Amino acid dipepetide frequency for Dokdonia sp. (strain 4H-3-7-5) (Krokinobacter sp. (strain 4H-3-7-5))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.331AlaAla: 5.331 ± 0.1	0.567AlaCys: 0.567 ± 0.024	3.859AlaAsp: 3.859 ± 0.104	4.001AlaGlu: 4.001 ± 0.074	3.685AlaPhe: 3.685 ± 0.065	5.107AlaGly: 5.107 ± 0.098	1.326AlaHis: 1.326 ± 0.039	6.074AlaIle: 6.074 ± 0.114	4.546AlaLys: 4.546 ± 0.097	6.943AlaLeu: 6.943 ± 0.101	1.826AlaMet: 1.826 ± 0.052	3.177AlaAsn: 3.177 ± 0.065	2.24AlaPro: 2.24 ± 0.063	3.149AlaGln: 3.149 ± 0.06	2.568AlaArg: 2.568 ± 0.055	4.89AlaSer: 4.89 ± 0.078	4.92AlaThr: 4.92 ± 0.11	4.77AlaVal: 4.77 ± 0.119	0.606AlaTrp: 0.606 ± 0.027	2.709AlaTyr: 2.709 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.501CysAla: 0.501 ± 0.023	0.088CysCys: 0.088 ± 0.009	0.493CysAsp: 0.493 ± 0.033	0.446CysGlu: 0.446 ± 0.024	0.325CysPhe: 0.325 ± 0.019	0.567CysGly: 0.567 ± 0.027	0.163CysHis: 0.163 ± 0.014	0.495CysIle: 0.495 ± 0.022	0.419CysLys: 0.419 ± 0.022	0.582CysLeu: 0.582 ± 0.027	0.139CysMet: 0.139 ± 0.011	0.354CysAsn: 0.354 ± 0.017	0.303CysPro: 0.303 ± 0.022	0.175CysGln: 0.175 ± 0.014	0.189CysArg: 0.189 ± 0.014	0.514CysSer: 0.514 ± 0.029	0.451CysThr: 0.451 ± 0.022	0.456CysVal: 0.456 ± 0.021	0.058CysTrp: 0.058 ± 0.007	0.264CysTyr: 0.264 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.713AspAla: 4.713 ± 0.123	0.42AspCys: 0.42 ± 0.027	3.495AspAsp: 3.495 ± 0.105	3.999AspGlu: 3.999 ± 0.08	3.601AspPhe: 3.601 ± 0.071	4.676AspGly: 4.676 ± 0.165	0.982AspHis: 0.982 ± 0.035	4.596AspIle: 4.596 ± 0.073	3.808AspLys: 3.808 ± 0.073	5.166AspLeu: 5.166 ± 0.084	1.259AspMet: 1.259 ± 0.036	3.385AspAsn: 3.385 ± 0.067	2.057AspPro: 2.057 ± 0.098	1.721AspGln: 1.721 ± 0.046	2.186AspArg: 2.186 ± 0.052	3.238AspSer: 3.238 ± 0.073	3.524AspThr: 3.524 ± 0.114	4.21AspVal: 4.21 ± 0.106	0.716AspTrp: 0.716 ± 0.031	2.859AspTyr: 2.859 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.65GluAla: 4.65 ± 0.085	0.32GluCys: 0.32 ± 0.018	4.195GluAsp: 4.195 ± 0.092	5.114GluGlu: 5.114 ± 0.091	2.702GluPhe: 2.702 ± 0.057	4.135GluGly: 4.135 ± 0.076	1.231GluHis: 1.231 ± 0.04	5.215GluIle: 5.215 ± 0.076	4.871GluLys: 4.871 ± 0.086	5.925GluLeu: 5.925 ± 0.087	1.648GluMet: 1.648 ± 0.039	4.133GluAsn: 4.133 ± 0.086	1.596GluPro: 1.596 ± 0.044	2.453GluGln: 2.453 ± 0.051	2.902GluArg: 2.902 ± 0.061	3.337GluSer: 3.337 ± 0.068	3.816GluThr: 3.816 ± 0.086	4.707GluVal: 4.707 ± 0.064	0.584GluTrp: 0.584 ± 0.025	2.237GluTyr: 2.237 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.355PheAla: 3.355 ± 0.062	0.375PheCys: 0.375 ± 0.021	3.331PheAsp: 3.331 ± 0.057	3.309PheGlu: 3.309 ± 0.06	2.442PhePhe: 2.442 ± 0.063	3.408PheGly: 3.408 ± 0.069	0.752PheHis: 0.752 ± 0.03	3.685PheIle: 3.685 ± 0.071	3.377PheLys: 3.377 ± 0.059	4.28PheLeu: 4.28 ± 0.08	1.11PheMet: 1.11 ± 0.036	2.906PheAsn: 2.906 ± 0.055	1.684PhePro: 1.684 ± 0.046	1.456PheGln: 1.456 ± 0.043	1.581PheArg: 1.581 ± 0.041	3.435PheSer: 3.435 ± 0.064	3.401PheThr: 3.401 ± 0.068	2.89PheVal: 2.89 ± 0.065	0.519PheTrp: 0.519 ± 0.024	2.007PheTyr: 2.007 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.028GlyAla: 5.028 ± 0.095	0.557GlyCys: 0.557 ± 0.029	4.174GlyAsp: 4.174 ± 0.111	3.808GlyGlu: 3.808 ± 0.079	3.528GlyPhe: 3.528 ± 0.066	4.852GlyGly: 4.852 ± 0.111	1.177GlyHis: 1.177 ± 0.037	5.195GlyIle: 5.195 ± 0.081	4.505GlyLys: 4.505 ± 0.085	5.883GlyLeu: 5.883 ± 0.095	1.726GlyMet: 1.726 ± 0.048	3.653GlyAsn: 3.653 ± 0.093	1.44GlyPro: 1.44 ± 0.054	1.978GlyGln: 1.978 ± 0.042	2.315GlyArg: 2.315 ± 0.058	4.048GlySer: 4.048 ± 0.068	4.564GlyThr: 4.564 ± 0.129	4.892GlyVal: 4.892 ± 0.08	0.741GlyTrp: 0.741 ± 0.026	2.759GlyTyr: 2.759 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.998HisAla: 0.998 ± 0.033	0.185HisCys: 0.185 ± 0.015	0.862HisAsp: 0.862 ± 0.031	0.943HisGlu: 0.943 ± 0.035	1.069HisPhe: 1.069 ± 0.031	1.007HisGly: 1.007 ± 0.037	0.441HisHis: 0.441 ± 0.023	1.478HisIle: 1.478 ± 0.039	1.206HisLys: 1.206 ± 0.038	1.899HisLeu: 1.899 ± 0.049	0.33HisMet: 0.33 ± 0.02	0.889HisAsn: 0.889 ± 0.031	0.837HisPro: 0.837 ± 0.027	0.647HisGln: 0.647 ± 0.029	0.678HisArg: 0.678 ± 0.027	0.992HisSer: 0.992 ± 0.035	1.059HisThr: 1.059 ± 0.034	0.931HisVal: 0.931 ± 0.034	0.228HisTrp: 0.228 ± 0.017	0.824HisTyr: 0.824 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.331IleAla: 6.331 ± 0.108	0.56IleCys: 0.56 ± 0.026	4.976IleAsp: 4.976 ± 0.077	4.984IleGlu: 4.984 ± 0.078	3.342IlePhe: 3.342 ± 0.06	4.912IleGly: 4.912 ± 0.086	1.264IleHis: 1.264 ± 0.039	5.719IleIle: 5.719 ± 0.095	5.139IleLys: 5.139 ± 0.07	6.643IleLeu: 6.643 ± 0.11	1.278IleMet: 1.278 ± 0.039	4.242IleAsn: 4.242 ± 0.085	3.17IlePro: 3.17 ± 0.078	2.311IleGln: 2.311 ± 0.048	2.405IleArg: 2.405 ± 0.046	5.028IleSer: 5.028 ± 0.074	5.42IleThr: 5.42 ± 0.105	4.777IleVal: 4.777 ± 0.063	0.609IleTrp: 0.609 ± 0.023	2.625IleTyr: 2.625 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.065LysAla: 5.065 ± 0.097	0.276LysCys: 0.276 ± 0.018	4.101LysAsp: 4.101 ± 0.067	5.849LysGlu: 5.849 ± 0.095	2.469LysPhe: 2.469 ± 0.055	4.137LysGly: 4.137 ± 0.081	1.19LysHis: 1.19 ± 0.035	4.675LysIle: 4.675 ± 0.074	5.73LysLys: 5.73 ± 0.104	5.696LysLeu: 5.696 ± 0.091	1.822LysMet: 1.822 ± 0.046	4.061LysAsn: 4.061 ± 0.064	2.135LysPro: 2.135 ± 0.047	2.379LysGln: 2.379 ± 0.053	3.025LysArg: 3.025 ± 0.062	3.99LysSer: 3.99 ± 0.07	4.067LysThr: 4.067 ± 0.069	4.185LysVal: 4.185 ± 0.081	0.67LysTrp: 0.67 ± 0.03	2.502LysTyr: 2.502 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.33LeuAla: 6.33 ± 0.092	0.67LeuCys: 0.67 ± 0.025	5.646LeuAsp: 5.646 ± 0.081	6.004LeuGlu: 6.004 ± 0.09	4.515LeuPhe: 4.515 ± 0.078	6.033LeuGly: 6.033 ± 0.085	1.545LeuHis: 1.545 ± 0.044	6.416LeuIle: 6.416 ± 0.105	6.549LeuLys: 6.549 ± 0.101	8.764LeuLeu: 8.764 ± 0.133	2.084LeuMet: 2.084 ± 0.056	4.76LeuAsn: 4.76 ± 0.075	3.48LeuPro: 3.48 ± 0.05	3.236LeuGln: 3.236 ± 0.063	3.613LeuArg: 3.613 ± 0.063	6.864LeuSer: 6.864 ± 0.103	5.252LeuThr: 5.252 ± 0.099	5.611LeuVal: 5.611 ± 0.086	0.791LeuTrp: 0.791 ± 0.027	3.1LeuTyr: 3.1 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.663MetAla: 1.663 ± 0.042	0.145MetCys: 0.145 ± 0.011	1.271MetAsp: 1.271 ± 0.037	1.41MetGlu: 1.41 ± 0.042	0.781MetPhe: 0.781 ± 0.029	1.477MetGly: 1.477 ± 0.044	0.41MetHis: 0.41 ± 0.022	1.572MetIle: 1.572 ± 0.041	1.98MetLys: 1.98 ± 0.045	2.054MetLeu: 2.054 ± 0.055	0.699MetMet: 0.699 ± 0.032	1.188MetAsn: 1.188 ± 0.039	0.854MetPro: 0.854 ± 0.027	0.819MetGln: 0.819 ± 0.031	1.023MetArg: 1.023 ± 0.028	1.538MetSer: 1.538 ± 0.043	1.307MetThr: 1.307 ± 0.036	1.378MetVal: 1.378 ± 0.043	0.165MetTrp: 0.165 ± 0.013	0.751MetTyr: 0.751 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.925AsnAla: 3.925 ± 0.091	0.363AsnCys: 0.363 ± 0.019	3.328AsnAsp: 3.328 ± 0.096	3.555AsnGlu: 3.555 ± 0.112	2.597AsnPhe: 2.597 ± 0.055	3.897AsnGly: 3.897 ± 0.115	0.96AsnHis: 0.96 ± 0.033	4.128AsnIle: 4.128 ± 0.084	3.515AsnLys: 3.515 ± 0.067	4.657AsnLeu: 4.657 ± 0.083	1.156AsnMet: 1.156 ± 0.033	3.312AsnAsn: 3.312 ± 0.098	2.609AsnPro: 2.609 ± 0.064	1.859AsnGln: 1.859 ± 0.055	2.11AsnArg: 2.11 ± 0.045	3.135AsnSer: 3.135 ± 0.062	3.596AsnThr: 3.596 ± 0.077	3.445AsnVal: 3.445 ± 0.078	0.655AsnTrp: 0.655 ± 0.026	2.443AsnTyr: 2.443 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.39ProAla: 2.39 ± 0.064	0.229ProCys: 0.229 ± 0.023	2.245ProAsp: 2.245 ± 0.06	2.905ProGlu: 2.905 ± 0.06	1.855ProPhe: 1.855 ± 0.05	1.954ProGly: 1.954 ± 0.062	0.601ProHis: 0.601 ± 0.025	2.524ProIle: 2.524 ± 0.048	2.15ProLys: 2.15 ± 0.052	3.089ProLeu: 3.089 ± 0.056	0.743ProMet: 0.743 ± 0.027	1.89ProAsn: 1.89 ± 0.05	0.85ProPro: 0.85 ± 0.033	1.315ProGln: 1.315 ± 0.046	1.039ProArg: 1.039 ± 0.033	2.331ProSer: 2.331 ± 0.054	2.2ProThr: 2.2 ± 0.071	2.482ProVal: 2.482 ± 0.065	0.336ProTrp: 0.336 ± 0.019	1.406ProTyr: 1.406 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.352GlnAla: 2.352 ± 0.057	0.169GlnCys: 0.169 ± 0.012	1.964GlnAsp: 1.964 ± 0.053	2.769GlnGlu: 2.769 ± 0.058	1.599GlnPhe: 1.599 ± 0.043	2.107GlnGly: 2.107 ± 0.046	0.636GlnHis: 0.636 ± 0.028	2.469GlnIle: 2.469 ± 0.053	2.365GlnLys: 2.365 ± 0.059	3.561GlnLeu: 3.561 ± 0.063	0.864GlnMet: 0.864 ± 0.031	1.78GlnAsn: 1.78 ± 0.069	1.133GlnPro: 1.133 ± 0.04	1.504GlnGln: 1.504 ± 0.048	1.425GlnArg: 1.425 ± 0.039	1.974GlnSer: 1.974 ± 0.048	1.904GlnThr: 1.904 ± 0.052	2.277GlnVal: 2.277 ± 0.049	0.384GlnTrp: 0.384 ± 0.021	1.282GlnTyr: 1.282 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.494ArgAla: 2.494 ± 0.059	0.191ArgCys: 0.191 ± 0.013	2.23ArgAsp: 2.23 ± 0.054	2.516ArgGlu: 2.516 ± 0.056	2.135ArgPhe: 2.135 ± 0.052	2.217ArgGly: 2.217 ± 0.048	0.612ArgHis: 0.612 ± 0.025	2.917ArgIle: 2.917 ± 0.055	2.834ArgLys: 2.834 ± 0.066	3.498ArgLeu: 3.498 ± 0.068	0.892ArgMet: 0.892 ± 0.032	2.203ArgAsn: 2.203 ± 0.051	1.222ArgPro: 1.222 ± 0.038	1.163ArgGln: 1.163 ± 0.038	1.487ArgArg: 1.487 ± 0.048	2.209ArgSer: 2.209 ± 0.051	2.081ArgThr: 2.081 ± 0.045	2.414ArgVal: 2.414 ± 0.049	0.386ArgTrp: 0.386 ± 0.023	1.614ArgTyr: 1.614 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.115SerAla: 4.115 ± 0.072	0.658SerCys: 0.658 ± 0.024	3.639SerAsp: 3.639 ± 0.086	3.615SerGlu: 3.615 ± 0.062	3.605SerPhe: 3.605 ± 0.066	4.544SerGly: 4.544 ± 0.081	1.082SerHis: 1.082 ± 0.033	4.908SerIle: 4.908 ± 0.071	4.224SerLys: 4.224 ± 0.077	6.169SerLeu: 6.169 ± 0.09	1.309SerMet: 1.309 ± 0.034	3.453SerAsn: 3.453 ± 0.072	2.14SerPro: 2.14 ± 0.05	2.311SerGln: 2.311 ± 0.053	2.439SerArg: 2.439 ± 0.054	4.228SerSer: 4.228 ± 0.084	3.762SerThr: 3.762 ± 0.074	3.843SerVal: 3.843 ± 0.064	0.698SerTrp: 0.698 ± 0.029	2.777SerTyr: 2.777 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.778ThrAla: 4.778 ± 0.11	0.344ThrCys: 0.344 ± 0.019	3.795ThrAsp: 3.795 ± 0.097	3.603ThrGlu: 3.603 ± 0.058	3.194ThrPhe: 3.194 ± 0.063	4.318ThrGly: 4.318 ± 0.106	1.051ThrHis: 1.051 ± 0.034	5.239ThrIle: 5.239 ± 0.138	3.401ThrLys: 3.401 ± 0.056	5.898ThrLeu: 5.898 ± 0.087	1.149ThrMet: 1.149 ± 0.035	3.143ThrAsn: 3.143 ± 0.095	2.831ThrPro: 2.831 ± 0.084	2.15ThrGln: 2.15 ± 0.079	1.936ThrArg: 1.936 ± 0.047	4.191ThrSer: 4.191 ± 0.08	4.561ThrThr: 4.561 ± 0.168	4.728ThrVal: 4.728 ± 0.216	0.564ThrTrp: 0.564 ± 0.027	2.582ThrTyr: 2.582 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	5.103ValAla: 5.103 ± 0.081	0.479ValCys: 0.479 ± 0.022	3.991ValAsp: 3.991 ± 0.078	3.894ValGlu: 3.894 ± 0.075	3.161ValPhe: 3.161 ± 0.068	4.224ValGly: 4.224 ± 0.078	1.076ValHis: 1.076 ± 0.035	5.153ValIle: 5.153 ± 0.075	3.916ValLys: 3.916 ± 0.071	6.072ValLeu: 6.072 ± 0.088	1.442ValMet: 1.442 ± 0.04	3.592ValAsn: 3.592 ± 0.083	2.34ValPro: 2.34 ± 0.051	2.159ValGln: 2.159 ± 0.052	2.314ValArg: 2.314 ± 0.053	4.543ValSer: 4.543 ± 0.08	4.629ValThr: 4.629 ± 0.219	4.733ValVal: 4.733 ± 0.097	0.613ValTrp: 0.613 ± 0.024	2.227ValTyr: 2.227 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.573TrpAla: 0.573 ± 0.022	0.085TrpCys: 0.085 ± 0.009	0.58TrpAsp: 0.58 ± 0.027	0.645TrpGlu: 0.645 ± 0.026	0.501TrpPhe: 0.501 ± 0.023	0.623TrpGly: 0.623 ± 0.028	0.204TrpHis: 0.204 ± 0.014	0.737TrpIle: 0.737 ± 0.028	0.723TrpLys: 0.723 ± 0.03	0.917TrpLeu: 0.917 ± 0.031	0.312TrpMet: 0.312 ± 0.017	0.668TrpAsn: 0.668 ± 0.031	0.232TrpPro: 0.232 ± 0.017	0.368TrpGln: 0.368 ± 0.019	0.412TrpArg: 0.412 ± 0.025	0.645TrpSer: 0.645 ± 0.03	0.504TrpThr: 0.504 ± 0.024	0.595TrpVal: 0.595 ± 0.024	0.148TrpTrp: 0.148 ± 0.013	0.421TrpTyr: 0.421 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.599TyrAla: 2.599 ± 0.052	0.304TyrCys: 0.304 ± 0.017	2.434TyrAsp: 2.434 ± 0.05	2.403TyrGlu: 2.403 ± 0.052	2.197TyrPhe: 2.197 ± 0.045	2.629TyrGly: 2.629 ± 0.058	0.801TyrHis: 0.801 ± 0.028	2.539TyrIle: 2.539 ± 0.046	2.765TyrLys: 2.765 ± 0.063	3.565TyrLeu: 3.565 ± 0.07	0.695TyrMet: 0.695 ± 0.025	2.458TyrAsn: 2.458 ± 0.071	1.384TyrPro: 1.384 ± 0.038	1.365TyrGln: 1.365 ± 0.042	1.669TyrArg: 1.669 ± 0.042	2.385TyrSer: 2.385 ± 0.058	2.437TyrThr: 2.437 ± 0.062	2.338TyrVal: 2.338 ± 0.049	0.422TyrTrp: 0.422 ± 0.021	1.678TyrTyr: 1.678 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2978 proteins (1016983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---