Amino acid dipepetide frequency for Mariprofundus ferrooxydans PV-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.306AlaAla: 12.306 ± 0.17	1.456AlaCys: 1.456 ± 0.04	6.312AlaAsp: 6.312 ± 0.085	6.524AlaGlu: 6.524 ± 0.116	3.576AlaPhe: 3.576 ± 0.072	9.018AlaGly: 9.018 ± 0.124	2.368AlaHis: 2.368 ± 0.054	5.845AlaIle: 5.845 ± 0.091	3.571AlaLys: 3.571 ± 0.069	11.148AlaLeu: 11.148 ± 0.118	3.565AlaMet: 3.565 ± 0.063	2.831AlaAsn: 2.831 ± 0.054	3.501AlaPro: 3.501 ± 0.076	3.319AlaGln: 3.319 ± 0.083	6.042AlaArg: 6.042 ± 0.09	6.035AlaSer: 6.035 ± 0.095	5.053AlaThr: 5.053 ± 0.074	7.575AlaVal: 7.575 ± 0.115	1.519AlaTrp: 1.519 ± 0.05	2.455AlaTyr: 2.455 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.037	0.19CysCys: 0.19 ± 0.016	0.708CysAsp: 0.708 ± 0.03	0.629CysGlu: 0.629 ± 0.025	0.485CysPhe: 0.485 ± 0.024	1.076CysGly: 1.076 ± 0.036	0.421CysHis: 0.421 ± 0.029	0.666CysIle: 0.666 ± 0.027	0.441CysLys: 0.441 ± 0.025	1.069CysLeu: 1.069 ± 0.033	0.34CysMet: 0.34 ± 0.021	0.38CysAsn: 0.38 ± 0.021	0.601CysPro: 0.601 ± 0.028	0.319CysGln: 0.319 ± 0.019	0.774CysArg: 0.774 ± 0.031	0.725CysSer: 0.725 ± 0.028	0.494CysThr: 0.494 ± 0.025	0.648CysVal: 0.648 ± 0.03	0.176CysTrp: 0.176 ± 0.014	0.321CysTyr: 0.321 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	6.572AspAla: 6.572 ± 0.105	0.619AspCys: 0.619 ± 0.031	3.306AspAsp: 3.306 ± 0.068	4.047AspGlu: 4.047 ± 0.065	2.184AspPhe: 2.184 ± 0.052	4.399AspGly: 4.399 ± 0.083	1.381AspHis: 1.381 ± 0.041	3.994AspIle: 3.994 ± 0.07	2.406AspLys: 2.406 ± 0.048	5.112AspLeu: 5.112 ± 0.081	1.823AspMet: 1.823 ± 0.048	1.618AspAsn: 1.618 ± 0.05	2.341AspPro: 2.341 ± 0.054	2.066AspGln: 2.066 ± 0.044	3.08AspArg: 3.08 ± 0.059	2.936AspSer: 2.936 ± 0.057	2.612AspThr: 2.612 ± 0.062	4.081AspVal: 4.081 ± 0.072	0.808AspTrp: 0.808 ± 0.031	1.751AspTyr: 1.751 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.395GluAla: 6.395 ± 0.102	0.498GluCys: 0.498 ± 0.022	2.619GluAsp: 2.619 ± 0.053	3.339GluGlu: 3.339 ± 0.083	1.909GluPhe: 1.909 ± 0.053	3.715GluGly: 3.715 ± 0.076	1.837GluHis: 1.837 ± 0.051	3.481GluIle: 3.481 ± 0.067	2.963GluLys: 2.963 ± 0.073	6.296GluLeu: 6.296 ± 0.096	1.94GluMet: 1.94 ± 0.052	1.849GluAsn: 1.849 ± 0.041	2.252GluPro: 2.252 ± 0.057	3.437GluGln: 3.437 ± 0.071	4.048GluArg: 4.048 ± 0.076	3.717GluSer: 3.717 ± 0.062	2.838GluThr: 2.838 ± 0.057	4.013GluVal: 4.013 ± 0.079	0.787GluTrp: 0.787 ± 0.032	1.391GluTyr: 1.391 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.536PheAla: 3.536 ± 0.073	0.48PheCys: 0.48 ± 0.021	2.579PheAsp: 2.579 ± 0.057	2.212PheGlu: 2.212 ± 0.053	1.431PhePhe: 1.431 ± 0.045	3.042PheGly: 3.042 ± 0.07	0.91PheHis: 0.91 ± 0.035	2.196PheIle: 2.196 ± 0.053	1.216PheLys: 1.216 ± 0.04	3.183PheLeu: 3.183 ± 0.065	0.953PheMet: 0.953 ± 0.033	1.307PheAsn: 1.307 ± 0.037	1.455PhePro: 1.455 ± 0.039	0.952PheGln: 0.952 ± 0.033	2.02PheArg: 2.02 ± 0.051	2.758PheSer: 2.758 ± 0.066	2.081PheThr: 2.081 ± 0.06	2.413PheVal: 2.413 ± 0.056	0.502PheTrp: 0.502 ± 0.025	1.075PheTyr: 1.075 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.347GlyAla: 6.347 ± 0.1	1.111GlyCys: 1.111 ± 0.037	4.263GlyAsp: 4.263 ± 0.072	4.691GlyGlu: 4.691 ± 0.078	3.058GlyPhe: 3.058 ± 0.061	5.816GlyGly: 5.816 ± 0.097	2.132GlyHis: 2.132 ± 0.047	4.953GlyIle: 4.953 ± 0.087	4.005GlyLys: 4.005 ± 0.071	7.688GlyLeu: 7.688 ± 0.108	2.846GlyMet: 2.846 ± 0.056	2.371GlyAsn: 2.371 ± 0.059	2.068GlyPro: 2.068 ± 0.061	2.641GlyGln: 2.641 ± 0.058	4.6GlyArg: 4.6 ± 0.085	4.487GlySer: 4.487 ± 0.08	3.536GlyThr: 3.536 ± 0.066	5.611GlyVal: 5.611 ± 0.098	1.276GlyTrp: 1.276 ± 0.044	2.405GlyTyr: 2.405 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.927HisAla: 2.927 ± 0.055	0.359HisCys: 0.359 ± 0.021	1.5HisAsp: 1.5 ± 0.046	1.4HisGlu: 1.4 ± 0.039	1.115HisPhe: 1.115 ± 0.034	2.318HisGly: 2.318 ± 0.055	0.921HisHis: 0.921 ± 0.04	1.641HisIle: 1.641 ± 0.043	0.903HisLys: 0.903 ± 0.038	2.732HisLeu: 2.732 ± 0.063	0.777HisMet: 0.777 ± 0.031	0.717HisAsn: 0.717 ± 0.032	1.553HisPro: 1.553 ± 0.04	1.037HisGln: 1.037 ± 0.041	1.552HisArg: 1.552 ± 0.04	1.372HisSer: 1.372 ± 0.042	1.213HisThr: 1.213 ± 0.036	1.728HisVal: 1.728 ± 0.044	0.401HisTrp: 0.401 ± 0.021	0.816HisTyr: 0.816 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.596IleAla: 6.596 ± 0.099	0.731IleCys: 0.731 ± 0.029	3.668IleAsp: 3.668 ± 0.065	4.033IleGlu: 4.033 ± 0.07	1.804IlePhe: 1.804 ± 0.049	4.848IleGly: 4.848 ± 0.085	1.57IleHis: 1.57 ± 0.049	3.362IleIle: 3.362 ± 0.066	2.264IleLys: 2.264 ± 0.056	5.03IleLeu: 5.03 ± 0.097	1.44IleMet: 1.44 ± 0.04	2.166IleAsn: 2.166 ± 0.058	2.702IlePro: 2.702 ± 0.059	1.798IleGln: 1.798 ± 0.049	4.019IleArg: 4.019 ± 0.079	3.906IleSer: 3.906 ± 0.079	3.198IleThr: 3.198 ± 0.062	3.891IleVal: 3.891 ± 0.073	0.679IleTrp: 0.679 ± 0.029	1.465IleTyr: 1.465 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.25LysAla: 4.25 ± 0.084	0.257LysCys: 0.257 ± 0.018	1.955LysAsp: 1.955 ± 0.048	2.338LysGlu: 2.338 ± 0.07	0.916LysPhe: 0.916 ± 0.034	2.803LysGly: 2.803 ± 0.075	1.144LysHis: 1.144 ± 0.038	2.052LysIle: 2.052 ± 0.048	2.303LysLys: 2.303 ± 0.07	4.341LysLeu: 4.341 ± 0.078	1.22LysMet: 1.22 ± 0.037	1.309LysAsn: 1.309 ± 0.04	2.248LysPro: 2.248 ± 0.055	2.408LysGln: 2.408 ± 0.063	2.909LysArg: 2.909 ± 0.061	2.405LysSer: 2.405 ± 0.048	2.257LysThr: 2.257 ± 0.066	2.705LysVal: 2.705 ± 0.061	0.333LysTrp: 0.333 ± 0.019	0.901LysTyr: 0.901 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.534LeuAla: 11.534 ± 0.135	1.173LeuCys: 1.173 ± 0.033	5.864LeuAsp: 5.864 ± 0.087	5.526LeuGlu: 5.526 ± 0.088	4.149LeuPhe: 4.149 ± 0.078	7.057LeuGly: 7.057 ± 0.107	2.809LeuHis: 2.809 ± 0.057	6.112LeuIle: 6.112 ± 0.096	4.689LeuLys: 4.689 ± 0.088	12.192LeuLeu: 12.192 ± 0.196	2.986LeuMet: 2.986 ± 0.065	3.374LeuAsn: 3.374 ± 0.068	5.253LeuPro: 5.253 ± 0.089	4.176LeuGln: 4.176 ± 0.082	5.906LeuArg: 5.906 ± 0.088	7.024LeuSer: 7.024 ± 0.091	5.192LeuThr: 5.192 ± 0.08	6.428LeuVal: 6.428 ± 0.102	1.29LeuTrp: 1.29 ± 0.049	2.483LeuTyr: 2.483 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.088MetAla: 3.088 ± 0.055	0.247MetCys: 0.247 ± 0.016	1.602MetAsp: 1.602 ± 0.043	1.493MetGlu: 1.493 ± 0.046	0.934MetPhe: 0.934 ± 0.032	2.084MetGly: 2.084 ± 0.054	0.931MetHis: 0.931 ± 0.034	1.856MetIle: 1.856 ± 0.041	1.381MetLys: 1.381 ± 0.038	3.579MetLeu: 3.579 ± 0.075	1.029MetMet: 1.029 ± 0.042	1.134MetAsn: 1.134 ± 0.039	1.682MetPro: 1.682 ± 0.038	1.696MetGln: 1.696 ± 0.044	2.018MetArg: 2.018 ± 0.045	1.947MetSer: 1.947 ± 0.049	1.655MetThr: 1.655 ± 0.045	1.922MetVal: 1.922 ± 0.052	0.245MetTrp: 0.245 ± 0.017	0.53MetTyr: 0.53 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.848AsnAla: 2.848 ± 0.063	0.299AsnCys: 0.299 ± 0.019	1.67AsnAsp: 1.67 ± 0.048	1.625AsnGlu: 1.625 ± 0.044	0.957AsnPhe: 0.957 ± 0.033	2.385AsnGly: 2.385 ± 0.059	0.851AsnHis: 0.851 ± 0.031	2.096AsnIle: 2.096 ± 0.051	1.341AsnLys: 1.341 ± 0.042	3.114AsnLeu: 3.114 ± 0.066	0.946AsnMet: 0.946 ± 0.03	1.155AsnAsn: 1.155 ± 0.04	1.851AsnPro: 1.851 ± 0.046	1.127AsnGln: 1.127 ± 0.033	2.123AsnArg: 2.123 ± 0.047	1.725AsnSer: 1.725 ± 0.052	1.538AsnThr: 1.538 ± 0.048	1.896AsnVal: 1.896 ± 0.052	0.454AsnTrp: 0.454 ± 0.02	0.826AsnTyr: 0.826 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.998ProAla: 4.998 ± 0.099	0.46ProCys: 0.46 ± 0.023	3.25ProAsp: 3.25 ± 0.06	3.429ProGlu: 3.429 ± 0.054	1.709ProPhe: 1.709 ± 0.046	3.44ProGly: 3.44 ± 0.069	1.025ProHis: 1.025 ± 0.033	1.983ProIle: 1.983 ± 0.051	1.473ProLys: 1.473 ± 0.046	4.36ProLeu: 4.36 ± 0.078	1.222ProMet: 1.222 ± 0.037	1.089ProAsn: 1.089 ± 0.04	1.611ProPro: 1.611 ± 0.057	1.454ProGln: 1.454 ± 0.041	1.793ProArg: 1.793 ± 0.043	2.242ProSer: 2.242 ± 0.056	1.802ProThr: 1.802 ± 0.045	4.089ProVal: 4.089 ± 0.085	0.661ProTrp: 0.661 ± 0.031	1.125ProTyr: 1.125 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.828GlnAla: 4.828 ± 0.096	0.38GlnCys: 0.38 ± 0.021	1.613GlnAsp: 1.613 ± 0.044	1.948GlnGlu: 1.948 ± 0.056	1.222GlnPhe: 1.222 ± 0.034	2.76GlnGly: 2.76 ± 0.061	1.206GlnHis: 1.206 ± 0.034	2.083GlnIle: 2.083 ± 0.057	1.557GlnLys: 1.557 ± 0.046	4.53GlnLeu: 4.53 ± 0.07	1.217GlnMet: 1.217 ± 0.037	0.972GlnAsn: 0.972 ± 0.038	1.851GlnPro: 1.851 ± 0.054	2.898GlnGln: 2.898 ± 0.086	2.627GlnArg: 2.627 ± 0.065	2.285GlnSer: 2.285 ± 0.053	1.791GlnThr: 1.791 ± 0.048	2.815GlnVal: 2.815 ± 0.057	0.668GlnTrp: 0.668 ± 0.035	0.873GlnTyr: 0.873 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.11ArgAla: 5.11 ± 0.073	0.659ArgCys: 0.659 ± 0.027	3.411ArgAsp: 3.411 ± 0.058	3.857ArgGlu: 3.857 ± 0.068	2.678ArgPhe: 2.678 ± 0.051	3.661ArgGly: 3.661 ± 0.064	1.817ArgHis: 1.817 ± 0.045	3.932ArgIle: 3.932 ± 0.068	2.803ArgLys: 2.803 ± 0.062	7.052ArgLeu: 7.052 ± 0.1	2.185ArgMet: 2.185 ± 0.051	1.973ArgAsn: 1.973 ± 0.054	2.334ArgPro: 2.334 ± 0.053	2.863ArgGln: 2.863 ± 0.061	3.92ArgArg: 3.92 ± 0.079	3.379ArgSer: 3.379 ± 0.058	2.457ArgThr: 2.457 ± 0.049	3.969ArgVal: 3.969 ± 0.066	0.942ArgTrp: 0.942 ± 0.036	1.984ArgTyr: 1.984 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.753SerAla: 5.753 ± 0.088	0.68SerCys: 0.68 ± 0.031	3.709SerAsp: 3.709 ± 0.068	3.556SerGlu: 3.556 ± 0.071	2.313SerPhe: 2.313 ± 0.063	5.559SerGly: 5.559 ± 0.085	1.545SerHis: 1.545 ± 0.047	3.527SerIle: 3.527 ± 0.07	2.185SerLys: 2.185 ± 0.053	6.356SerLeu: 6.356 ± 0.107	1.971SerMet: 1.971 ± 0.048	1.798SerAsn: 1.798 ± 0.048	2.523SerPro: 2.523 ± 0.062	1.902SerGln: 1.902 ± 0.045	3.694SerArg: 3.694 ± 0.059	3.507SerSer: 3.507 ± 0.076	2.8SerThr: 2.8 ± 0.048	4.304SerVal: 4.304 ± 0.072	0.811SerTrp: 0.811 ± 0.033	1.475SerTyr: 1.475 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.264ThrAla: 5.264 ± 0.083	0.512ThrCys: 0.512 ± 0.022	2.831ThrAsp: 2.831 ± 0.062	2.523ThrGlu: 2.523 ± 0.056	1.653ThrPhe: 1.653 ± 0.046	4.614ThrGly: 4.614 ± 0.071	1.237ThrHis: 1.237 ± 0.036	2.853ThrIle: 2.853 ± 0.052	1.431ThrLys: 1.431 ± 0.042	5.461ThrLeu: 5.461 ± 0.077	1.334ThrMet: 1.334 ± 0.044	1.263ThrAsn: 1.263 ± 0.046	2.674ThrPro: 2.674 ± 0.06	1.62ThrGln: 1.62 ± 0.046	2.685ThrArg: 2.685 ± 0.056	2.678ThrSer: 2.678 ± 0.055	2.717ThrThr: 2.717 ± 0.065	3.527ThrVal: 3.527 ± 0.076	0.545ThrTrp: 0.545 ± 0.026	1.21ThrTyr: 1.21 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.168ValAla: 7.168 ± 0.1	0.851ValCys: 0.851 ± 0.034	4.208ValAsp: 4.208 ± 0.075	4.294ValGlu: 4.294 ± 0.088	2.552ValPhe: 2.552 ± 0.052	4.543ValGly: 4.543 ± 0.072	1.696ValHis: 1.696 ± 0.048	4.38ValIle: 4.38 ± 0.079	2.587ValLys: 2.587 ± 0.058	7.038ValLeu: 7.038 ± 0.112	2.103ValMet: 2.103 ± 0.047	2.321ValAsn: 2.321 ± 0.054	2.892ValPro: 2.892 ± 0.059	2.29ValGln: 2.29 ± 0.055	4.228ValArg: 4.228 ± 0.074	4.55ValSer: 4.55 ± 0.071	3.747ValThr: 3.747 ± 0.068	5.184ValVal: 5.184 ± 0.09	0.84ValTrp: 0.84 ± 0.033	1.703ValTyr: 1.703 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.962TrpAla: 0.962 ± 0.036	0.163TrpCys: 0.163 ± 0.014	0.612TrpAsp: 0.612 ± 0.027	0.545TrpGlu: 0.545 ± 0.025	0.584TrpPhe: 0.584 ± 0.029	0.75TrpGly: 0.75 ± 0.029	0.447TrpHis: 0.447 ± 0.025	0.738TrpIle: 0.738 ± 0.028	0.595TrpLys: 0.595 ± 0.031	2.091TrpLeu: 2.091 ± 0.056	0.459TrpMet: 0.459 ± 0.023	0.384TrpAsn: 0.384 ± 0.022	0.58TrpPro: 0.58 ± 0.028	0.979TrpGln: 0.979 ± 0.036	0.923TrpArg: 0.923 ± 0.034	0.773TrpSer: 0.773 ± 0.035	0.478TrpThr: 0.478 ± 0.024	0.866TrpVal: 0.866 ± 0.034	0.232TrpTrp: 0.232 ± 0.017	0.361TrpTyr: 0.361 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.543TyrAla: 2.543 ± 0.058	0.331TyrCys: 0.331 ± 0.019	1.451TyrAsp: 1.451 ± 0.04	1.318TyrGlu: 1.318 ± 0.04	1.075TyrPhe: 1.075 ± 0.04	2.019TyrGly: 2.019 ± 0.055	0.736TyrHis: 0.736 ± 0.027	1.421TyrIle: 1.421 ± 0.043	0.938TyrLys: 0.938 ± 0.031	2.845TyrLeu: 2.845 ± 0.055	0.694TyrMet: 0.694 ± 0.03	0.815TyrAsn: 0.815 ± 0.028	1.242TyrPro: 1.242 ± 0.04	1.143TyrGln: 1.143 ± 0.041	2.025TyrArg: 2.025 ± 0.059	1.517TyrSer: 1.517 ± 0.045	1.174TyrThr: 1.174 ± 0.038	1.509TyrVal: 1.509 ± 0.047	0.354TyrTrp: 0.354 ± 0.019	0.781TyrTyr: 0.781 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2856 proteins (856874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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