Amino acid dipepetide frequency for Acetobacteraceae bacterium AT-5844

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.505AlaAla: 21.505 ± 0.151	1.206AlaCys: 1.206 ± 0.034	6.414AlaAsp: 6.414 ± 0.068	9.061AlaGlu: 9.061 ± 0.085	4.426AlaPhe: 4.426 ± 0.058	12.539AlaGly: 12.539 ± 0.09	2.337AlaHis: 2.337 ± 0.031	5.915AlaIle: 5.915 ± 0.067	3.187AlaLys: 3.187 ± 0.052	16.087AlaLeu: 16.087 ± 0.131	4.238AlaMet: 4.238 ± 0.053	2.595AlaAsn: 2.595 ± 0.043	7.142AlaPro: 7.142 ± 0.08	4.57AlaGln: 4.57 ± 0.059	10.656AlaArg: 10.656 ± 0.102	6.508AlaSer: 6.508 ± 0.066	6.563AlaThr: 6.563 ± 0.067	9.38AlaVal: 9.38 ± 0.081	1.904AlaTrp: 1.904 ± 0.036	2.257AlaTyr: 2.257 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.027	0.131CysCys: 0.131 ± 0.01	0.458CysAsp: 0.458 ± 0.018	0.406CysGlu: 0.406 ± 0.017	0.317CysPhe: 0.317 ± 0.013	0.915CysGly: 0.915 ± 0.028	0.223CysHis: 0.223 ± 0.011	0.39CysIle: 0.39 ± 0.016	0.123CysLys: 0.123 ± 0.009	0.825CysLeu: 0.825 ± 0.022	0.192CysMet: 0.192 ± 0.01	0.169CysAsn: 0.169 ± 0.011	0.443CysPro: 0.443 ± 0.017	0.232CysGln: 0.232 ± 0.013	0.672CysArg: 0.672 ± 0.022	0.413CysSer: 0.413 ± 0.016	0.47CysThr: 0.47 ± 0.018	0.611CysVal: 0.611 ± 0.02	0.129CysTrp: 0.129 ± 0.009	0.164CysTyr: 0.164 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.856AspAla: 6.856 ± 0.067	0.397AspCys: 0.397 ± 0.016	2.304AspAsp: 2.304 ± 0.043	2.763AspGlu: 2.763 ± 0.045	1.824AspPhe: 1.824 ± 0.031	4.892AspGly: 4.892 ± 0.072	1.007AspHis: 1.007 ± 0.027	2.513AspIle: 2.513 ± 0.048	1.039AspLys: 1.039 ± 0.03	5.191AspLeu: 5.191 ± 0.053	1.29AspMet: 1.29 ± 0.025	0.992AspAsn: 0.992 ± 0.026	3.413AspPro: 3.413 ± 0.049	1.32AspGln: 1.32 ± 0.029	3.805AspArg: 3.805 ± 0.054	2.01AspSer: 2.01 ± 0.036	2.391AspThr: 2.391 ± 0.038	3.646AspVal: 3.646 ± 0.054	0.914AspTrp: 0.914 ± 0.023	1.135AspTyr: 1.135 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	9.094GluAla: 9.094 ± 0.088	0.353GluCys: 0.353 ± 0.014	2.659GluAsp: 2.659 ± 0.048	3.539GluGlu: 3.539 ± 0.055	1.575GluPhe: 1.575 ± 0.034	5.039GluGly: 5.039 ± 0.06	1.124GluHis: 1.124 ± 0.03	2.69GluIle: 2.69 ± 0.047	1.719GluLys: 1.719 ± 0.042	5.21GluLeu: 5.21 ± 0.06	1.552GluMet: 1.552 ± 0.032	1.289GluAsn: 1.289 ± 0.029	2.747GluPro: 2.747 ± 0.047	2.2GluGln: 2.2 ± 0.046	4.919GluArg: 4.919 ± 0.067	2.244GluSer: 2.244 ± 0.033	2.999GluThr: 2.999 ± 0.04	4.007GluVal: 4.007 ± 0.057	0.812GluTrp: 0.812 ± 0.022	0.875GluTyr: 0.875 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.269PheAla: 4.269 ± 0.053	0.376PheCys: 0.376 ± 0.018	2.062PheAsp: 2.062 ± 0.041	1.696PheGlu: 1.696 ± 0.032	1.172PhePhe: 1.172 ± 0.035	3.505PheGly: 3.505 ± 0.051	0.751PheHis: 0.751 ± 0.022	1.428PheIle: 1.428 ± 0.038	0.625PheLys: 0.625 ± 0.023	3.359PheLeu: 3.359 ± 0.046	0.716PheMet: 0.716 ± 0.021	0.932PheAsn: 0.932 ± 0.027	1.697PhePro: 1.697 ± 0.036	0.978PheGln: 0.978 ± 0.024	2.453PheArg: 2.453 ± 0.039	2.045PheSer: 2.045 ± 0.037	1.938PheThr: 1.938 ± 0.031	2.401PheVal: 2.401 ± 0.037	0.558PheTrp: 0.558 ± 0.018	0.697PheTyr: 0.697 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.547GlyAla: 10.547 ± 0.098	0.891GlyCys: 0.891 ± 0.028	3.815GlyAsp: 3.815 ± 0.06	4.916GlyGlu: 4.916 ± 0.066	3.631GlyPhe: 3.631 ± 0.051	8.317GlyGly: 8.317 ± 0.123	1.997GlyHis: 1.997 ± 0.034	4.453GlyIle: 4.453 ± 0.056	2.564GlyLys: 2.564 ± 0.047	10.137GlyLeu: 10.137 ± 0.082	2.741GlyMet: 2.741 ± 0.038	2.097GlyAsn: 2.097 ± 0.04	4.202GlyPro: 4.202 ± 0.061	3.447GlyGln: 3.447 ± 0.047	7.131GlyArg: 7.131 ± 0.063	4.614GlySer: 4.614 ± 0.062	5.089GlyThr: 5.089 ± 0.065	6.454GlyVal: 6.454 ± 0.067	1.666GlyTrp: 1.666 ± 0.036	2.085GlyTyr: 2.085 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.707HisAla: 2.707 ± 0.047	0.209HisCys: 0.209 ± 0.01	1.132HisAsp: 1.132 ± 0.027	0.982HisGlu: 0.982 ± 0.025	0.774HisPhe: 0.774 ± 0.022	2.122HisGly: 2.122 ± 0.035	0.536HisHis: 0.536 ± 0.019	0.837HisIle: 0.837 ± 0.026	0.357HisLys: 0.357 ± 0.017	2.206HisLeu: 2.206 ± 0.041	0.453HisMet: 0.453 ± 0.017	0.418HisAsn: 0.418 ± 0.018	1.444HisPro: 1.444 ± 0.031	0.564HisGln: 0.564 ± 0.02	1.588HisArg: 1.588 ± 0.037	0.902HisSer: 0.902 ± 0.023	0.856HisThr: 0.856 ± 0.021	1.428HisVal: 1.428 ± 0.033	0.362HisTrp: 0.362 ± 0.016	0.425HisTyr: 0.425 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.43IleAla: 6.43 ± 0.068	0.448IleCys: 0.448 ± 0.018	2.42IleAsp: 2.42 ± 0.037	2.626IleGlu: 2.626 ± 0.048	1.307IlePhe: 1.307 ± 0.029	4.567IleGly: 4.567 ± 0.063	0.819IleHis: 0.819 ± 0.02	1.827IleIle: 1.827 ± 0.042	0.798IleLys: 0.798 ± 0.022	4.211IleLeu: 4.211 ± 0.051	0.842IleMet: 0.842 ± 0.027	1.007IleAsn: 1.007 ± 0.029	2.363IlePro: 2.363 ± 0.04	1.198IleGln: 1.198 ± 0.026	3.258IleArg: 3.258 ± 0.052	2.41IleSer: 2.41 ± 0.043	2.382IleThr: 2.382 ± 0.04	3.192IleVal: 3.192 ± 0.05	0.55IleTrp: 0.55 ± 0.02	0.823IleTyr: 0.823 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.206LysAla: 3.206 ± 0.049	0.098LysCys: 0.098 ± 0.007	1.174LysAsp: 1.174 ± 0.032	1.242LysGlu: 1.242 ± 0.032	0.541LysPhe: 0.541 ± 0.02	2.024LysGly: 2.024 ± 0.04	0.422LysHis: 0.422 ± 0.017	0.926LysIle: 0.926 ± 0.025	0.746LysLys: 0.746 ± 0.028	2.698LysLeu: 2.698 ± 0.039	0.493LysMet: 0.493 ± 0.017	0.51LysAsn: 0.51 ± 0.02	1.685LysPro: 1.685 ± 0.036	0.8LysGln: 0.8 ± 0.026	1.869LysArg: 1.869 ± 0.04	1.072LysSer: 1.072 ± 0.031	1.11LysThr: 1.11 ± 0.031	1.889LysVal: 1.889 ± 0.043	0.241LysTrp: 0.241 ± 0.014	0.341LysTyr: 0.341 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.238LeuAla: 16.238 ± 0.128	1.005LeuCys: 1.005 ± 0.026	5.704LeuAsp: 5.704 ± 0.067	5.743LeuGlu: 5.743 ± 0.061	3.318LeuPhe: 3.318 ± 0.054	9.511LeuGly: 9.511 ± 0.076	2.234LeuHis: 2.234 ± 0.044	4.098LeuIle: 4.098 ± 0.059	2.551LeuLys: 2.551 ± 0.047	12.107LeuLeu: 12.107 ± 0.125	2.403LeuMet: 2.403 ± 0.043	2.344LeuAsn: 2.344 ± 0.038	7.354LeuPro: 7.354 ± 0.066	2.907LeuGln: 2.907 ± 0.051	9.284LeuArg: 9.284 ± 0.087	6.375LeuSer: 6.375 ± 0.077	5.497LeuThr: 5.497 ± 0.062	7.46LeuVal: 7.46 ± 0.071	1.366LeuTrp: 1.366 ± 0.028	1.86LeuTyr: 1.86 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.799MetAla: 3.799 ± 0.048	0.135MetCys: 0.135 ± 0.008	1.193MetAsp: 1.193 ± 0.027	1.231MetGlu: 1.231 ± 0.028	0.613MetPhe: 0.613 ± 0.02	1.954MetGly: 1.954 ± 0.037	0.409MetHis: 0.409 ± 0.015	1.058MetIle: 1.058 ± 0.03	0.656MetLys: 0.656 ± 0.021	2.864MetLeu: 2.864 ± 0.046	0.661MetMet: 0.661 ± 0.019	0.68MetAsn: 0.68 ± 0.02	1.861MetPro: 1.861 ± 0.035	0.954MetGln: 0.954 ± 0.026	2.068MetArg: 2.068 ± 0.037	1.506MetSer: 1.506 ± 0.031	1.661MetThr: 1.661 ± 0.032	1.848MetVal: 1.848 ± 0.034	0.218MetTrp: 0.218 ± 0.011	0.25MetTyr: 0.25 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.876AsnAla: 2.876 ± 0.046	0.182AsnCys: 0.182 ± 0.01	1.082AsnAsp: 1.082 ± 0.028	0.913AsnGlu: 0.913 ± 0.022	0.786AsnPhe: 0.786 ± 0.025	2.109AsnGly: 2.109 ± 0.044	0.483AsnHis: 0.483 ± 0.017	1.054AsnIle: 1.054 ± 0.026	0.466AsnLys: 0.466 ± 0.018	2.332AsnLeu: 2.332 ± 0.036	0.485AsnMet: 0.485 ± 0.017	0.606AsnAsn: 0.606 ± 0.022	1.845AsnPro: 1.845 ± 0.036	0.617AsnGln: 0.617 ± 0.021	1.742AsnArg: 1.742 ± 0.034	1.038AsnSer: 1.038 ± 0.025	1.214AsnThr: 1.214 ± 0.031	1.65AsnVal: 1.65 ± 0.038	0.399AsnTrp: 0.399 ± 0.016	0.516AsnTyr: 0.516 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.416ProAla: 8.416 ± 0.092	0.376ProCys: 0.376 ± 0.015	3.564ProAsp: 3.564 ± 0.047	4.37ProGlu: 4.37 ± 0.056	2.12ProPhe: 2.12 ± 0.035	5.895ProGly: 5.895 ± 0.059	1.24ProHis: 1.24 ± 0.029	2.067ProIle: 2.067 ± 0.039	1.215ProLys: 1.215 ± 0.028	5.929ProLeu: 5.929 ± 0.072	1.428ProMet: 1.428 ± 0.033	1.323ProAsn: 1.323 ± 0.033	3.818ProPro: 3.818 ± 0.064	1.949ProGln: 1.949 ± 0.037	3.981ProArg: 3.981 ± 0.055	2.959ProSer: 2.959 ± 0.047	2.599ProThr: 2.599 ± 0.039	4.681ProVal: 4.681 ± 0.051	0.903ProTrp: 0.903 ± 0.028	1.216ProTyr: 1.216 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.006GlnAla: 5.006 ± 0.065	0.185GlnCys: 0.185 ± 0.01	1.659GlnAsp: 1.659 ± 0.028	1.745GlnGlu: 1.745 ± 0.038	0.876GlnPhe: 0.876 ± 0.023	3.05GlnGly: 3.05 ± 0.041	0.708GlnHis: 0.708 ± 0.02	1.445GlnIle: 1.445 ± 0.033	0.774GlnLys: 0.774 ± 0.021	2.854GlnLeu: 2.854 ± 0.053	0.821GlnMet: 0.821 ± 0.023	0.755GlnAsn: 0.755 ± 0.025	2.271GlnPro: 2.271 ± 0.038	1.46GlnGln: 1.46 ± 0.036	2.851GlnArg: 2.851 ± 0.048	1.582GlnSer: 1.582 ± 0.036	1.531GlnThr: 1.531 ± 0.036	2.333GlnVal: 2.333 ± 0.041	0.417GlnTrp: 0.417 ± 0.016	0.512GlnTyr: 0.512 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.779ArgAla: 9.779 ± 0.091	0.629ArgCys: 0.629 ± 0.019	4.093ArgAsp: 4.093 ± 0.06	4.415ArgGlu: 4.415 ± 0.058	3.03ArgPhe: 3.03 ± 0.044	5.849ArgGly: 5.849 ± 0.064	1.971ArgHis: 1.971 ± 0.037	3.872ArgIle: 3.872 ± 0.053	1.841ArgLys: 1.841 ± 0.037	9.373ArgLeu: 9.373 ± 0.095	2.211ArgMet: 2.211 ± 0.03	1.88ArgAsn: 1.88 ± 0.037	4.593ArgPro: 4.593 ± 0.055	3.107ArgGln: 3.107 ± 0.045	7.173ArgArg: 7.173 ± 0.086	3.486ArgSer: 3.486 ± 0.056	3.338ArgThr: 3.338 ± 0.051	5.26ArgVal: 5.26 ± 0.06	1.266ArgTrp: 1.266 ± 0.029	1.631ArgTyr: 1.631 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.433SerAla: 6.433 ± 0.07	0.395SerCys: 0.395 ± 0.016	2.216SerAsp: 2.216 ± 0.04	2.332SerGlu: 2.332 ± 0.037	2.038SerPhe: 2.038 ± 0.041	5.293SerGly: 5.293 ± 0.063	1.001SerHis: 1.001 ± 0.027	2.248SerIle: 2.248 ± 0.038	0.947SerLys: 0.947 ± 0.025	5.646SerLeu: 5.646 ± 0.06	1.286SerMet: 1.286 ± 0.03	1.086SerAsn: 1.086 ± 0.029	3.01SerPro: 3.01 ± 0.046	1.508SerGln: 1.508 ± 0.032	3.792SerArg: 3.792 ± 0.05	2.612SerSer: 2.612 ± 0.046	2.566SerThr: 2.566 ± 0.035	3.526SerVal: 3.526 ± 0.052	0.863SerTrp: 0.863 ± 0.027	1.088SerTyr: 1.088 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.575ThrAla: 6.575 ± 0.072	0.356ThrCys: 0.356 ± 0.017	2.503ThrAsp: 2.503 ± 0.044	2.564ThrGlu: 2.564 ± 0.044	1.697ThrPhe: 1.697 ± 0.037	4.972ThrGly: 4.972 ± 0.057	0.991ThrHis: 0.991 ± 0.025	2.285ThrIle: 2.285 ± 0.035	1.007ThrLys: 1.007 ± 0.027	6.217ThrLeu: 6.217 ± 0.065	1.128ThrMet: 1.128 ± 0.028	1.108ThrAsn: 1.108 ± 0.027	3.745ThrPro: 3.745 ± 0.054	1.481ThrGln: 1.481 ± 0.031	3.453ThrArg: 3.453 ± 0.046	2.43ThrSer: 2.43 ± 0.039	2.742ThrThr: 2.742 ± 0.048	4.146ThrVal: 4.146 ± 0.055	0.585ThrTrp: 0.585 ± 0.022	1.005ThrTyr: 1.005 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.744ValAla: 9.744 ± 0.078	0.576ValCys: 0.576 ± 0.019	3.414ValAsp: 3.414 ± 0.047	4.532ValGlu: 4.532 ± 0.059	2.448ValPhe: 2.448 ± 0.041	5.297ValGly: 5.297 ± 0.06	1.268ValHis: 1.268 ± 0.029	3.141ValIle: 3.141 ± 0.048	1.721ValLys: 1.721 ± 0.037	8.36ValLeu: 8.36 ± 0.073	1.911ValMet: 1.911 ± 0.035	1.713ValAsn: 1.713 ± 0.031	4.472ValPro: 4.472 ± 0.057	2.327ValGln: 2.327 ± 0.046	4.942ValArg: 4.942 ± 0.057	3.966ValSer: 3.966 ± 0.047	4.303ValThr: 4.303 ± 0.05	6.148ValVal: 6.148 ± 0.064	0.903ValTrp: 0.903 ± 0.023	1.096ValTyr: 1.096 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.52TrpAla: 1.52 ± 0.031	0.155TrpCys: 0.155 ± 0.01	0.639TrpAsp: 0.639 ± 0.019	0.632TrpGlu: 0.632 ± 0.022	0.51TrpPhe: 0.51 ± 0.017	1.093TrpGly: 1.093 ± 0.03	0.395TrpHis: 0.395 ± 0.017	0.574TrpIle: 0.574 ± 0.021	0.391TrpLys: 0.391 ± 0.015	1.869TrpLeu: 1.869 ± 0.035	0.393TrpMet: 0.393 ± 0.017	0.415TrpAsn: 0.415 ± 0.015	0.904TrpPro: 0.904 ± 0.025	0.656TrpGln: 0.656 ± 0.02	1.522TrpArg: 1.522 ± 0.033	0.778TrpSer: 0.778 ± 0.023	0.762TrpThr: 0.762 ± 0.024	0.912TrpVal: 0.912 ± 0.024	0.271TrpTrp: 0.271 ± 0.012	0.273TrpTyr: 0.273 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.487TyrAla: 2.487 ± 0.037	0.183TyrCys: 0.183 ± 0.011	1.198TyrAsp: 1.198 ± 0.029	0.939TyrGlu: 0.939 ± 0.024	0.656TyrPhe: 0.656 ± 0.021	1.849TyrGly: 1.849 ± 0.036	0.387TyrHis: 0.387 ± 0.016	0.655TyrIle: 0.655 ± 0.023	0.36TyrLys: 0.36 ± 0.015	1.886TyrLeu: 1.886 ± 0.034	0.373TyrMet: 0.373 ± 0.014	0.476TyrAsn: 0.476 ± 0.021	1.042TyrPro: 1.042 ± 0.023	0.56TyrGln: 0.56 ± 0.019	1.638TyrArg: 1.638 ± 0.033	0.935TyrSer: 0.935 ± 0.025	0.979TyrThr: 0.979 ± 0.025	1.31TyrVal: 1.31 ± 0.031	0.337TyrTrp: 0.337 ± 0.016	0.438TyrTyr: 0.438 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5288 proteins (1570546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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