSer: 1.989 ± 0.043
2.45PheThr: 2.45 ± 0.05
2.288PheVal: 2.288 ± 0.047
0.468PheTrp: 0.468 ± 0.02
0.837PheTyr: 0.837 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
8.203GlyAla: 8.203 ± 0.105
0.552GlyCys: 0.552 ± 0.025
3.993GlyAsp: 3.993 ± 0.064
5.183GlyGlu: 5.183 ± 0.079
2.99GlyPhe: 2.99 ± 0.061
7.418GlyGly: 7.418 ± 0.1
2.056GlyHis: 2.056 ± 0.041
3.377GlyIle: 3.377 ± 0.068
3.495GlyLys: 3.495 ± 0.059
9.619GlyLeu: 9.619 ± 0.094
1.963GlyMet: 1.963 ± 0.04
2.372GlyAsn: 2.372 ± 0.046
3.198GlyPro: 3.198 ± 0.056
4.574GlyGln: 4.574 ± 0.072
5.881GlyArg: 5.881 ± 0.072
4.458GlySer: 4.458 ± 0.067
5.236GlyThr: 5.236 ± 0.102
6.959GlyVal: 6.959 ± 0.088
1.498GlyTrp: 1.498 ± 0.032
2.226GlyTyr: 2.226 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.835HisAla: 2.835 ± 0.063
0.177HisCys: 0.177 ± 0.013
1.178HisAsp: 1.178 ± 0.035
1.293HisGlu: 1.293 ± 0.037
0.781HisPhe: 0.781 ± 0.023
1.969HisGly: 1.969 ± 0.043
0.747HisHis: 0.747 ± 0.029
0.763HisIle: 0.763 ± 0.029
0.439HisLys: 0.439 ± 0.017
3.143HisLeu: 3.143 ± 0.055
0.373HisMet: 0.373 ± 0.016
0.456HisAsn: 0.456 ± 0.021
1.745HisPro: 1.745 ± 0.046
0.831HisGln: 0.831 ± 0.031
1.485HisArg: 1.485 ± 0.04
1.172HisSer: 1.172 ± 0.034
1.257HisThr: 1.257 ± 0.03
1.636HisVal: 1.636 ± 0.038
0.388HisTrp: 0.388 ± 0.018
0.597HisTyr: 0.597 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
3.995IleAla: 3.995 ± 0.069
0.256IleCys: 0.256 ± 0.012
2.096IleAsp: 2.096 ± 0.044
2.398IleGlu: 2.398 ± 0.05
1.117IlePhe: 1.117 ± 0.033
3.362IleGly: 3.362 ± 0.055
0.968IleHis: 0.968 ± 0.03
1.478IleIle: 1.478 ± 0.041
1.198IleLys: 1.198 ± 0.037
3.725IleLeu: 3.725 ± 0.056
0.712IleMet: 0.712 ± 0.027
1.101IleAsn: 1.101 ± 0.03
2.244IlePro: 2.244 ± 0.048
1.452IleGln: 1.452 ± 0.033
2.629IleArg: 2.629 ± 0.042
2.145IleSer: 2.145 ± 0.045
2.485IleThr: 2.485 ± 0.045
2.874IleVal: 2.874 ± 0.056
0.387IleTrp: 0.387 ± 0.017
0.909IleTyr: 0.909 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.708LysAla: 3.708 ± 0.072
0.163LysCys: 0.163 ± 0.012
1.547LysAsp: 1.547 ± 0.045
1.59LysGlu: 1.59 ± 0.039
1.051LysPhe: 1.051 ± 0.034
2.488LysGly: 2.488 ± 0.05
0.626LysHis: 0.626 ± 0.02
1.311LysIle: 1.311 ± 0.035
1.551LysLys: 1.551 ± 0.043
3.444LysLeu: 3.444 ± 0.057
0.859LysMet: 0.859 ± 0.024
1.077LysAsn: 1.077 ± 0.029
1.852LysPro: 1.852 ± 0.046
1.122LysGln: 1.122 ± 0.034
2.187LysArg: 2.187 ± 0.041
1.435LysSer: 1.435 ± 0.037
2.218LysThr: 2.218 ± 0.054
2.697LysVal: 2.697 ± 0.05
0.392LysTrp: 0.392 ± 0.019
0.854LysTyr: 0.854 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
13.069LeuAla: 13.069 ± 0.132
0.765LeuCys: 0.765 ± 0.027
5.886LeuAsp: 5.886 ± 0.075
6.479LeuGlu: 6.479 ± 0.085
2.999LeuPhe: 2.999 ± 0.059
9.697LeuGly: 9.697 ± 0.109
2.829LeuHis: 2.829 ± 0.054
4.396LeuIle: 4.396 ± 0.065
4.323LeuLys: 4.323 ± 0.066
13.076LeuLeu: 13.076 ± 0.147
2.307LeuMet: 2.307 ± 0.046
4.052LeuAsn: 4.052 ± 0.077
7.311LeuPro: 7.311 ± 0.096
4.207LeuGln: 4.207 ± 0.066
8.121LeuArg: 8.121 ± 0.093
7.132LeuSer: 7.132 ± 0.089
7.726LeuThr: 7.726 ± 0.1
7.133LeuVal: 7.133 ± 0.086
1.308LeuTrp: 1.308 ± 0.034
2.34LeuTyr: 2.34 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.964MetAla: 1.964 ± 0.044
0.094MetCys: 0.094 ± 0.009
0.867MetAsp: 0.867 ± 0.029
0.958MetGlu: 0.958 ± 0.03
0.575MetPhe: 0.575 ± 0.02
1.576MetGly: 1.576 ± 0.04
0.466MetHis: 0.466 ± 0.02
0.844MetIle: 0.844 ± 0.031
0.993MetLys: 0.993 ± 0.031
2.281MetLeu: 2.281 ± 0.048
0.441MetMet: 0.441 ± 0.019
0.878MetAsn: 0.878 ± 0.025
1.264MetPro: 1.264 ± 0.036
0.968MetGln: 0.968 ± 0.027
1.428MetArg: 1.428 ± 0.035
1.2MetSer: 1.2 ± 0.032
2.046MetThr: 2.046 ± 0.04
1.181MetVal: 1.181 ± 0.032
0.193MetTrp: 0.193 ± 0.015
0.375MetTyr: 0.375 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.34AsnAla: 3.34 ± 0.058
0.166AsnCys: 0.166 ± 0.012
1.305AsnAsp: 1.305 ± 0.032
1.234AsnGlu: 1.234 ± 0.031
1.001AsnPhe: 1.001 ± 0.028
2.221AsnGly: 2.221 ± 0.047
0.566AsnHis: 0.566 ± 0.02
1.26AsnIle: 1.26 ± 0.032
0.736AsnLys: 0.736 ± 0.03
3.352AsnLeu: 3.352 ± 0.069
0.595AsnMet: 0.595 ± 0.026
0.744AsnAsn: 0.744 ± 0.026
2.082AsnPro: 2.082 ± 0.042
0.858AsnGln: 0.858 ± 0.03
1.734AsnArg: 1.734 ± 0.038
1.318AsnSer: 1.318 ± 0.033
1.718AsnThr: 1.718 ± 0.046
2.446AsnVal: 2.446 ± 0.06
0.449AsnTrp: 0.449 ± 0.018
0.728AsnTyr: 0.728 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.043ProAla: 7.043 ± 0.107
0.326ProCys: 0.326 ± 0.018
3.885ProAsp: 3.885 ± 0.059
4.281ProGlu: 4.281 ± 0.066
1.784ProPhe: 1.784 ± 0.037
5.007ProGly: 5.007 ± 0.072
1.386ProHis: 1.386 ± 0.033
1.774ProIle: 1.774 ± 0.036
1.476ProLys: 1.476 ± 0.039
5.954ProLeu: 5.954 ± 0.076
1.104ProMet: 1.104 ± 0.03
1.472ProAsn: 1.472 ± 0.035
2.992ProPro: 2.992 ± 0.068
2.575ProGln: 2.575 ± 0.049
3.212ProArg: 3.212 ± 0.057
2.777ProSer: 2.777 ± 0.05
3.179ProThr: 3.179 ± 0.061
4.37ProVal: 4.37 ± 0.066
0.755ProTrp: 0.755 ± 0.024
1.265ProTyr: 1.265 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
6.286GlnAla: 6.286 ± 0.093
0.197GlnCys: 0.197 ± 0.012
2.187GlnAsp: 2.187 ± 0.048
2.736GlnGlu: 2.736 ± 0.049
1.25GlnPhe: 1.25 ± 0.036
3.983GlnGly: 3.983 ± 0.055
1.055GlnHis: 1.055 ± 0.029
1.43GlnIle: 1.43 ± 0.036
1.467GlnLys: 1.467 ± 0.034
4.29GlnLeu: 4.29 ± 0.078
0.888GlnMet: 0.888 ± 0.027
1.328GlnAsn: 1.328 ± 0.039
2.532GlnPro: 2.532 ± 0.052
2.36GlnGln: 2.36 ± 0.057
3.008GlnArg: 3.008 ± 0.057
1.886GlnSer: 1.886 ± 0.042
2.385GlnThr: 2.385 ± 0.045
3.767GlnVal: 3.767 ± 0.065
0.54GlnTrp: 0.54 ± 0.021
0.965GlnTyr: 0.965 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
7.74ArgAla: 7.74 ± 0.089
0.396ArgCys: 0.396 ± 0.018
3.645ArgAsp: 3.645 ± 0.052
5.085ArgGlu: 5.085 ± 0.07
2.344ArgPhe: 2.344 ± 0.047
5.085ArgGly: 5.085 ± 0.068
1.748ArgHis: 1.748 ± 0.04
2.661ArgIle: 2.661 ± 0.049
2.148ArgLys: 2.148 ± 0.044
7.884ArgLeu: 7.884 ± 0.088
1.474ArgMet: 1.474 ± 0.038
1.727ArgAsn: 1.727 ± 0.039
3.861ArgPro: 3.861 ± 0.055
3.559ArgGln: 3.559 ± 0.063
5.269ArgArg: 5.269 ± 0.086
3.374ArgSer: 3.374 ± 0.058
3.833ArgThr: 3.833 ± 0.06
5.613ArgVal: 5.613 ± 0.068
1.086ArgTrp: 1.086 ± 0.031
1.755ArgTyr: 1.755 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.979SerAla: 5.979 ± 0.078
0.36SerCys: 0.36 ± 0.019
2.462SerAsp: 2.462 ± 0.044
2.679SerGlu: 2.679 ± 0.051
1.866SerPhe: 1.866 ± 0.039
5.638SerGly: 5.638 ± 0.088
0.973SerHis: 0.973 ± 0.029
1.882SerIle: 1.882 ± 0.044
1.454SerLys: 1.454 ± 0.039
5.637SerLeu: 5.637 ± 0.075
1.124SerMet: 1.124 ± 0.031
1.245SerAsn: 1.245 ± 0.038
2.981SerPro: 2.981 ± 0.056
1.78SerGln: 1.78 ± 0.047
3.556SerArg: 3.556 ± 0.055
2.926SerSer: 2.926 ± 0.056
2.972SerThr: 2.972 ± 0.056
4.255SerVal: 4.255 ± 0.059
0.664SerTrp: 0.664 ± 0.026
1.138SerTyr: 1.138 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.449ThrAla: 6.449 ± 0.088
0.392ThrCys: 0.392 ± 0.019
2.91ThrAsp: 2.91 ± 0.049
2.848ThrGlu: 2.848 ± 0.049
2.293ThrPhe: 2.293 ± 0.049
5.272ThrGly: 5.272 ± 0.081
1.363ThrHis: 1.363 ± 0.03
2.041ThrIle: 2.041 ± 0.046
1.261ThrLys: 1.261 ± 0.036
8.168ThrLeu: 8.168 ± 0.112
0.92ThrMet: 0.92 ± 0.028
1.373ThrAsn: 1.373 ± 0.031
4.93ThrPro: 4.93 ± 0.075
2.229ThrGln: 2.229 ± 0.037
4.215ThrArg: 4.215 ± 0.06
2.999ThrSer: 2.999 ± 0.053
3.367ThrThr: 3.367 ± 0.066
4.846ThrVal: 4.846 ± 0.071
0.808ThrTrp: 0.808 ± 0.029
1.64ThrTyr: 1.64 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
7.662ValAla: 7.662 ± 0.092
0.505ValCys: 0.505 ± 0.024
3.479ValAsp: 3.479 ± 0.053
3.861ValGlu: 3.861 ± 0.068
2.424ValPhe: 2.424 ± 0.046
5.643ValGly: 5.643 ± 0.07
1.446ValHis: 1.446 ± 0.042
3.466ValIle: 3.466 ± 0.054
2.983ValLys: 2.983 ± 0.054
8.289ValLeu: 8.289 ± 0.091
1.828ValMet: 1.828 ± 0.039
2.726ValAsn: 2.726 ± 0.052
4.185ValPro: 4.185 ± 0.065
3.708ValGln: 3.708 ± 0.066
5.242ValArg: 5.242 ± 0.063
4.312ValSer: 4.312 ± 0.068
5.467ValThr: 5.467 ± 0.09
5.535ValVal: 5.535 ± 0.08
1.057ValTrp: 1.057 ± 0.032
1.784ValTyr: 1.784 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.413TrpAla: 1.413 ± 0.034
0.114TrpCys: 0.114 ± 0.01
0.614TrpAsp: 0.614 ± 0.019
0.666TrpGlu: 0.666 ± 0.027
0.423TrpPhe: 0.423 ± 0.018
1.032TrpGly: 1.032 ± 0.032
0.407TrpHis: 0.407 ± 0.019
0.441TrpIle: 0.441 ± 0.02
0.485TrpLys: 0.485 ± 0.022
1.808TrpLeu: 1.808 ± 0.045
0.336TrpMet: 0.336 ± 0.016
0.57TrpAsn: 0.57 ± 0.025
0.786TrpPro: 0.786 ± 0.027
0.835TrpGln: 0.835 ± 0.028
1.145TrpArg: 1.145 ± 0.031
0.648TrpSer: 0.648 ± 0.025
0.863TrpThr: 0.863 ± 0.028
1.006TrpVal: 1.006 ± 0.029
0.289TrpTrp: 0.289 ± 0.017
0.291TrpTyr: 0.291 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.846TyrAla: 2.846 ± 0.047
0.164TyrCys: 0.164 ± 0.011
1.386TyrAsp: 1.386 ± 0.037
1.122TyrGlu: 1.122 ± 0.03
0.841TyrPhe: 0.841 ± 0.029
2.211TyrGly: 2.211 ± 0.046
0.544TyrHis: 0.544 ± 0.02
0.686TyrIle: 0.686 ± 0.025
0.589TyrLys: 0.589 ± 0.027
2.716TyrLeu: 2.716 ± 0.053
0.391TyrMet: 0.391 ± 0.02
0.607TyrAsn: 0.607 ± 0.026
1.329TyrPro: 1.329 ± 0.036
1.041TyrGln: 1.041 ± 0.028
2.034TyrArg: 2.034 ± 0.038
1.238TyrSer: 1.238 ± 0.033
1.525TyrThr: 1.525 ± 0.037
1.608TyrVal: 1.608 ± 0.042
0.355TyrTrp: 0.355 ± 0.016
0.624TyrTyr: 0.624 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4078 proteins (1205993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski