Amino acid dipepetide frequency for Rhodobacter sp. SGA-6-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.082AlaAla: 22.082 ± 0.262
1.212AlaCys: 1.212 ± 0.031
6.983AlaAsp: 6.983 ± 0.077
10.113AlaGlu: 10.113 ± 0.109
4.564AlaPhe: 4.564 ± 0.059
12.794AlaGly: 12.794 ± 0.125
2.45AlaHis: 2.45 ± 0.044
5.497AlaIle: 5.497 ± 0.072
3.644AlaLys: 3.644 ± 0.063
16.286AlaLeu: 16.286 ± 0.154
4.024AlaMet: 4.024 ± 0.065
2.366AlaAsn: 2.366 ± 0.045
6.871AlaPro: 6.871 ± 0.097
4.209AlaGln: 4.209 ± 0.059
10.657AlaArg: 10.657 ± 0.122
5.131AlaSer: 5.131 ± 0.064
5.824AlaThr: 5.824 ± 0.077
9.611AlaVal: 9.611 ± 0.107
1.691AlaTrp: 1.691 ± 0.037
2.413AlaTyr: 2.413 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.016CysAla: 1.016 ± 0.027
0.098CysCys: 0.098 ± 0.009
0.551CysAsp: 0.551 ± 0.023
0.412CysGlu: 0.412 ± 0.018
0.322CysPhe: 0.322 ± 0.016
0.994CysGly: 0.994 ± 0.03
0.228CysHis: 0.228 ± 0.013
0.394CysIle: 0.394 ± 0.02
0.188CysLys: 0.188 ± 0.011
0.937CysLeu: 0.937 ± 0.025
0.149CysMet: 0.149 ± 0.011
0.197CysAsn: 0.197 ± 0.013
0.534CysPro: 0.534 ± 0.022
0.193CysGln: 0.193 ± 0.011
0.658CysArg: 0.658 ± 0.026
0.407CysSer: 0.407 ± 0.02
0.454CysThr: 0.454 ± 0.019
0.574CysVal: 0.574 ± 0.019
0.137CysTrp: 0.137 ± 0.009
0.187CysTyr: 0.187 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.391AspAla: 6.391 ± 0.081
0.547AspCys: 0.547 ± 0.022
2.727AspAsp: 2.727 ± 0.072
3.056AspGlu: 3.056 ± 0.055
2.264AspPhe: 2.264 ± 0.046
5.091AspGly: 5.091 ± 0.07
1.281AspHis: 1.281 ± 0.033
2.46AspIle: 2.46 ± 0.053
1.262AspLys: 1.262 ± 0.035
6.55AspLeu: 6.55 ± 0.082
1.344AspMet: 1.344 ± 0.036
0.952AspAsn: 0.952 ± 0.03
4.077AspPro: 4.077 ± 0.064
1.574AspGln: 1.574 ± 0.043
4.878AspArg: 4.878 ± 0.063
1.984AspSer: 1.984 ± 0.04
2.354AspThr: 2.354 ± 0.051
3.316AspVal: 3.316 ± 0.056
1.307AspTrp: 1.307 ± 0.028
1.479AspTyr: 1.479 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
9.534GluAla: 9.534 ± 0.111
0.333GluCys: 0.333 ± 0.017
3.199GluAsp: 3.199 ± 0.053
3.897GluGlu: 3.897 ± 0.075
1.686GluPhe: 1.686 ± 0.036
5.909GluGly: 5.909 ± 0.077
0.991GluHis: 0.991 ± 0.033
3.332GluIle: 3.332 ± 0.058
2.002GluLys: 2.002 ± 0.047
4.722GluLeu: 4.722 ± 0.068
1.809GluMet: 1.809 ± 0.035
1.363GluAsn: 1.363 ± 0.031
2.792GluPro: 2.792 ± 0.05
1.665GluGln: 1.665 ± 0.04
4.207GluArg: 4.207 ± 0.071
1.942GluSer: 1.942 ± 0.035
3.536GluThr: 3.536 ± 0.051
4.78GluVal: 4.78 ± 0.063
