Amino acid dipepetide frequency for Anhanga virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.066AlaAla: 5.066 ± 4.103
2.533AlaCys: 2.533 ± 0.68
1.773AlaAsp: 1.773 ± 0.575
3.293AlaGlu: 3.293 ± 0.513
2.786AlaPhe: 2.786 ± 0.981
1.773AlaGly: 1.773 ± 0.345
2.026AlaHis: 2.026 ± 1.142
4.053AlaIle: 4.053 ± 1.22
1.773AlaLys: 1.773 ± 0.643
4.559AlaLeu: 4.559 ± 1.2
2.28AlaMet: 2.28 ± 1.146
1.773AlaAsn: 1.773 ± 0.919
1.773AlaPro: 1.773 ± 0.394
1.52AlaGln: 1.52 ± 0.464
3.293AlaArg: 3.293 ± 1.213
4.559AlaSer: 4.559 ± 0.824
2.026AlaThr: 2.026 ± 0.72
2.786AlaVal: 2.786 ± 0.639
0.507AlaTrp: 0.507 ± 0.552
1.52AlaTyr: 1.52 ± 1.116
0.0AlaXaa: 0.0 ± 0.0
Cys
1.013CysAla: 1.013 ± 0.382
0.76CysCys: 0.76 ± 0.49
0.507CysAsp: 0.507 ± 0.155
0.76CysGlu: 0.76 ± 0.223
1.773CysPhe: 1.773 ± 0.643
1.013CysGly: 1.013 ± 0.572
0.76CysHis: 0.76 ± 0.449
1.266CysIle: 1.266 ± 0.494
2.533CysLys: 2.533 ± 0.695
2.28CysLeu: 2.28 ± 0.9
1.013CysMet: 1.013 ± 0.309
1.013CysAsn: 1.013 ± 0.359
1.013CysPro: 1.013 ± 0.309
3.04CysGln: 3.04 ± 1.001
1.773CysArg: 1.773 ± 0.922
4.053CysSer: 4.053 ± 2.286
1.52CysThr: 1.52 ± 0.446
1.013CysVal: 1.013 ± 0.514
0.253CysTrp: 0.253 ± 0.227
1.013CysTyr: 1.013 ± 0.514
0.0CysXaa: 0.0 ± 0.0
Asp
3.293AspAla: 3.293 ± 0.332
1.52AspCys: 1.52 ± 0.464
5.826AspAsp: 5.826 ± 1.108
5.572AspGlu: 5.572 ± 1.955
1.52AspPhe: 1.52 ± 0.979
3.799AspGly: 3.799 ± 1.25
1.52AspHis: 1.52 ± 0.312
4.306AspIle: 4.306 ± 0.651
4.306AspLys: 4.306 ± 1.308
4.559AspLeu: 4.559 ± 1.444
1.013AspMet: 1.013 ± 0.653
3.546AspAsn: 3.546 ± 0.957
2.28AspPro: 2.28 ± 0.502
1.52AspGln: 1.52 ± 0.337
2.786AspArg: 2.786 ± 0.656
4.306AspSer: 4.306 ± 1.848
1.773AspThr: 1.773 ± 0.575
3.799AspVal: 3.799 ± 1.312
1.013AspTrp: 1.013 ± 0.43
0.76AspTyr: 0.76 ± 0.352
0.0AspXaa: 0.0 ± 0.0
Glu
3.546GluAla: 3.546 ± 1.209
2.786GluCys: 2.786 ± 1.493
3.293GluAsp: 3.293 ± 0.539
5.319GluGlu: 5.319 ± 1.944
4.053GluPhe: 4.053 ± 1.699
5.066GluGly: 5.066 ± 0.977
0.76GluHis: 0.76 ± 0.223
3.799GluIle: 3.799 ± 0.943
3.799GluLys: 3.799 ± 1.076
6.332GluLeu: 6.332 ± 2.205
4.306GluMet: 4.306 ± 1.044
2.786GluAsn: 2.786 ± 0.787
1.266GluPro: 1.266 ± 0.393
1.013GluGln: 1.013 ± 0.309
5.319GluArg: 5.319 ± 1.208
4.813GluSer: 4.813 ± 0.336
2.786GluThr: 2.786 ± 0.495
4.813GluVal: 4.813 ± 0.979
0.507GluTrp: 0.507 ± 0.326
1.773GluTyr: 1.773 ± 1.017
0.0GluXaa: 0.0 ± 0.0
Phe
2.28PheAla: 2.28 ± 1.436
0.76PheCys: 0.76 ± 0.352
4.053PheAsp: 4.053 ± 1.024
2.28PheGlu: 2.28 ± 0.904
2.28PhePhe: 2.28 ± 0.305
1.266PheGly: 1.266 ± 0.437
0.76PheHis: 0.76 ± 1.025
2.786PheIle: 2.786 ± 1.445
5.319PheLys: 5.319 ± 1.208
4.053PheLeu: 4.053 ± 0.843
1.013PheMet: 1.013 ± 0.309
2.28PheAsn: 2.28 ± 0.638
2.026PhePro: 2.026 ± 0.861
0.76PheGln: 0.76 ± 0.223
1.266PheArg: 1.266 ± 0.511
5.066PheSer: 5.066 ± 1.074
1.52PheThr: 1.52 ± 0.669
3.293PheVal: 3.293 ± 1.227
0.76PheTrp: 0.76 ± 0.352
1.013PheTyr: 1.013 ± 0.54
0.0PheXaa: 0.0 ± 0.0
Gly
2.533GlyAla: 2.533 ± 0.391
1.013GlyCys: 1.013 ± 0.309
4.306GlyAsp: 4.306 ± 1.107
3.799GlyGlu: 3.799 ± 1.116
3.546GlyPhe: 3.546 ± 0.934
5.572GlyGly: 5.572 ± 0.417
1.52GlyHis: 1.52 ± 0.669
3.546GlyIle: 3.546 ± 0.289
3.546GlyLys: 3.546 ± 0.98
3.799GlyLeu: 3.799 ± 0.693
1.013GlyMet: 1.013 ± 0.333
2.533GlyAsn: 2.533 ± 0.338
1.773GlyPro: 1.773 ± 0.307
1.266GlyGln: 1.266 ± 1.133
3.04GlyArg: 3.04 ± 1.587
7.092GlySer: 7.092 ± 2.349
1.773GlyThr: 1.773 ± 1.034
4.053GlyVal: 4.053 ± 0.604
0.76GlyTrp: 0.76 ± 0.68
2.533GlyTyr: 2.533 ± 1.128
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 0.494
0.76HisCys: 0.76 ± 0.223
1.266HisAsp: 1.266 ± 0.348
1.266HisGlu: 1.266 ± 0.378
1.52HisPhe: 1.52 ± 0.312
1.773HisGly: 1.773 ± 0.848
0.507HisHis: 0.507 ± 0.491
2.026HisIle: 2.026 ± 0.674
2.026HisLys: 2.026 ± 1.143
1.773HisLeu: 1.773 ± 0.643
0.253HisMet: 0.253 ± 0.227
1.266HisAsn: 1.266 ± 0.378
0.76HisPro: 0.76 ± 0.558
1.266HisGln: 1.266 ± 0.348
0.76HisArg: 0.76 ± 0.223
1.773HisSer: 1.773 ± 0.373
1.013HisThr: 1.013 ± 0.359
1.52HisVal: 1.52 ± 0.669
0.253HisTrp: 0.253 ± 0.545
1.266HisTyr: 1.266 ± 0.348
0.0HisXaa: 0.0 ± 0.0
Ile
3.799IleAla: 3.799 ± 1.226
0.76IleCys: 0.76 ± 0.449
4.306IleAsp: 4.306 ± 0.857
5.319IleGlu: 5.319 ± 0.399
2.786IlePhe: 2.786 ± 0.804
2.786IleGly: 2.786 ± 0.783
2.533IleHis: 2.533 ± 0.774
5.826IleIle: 5.826 ± 1.616
4.559IleLys: 4.559 ± 1.586
5.066IleLeu: 5.066 ± 0.497
1.013IleMet: 1.013 ± 0.653
3.546IleAsn: 3.546 ± 1.971
3.293IlePro: 3.293 ± 1.098
1.52IleGln: 1.52 ± 1.321
5.572IleArg: 5.572 ± 0.54
6.079IleSer: 6.079 ± 0.62
4.053IleThr: 4.053 ± 1.689
5.066IleVal: 5.066 ± 0.892
0.76IleTrp: 0.76 ± 0.223
2.28IleTyr: 2.28 ± 0.67
0.0IleXaa: 0.0 ± 0.0
Lys
3.293LysAla: 3.293 ± 0.831
1.773LysCys: 1.773 ± 0.922
4.053LysAsp: 4.053 ± 1.239
5.319LysGlu: 5.319 ± 0.959
1.773LysPhe: 1.773 ± 0.828
3.293LysGly: 3.293 ± 1.625
2.28LysHis: 2.28 ± 0.793
6.839LysIle: 6.839 ± 1.678
3.546LysLys: 3.546 ± 1.278
7.345LysLeu: 7.345 ± 0.966
3.293LysMet: 3.293 ± 1.974
2.786LysAsn: 2.786 ± 0.787
2.28LysPro: 2.28 ± 2.182
2.28LysGln: 2.28 ± 0.793
2.28LysArg: 2.28 ± 1.2
6.079LysSer: 6.079 ± 0.571
3.04LysThr: 3.04 ± 0.893
3.293LysVal: 3.293 ± 0.94
1.013LysTrp: 1.013 ± 0.609
1.773LysTyr: 1.773 ± 0.49
0.0LysXaa: 0.0 ± 0.0
Leu
3.546LeuAla: 3.546 ± 1.284
2.786LeuCys: 2.786 ± 0.374
3.546LeuAsp: 3.546 ± 1.339
5.826LeuGlu: 5.826 ± 0.691
4.053LeuPhe: 4.053 ± 1.223
4.053LeuGly: 4.053 ± 0.604
1.773LeuHis: 1.773 ± 0.575
6.332LeuIle: 6.332 ± 1.628
6.839LeuLys: 6.839 ± 1.63
6.332LeuLeu: 6.332 ± 1.345
3.04LeuMet: 3.04 ± 0.491
3.293LeuAsn: 3.293 ± 0.781
2.026LeuPro: 2.026 ± 0.38
3.04LeuGln: 3.04 ± 0.434
6.586LeuArg: 6.586 ± 1.324
9.878LeuSer: 9.878 ± 2.459
5.826LeuThr: 5.826 ± 1.306
4.306LeuVal: 4.306 ± 0.702
0.0LeuTrp: 0.0 ± 0.0
1.773LeuTyr: 1.773 ± 0.828
0.0LeuXaa: 0.0 ± 0.0
Met
1.013MetAla: 1.013 ± 0.382
0.76MetCys: 0.76 ± 0.49
2.28MetAsp: 2.28 ± 1.618
1.773MetGlu: 1.773 ± 0.575
1.773MetPhe: 1.773 ± 0.575
3.04MetGly: 3.04 ± 0.491
1.773MetHis: 1.773 ± 0.628
2.28MetIle: 2.28 ± 0.543
1.266MetLys: 1.266 ± 0.629
2.533MetLeu: 2.533 ± 1.752
2.786MetMet: 2.786 ± 0.965
1.773MetAsn: 1.773 ± 0.345
0.253MetPro: 0.253 ± 0.592
1.773MetGln: 1.773 ± 0.575
1.013MetArg: 1.013 ± 0.43
3.04MetSer: 3.04 ± 1.608
1.773MetThr: 1.773 ± 0.575
1.52MetVal: 1.52 ± 0.669
0.507MetTrp: 0.507 ± 0.155
0.507MetTyr: 0.507 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
1.266AsnAla: 1.266 ± 0.437
1.013AsnCys: 1.013 ± 0.572
1.52AsnAsp: 1.52 ± 0.669
3.04AsnGlu: 3.04 ± 0.928
2.026AsnPhe: 2.026 ± 0.421
2.533AsnGly: 2.533 ± 0.911
0.76AsnHis: 0.76 ± 0.223
2.533AsnIle: 2.533 ± 0.377
2.28AsnLys: 2.28 ± 0.865
4.053AsnLeu: 4.053 ± 1.239
0.76AsnMet: 0.76 ± 0.223
1.773AsnAsn: 1.773 ± 0.394
3.293AsnPro: 3.293 ± 1.017
1.266AsnGln: 1.266 ± 0.348
3.293AsnArg: 3.293 ± 1.148
3.799AsnSer: 3.799 ± 0.726
1.773AsnThr: 1.773 ± 0.643
1.773AsnVal: 1.773 ± 0.969
0.507AsnTrp: 0.507 ± 0.557
2.786AsnTyr: 2.786 ± 1.8
0.0AsnXaa: 0.0 ± 0.0
Pro
1.773ProAla: 1.773 ± 0.575
0.76ProCys: 0.76 ± 0.223
2.533ProAsp: 2.533 ± 1.071
3.293ProGlu: 3.293 ± 1.092
1.773ProPhe: 1.773 ± 0.922
3.04ProGly: 3.04 ± 0.862
0.507ProHis: 0.507 ± 0.326
1.266ProIle: 1.266 ± 0.494
1.266ProLys: 1.266 ± 0.629
2.533ProLeu: 2.533 ± 0.377
1.266ProMet: 1.266 ± 0.765
0.76ProAsn: 0.76 ± 0.223
1.013ProPro: 1.013 ± 0.986
1.266ProGln: 1.266 ± 1.05
1.773ProArg: 1.773 ± 0.753
3.04ProSer: 3.04 ± 1.955
2.28ProThr: 2.28 ± 0.742
2.28ProVal: 2.28 ± 1.656
0.76ProTrp: 0.76 ± 0.49
1.013ProTyr: 1.013 ± 0.359
0.0ProXaa: 0.0 ± 0.0
Gln
2.026GlnAla: 2.026 ± 0.3
2.533GlnCys: 2.533 ± 0.642
1.013GlnAsp: 1.013 ± 0.309
1.773GlnGlu: 1.773 ± 0.643
1.013GlnPhe: 1.013 ± 0.514
2.533GlnGly: 2.533 ± 0.418
1.266GlnHis: 1.266 ± 0.511
2.533GlnIle: 2.533 ± 1.313
1.52GlnLys: 1.52 ± 0.669
2.28GlnLeu: 2.28 ± 1.046
1.013GlnMet: 1.013 ± 0.359
1.013GlnAsn: 1.013 ± 0.309
0.76GlnPro: 0.76 ± 0.558
1.52GlnGln: 1.52 ± 0.337
1.52GlnArg: 1.52 ± 0.491
2.533GlnSer: 2.533 ± 0.989
1.52GlnThr: 1.52 ± 0.464
2.026GlnVal: 2.026 ± 0.312
0.253GlnTrp: 0.253 ± 0.227
1.266GlnTyr: 1.266 ± 1.204
0.0GlnXaa: 0.0 ± 0.0
Arg
3.546ArgAla: 3.546 ± 0.69
0.76ArgCys: 0.76 ± 0.68
4.053ArgAsp: 4.053 ± 1.793
4.559ArgGlu: 4.559 ± 0.874
1.52ArgPhe: 1.52 ± 0.807
3.04ArgGly: 3.04 ± 1.428
0.0ArgHis: 0.0 ± 0.0
4.053ArgIle: 4.053 ± 1.127
5.826ArgLys: 5.826 ± 1.462
2.533ArgLeu: 2.533 ± 0.989
2.533ArgMet: 2.533 ± 1.03
3.546ArgAsn: 3.546 ± 0.605
2.28ArgPro: 2.28 ± 0.688
0.76ArgGln: 0.76 ± 0.49
2.28ArgArg: 2.28 ± 0.688
5.319ArgSer: 5.319 ± 1.742
2.026ArgThr: 2.026 ± 0.619
4.559ArgVal: 4.559 ± 1.303
0.76ArgTrp: 0.76 ± 0.449
1.52ArgTyr: 1.52 ± 0.669
0.0ArgXaa: 0.0 ± 0.0
Ser
5.572SerAla: 5.572 ± 0.38
3.799SerCys: 3.799 ± 1.483
4.813SerAsp: 4.813 ± 0.661
6.079SerGlu: 6.079 ± 1.363
5.066SerPhe: 5.066 ± 1.074
4.306SerGly: 4.306 ± 1.246
2.28SerHis: 2.28 ± 0.67
6.839SerIle: 6.839 ± 2.175
8.105SerLys: 8.105 ± 0.011
11.905SerLeu: 11.905 ± 2.432
2.533SerMet: 2.533 ± 0.756
2.28SerAsn: 2.28 ± 0.405
3.799SerPro: 3.799 ± 1.249
4.306SerGln: 4.306 ± 0.076
4.053SerArg: 4.053 ± 0.6
8.105SerSer: 8.105 ± 1.064
3.293SerThr: 3.293 ± 0.539
4.053SerVal: 4.053 ± 0.6
1.773SerTrp: 1.773 ± 0.575
1.52SerTyr: 1.52 ± 0.669
0.0SerXaa: 0.0 ± 0.0
Thr
3.04ThrAla: 3.04 ± 0.671
0.76ThrCys: 0.76 ± 0.482
3.293ThrAsp: 3.293 ± 0.666
3.293ThrGlu: 3.293 ± 1.423
1.52ThrPhe: 1.52 ± 0.669
4.053ThrGly: 4.053 ± 0.542
0.507ThrHis: 0.507 ± 0.326
3.546ThrIle: 3.546 ± 1.285
1.773ThrLys: 1.773 ± 0.828
5.066ThrLeu: 5.066 ± 0.429
0.76ThrMet: 0.76 ± 0.223
1.52ThrAsn: 1.52 ± 0.446
1.52ThrPro: 1.52 ± 0.312
0.76ThrGln: 0.76 ± 0.223
2.28ThrArg: 2.28 ± 0.543
5.826ThrSer: 5.826 ± 0.691
2.786ThrThr: 2.786 ± 0.85
3.546ThrVal: 3.546 ± 1.547
0.0ThrTrp: 0.0 ± 0.0
1.013ThrTyr: 1.013 ± 0.309
0.0ThrXaa: 0.0 ± 0.0
Val
2.533ValAla: 2.533 ± 1.071
2.026ValCys: 2.026 ± 0.844
3.293ValAsp: 3.293 ± 1.589
3.546ValGlu: 3.546 ± 0.69
2.28ValPhe: 2.28 ± 0.67
3.799ValGly: 3.799 ± 1.043
1.52ValHis: 1.52 ± 0.464
4.306ValIle: 4.306 ± 1.055
5.066ValLys: 5.066 ± 1.524
3.799ValLeu: 3.799 ± 0.596
1.773ValMet: 1.773 ± 0.575
2.026ValAsn: 2.026 ± 0.841
1.013ValPro: 1.013 ± 0.43
2.28ValGln: 2.28 ± 0.868
4.306ValArg: 4.306 ± 0.595
6.332ValSer: 6.332 ± 0.702
3.799ValThr: 3.799 ± 0.851
3.546ValVal: 3.546 ± 1.278
0.76ValTrp: 0.76 ± 0.49
2.786ValTyr: 2.786 ± 0.397
0.0ValXaa: 0.0 ± 0.0
Trp
0.507TrpAla: 0.507 ± 0.326
0.0TrpCys: 0.0 ± 0.0
1.013TrpAsp: 1.013 ± 0.309
0.507TrpGlu: 0.507 ± 0.155
0.253TrpPhe: 0.253 ± 0.163
0.76TrpGly: 0.76 ± 0.352
0.0TrpHis: 0.0 ± 0.0
0.76TrpIle: 0.76 ± 0.223
0.507TrpLys: 0.507 ± 0.577
1.266TrpLeu: 1.266 ± 0.348
0.507TrpMet: 0.507 ± 0.155
0.76TrpAsn: 0.76 ± 0.223
0.507TrpPro: 0.507 ± 0.491
0.0TrpGln: 0.0 ± 0.0
0.76TrpArg: 0.76 ± 0.49
0.507TrpSer: 0.507 ± 0.155
1.266TrpThr: 1.266 ± 0.765
1.266TrpVal: 1.266 ± 0.402
0.253TrpTrp: 0.253 ± 0.163
0.507TrpTyr: 0.507 ± 0.326
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.76TyrAla: 0.76 ± 0.352
0.507TyrCys: 0.507 ± 0.453
2.28TyrAsp: 2.28 ± 1.671
1.52TyrGlu: 1.52 ± 0.446
1.52TyrPhe: 1.52 ± 0.312
1.52TyrGly: 1.52 ± 0.337
1.266TyrHis: 1.266 ± 0.378
2.28TyrIle: 2.28 ± 0.67
1.773TyrLys: 1.773 ± 0.345
2.786TyrLeu: 2.786 ± 0.804
1.013TyrMet: 1.013 ± 0.865
1.773TyrAsn: 1.773 ± 0.307
1.266TyrPro: 1.266 ± 0.402
0.76TyrGln: 0.76 ± 0.646
1.52TyrArg: 1.52 ± 0.669
2.28TyrSer: 2.28 ± 0.67
1.013TyrThr: 1.013 ± 0.54
2.28TyrVal: 2.28 ± 0.305
0.507TyrTrp: 0.507 ± 0.155
1.52TyrTyr: 1.52 ± 0.979
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski