Amino acid dipepetide frequency for Psychroflexus sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.93AlaAla: 3.93 ± 0.089
0.542AlaCys: 0.542 ± 0.027
3.326AlaAsp: 3.326 ± 0.076
4.608AlaGlu: 4.608 ± 0.087
3.461AlaPhe: 3.461 ± 0.075
4.279AlaGly: 4.279 ± 0.071
1.134AlaHis: 1.134 ± 0.042
4.882AlaIle: 4.882 ± 0.092
4.612AlaLys: 4.612 ± 0.086
6.454AlaLeu: 6.454 ± 0.11
1.559AlaMet: 1.559 ± 0.044
2.94AlaAsn: 2.94 ± 0.062
1.707AlaPro: 1.707 ± 0.043
2.428AlaGln: 2.428 ± 0.059
2.157AlaArg: 2.157 ± 0.051
4.302AlaSer: 4.302 ± 0.084
2.999AlaThr: 2.999 ± 0.074
3.921AlaVal: 3.921 ± 0.075
0.613AlaTrp: 0.613 ± 0.031
2.669AlaTyr: 2.669 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.374CysAla: 0.374 ± 0.021
0.078CysCys: 0.078 ± 0.01
0.388CysAsp: 0.388 ± 0.021
0.481CysGlu: 0.481 ± 0.024
0.369CysPhe: 0.369 ± 0.022
0.534CysGly: 0.534 ± 0.026
0.159CysHis: 0.159 ± 0.014
0.489CysIle: 0.489 ± 0.026
0.373CysLys: 0.373 ± 0.02
0.589CysLeu: 0.589 ± 0.025
0.125CysMet: 0.125 ± 0.012
0.301CysAsn: 0.301 ± 0.019
0.292CysPro: 0.292 ± 0.022
0.226CysGln: 0.226 ± 0.018
0.187CysArg: 0.187 ± 0.017
0.461CysSer: 0.461 ± 0.025
0.329CysThr: 0.329 ± 0.02
0.41CysVal: 0.41 ± 0.022
0.058CysTrp: 0.058 ± 0.009
0.209CysTyr: 0.209 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.472AspAla: 3.472 ± 0.07
0.362AspCys: 0.362 ± 0.024
2.856AspAsp: 2.856 ± 0.069
4.536AspGlu: 4.536 ± 0.077
3.983AspPhe: 3.983 ± 0.069
3.291AspGly: 3.291 ± 0.076
1.062AspHis: 1.062 ± 0.031
4.493AspIle: 4.493 ± 0.078
4.235AspLys: 4.235 ± 0.075
6.06AspLeu: 6.06 ± 0.091
1.209AspMet: 1.209 ± 0.035
2.663AspAsn: 2.663 ± 0.071
1.871AspPro: 1.871 ± 0.051
2.015AspGln: 2.015 ± 0.048
2.085AspArg: 2.085 ± 0.049
3.444AspSer: 3.444 ± 0.067
2.617AspThr: 2.617 ± 0.053
3.64AspVal: 3.64 ± 0.07
0.744AspTrp: 0.744 ± 0.032
2.96AspTyr: 2.96 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.019GluAla: 5.019 ± 0.092
0.298GluCys: 0.298 ± 0.022
4.553GluAsp: 4.553 ± 0.081
5.798GluGlu: 5.798 ± 0.098
3.732GluPhe: 3.732 ± 0.074
4.082GluGly: 4.082 ± 0.073
1.336GluHis: 1.336 ± 0.04
5.604GluIle: 5.604 ± 0.093
5.915GluLys: 5.915 ± 0.092
6.779GluLeu: 6.779 ± 0.094
1.698GluMet: 1.698 ± 0.041
4.771GluAsn: 4.771 ± 0.085
1.803GluPro: 1.803 ± 0.043
2.486GluGln: 2.486 ± 0.057
2.754GluArg: 2.754 ± 0.057
4.032GluSer: 4.032 ± 0.075
3.936GluThr: 3.936 ± 0.075
5.206GluVal: 5.206 ± 0.088
0.673GluTrp: 0.673 ± 0.032
2.23GluTyr: 2.23 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
2.942PheAla: 2.942 ± 0.072
0.401PheCys: 0.401 ± 0.021
3.444PheAsp: 3.444 ± 0.069
4.184PheGlu: 4.184 ± 0.07
2.825PhePhe: 2.825 ± 0.076
3.819PheGly: 3.819 ± 0.087
0.872PheHis: 0.872 ± 0.033
4.045PheIle: 4.045 ± 0.082
3.935PheLys: 3.935 ± 0.07
4.894PheLeu: 4.894 ± 0.098
1.132PheMet: 1.132 ± 0.038
3.006PheAsn: 3.006 ± 0.075
1.708PhePro: 1.708 ± 0.04
1.951PheGln: 1.951 ± 0.05
1.83PheArg: 1.83 ± 0.045
4.269PheSer: 4.269 ± 0.079
3.047PheThr: 3.047 ± 0.059
3.023PheVal: 3.023 ± 0.059
0.636PheTrp: 0.636 ± 0.028
2.176PheTyr: 2.176 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
3.9GlyAla: 3.9 ± 0.072
0.474GlyCys: 0.474 ± 0.027
3.468GlyAsp: 3.468 ± 0.068
4.15GlyGlu: 4.15 ± 0.079
3.939GlyPhe: 3.939 ± 0.081
4.548GlyGly: 4.548 ± 0.105
1.199GlyHis: 1.199 ± 0.041
5.384GlyIle: 5.384 ± 0.083
4.513GlyLys: 4.513 ± 0.083
6.001GlyLeu: 6.001 ± 0.091
1.525GlyMet: 1.525 ± 0.047
3.234GlyAsn: 3.234 ± 0.077
1.362GlyPro: 1.362 ± 0.036
1.982GlyGln: 1.982 ± 0.049
2.203GlyArg: 2.203 ± 0.054
4.021GlySer: 4.021 ± 0.075
3.507GlyThr: 3.507 ± 0.09
4.183GlyVal: 4.183 ± 0.075
0.696GlyTrp: 0.696 ± 0.026
2.521GlyTyr: 2.521 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
0.978HisAla: 0.978 ± 0.038
0.166HisCys: 0.166 ± 0.015
0.893HisAsp: 0.893 ± 0.032
1.088HisGlu: 1.088 ± 0.042
1.186HisPhe: 1.186 ± 0.036
1.031HisGly: 1.031 ± 0.035
0.505HisHis: 0.505 ± 0.025
1.429HisIle: 1.429 ± 0.042
1.287HisLys: 1.287 ± 0.039
2.013HisLeu: 2.013 ± 0.047
0.356HisMet: 0.356 ± 0.02
0.833HisAsn: 0.833 ± 0.033
1.01HisPro: 1.01 ± 0.037
0.863HisGln: 0.863 ± 0.034
0.728HisArg: 0.728 ± 0.034
1.16HisSer: 1.16 ± 0.039
0.861HisThr: 0.861 ± 0.03
1.026HisVal: 1.026 ± 0.036
0.246HisTrp: 0.246 ± 0.018
0.855HisTyr: 0.855 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.012IleAla: 5.012 ± 0.086
0.543IleCys: 0.543 ± 0.025
4.87IleAsp: 4.87 ± 0.071
5.576IleGlu: 5.576 ± 0.09
3.64IlePhe: 3.64 ± 0.083
4.857IleGly: 4.857 ± 0.096
1.407IleHis: 1.407 ± 0.036
5.504IleIle: 5.504 ± 0.108
5.186IleLys: 5.186 ± 0.074
7.598IleLeu: 7.598 ± 0.099
1.305IleMet: 1.305 ± 0.039
4.089IleAsn: 4.089 ± 0.078
3.092IlePro: 3.092 ± 0.068
2.864IleGln: 2.864 ± 0.065
2.654IleArg: 2.654 ± 0.06
6.02IleSer: 6.02 ± 0.091
4.045IleThr: 4.045 ± 0.078
4.251IleVal: 4.251 ± 0.081
0.683IleTrp: 0.683 ± 0.024
2.701IleTyr: 2.701 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.441LysAla: 5.441 ± 0.093
0.295LysCys: 0.295 ± 0.018
4.465LysAsp: 4.465 ± 0.086
5.764LysGlu: 5.764 ± 0.098
3.176LysPhe: 3.176 ± 0.062
3.987LysGly: 3.987 ± 0.072
1.563LysHis: 1.563 ± 0.047
5.674LysIle: 5.674 ± 0.089
6.196LysLys: 6.196 ± 0.109
7.01LysLeu: 7.01 ± 0.1
1.789LysMet: 1.789 ± 0.045
4.459LysAsn: 4.459 ± 0.069
2.568LysPro: 2.568 ± 0.051
2.621LysGln: 2.621 ± 0.053
3.028LysArg: 3.028 ± 0.068
5.178LysSer: 5.178 ± 0.082
4.814LysThr: 4.814 ± 0.083
4.381LysVal: 4.381 ± 0.068
0.634LysTrp: 0.634 ± 0.027
2.56LysTyr: 2.56 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
5.954LeuAla: 5.954 ± 0.087
0.62LeuCys: 0.62 ± 0.029
5.507LeuAsp: 5.507 ± 0.094
6.883LeuGlu: 6.883 ± 0.098
4.85LeuPhe: 4.85 ± 0.104
6.153LeuGly: 6.153 ± 0.086
1.574LeuHis: 1.574 ± 0.049
7.46LeuIle: 7.46 ± 0.118
8.664LeuLys: 8.664 ± 0.117
8.668LeuLeu: 8.668 ± 0.132
2.29LeuMet: 2.29 ± 0.051
5.699LeuAsn: 5.699 ± 0.099
3.612LeuPro: 3.612 ± 0.058
3.378LeuGln: 3.378 ± 0.062
3.54LeuArg: 3.54 ± 0.062
7.706LeuSer: 7.706 ± 0.102
4.852LeuThr: 4.852 ± 0.071
5.759LeuVal: 5.759 ± 0.092
0.825LeuTrp: 0.825 ± 0.035
3.197LeuTyr: 3.197 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.506MetAla: 1.506 ± 0.051
0.114MetCys: 0.114 ± 0.012
1.216MetAsp: 1.216 ± 0.039
1.378MetGlu: 1.378 ± 0.044
0.831MetPhe: 0.831 ± 0.027
1.336MetGly: 1.336 ± 0.041
0.413MetHis: 0.413 ± 0.024
1.535MetIle: 1.535 ± 0.045
2.236MetLys: 2.236 ± 0.05
2.071MetLeu: 2.071 ± 0.05
0.635MetMet: 0.635 ± 0.034
1.292MetAsn: 1.292 ± 0.039
0.838MetPro: 0.838 ± 0.032
0.872MetGln: 0.872 ± 0.03
0.927MetArg: 0.927 ± 0.035
1.574MetSer: 1.574 ± 0.04
1.19MetThr: 1.19 ± 0.034
1.164MetVal: 1.164 ± 0.035
0.153MetTrp: 0.153 ± 0.014
0.647MetTyr: 0.647 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.533AsnAla: 3.533 ± 0.059
0.377AsnCys: 0.377 ± 0.028
2.786AsnAsp: 2.786 ± 0.06
3.388AsnGlu: 3.388 ± 0.07
3.156AsnPhe: 3.156 ± 0.061
3.004AsnGly: 3.004 ± 0.08
0.971AsnHis: 0.971 ± 0.036
4.019AsnIle: 4.019 ± 0.071
3.554AsnLys: 3.554 ± 0.077
5.737AsnLeu: 5.737 ± 0.093
1.145AsnMet: 1.145 ± 0.036
2.698AsnAsn: 2.698 ± 0.08
2.621AsnPro: 2.621 ± 0.053
2.312AsnGln: 2.312 ± 0.05
2.14AsnArg: 2.14 ± 0.049
3.895AsnSer: 3.895 ± 0.084
3.118AsnThr: 3.118 ± 0.067
2.911AsnVal: 2.911 ± 0.067
0.681AsnTrp: 0.681 ± 0.03
2.539AsnTyr: 2.539 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.852ProAla: 1.852 ± 0.051
0.171ProCys: 0.171 ± 0.015
2.222ProAsp: 2.222 ± 0.054
3.26ProGlu: 3.26 ± 0.068
1.801ProPhe: 1.801 ± 0.043
2.228ProGly: 2.228 ± 0.063
0.645ProHis: 0.645 ± 0.027
2.4ProIle: 2.4 ± 0.054
2.553ProLys: 2.553 ± 0.051
2.95ProLeu: 2.95 ± 0.056
0.69ProMet: 0.69 ± 0.03
2.003ProAsn: 2.003 ± 0.049
0.852ProPro: 0.852 ± 0.039
1.283ProGln: 1.283 ± 0.041
1.059ProArg: 1.059 ± 0.037
2.246ProSer: 2.246 ± 0.058
1.703ProThr: 1.703 ± 0.047
2.481ProVal: 2.481 ± 0.054
0.326ProTrp: 0.326 ± 0.018
1.351ProTyr: 1.351 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.347GlnAla: 2.347 ± 0.058
0.156GlnCys: 0.156 ± 0.014
2.199GlnAsp: 2.199 ± 0.048
2.485GlnGlu: 2.485 ± 0.052
1.788GlnPhe: 1.788 ± 0.049
1.944GlnGly: 1.944 ± 0.051
0.718GlnHis: 0.718 ± 0.03
2.736GlnIle: 2.736 ± 0.052
3.1GlnLys: 3.1 ± 0.066
3.697GlnLeu: 3.697 ± 0.072
0.815GlnMet: 0.815 ± 0.029
2.39GlnAsn: 2.39 ± 0.053
1.22GlnPro: 1.22 ± 0.042
1.49GlnGln: 1.49 ± 0.05
1.367GlnArg: 1.367 ± 0.036
2.127GlnSer: 2.127 ± 0.051
2.017GlnThr: 2.017 ± 0.049
2.256GlnVal: 2.256 ± 0.049
0.342GlnTrp: 0.342 ± 0.022
1.198GlnTyr: 1.198 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.124ArgAla: 2.124 ± 0.056
0.187ArgCys: 0.187 ± 0.015
1.999ArgAsp: 1.999 ± 0.05
2.519ArgGlu: 2.519 ± 0.054
2.137ArgPhe: 2.137 ± 0.058
2.052ArgGly: 2.052 ± 0.056
0.76ArgHis: 0.76 ± 0.03
2.934ArgIle: 2.934 ± 0.059
2.773ArgLys: 2.773 ± 0.059
3.675ArgLeu: 3.675 ± 0.071
0.938ArgMet: 0.938 ± 0.034
2.016ArgAsn: 2.016 ± 0.049
1.155ArgPro: 1.155 ± 0.035
1.354ArgGln: 1.354 ± 0.039
1.559ArgArg: 1.559 ± 0.041
2.282ArgSer: 2.282 ± 0.059
1.916ArgThr: 1.916 ± 0.047
2.195ArgVal: 2.195 ± 0.058
0.363ArgTrp: 0.363 ± 0.022
1.619ArgTyr: 1.619 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
3.986SerAla: 3.986 ± 0.077
0.539SerCys: 0.539 ± 0.024
3.689SerAsp: 3.689 ± 0.067
5.206SerGlu: 5.206 ± 0.074
3.935SerPhe: 3.935 ± 0.08
4.74SerGly: 4.74 ± 0.092
1.183SerHis: 1.183 ± 0.03
5.576SerIle: 5.576 ± 0.095
5.146SerLys: 5.146 ± 0.08
6.872SerLeu: 6.872 ± 0.104
1.437SerMet: 1.437 ± 0.036
3.415SerAsn: 3.415 ± 0.074
2.372SerPro: 2.372 ± 0.049
2.504SerGln: 2.504 ± 0.052
2.555SerArg: 2.555 ± 0.049
5.1SerSer: 5.1 ± 0.096
3.594SerThr: 3.594 ± 0.071
4.232SerVal: 4.232 ± 0.072
0.731SerTrp: 0.731 ± 0.032
2.774SerTyr: 2.774 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
3.494ThrAla: 3.494 ± 0.079
0.346ThrCys: 0.346 ± 0.025
3.197ThrAsp: 3.197 ± 0.064
3.676ThrGlu: 3.676 ± 0.068
2.766ThrPhe: 2.766 ± 0.056
4.035ThrGly: 4.035 ± 0.075
1.06ThrHis: 1.06 ± 0.041
3.639ThrIle: 3.639 ± 0.063
3.447ThrLys: 3.447 ± 0.074
5.284ThrLeu: 5.284 ± 0.089
0.858ThrMet: 0.858 ± 0.029
2.586ThrAsn: 2.586 ± 0.059
2.177ThrPro: 2.177 ± 0.055
1.937ThrGln: 1.937 ± 0.046
1.785ThrArg: 1.785 ± 0.049
4.068ThrSer: 4.068 ± 0.071
3.03ThrThr: 3.03 ± 0.074
3.152ThrVal: 3.152 ± 0.089
0.501ThrTrp: 0.501 ± 0.024
2.395ThrTyr: 2.395 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.677ValAla: 3.677 ± 0.077
0.448ValCys: 0.448 ± 0.027
3.666ValAsp: 3.666 ± 0.063
4.413ValGlu: 4.413 ± 0.076
3.512ValPhe: 3.512 ± 0.074
3.83ValGly: 3.83 ± 0.071
0.99ValHis: 0.99 ± 0.036
4.775ValIle: 4.775 ± 0.087
4.285ValLys: 4.285 ± 0.083
6.071ValLeu: 6.071 ± 0.097
1.395ValMet: 1.395 ± 0.042
3.362ValAsn: 3.362 ± 0.064
2.058ValPro: 2.058 ± 0.052
1.829ValGln: 1.829 ± 0.044
1.951ValArg: 1.951 ± 0.053
4.508ValSer: 4.508 ± 0.074
3.125ValThr: 3.125 ± 0.092
3.974ValVal: 3.974 ± 0.074
0.621ValTrp: 0.621 ± 0.029
2.372ValTyr: 2.372 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.586TrpAla: 0.586 ± 0.026
0.072TrpCys: 0.072 ± 0.01
0.56TrpAsp: 0.56 ± 0.025
0.707TrpGlu: 0.707 ± 0.027
0.582TrpPhe: 0.582 ± 0.028
0.593TrpGly: 0.593 ± 0.026
0.201TrpHis: 0.201 ± 0.015
0.771TrpIle: 0.771 ± 0.033
0.743TrpLys: 0.743 ± 0.029
1.024TrpLeu: 1.024 ± 0.04
0.326TrpMet: 0.326 ± 0.019
0.629TrpAsn: 0.629 ± 0.026
0.271TrpPro: 0.271 ± 0.018
0.401TrpGln: 0.401 ± 0.025
0.423TrpArg: 0.423 ± 0.023
0.631TrpSer: 0.631 ± 0.03
0.546TrpThr: 0.546 ± 0.025
0.566TrpVal: 0.566 ± 0.026
0.154TrpTrp: 0.154 ± 0.017
0.371TrpTyr: 0.371 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.398TyrAla: 2.398 ± 0.059
0.244TyrCys: 0.244 ± 0.016
2.292TyrAsp: 2.292 ± 0.05
2.605TyrGlu: 2.605 ± 0.062
2.471TyrPhe: 2.471 ± 0.057
2.465TyrGly: 2.465 ± 0.053
0.762TyrHis: 0.762 ± 0.031
2.547TyrIle: 2.547 ± 0.059
2.848TyrLys: 2.848 ± 0.061
3.745TyrLeu: 3.745 ± 0.081
0.699TyrMet: 0.699 ± 0.031
2.198TyrAsn: 2.198 ± 0.054
1.486TyrPro: 1.486 ± 0.043
1.596TyrGln: 1.596 ± 0.05
1.627TyrArg: 1.627 ± 0.044
2.562TyrSer: 2.562 ± 0.058
2.188TyrThr: 2.188 ± 0.057
2.133TyrVal: 2.133 ± 0.053
0.478TyrTrp: 0.478 ± 0.025
1.665TyrTyr: 1.665 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2655 proteins (886846 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski