Amino acid dipepetide frequency for Malus baccata (Siberian crab apple) (Pyrus baccata)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.587AlaAla: 6.587 ± 0.031	1.261AlaCys: 1.261 ± 0.01	3.191AlaAsp: 3.191 ± 0.016	4.275AlaGlu: 4.275 ± 0.023	2.775AlaPhe: 2.775 ± 0.014	4.178AlaGly: 4.178 ± 0.019	1.352AlaHis: 1.352 ± 0.011	3.621AlaIle: 3.621 ± 0.018	3.916AlaLys: 3.916 ± 0.018	6.587AlaLeu: 6.587 ± 0.025	1.783AlaMet: 1.783 ± 0.012	2.622AlaAsn: 2.622 ± 0.013	2.956AlaPro: 2.956 ± 0.019	2.206AlaGln: 2.206 ± 0.012	3.367AlaArg: 3.367 ± 0.016	6.089AlaSer: 6.089 ± 0.025	3.706AlaThr: 3.706 ± 0.017	4.9AlaVal: 4.9 ± 0.021	0.781AlaTrp: 0.781 ± 0.008	1.79AlaTyr: 1.79 ± 0.012	0.001AlaXaa: 0.001 ± 0.0
Cys	1.012CysAla: 1.012 ± 0.009	0.522CysCys: 0.522 ± 0.008	0.857CysAsp: 0.857 ± 0.008	0.894CysGlu: 0.894 ± 0.008	0.913CysPhe: 0.913 ± 0.008	1.392CysGly: 1.392 ± 0.01	0.456CysHis: 0.456 ± 0.006	0.988CysIle: 0.988 ± 0.008	1.168CysLys: 1.168 ± 0.01	1.855CysLeu: 1.855 ± 0.012	0.464CysMet: 0.464 ± 0.006	0.845CysAsn: 0.845 ± 0.009	0.958CysPro: 0.958 ± 0.009	0.623CysGln: 0.623 ± 0.006	1.08CysArg: 1.08 ± 0.008	1.831CysSer: 1.831 ± 0.014	0.918CysThr: 0.918 ± 0.008	1.065CysVal: 1.065 ± 0.008	0.26CysTrp: 0.26 ± 0.004	0.537CysTyr: 0.537 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.475AspAla: 3.475 ± 0.015	0.97AspCys: 0.97 ± 0.007	3.659AspAsp: 3.659 ± 0.02	3.973AspGlu: 3.973 ± 0.021	2.3AspPhe: 2.3 ± 0.013	3.878AspGly: 3.878 ± 0.015	1.332AspHis: 1.332 ± 0.01	2.873AspIle: 2.873 ± 0.014	2.701AspLys: 2.701 ± 0.017	5.054AspLeu: 5.054 ± 0.022	1.347AspMet: 1.347 ± 0.009	2.049AspAsn: 2.049 ± 0.012	2.582AspPro: 2.582 ± 0.013	1.843AspGln: 1.843 ± 0.012	2.425AspArg: 2.425 ± 0.014	4.189AspSer: 4.189 ± 0.019	2.173AspThr: 2.173 ± 0.013	3.656AspVal: 3.656 ± 0.017	0.72AspTrp: 0.72 ± 0.007	1.541AspTyr: 1.541 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.825GluAla: 4.825 ± 0.02	0.911GluCys: 0.911 ± 0.009	3.949GluAsp: 3.949 ± 0.02	6.142GluGlu: 6.142 ± 0.038	2.376GluPhe: 2.376 ± 0.012	3.896GluGly: 3.896 ± 0.017	1.257GluHis: 1.257 ± 0.009	3.621GluIle: 3.621 ± 0.018	4.68GluLys: 4.68 ± 0.026	5.987GluLeu: 5.987 ± 0.023	1.739GluMet: 1.739 ± 0.012	3.029GluAsn: 3.029 ± 0.015	2.163GluPro: 2.163 ± 0.013	2.182GluGln: 2.182 ± 0.015	3.398GluArg: 3.398 ± 0.018	4.587GluSer: 4.587 ± 0.021	3.033GluThr: 3.033 ± 0.017	4.243GluVal: 4.243 ± 0.017	0.742GluTrp: 0.742 ± 0.008	1.613GluTyr: 1.613 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.482PheAla: 2.482 ± 0.015	0.905PheCys: 0.905 ± 0.009	2.341PheAsp: 2.341 ± 0.012	2.308PheGlu: 2.308 ± 0.013	1.912PhePhe: 1.912 ± 0.013	3.088PheGly: 3.088 ± 0.014	1.091PheHis: 1.091 ± 0.009	1.966PheIle: 1.966 ± 0.011	2.104PheLys: 2.104 ± 0.012	4.223PheLeu: 4.223 ± 0.022	0.983PheMet: 0.983 ± 0.008	1.738PheAsn: 1.738 ± 0.012	2.133PhePro: 2.133 ± 0.014	1.59PheGln: 1.59 ± 0.009	2.08PheArg: 2.08 ± 0.012	4.055PheSer: 4.055 ± 0.016	1.992PheThr: 1.992 ± 0.012	2.812PheVal: 2.812 ± 0.016	0.57PheTrp: 0.57 ± 0.005	1.248PheTyr: 1.248 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	3.951GlyAla: 3.951 ± 0.019	1.361GlyCys: 1.361 ± 0.011	3.475GlyAsp: 3.475 ± 0.016	3.767GlyGlu: 3.767 ± 0.017	3.231GlyPhe: 3.231 ± 0.016	5.858GlyGly: 5.858 ± 0.05	1.573GlyHis: 1.573 ± 0.012	3.578GlyIle: 3.578 ± 0.015	4.121GlyLys: 4.121 ± 0.017	5.998GlyLeu: 5.998 ± 0.024	1.587GlyMet: 1.587 ± 0.011	3.147GlyAsn: 3.147 ± 0.016	2.482GlyPro: 2.482 ± 0.015	2.137GlyGln: 2.137 ± 0.013	3.702GlyArg: 3.702 ± 0.019	6.163GlySer: 6.163 ± 0.026	3.288GlyThr: 3.288 ± 0.015	4.313GlyVal: 4.313 ± 0.019	0.926GlyTrp: 0.926 ± 0.008	2.045GlyTyr: 2.045 ± 0.013	0.001GlyXaa: 0.001 ± 0.0
His	1.427HisAla: 1.427 ± 0.012	0.525HisCys: 0.525 ± 0.006	1.187HisAsp: 1.187 ± 0.008	1.338HisGlu: 1.338 ± 0.009	1.064HisPhe: 1.064 ± 0.008	1.755HisGly: 1.755 ± 0.011	1.018HisHis: 1.018 ± 0.011	1.189HisIle: 1.189 ± 0.01	1.209HisLys: 1.209 ± 0.009	2.472HisLeu: 2.472 ± 0.015	0.573HisMet: 0.573 ± 0.006	0.985HisAsn: 0.985 ± 0.008	1.432HisPro: 1.432 ± 0.01	1.087HisGln: 1.087 ± 0.009	1.405HisArg: 1.405 ± 0.01	1.962HisSer: 1.962 ± 0.014	1.018HisThr: 1.018 ± 0.009	1.568HisVal: 1.568 ± 0.01	0.301HisTrp: 0.301 ± 0.004	0.692HisTyr: 0.692 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	3.444IleAla: 3.444 ± 0.017	1.051IleCys: 1.051 ± 0.008	2.744IleAsp: 2.744 ± 0.015	3.047IleGlu: 3.047 ± 0.015	2.203IlePhe: 2.203 ± 0.012	3.329IleGly: 3.329 ± 0.015	1.252IleHis: 1.252 ± 0.009	2.536IleIle: 2.536 ± 0.014	2.801IleLys: 2.801 ± 0.016	4.923IleLeu: 4.923 ± 0.02	1.11IleMet: 1.11 ± 0.01	2.075IleAsn: 2.075 ± 0.011	2.97IlePro: 2.97 ± 0.016	1.917IleGln: 1.917 ± 0.01	2.623IleArg: 2.623 ± 0.013	4.723IleSer: 4.723 ± 0.018	2.517IleThr: 2.517 ± 0.013	3.425IleVal: 3.425 ± 0.018	0.706IleTrp: 0.706 ± 0.008	1.419IleTyr: 1.419 ± 0.01	0.001IleXaa: 0.001 ± 0.0
Lys	4.061LysAla: 4.061 ± 0.019	0.974LysCys: 0.974 ± 0.009	3.211LysAsp: 3.211 ± 0.014	4.537LysGlu: 4.537 ± 0.022	2.207LysPhe: 2.207 ± 0.013	3.649LysGly: 3.649 ± 0.017	1.364LysHis: 1.364 ± 0.009	3.107LysIle: 3.107 ± 0.013	4.76LysLys: 4.76 ± 0.03	6.036LysLeu: 6.036 ± 0.023	1.505LysMet: 1.505 ± 0.01	2.663LysAsn: 2.663 ± 0.015	2.81LysPro: 2.81 ± 0.015	2.303LysGln: 2.303 ± 0.015	3.577LysArg: 3.577 ± 0.018	4.699LysSer: 4.699 ± 0.021	2.905LysThr: 2.905 ± 0.013	3.875LysVal: 3.875 ± 0.017	0.794LysTrp: 0.794 ± 0.007	1.626LysTyr: 1.626 ± 0.012	0.001LysXaa: 0.001 ± 0.0
Leu	6.435LeuAla: 6.435 ± 0.024	1.859LeuCys: 1.859 ± 0.011	5.113LeuAsp: 5.113 ± 0.021	6.288LeuGlu: 6.288 ± 0.025	3.788LeuPhe: 3.788 ± 0.018	5.929LeuGly: 5.929 ± 0.02	2.591LeuHis: 2.591 ± 0.015	4.492LeuIle: 4.492 ± 0.02	6.189LeuLys: 6.189 ± 0.024	9.709LeuLeu: 9.709 ± 0.036	2.132LeuMet: 2.132 ± 0.012	3.933LeuAsn: 3.933 ± 0.017	5.362LeuPro: 5.362 ± 0.024	4.32LeuGln: 4.32 ± 0.018	5.443LeuArg: 5.443 ± 0.021	8.601LeuSer: 8.601 ± 0.03	4.494LeuThr: 4.494 ± 0.02	6.466LeuVal: 6.466 ± 0.02	1.16LeuTrp: 1.16 ± 0.009	2.456LeuTyr: 2.456 ± 0.016	0.001LeuXaa: 0.001 ± 0.0
Met	2.134MetAla: 2.134 ± 0.012	0.344MetCys: 0.344 ± 0.004	1.424MetAsp: 1.424 ± 0.008	1.981MetGlu: 1.981 ± 0.012	0.828MetPhe: 0.828 ± 0.007	1.661MetGly: 1.661 ± 0.011	0.568MetHis: 0.568 ± 0.006	1.149MetIle: 1.149 ± 0.009	1.614MetLys: 1.614 ± 0.011	2.173MetLeu: 2.173 ± 0.013	0.683MetMet: 0.683 ± 0.007	1.02MetAsn: 1.02 ± 0.008	1.125MetPro: 1.125 ± 0.008	0.95MetGln: 0.95 ± 0.008	1.237MetArg: 1.237 ± 0.01	1.784MetSer: 1.784 ± 0.011	1.053MetThr: 1.053 ± 0.008	1.683MetVal: 1.683 ± 0.011	0.266MetTrp: 0.266 ± 0.004	0.581MetTyr: 0.581 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.679AsnAla: 2.679 ± 0.013	0.876AsnCys: 0.876 ± 0.009	2.049AsnAsp: 2.049 ± 0.014	2.436AsnGlu: 2.436 ± 0.012	1.946AsnPhe: 1.946 ± 0.012	3.28AsnGly: 3.28 ± 0.015	1.113AsnHis: 1.113 ± 0.008	2.314AsnIle: 2.314 ± 0.011	2.338AsnLys: 2.338 ± 0.014	4.702AsnLeu: 4.702 ± 0.024	1.108AsnMet: 1.108 ± 0.009	2.251AsnAsn: 2.251 ± 0.017	2.465AsnPro: 2.465 ± 0.015	1.723AsnGln: 1.723 ± 0.015	2.012AsnArg: 2.012 ± 0.012	3.908AsnSer: 3.908 ± 0.018	1.96AsnThr: 1.96 ± 0.01	2.828AsnVal: 2.828 ± 0.011	0.573AsnTrp: 0.573 ± 0.005	1.311AsnTyr: 1.311 ± 0.01	0.001AsnXaa: 0.001 ± 0.0
Pro	3.202ProAla: 3.202 ± 0.018	0.782ProCys: 0.782 ± 0.008	2.507ProAsp: 2.507 ± 0.014	3.154ProGlu: 3.154 ± 0.015	1.976ProPhe: 1.976 ± 0.013	2.736ProGly: 2.736 ± 0.016	1.194ProHis: 1.194 ± 0.01	2.332ProIle: 2.332 ± 0.013	2.901ProLys: 2.901 ± 0.017	4.393ProLeu: 4.393 ± 0.02	1.028ProMet: 1.028 ± 0.009	2.461ProAsn: 2.461 ± 0.016	4.267ProPro: 4.267 ± 0.058	1.924ProGln: 1.924 ± 0.017	2.447ProArg: 2.447 ± 0.014	5.337ProSer: 5.337 ± 0.027	2.815ProThr: 2.815 ± 0.015	3.113ProVal: 3.113 ± 0.017	0.601ProTrp: 0.601 ± 0.006	1.342ProTyr: 1.342 ± 0.012	0.001ProXaa: 0.001 ± 0.0
Gln	2.413GlnAla: 2.413 ± 0.014	0.587GlnCys: 0.587 ± 0.007	1.672GlnAsp: 1.672 ± 0.011	2.393GlnGlu: 2.393 ± 0.014	1.381GlnPhe: 1.381 ± 0.011	2.168GlnGly: 2.168 ± 0.014	0.973GlnHis: 0.973 ± 0.009	1.974GlnIle: 1.974 ± 0.011	2.343GlnLys: 2.343 ± 0.014	3.716GlnLeu: 3.716 ± 0.017	0.995GlnMet: 0.995 ± 0.009	1.801GlnAsn: 1.801 ± 0.011	1.884GlnPro: 1.884 ± 0.013	2.109GlnGln: 2.109 ± 0.021	2.152GlnArg: 2.152 ± 0.012	2.959GlnSer: 2.959 ± 0.015	1.814GlnThr: 1.814 ± 0.01	2.454GlnVal: 2.454 ± 0.014	0.476GlnTrp: 0.476 ± 0.006	0.929GlnTyr: 0.929 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.245ArgAla: 3.245 ± 0.018	1.004ArgCys: 1.004 ± 0.009	2.626ArgAsp: 2.626 ± 0.014	3.377ArgGlu: 3.377 ± 0.019	2.217ArgPhe: 2.217 ± 0.014	3.295ArgGly: 3.295 ± 0.018	1.332ArgHis: 1.332 ± 0.011	2.763ArgIle: 2.763 ± 0.014	3.76ArgLys: 3.76 ± 0.021	5.036ArgLeu: 5.036 ± 0.023	1.354ArgMet: 1.354 ± 0.008	2.42ArgAsn: 2.42 ± 0.014	2.426ArgPro: 2.426 ± 0.013	1.887ArgGln: 1.887 ± 0.012	3.983ArgArg: 3.983 ± 0.022	4.429ArgSer: 4.429 ± 0.023	2.542ArgThr: 2.542 ± 0.013	3.376ArgVal: 3.376 ± 0.015	0.758ArgTrp: 0.758 ± 0.007	1.43ArgTyr: 1.43 ± 0.01	0.001ArgXaa: 0.001 ± 0.0
Ser	5.579SerAla: 5.579 ± 0.026	1.717SerCys: 1.717 ± 0.012	4.437SerAsp: 4.437 ± 0.018	4.801SerGlu: 4.801 ± 0.02	3.881SerPhe: 3.881 ± 0.018	6.097SerGly: 6.097 ± 0.025	2.053SerHis: 2.053 ± 0.013	4.323SerIle: 4.323 ± 0.019	4.928SerLys: 4.928 ± 0.021	8.814SerLeu: 8.814 ± 0.033	2.071SerMet: 2.071 ± 0.012	4.091SerAsn: 4.091 ± 0.021	4.718SerPro: 4.718 ± 0.032	3.042SerGln: 3.042 ± 0.018	4.453SerArg: 4.453 ± 0.02	11.153SerSer: 11.153 ± 0.049	4.845SerThr: 4.845 ± 0.022	5.329SerVal: 5.329 ± 0.021	1.175SerTrp: 1.175 ± 0.011	2.272SerTyr: 2.272 ± 0.013	0.001SerXaa: 0.001 ± 0.0
Thr	3.543ThrAla: 3.543 ± 0.016	0.927ThrCys: 0.927 ± 0.008	2.282ThrAsp: 2.282 ± 0.014	2.851ThrGlu: 2.851 ± 0.016	2.057ThrPhe: 2.057 ± 0.013	3.268ThrGly: 3.268 ± 0.016	1.08ThrHis: 1.08 ± 0.01	2.633ThrIle: 2.633 ± 0.014	2.751ThrLys: 2.751 ± 0.014	4.688ThrLeu: 4.688 ± 0.019	1.17ThrMet: 1.17 ± 0.009	2.112ThrAsn: 2.112 ± 0.012	2.729ThrPro: 2.729 ± 0.017	1.613ThrGln: 1.613 ± 0.01	2.427ThrArg: 2.427 ± 0.012	4.672ThrSer: 4.672 ± 0.022	3.168ThrThr: 3.168 ± 0.018	3.381ThrVal: 3.381 ± 0.016	0.648ThrTrp: 0.648 ± 0.008	1.38ThrTyr: 1.38 ± 0.012	0.001ThrXaa: 0.001 ± 0.0
Val	4.898ValAla: 4.898 ± 0.019	1.192ValCys: 1.192 ± 0.01	3.77ValAsp: 3.77 ± 0.014	4.496ValGlu: 4.496 ± 0.021	2.767ValPhe: 2.767 ± 0.013	4.359ValGly: 4.359 ± 0.018	1.585ValHis: 1.585 ± 0.011	3.286ValIle: 3.286 ± 0.014	3.88ValLys: 3.88 ± 0.017	6.465ValLeu: 6.465 ± 0.022	1.564ValMet: 1.564 ± 0.011	2.612ValAsn: 2.612 ± 0.014	3.281ValPro: 3.281 ± 0.017	2.367ValGln: 2.367 ± 0.013	3.201ValArg: 3.201 ± 0.015	5.452ValSer: 5.452 ± 0.019	3.225ValThr: 3.225 ± 0.018	5.098ValVal: 5.098 ± 0.02	0.799ValTrp: 0.799 ± 0.007	1.902ValTyr: 1.902 ± 0.012	0.001ValXaa: 0.001 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.008	0.258TrpCys: 0.258 ± 0.004	0.706TrpAsp: 0.706 ± 0.008	0.771TrpGlu: 0.771 ± 0.008	0.562TrpPhe: 0.562 ± 0.007	0.778TrpGly: 0.778 ± 0.008	0.307TrpHis: 0.307 ± 0.004	0.685TrpIle: 0.685 ± 0.006	0.954TrpLys: 0.954 ± 0.008	1.232TrpLeu: 1.232 ± 0.009	0.342TrpMet: 0.342 ± 0.005	0.695TrpAsn: 0.695 ± 0.007	0.504TrpPro: 0.504 ± 0.006	0.435TrpGln: 0.435 ± 0.005	0.836TrpArg: 0.836 ± 0.007	0.987TrpSer: 0.987 ± 0.009	0.637TrpThr: 0.637 ± 0.006	0.854TrpVal: 0.854 ± 0.007	0.25TrpTrp: 0.25 ± 0.004	0.338TrpTyr: 0.338 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.786TyrAla: 1.786 ± 0.012	0.61TyrCys: 0.61 ± 0.007	1.539TyrAsp: 1.539 ± 0.011	1.544TyrGlu: 1.544 ± 0.011	1.24TyrPhe: 1.24 ± 0.009	2.11TyrGly: 2.11 ± 0.015	0.715TyrHis: 0.715 ± 0.007	1.384TyrIle: 1.384 ± 0.011	1.541TyrLys: 1.541 ± 0.012	2.698TyrLeu: 2.698 ± 0.015	0.719TyrMet: 0.719 ± 0.007	1.321TyrAsn: 1.321 ± 0.012	1.268TyrPro: 1.268 ± 0.012	0.936TyrGln: 0.936 ± 0.009	1.413TyrArg: 1.413 ± 0.011	2.2TyrSer: 2.2 ± 0.014	1.276TyrThr: 1.276 ± 0.01	1.762TyrVal: 1.762 ± 0.012	0.391TyrTrp: 0.391 ± 0.005	0.948TyrTyr: 0.948 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.761XaaXaa: 0.761 ± 0.167

Statistics based on 45510 proteins (16148503 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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