0.701GluTrp: 0.701 ± 0.026
0.944GluTyr: 0.944 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.697PheAla: 4.697 ± 0.067
0.391PheCys: 0.391 ± 0.018
2.575PheAsp: 2.575 ± 0.048
1.779PheGlu: 1.779 ± 0.037
1.246PhePhe: 1.246 ± 0.041
3.629PheGly: 3.629 ± 0.063
0.77PheHis: 0.77 ± 0.024
1.398PheIle: 1.398 ± 0.036
0.694PheLys: 0.694 ± 0.025
3.673PheLeu: 3.673 ± 0.062
0.714PheMet: 0.714 ± 0.026
0.827PheAsn: 0.827 ± 0.031
1.741PhePro: 1.741 ± 0.04
0.929PheGln: 0.929 ± 0.026
2.571PheArg: 2.571 ± 0.049
1.867PheSer: 1.867 ± 0.035
2.03PheThr: 2.03 ± 0.042
2.475PheVal: 2.475 ± 0.043
0.586PheTrp: 0.586 ± 0.028
0.85PheTyr: 0.85 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.766GlyAla: 10.766 ± 0.11
0.864GlyCys: 0.864 ± 0.028
4.469GlyAsp: 4.469 ± 0.071
5.09GlyGlu: 5.09 ± 0.076
3.786GlyPhe: 3.786 ± 0.057
8.164GlyGly: 8.164 ± 0.13
2.069GlyHis: 2.069 ± 0.043
4.632GlyIle: 4.632 ± 0.067
3.072GlyLys: 3.072 ± 0.056
10.473GlyLeu: 10.473 ± 0.1
2.901GlyMet: 2.901 ± 0.049
1.984GlyAsn: 1.984 ± 0.057
4.584GlyPro: 4.584 ± 0.064
3.18GlyGln: 3.18 ± 0.051
7.055GlyArg: 7.055 ± 0.086
4.07GlySer: 4.07 ± 0.055
4.521GlyThr: 4.521 ± 0.074
6.358GlyVal: 6.358 ± 0.077
1.811GlyTrp: 1.811 ± 0.039
2.255GlyTyr: 2.255 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.346HisAla: 2.346 ± 0.044
0.243HisCys: 0.243 ± 0.013
1.265HisAsp: 1.265 ± 0.036
1.023HisGlu: 1.023 ± 0.028
0.801HisPhe: 0.801 ± 0.025
1.956HisGly: 1.956 ± 0.04
0.52HisHis: 0.52 ± 0.021
0.824HisIle: 0.824 ± 0.026
0.358HisLys: 0.358 ± 0.017
2.26HisLeu: 2.26 ± 0.045
0.491HisMet: 0.491 ± 0.019
0.367HisAsn: 0.367 ± 0.018
1.481HisPro: 1.481 ± 0.033
0.515HisGln: 0.515 ± 0.018
1.522HisArg: 1.522 ± 0.035
0.862HisSer: 0.862 ± 0.029
0.677HisThr: 0.677 ± 0.025
1.544HisVal: 1.544 ± 0.038
0.401HisTrp: 0.401 ± 0.018
0.51HisTyr: 0.51 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.925IleAla: 6.925 ± 0.08
0.517IleCys: 0.517 ± 0.021
2.933IleAsp: 2.933 ± 0.052
2.965IleGlu: 2.965 ± 0.055
1.495IlePhe: 1.495 ± 0.036
4.72IleGly: 4.72 ± 0.068
0.877IleHis: 0.877 ± 0.027
1.597IleIle: 1.597 ± 0.042
0.967IleLys: 0.967 ± 0.031
4.757IleLeu: 4.757 ± 0.063
0.843IleMet: 0.843 ± 0.031
0.955IleAsn: 0.955 ± 0.031
2.35IlePro: 2.35 ± 0.041
0.938IleGln: 0.938 ± 0.03
3.507IleArg: 3.507 ± 0.054
2.347IleSer: 2.347 ± 0.044
2.332IleThr: 2.332 ± 0.047
3.346IleVal: 3.346 ± 0.053
0.631IleTrp: 0.631 ± 0.021
0.941IleTyr: 0.941 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.012LysAla: 4.012 ± 0.073
0.141LysCys: 0.141 ± 0.01
1.497LysAsp: 1.497 ± 0.039
1.36LysGlu: 1.36 ± 0.034
0.7LysPhe: 0.7 ± 0.023
2.908LysGly: 2.908 ± 0.05
0.475LysHis: 0.475 ± 0.021
1.284LysIle: 1.284 ± 0.041
0.979LysLys: 0.979 ± 0.039
2.622LysLeu: 2.622 ± 0.048
0.695LysMet: 0.695 ± 0.024
0.59LysAsn: 0.59 ± 0.022
1.741LysPro: 1.741 ± 0.043
0.714LysGln: 0.714 ± 0.025
1.941LysArg: 1.941 ± 0.046
1.367LysSer: 1.367 ± 0.035
1.615LysThr: 1.615 ± 0.04
2.234LysVal: 2.234 ± 0.046
0.323LysTrp: 0.323 ± 0.015
0.523LysTyr: 0.523 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
16.586LeuAla: 16.586 ± 0.169
1.014LeuCys: 1.014 ± 0.025
5.839LeuAsp: 5.839 ± 0.074
5.335LeuGlu: 5.335 ± 0.07
3.37LeuPhe: 3.37 ± 0.059
8.726LeuGly: 8.726 ± 0.104
1.994LeuHis: 1.994 ± 0.039
4.795LeuIle: 4.795 ± 0.074
3.152LeuLys: 3.152 ± 0.056
9.939LeuLeu: 9.939 ± 0.13
2.641LeuMet: 2.641 ± 0.05
2.313LeuAsn: 2.313 ± 0.051
6.691LeuPro: 6.691 ± 0.082
2.697LeuGln: 2.697 ± 0.047
7.983LeuArg: 7.983 ± 0.091
6.189LeuSer: 6.189 ± 0.071
6.058LeuThr: 6.058 ± 0.07
7.522LeuVal: 7.522 ± 0.08
1.564LeuTrp: 1.564 ± 0.043
1.99LeuTyr: 1.99 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.792MetAla: 3.792 ± 0.055
0.144MetCys: 0.144 ± 0.009
1.309MetAsp: 1.309 ± 0.032
1.461MetGlu: 1.461 ± 0.035
0.712MetPhe: 0.712 ± 0.025
2.186MetGly: 2.186 ± 0.039
0.401MetHis: 0.401 ± 0.02
1.352MetIle: 1.352 ± 0.032
0.963MetLys: 0.963 ± 0.032
2.551MetLeu: 2.551 ± 0.052
0.655MetMet: 0.655 ± 0.025
0.691MetAsn: 0.691 ± 0.022
1.529MetPro: 1.529 ± 0.037
0.946MetGln: 0.946 ± 0.029
1.986MetArg: 1.986 ± 0.037
1.365MetSer: 1.365 ± 0.035
2.009MetThr: 2.009 ± 0.037
1.927MetVal: 1.927 ± 0.036
0.209MetTrp: 0.209 ± 0.014
0.269MetTyr: 0.269 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.674AsnAla: 2.674 ± 0.047
0.218AsnCys: 0.218 ± 0.014
1.136AsnAsp: 1.136 ± 0.048
0.899AsnGlu: 0.899 ± 0.028
0.8AsnPhe: 0.8 ± 0.024
1.927AsnGly: 1.927 ± 0.047
0.423AsnHis: 0.423 ± 0.02
1.089AsnIle: 1.089 ± 0.031
0.439AsnLys: 0.439 ± 0.021
2.253AsnLeu: 2.253 ± 0.037
0.533AsnMet: 0.533 ± 0.02
0.413AsnAsn: 0.413 ± 0.018
1.736AsnPro: 1.736 ± 0.036
0.546AsnGln: 0.546 ± 0.021
1.619AsnArg: 1.619 ± 0.039
0.904AsnSer: 0.904 ± 0.031
1.038AsnThr: 1.038 ± 0.029
1.525AsnVal: 1.525 ± 0.037
0.375AsnTrp: 0.375 ± 0.019
0.502AsnTyr: 0.502 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.798ProAla: 7.798 ± 0.105
0.388ProCys: 0.388 ± 0.019
3.734ProAsp: 3.734 ± 0.061
4.777ProGlu: 4.777 ± 0.079
2.152ProPhe: 2.152 ± 0.036
5.924ProGly: 5.924 ± 0.076
1.115ProHis: 1.115 ± 0.031
1.84ProIle: 1.84 ± 0.04
1.636ProLys: 1.636 ± 0.04
5.283ProLeu: 5.283 ± 0.061
1.462ProMet: 1.462 ± 0.04
1.075ProAsn: 1.075 ± 0.029
3.033ProPro: 3.033 ± 0.077
1.804ProGln: 1.804 ± 0.039
3.421ProArg: 3.421 ± 0.058
2.359ProSer: 2.359 ± 0.05
2.158ProThr: 2.158 ± 0.038
4.85ProVal: 4.85 ± 0.066
0.844ProTrp: 0.844 ± 0.025
1.084ProTyr: 1.084 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.137GlnAla: 4.137 ± 0.064
0.176GlnCys: 0.176 ± 0.012
1.546GlnAsp: 1.546 ± 0.04
1.517GlnGlu: 1.517 ± 0.037
0.85GlnPhe: 0.85 ± 0.025
2.826GlnGly: 2.826 ± 0.052
0.511GlnHis: 0.511 ± 0.02
1.662GlnIle: 1.662 ± 0.041
0.899GlnLys: 0.899 ± 0.032
2.629GlnLeu: 2.629 ± 0.047
0.884GlnMet: 0.884 ± 0.028
0.706GlnAsn: 0.706 ± 0.023
1.698GlnPro: 1.698 ± 0.042
0.839GlnGln: 0.839 ± 0.028
2.045GlnArg: 2.045 ± 0.044
1.382GlnSer: 1.382 ± 0.033
1.385GlnThr: 1.385 ± 0.034
2.498GlnVal: 2.498 ± 0.041
0.371GlnTrp: 0.371 ± 0.02
0.468GlnTyr: 0.468 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
9.88ArgAla: 9.88 ± 0.117
0.508ArgCys: 0.508 ± 0.021
4.219ArgAsp: 4.219 ± 0.059
3.977ArgGlu: 3.977 ± 0.063
2.782ArgPhe: 2.782 ± 0.054
5.46ArgGly: 5.46 ± 0.074
1.738ArgHis: 1.738 ± 0.038
4.084ArgIle: 4.084 ± 0.063
2.17ArgLys: 2.17 ± 0.047
8.94ArgLeu: 8.94 ± 0.11
2.173ArgMet: 2.173 ± 0.04
1.615ArgAsn: 1.615 ± 0.038
4.165ArgPro: 4.165 ± 0.071
2.453ArgGln: 2.453 ± 0.043
6.0ArgArg: 6.0 ± 0.09
3.157ArgSer: 3.157 ± 0.047
2.934ArgThr: 2.934 ± 0.044
5.114ArgVal: 5.114 ± 0.06
1.081ArgTrp: 1.081 ± 0.032
1.51ArgTyr: 1.51 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.555SerAla: 5.555 ± 0.065
0.412SerCys: 0.412 ± 0.017
2.491SerAsp: 2.491 ± 0.046
2.246SerGlu: 2.246 ± 0.042
2.012SerPhe: 2.012 ± 0.043
5.055SerGly: 5.055 ± 0.073
0.976SerHis: 0.976 ± 0.027
2.021SerIle: 2.021 ± 0.039
1.091SerLys: 1.091 ± 0.03
4.673SerLeu: 4.673 ± 0.061
1.062SerMet: 1.062 ± 0.029
0.958SerAsn: 0.958 ± 0.03
2.67SerPro: 2.67 ± 0.048
1.149SerGln: 1.149 ± 0.031
3.271SerArg: 3.271 ± 0.055
2.03SerSer: 2.03 ± 0.042
2.234SerThr: 2.234 ± 0.045
3.364SerVal: 3.364 ± 0.05
0.717SerTrp: 0.717 ± 0.023
1.167SerTyr: 1.167 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.445ThrAla: 6.445 ± 0.083
0.469ThrCys: 0.469 ± 0.022
2.637ThrAsp: 2.637 ± 0.048
2.849ThrGlu: 2.849 ± 0.049
1.788ThrPhe: 1.788 ± 0.039
5.446ThrGly: 5.446 ± 0.073
1.033ThrHis: 1.033 ± 0.026
2.3ThrIle: 2.3 ± 0.047
1.061ThrLys: 1.061 ± 0.032
5.615ThrLeu: 5.615 ± 0.068
1.162ThrMet: 1.162 ± 0.036
1.03ThrAsn: 1.03 ± 0.033
3.292ThrPro: 3.292 ± 0.049
1.206ThrGln: 1.206 ± 0.033
3.451ThrArg: 3.451 ± 0.05
2.221ThrSer: 2.221 ± 0.042
2.436ThrThr: 2.436 ± 0.052
4.037ThrVal: 4.037 ± 0.065
0.669ThrTrp: 0.669 ± 0.024
1.012ThrTyr: 1.012 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.698ValAla: 9.698 ± 0.106
0.614ValCys: 0.614 ± 0.022
3.618ValAsp: 3.618 ± 0.064
4.799ValGlu: 4.799 ± 0.063
2.775ValPhe: 2.775 ± 0.05
5.222ValGly: 5.222 ± 0.06
1.273ValHis: 1.273 ± 0.033
3.898ValIle: 3.898 ± 0.067
2.173ValLys: 2.173 ± 0.044
8.134ValLeu: 8.134 ± 0.093
2.1ValMet: 2.1 ± 0.042
1.751ValAsn: 1.751 ± 0.038
3.864ValPro: 3.864 ± 0.052
2.215ValGln: 2.215 ± 0.042
4.326ValArg: 4.326 ± 0.061
3.776ValSer: 3.776 ± 0.054
4.698ValThr: 4.698 ± 0.068
5.808ValVal: 5.808 ± 0.08
1.069ValTrp: 1.069 ± 0.03
1.389ValTyr: 1.389 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.611TrpAla: 1.611 ± 0.036
0.14TrpCys: 0.14 ± 0.012
0.762TrpAsp: 0.762 ± 0.028
0.706TrpGlu: 0.706 ± 0.025
0.583TrpPhe: 0.583 ± 0.026
1.167TrpGly: 1.167 ± 0.033
0.371TrpHis: 0.371 ± 0.019
0.658TrpIle: 0.658 ± 0.021
0.477TrpLys: 0.477 ± 0.02
1.947TrpLeu: 1.947 ± 0.05
0.396TrpMet: 0.396 ± 0.018
0.411TrpAsn: 0.411 ± 0.018
0.85TrpPro: 0.85 ± 0.028
0.685TrpGln: 0.685 ± 0.022
1.194TrpArg: 1.194 ± 0.033
0.801TrpSer: 0.801 ± 0.027
0.854TrpThr: 0.854 ± 0.029
0.947TrpVal: 0.947 ± 0.028
0.273TrpTrp: 0.273 ± 0.016
0.278TrpTyr: 0.278 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.479TyrAla: 2.479 ± 0.048
0.201TyrCys: 0.201 ± 0.013
1.404TyrAsp: 1.404 ± 0.03
1.084TyrGlu: 1.084 ± 0.031
0.753TyrPhe: 0.753 ± 0.023
1.999TyrGly: 1.999 ± 0.049
0.47TyrHis: 0.47 ± 0.02
0.824TyrIle: 0.824 ± 0.026
0.493TyrLys: 0.493 ± 0.019
2.155TyrLeu: 2.155 ± 0.044
0.416TyrMet: 0.416 ± 0.019
0.486TyrAsn: 0.486 ± 0.019
1.039TyrPro: 1.039 ± 0.025
0.572TyrGln: 0.572 ± 0.02
1.667TyrArg: 1.667 ± 0.041
0.994TyrSer: 0.994 ± 0.028
1.012TyrThr: 1.012 ± 0.028
1.373TyrVal: 1.373 ± 0.037
0.35TyrTrp: 0.35 ± 0.017
0.511TyrTyr: 0.511 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4072 proteins (1265259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski