Amino acid dipepetide frequency for Streptomyces caatingaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.234AlaAla: 24.234 ± 0.232	1.177AlaCys: 1.177 ± 0.024	8.369AlaAsp: 8.369 ± 0.078	9.126AlaGlu: 9.126 ± 0.123	3.692AlaPhe: 3.692 ± 0.051	14.92AlaGly: 14.92 ± 0.118	3.075AlaHis: 3.075 ± 0.046	2.929AlaIle: 2.929 ± 0.049	2.751AlaLys: 2.751 ± 0.058	15.546AlaLeu: 15.546 ± 0.12	2.492AlaMet: 2.492 ± 0.038	1.752AlaAsn: 1.752 ± 0.034	7.988AlaPro: 7.988 ± 0.105	3.248AlaGln: 3.248 ± 0.046	11.874AlaArg: 11.874 ± 0.098	5.53AlaSer: 5.53 ± 0.06	6.588AlaThr: 6.588 ± 0.067	13.247AlaVal: 13.247 ± 0.113	1.944AlaTrp: 1.944 ± 0.036	2.773AlaTyr: 2.773 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.318CysAla: 1.318 ± 0.027	0.089CysCys: 0.089 ± 0.008	0.547CysAsp: 0.547 ± 0.021	0.391CysGlu: 0.391 ± 0.015	0.222CysPhe: 0.222 ± 0.012	1.046CysGly: 1.046 ± 0.031	0.199CysHis: 0.199 ± 0.011	0.14CysIle: 0.14 ± 0.01	0.115CysLys: 0.115 ± 0.007	0.792CysLeu: 0.792 ± 0.024	0.126CysMet: 0.126 ± 0.009	0.123CysAsn: 0.123 ± 0.009	0.529CysPro: 0.529 ± 0.019	0.146CysGln: 0.146 ± 0.01	0.718CysArg: 0.718 ± 0.02	0.454CysSer: 0.454 ± 0.017	0.509CysThr: 0.509 ± 0.016	0.697CysVal: 0.697 ± 0.019	0.118CysTrp: 0.118 ± 0.009	0.155CysTyr: 0.155 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.049AspAla: 8.049 ± 0.079	0.44AspCys: 0.44 ± 0.017	3.445AspAsp: 3.445 ± 0.052	3.859AspGlu: 3.859 ± 0.053	1.546AspPhe: 1.546 ± 0.031	6.599AspGly: 6.599 ± 0.06	1.414AspHis: 1.414 ± 0.027	1.636AspIle: 1.636 ± 0.031	1.114AspLys: 1.114 ± 0.033	5.876AspLeu: 5.876 ± 0.055	0.728AspMet: 0.728 ± 0.021	0.807AspAsn: 0.807 ± 0.021	4.417AspPro: 4.417 ± 0.05	1.168AspGln: 1.168 ± 0.029	5.164AspArg: 5.164 ± 0.061	2.062AspSer: 2.062 ± 0.033	2.797AspThr: 2.797 ± 0.041	4.788AspVal: 4.788 ± 0.055	0.942AspTrp: 0.942 ± 0.023	1.045AspTyr: 1.045 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.68GluAla: 7.68 ± 0.103	0.374GluCys: 0.374 ± 0.017	2.917GluAsp: 2.917 ± 0.042	3.796GluGlu: 3.796 ± 0.069	1.446GluPhe: 1.446 ± 0.027	4.5GluGly: 4.5 ± 0.058	1.522GluHis: 1.522 ± 0.03	2.135GluIle: 2.135 ± 0.037	1.442GluLys: 1.442 ± 0.038	6.789GluLeu: 6.789 ± 0.071	0.857GluMet: 0.857 ± 0.022	0.927GluAsn: 0.927 ± 0.024	3.276GluPro: 3.276 ± 0.049	1.92GluGln: 1.92 ± 0.036	6.143GluArg: 6.143 ± 0.066	2.229GluSer: 2.229 ± 0.039	2.725GluThr: 2.725 ± 0.044	4.356GluVal: 4.356 ± 0.058	0.779GluTrp: 0.779 ± 0.021	1.007GluTyr: 1.007 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.879PheAla: 3.879 ± 0.047	0.294PheCys: 0.294 ± 0.012	1.852PheAsp: 1.852 ± 0.032	1.357PheGlu: 1.357 ± 0.028	0.89PhePhe: 0.89 ± 0.027	2.996PheGly: 2.996 ± 0.041	0.642PheHis: 0.642 ± 0.02	0.604PheIle: 0.604 ± 0.02	0.482PheLys: 0.482 ± 0.016	2.633PheLeu: 2.633 ± 0.04	0.356PheMet: 0.356 ± 0.014	0.491PheAsn: 0.491 ± 0.017	1.457PhePro: 1.457 ± 0.029	0.588PheGln: 0.588 ± 0.019	1.95PheArg: 1.95 ± 0.033	1.393PheSer: 1.393 ± 0.031	1.972PheThr: 1.972 ± 0.033	2.227PheVal: 2.227 ± 0.038	0.429PheTrp: 0.429 ± 0.016	0.533PheTyr: 0.533 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	12.126GlyAla: 12.126 ± 0.101	0.914GlyCys: 0.914 ± 0.027	5.17GlyAsp: 5.17 ± 0.055	5.235GlyGlu: 5.235 ± 0.058	2.804GlyPhe: 2.804 ± 0.042	9.57GlyGly: 9.57 ± 0.087	2.548GlyHis: 2.548 ± 0.042	3.179GlyIle: 3.179 ± 0.045	2.426GlyLys: 2.426 ± 0.052	10.021GlyLeu: 10.021 ± 0.086	2.059GlyMet: 2.059 ± 0.034	1.631GlyAsn: 1.631 ± 0.037	5.854GlyPro: 5.854 ± 0.065	2.412GlyGln: 2.412 ± 0.042	9.225GlyArg: 9.225 ± 0.078	4.924GlySer: 4.924 ± 0.057	6.479GlyThr: 6.479 ± 0.061	7.88GlyVal: 7.88 ± 0.08	1.719GlyTrp: 1.719 ± 0.035	2.199GlyTyr: 2.199 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.826HisAla: 2.826 ± 0.045	0.247HisCys: 0.247 ± 0.011	1.377HisAsp: 1.377 ± 0.032	1.23HisGlu: 1.23 ± 0.026	0.666HisPhe: 0.666 ± 0.02	2.595HisGly: 2.595 ± 0.037	0.69HisHis: 0.69 ± 0.022	0.648HisIle: 0.648 ± 0.024	0.352HisLys: 0.352 ± 0.014	2.538HisLeu: 2.538 ± 0.04	0.338HisMet: 0.338 ± 0.013	0.351HisAsn: 0.351 ± 0.014	1.929HisPro: 1.929 ± 0.032	0.585HisGln: 0.585 ± 0.018	2.37HisArg: 2.37 ± 0.038	0.955HisSer: 0.955 ± 0.024	1.299HisThr: 1.299 ± 0.026	1.764HisVal: 1.764 ± 0.034	0.395HisTrp: 0.395 ± 0.017	0.484HisTyr: 0.484 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.255IleAla: 4.255 ± 0.058	0.276IleCys: 0.276 ± 0.012	1.889IleAsp: 1.889 ± 0.034	1.706IleGlu: 1.706 ± 0.032	0.604IlePhe: 0.604 ± 0.019	3.207IleGly: 3.207 ± 0.045	0.567IleHis: 0.567 ± 0.019	0.681IleIle: 0.681 ± 0.022	0.683IleLys: 0.683 ± 0.025	2.07IleLeu: 2.07 ± 0.04	0.389IleMet: 0.389 ± 0.014	0.612IleAsn: 0.612 ± 0.019	1.608IlePro: 1.608 ± 0.033	0.558IleGln: 0.558 ± 0.019	2.067IleArg: 2.067 ± 0.033	1.411IleSer: 1.411 ± 0.028	1.897IleThr: 1.897 ± 0.037	2.46IleVal: 2.46 ± 0.046	0.311IleTrp: 0.311 ± 0.012	0.43IleTyr: 0.43 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.806LysAla: 2.806 ± 0.055	0.12LysCys: 0.12 ± 0.008	1.351LysAsp: 1.351 ± 0.039	1.16LysGlu: 1.16 ± 0.029	0.451LysPhe: 0.451 ± 0.015	1.924LysGly: 1.924 ± 0.046	0.402LysHis: 0.402 ± 0.016	0.784LysIle: 0.784 ± 0.019	0.849LysLys: 0.849 ± 0.032	1.809LysLeu: 1.809 ± 0.036	0.37LysMet: 0.37 ± 0.015	0.502LysAsn: 0.502 ± 0.021	1.237LysPro: 1.237 ± 0.037	0.598LysGln: 0.598 ± 0.018	1.501LysArg: 1.501 ± 0.034	1.036LysSer: 1.036 ± 0.028	1.078LysThr: 1.078 ± 0.032	1.813LysVal: 1.813 ± 0.038	0.239LysTrp: 0.239 ± 0.012	0.397LysTyr: 0.397 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.183LeuAla: 16.183 ± 0.11	0.94LeuCys: 0.94 ± 0.026	6.674LeuAsp: 6.674 ± 0.072	4.859LeuGlu: 4.859 ± 0.053	2.663LeuPhe: 2.663 ± 0.046	9.675LeuGly: 9.675 ± 0.083	2.406LeuHis: 2.406 ± 0.035	2.791LeuIle: 2.791 ± 0.041	1.795LeuLys: 1.795 ± 0.034	11.831LeuLeu: 11.831 ± 0.126	1.585LeuMet: 1.585 ± 0.034	1.51LeuAsn: 1.51 ± 0.03	6.813LeuPro: 6.813 ± 0.073	1.939LeuGln: 1.939 ± 0.039	9.534LeuArg: 9.534 ± 0.086	4.948LeuSer: 4.948 ± 0.062	6.626LeuThr: 6.626 ± 0.073	9.042LeuVal: 9.042 ± 0.079	1.304LeuTrp: 1.304 ± 0.031	1.839LeuTyr: 1.839 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.283MetAla: 2.283 ± 0.04	0.144MetCys: 0.144 ± 0.009	0.906MetAsp: 0.906 ± 0.022	0.745MetGlu: 0.745 ± 0.019	0.434MetPhe: 0.434 ± 0.017	1.362MetGly: 1.362 ± 0.029	0.318MetHis: 0.318 ± 0.014	0.604MetIle: 0.604 ± 0.022	0.389MetLys: 0.389 ± 0.014	1.592MetLeu: 1.592 ± 0.036	0.293MetMet: 0.293 ± 0.013	0.425MetAsn: 0.425 ± 0.015	1.102MetPro: 1.102 ± 0.022	0.37MetGln: 0.37 ± 0.016	1.485MetArg: 1.485 ± 0.031	1.192MetSer: 1.192 ± 0.025	1.464MetThr: 1.464 ± 0.026	1.154MetVal: 1.154 ± 0.03	0.216MetTrp: 0.216 ± 0.011	0.292MetTyr: 0.292 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.103AsnAla: 2.103 ± 0.042	0.147AsnCys: 0.147 ± 0.009	0.852AsnAsp: 0.852 ± 0.023	0.721AsnGlu: 0.721 ± 0.02	0.435AsnPhe: 0.435 ± 0.017	1.721AsnGly: 1.721 ± 0.036	0.352AsnHis: 0.352 ± 0.014	0.541AsnIle: 0.541 ± 0.017	0.399AsnLys: 0.399 ± 0.015	1.498AsnLeu: 1.498 ± 0.032	0.266AsnMet: 0.266 ± 0.012	0.354AsnAsn: 0.354 ± 0.016	1.209AsnPro: 1.209 ± 0.028	0.423AsnGln: 0.423 ± 0.015	1.2AsnArg: 1.2 ± 0.026	0.779AsnSer: 0.779 ± 0.023	0.959AsnThr: 0.959 ± 0.027	1.292AsnVal: 1.292 ± 0.026	0.263AsnTrp: 0.263 ± 0.013	0.348AsnTyr: 0.348 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.775ProAla: 9.775 ± 0.106	0.41ProCys: 0.41 ± 0.017	4.424ProAsp: 4.424 ± 0.056	4.297ProGlu: 4.297 ± 0.062	1.575ProPhe: 1.575 ± 0.033	7.517ProGly: 7.517 ± 0.08	1.476ProHis: 1.476 ± 0.032	0.987ProIle: 0.987 ± 0.023	1.098ProLys: 1.098 ± 0.031	5.579ProLeu: 5.579 ± 0.063	0.972ProMet: 0.972 ± 0.025	0.785ProAsn: 0.785 ± 0.022	3.942ProPro: 3.942 ± 0.065	1.537ProGln: 1.537 ± 0.038	4.664ProArg: 4.664 ± 0.054	2.998ProSer: 2.998 ± 0.049	2.673ProThr: 2.673 ± 0.042	5.868ProVal: 5.868 ± 0.059	0.975ProTrp: 0.975 ± 0.026	1.437ProTyr: 1.437 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.162GlnAla: 3.162 ± 0.046	0.171GlnCys: 0.171 ± 0.011	1.242GlnAsp: 1.242 ± 0.032	1.307GlnGlu: 1.307 ± 0.027	0.606GlnPhe: 0.606 ± 0.02	2.039GlnGly: 2.039 ± 0.04	0.622GlnHis: 0.622 ± 0.019	0.897GlnIle: 0.897 ± 0.023	0.557GlnLys: 0.557 ± 0.019	2.664GlnLeu: 2.664 ± 0.041	0.427GlnMet: 0.427 ± 0.017	0.391GlnAsn: 0.391 ± 0.016	1.414GlnPro: 1.414 ± 0.031	1.057GlnGln: 1.057 ± 0.035	2.22GlnArg: 2.22 ± 0.036	1.015GlnSer: 1.015 ± 0.024	1.066GlnThr: 1.066 ± 0.026	1.982GlnVal: 1.982 ± 0.037	0.416GlnTrp: 0.416 ± 0.016	0.515GlnTyr: 0.515 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	11.44ArgAla: 11.44 ± 0.103	0.694ArgCys: 0.694 ± 0.021	4.573ArgAsp: 4.573 ± 0.052	5.259ArgGlu: 5.259 ± 0.067	2.453ArgPhe: 2.453 ± 0.041	6.478ArgGly: 6.478 ± 0.058	2.431ArgHis: 2.431 ± 0.04	3.073ArgIle: 3.073 ± 0.05	1.679ArgLys: 1.679 ± 0.038	9.786ArgLeu: 9.786 ± 0.085	1.846ArgMet: 1.846 ± 0.03	1.358ArgAsn: 1.358 ± 0.026	5.904ArgPro: 5.904 ± 0.07	2.249ArgGln: 2.249 ± 0.036	9.089ArgArg: 9.089 ± 0.098	3.996ArgSer: 3.996 ± 0.049	5.771ArgThr: 5.771 ± 0.056	6.399ArgVal: 6.399 ± 0.065	1.516ArgTrp: 1.516 ± 0.031	1.825ArgTyr: 1.825 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.382SerAla: 6.382 ± 0.065	0.422SerCys: 0.422 ± 0.017	2.24SerAsp: 2.24 ± 0.031	1.983SerGlu: 1.983 ± 0.035	1.522SerPhe: 1.522 ± 0.031	5.568SerGly: 5.568 ± 0.059	0.927SerHis: 0.927 ± 0.025	1.116SerIle: 1.116 ± 0.026	0.893SerLys: 0.893 ± 0.023	4.631SerLeu: 4.631 ± 0.049	0.897SerMet: 0.897 ± 0.023	0.715SerAsn: 0.715 ± 0.021	3.069SerPro: 3.069 ± 0.052	0.983SerGln: 0.983 ± 0.027	3.509SerArg: 3.509 ± 0.039	2.47SerSer: 2.47 ± 0.047	2.526SerThr: 2.526 ± 0.043	4.033SerVal: 4.033 ± 0.051	0.843SerTrp: 0.843 ± 0.022	1.094SerTyr: 1.094 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.96ThrAla: 8.96 ± 0.086	0.404ThrCys: 0.404 ± 0.018	3.327ThrAsp: 3.327 ± 0.041	2.988ThrGlu: 2.988 ± 0.048	1.522ThrPhe: 1.522 ± 0.032	6.831ThrGly: 6.831 ± 0.063	1.135ThrHis: 1.135 ± 0.025	1.43ThrIle: 1.43 ± 0.032	1.013ThrLys: 1.013 ± 0.027	5.37ThrLeu: 5.37 ± 0.062	0.857ThrMet: 0.857 ± 0.024	0.851ThrAsn: 0.851 ± 0.023	3.785ThrPro: 3.785 ± 0.057	1.07ThrGln: 1.07 ± 0.027	3.776ThrArg: 3.776 ± 0.053	2.735ThrSer: 2.735 ± 0.041	3.427ThrThr: 3.427 ± 0.057	6.022ThrVal: 6.022 ± 0.066	0.833ThrTrp: 0.833 ± 0.026	1.243ThrTyr: 1.243 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.222ValAla: 11.222 ± 0.087	0.813ValCys: 0.813 ± 0.019	4.603ValAsp: 4.603 ± 0.053	4.822ValGlu: 4.822 ± 0.055	2.407ValPhe: 2.407 ± 0.045	6.525ValGly: 6.525 ± 0.073	2.118ValHis: 2.118 ± 0.034	2.542ValIle: 2.542 ± 0.043	1.665ValLys: 1.665 ± 0.037	10.127ValLeu: 10.127 ± 0.088	1.409ValMet: 1.409 ± 0.033	1.575ValAsn: 1.575 ± 0.034	5.619ValPro: 5.619 ± 0.055	1.897ValGln: 1.897 ± 0.034	7.95ValArg: 7.95 ± 0.066	4.023ValSer: 4.023 ± 0.054	5.586ValThr: 5.586 ± 0.059	8.41ValVal: 8.41 ± 0.094	1.151ValTrp: 1.151 ± 0.025	1.505ValTyr: 1.505 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.751TrpAla: 1.751 ± 0.035	0.178TrpCys: 0.178 ± 0.011	0.822TrpAsp: 0.822 ± 0.021	0.741TrpGlu: 0.741 ± 0.021	0.502TrpPhe: 0.502 ± 0.019	1.087TrpGly: 1.087 ± 0.03	0.374TrpHis: 0.374 ± 0.017	0.544TrpIle: 0.544 ± 0.018	0.359TrpLys: 0.359 ± 0.015	1.775TrpLeu: 1.775 ± 0.036	0.273TrpMet: 0.273 ± 0.013	0.357TrpAsn: 0.357 ± 0.016	0.79TrpPro: 0.79 ± 0.025	0.528TrpGln: 0.528 ± 0.017	1.473TrpArg: 1.473 ± 0.035	0.842TrpSer: 0.842 ± 0.024	1.065TrpThr: 1.065 ± 0.027	0.932TrpVal: 0.932 ± 0.022	0.344TrpTrp: 0.344 ± 0.016	0.326TrpTyr: 0.326 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.822TyrAla: 2.822 ± 0.042	0.183TyrCys: 0.183 ± 0.011	1.315TyrAsp: 1.315 ± 0.031	1.235TyrGlu: 1.235 ± 0.028	0.585TyrPhe: 0.585 ± 0.017	2.216TyrGly: 2.216 ± 0.034	0.421TyrHis: 0.421 ± 0.015	0.418TyrIle: 0.418 ± 0.016	0.366TyrLys: 0.366 ± 0.015	2.031TyrLeu: 2.031 ± 0.041	0.231TyrMet: 0.231 ± 0.012	0.345TyrAsn: 0.345 ± 0.015	1.05TyrPro: 1.05 ± 0.025	0.494TyrGln: 0.494 ± 0.017	1.906TyrArg: 1.906 ± 0.032	0.83TyrSer: 0.83 ± 0.025	1.074TyrThr: 1.074 ± 0.023	1.602TyrVal: 1.602 ± 0.033	0.323TyrTrp: 0.323 ± 0.013	0.402TyrTyr: 0.402 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5460 proteins (1788902 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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