Amino acid dipepetide frequency for Magnetospirillum sp. SS-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.15AlaAla: 19.15 ± 0.268	1.356AlaCys: 1.356 ± 0.037	7.363AlaAsp: 7.363 ± 0.094	8.757AlaGlu: 8.757 ± 0.099	3.945AlaPhe: 3.945 ± 0.057	11.476AlaGly: 11.476 ± 0.134	2.335AlaHis: 2.335 ± 0.045	5.908AlaIle: 5.908 ± 0.069	3.828AlaLys: 3.828 ± 0.065	13.059AlaLeu: 13.059 ± 0.134	3.67AlaMet: 3.67 ± 0.055	2.795AlaAsn: 2.795 ± 0.069	5.229AlaPro: 5.229 ± 0.067	3.427AlaGln: 3.427 ± 0.069	9.358AlaArg: 9.358 ± 0.125	6.047AlaSer: 6.047 ± 0.105	5.661AlaThr: 5.661 ± 0.114	9.497AlaVal: 9.497 ± 0.098	1.669AlaTrp: 1.669 ± 0.043	2.25AlaTyr: 2.25 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.032	0.145CysCys: 0.145 ± 0.01	0.633CysAsp: 0.633 ± 0.022	0.497CysGlu: 0.497 ± 0.017	0.348CysPhe: 0.348 ± 0.017	1.083CysGly: 1.083 ± 0.028	0.327CysHis: 0.327 ± 0.015	0.43CysIle: 0.43 ± 0.019	0.293CysLys: 0.293 ± 0.014	0.996CysLeu: 0.996 ± 0.033	0.207CysMet: 0.207 ± 0.012	0.247CysAsn: 0.247 ± 0.013	0.692CysPro: 0.692 ± 0.028	0.292CysGln: 0.292 ± 0.016	0.935CysArg: 0.935 ± 0.028	0.532CysSer: 0.532 ± 0.019	0.438CysThr: 0.438 ± 0.018	0.705CysVal: 0.705 ± 0.025	0.15CysTrp: 0.15 ± 0.01	0.24CysTyr: 0.24 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.577AspAla: 6.577 ± 0.092	0.63AspCys: 0.63 ± 0.023	3.54AspAsp: 3.54 ± 0.063	3.646AspGlu: 3.646 ± 0.058	2.149AspPhe: 2.149 ± 0.041	6.006AspGly: 6.006 ± 0.087	1.527AspHis: 1.527 ± 0.037	3.162AspIle: 3.162 ± 0.051	1.793AspLys: 1.793 ± 0.037	6.35AspLeu: 6.35 ± 0.072	1.518AspMet: 1.518 ± 0.033	1.316AspAsn: 1.316 ± 0.035	3.437AspPro: 3.437 ± 0.057	1.781AspGln: 1.781 ± 0.038	4.659AspArg: 4.659 ± 0.065	2.947AspSer: 2.947 ± 0.054	2.54AspThr: 2.54 ± 0.07	4.072AspVal: 4.072 ± 0.048	0.973AspTrp: 0.973 ± 0.027	1.342AspTyr: 1.342 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.135GluAla: 8.135 ± 0.096	0.501GluCys: 0.501 ± 0.021	2.802GluAsp: 2.802 ± 0.049	2.942GluGlu: 2.942 ± 0.062	1.776GluPhe: 1.776 ± 0.037	4.038GluGly: 4.038 ± 0.064	1.184GluHis: 1.184 ± 0.034	3.338GluIle: 3.338 ± 0.053	1.923GluLys: 1.923 ± 0.043	5.068GluLeu: 5.068 ± 0.078	1.766GluMet: 1.766 ± 0.042	1.139GluAsn: 1.139 ± 0.033	2.504GluPro: 2.504 ± 0.052	1.953GluGln: 1.953 ± 0.041	5.103GluArg: 5.103 ± 0.083	2.663GluSer: 2.663 ± 0.052	3.504GluThr: 3.504 ± 0.045	4.225GluVal: 4.225 ± 0.063	0.735GluTrp: 0.735 ± 0.023	0.965GluTyr: 0.965 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.091PheAla: 4.091 ± 0.06	0.439PheCys: 0.439 ± 0.016	2.505PheAsp: 2.505 ± 0.046	1.96PheGlu: 1.96 ± 0.042	1.17PhePhe: 1.17 ± 0.032	3.203PheGly: 3.203 ± 0.049	0.793PheHis: 0.793 ± 0.027	1.527PheIle: 1.527 ± 0.037	1.083PheLys: 1.083 ± 0.029	3.169PheLeu: 3.169 ± 0.052	0.735PheMet: 0.735 ± 0.025	0.958PheAsn: 0.958 ± 0.025	1.598PhePro: 1.598 ± 0.038	1.002PheGln: 1.002 ± 0.026	2.348PheArg: 2.348 ± 0.046	1.96PheSer: 1.96 ± 0.036	1.908PheThr: 1.908 ± 0.041	2.542PheVal: 2.542 ± 0.045	0.461PheTrp: 0.461 ± 0.018	0.742PheTyr: 0.742 ± 0.026	0.001PheXaa: 0.001 ± 0.001
Gly	8.749GlyAla: 8.749 ± 0.101	1.078GlyCys: 1.078 ± 0.031	5.06GlyAsp: 5.06 ± 0.093	4.83GlyGlu: 4.83 ± 0.068	3.382GlyPhe: 3.382 ± 0.053	8.223GlyGly: 8.223 ± 0.159	2.206GlyHis: 2.206 ± 0.044	4.713GlyIle: 4.713 ± 0.057	3.266GlyLys: 3.266 ± 0.059	9.417GlyLeu: 9.417 ± 0.097	2.542GlyMet: 2.542 ± 0.045	2.187GlyAsn: 2.187 ± 0.061	3.456GlyPro: 3.456 ± 0.06	2.877GlyGln: 2.877 ± 0.053	7.465GlyArg: 7.465 ± 0.098	4.291GlySer: 4.291 ± 0.107	4.421GlyThr: 4.421 ± 0.134	5.851GlyVal: 5.851 ± 0.068	1.476GlyTrp: 1.476 ± 0.035	2.009GlyTyr: 2.009 ± 0.04	0.002GlyXaa: 0.002 ± 0.001
His	2.587HisAla: 2.587 ± 0.046	0.324HisCys: 0.324 ± 0.016	1.39HisAsp: 1.39 ± 0.034	1.035HisGlu: 1.035 ± 0.029	0.87HisPhe: 0.87 ± 0.025	2.145HisGly: 2.145 ± 0.042	0.717HisHis: 0.717 ± 0.029	0.931HisIle: 0.931 ± 0.026	0.516HisLys: 0.516 ± 0.02	2.391HisLeu: 2.391 ± 0.055	0.522HisMet: 0.522 ± 0.02	0.476HisAsn: 0.476 ± 0.018	1.592HisPro: 1.592 ± 0.042	0.699HisGln: 0.699 ± 0.023	1.748HisArg: 1.748 ± 0.043	1.081HisSer: 1.081 ± 0.029	0.821HisThr: 0.821 ± 0.024	1.659HisVal: 1.659 ± 0.036	0.35HisTrp: 0.35 ± 0.02	0.577HisTyr: 0.577 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.266IleAla: 6.266 ± 0.073	0.553IleCys: 0.553 ± 0.022	3.549IleAsp: 3.549 ± 0.055	3.116IleGlu: 3.116 ± 0.051	1.312IlePhe: 1.312 ± 0.036	4.608IleGly: 4.608 ± 0.064	1.093IleHis: 1.093 ± 0.032	2.007IleIle: 2.007 ± 0.043	1.547IleLys: 1.547 ± 0.038	4.396IleLeu: 4.396 ± 0.065	0.941IleMet: 0.941 ± 0.03	1.439IleAsn: 1.439 ± 0.035	2.341IlePro: 2.341 ± 0.045	1.296IleGln: 1.296 ± 0.031	3.773IleArg: 3.773 ± 0.06	2.614IleSer: 2.614 ± 0.047	2.575IleThr: 2.575 ± 0.062	3.466IleVal: 3.466 ± 0.063	0.494IleTrp: 0.494 ± 0.019	0.858IleTyr: 0.858 ± 0.025	0.001IleXaa: 0.001 ± 0.001
Lys	4.471LysAla: 4.471 ± 0.069	0.218LysCys: 0.218 ± 0.014	1.752LysAsp: 1.752 ± 0.04	1.519LysGlu: 1.519 ± 0.044	0.875LysPhe: 0.875 ± 0.026	2.844LysGly: 2.844 ± 0.046	0.557LysHis: 0.557 ± 0.019	1.523LysIle: 1.523 ± 0.036	1.192LysLys: 1.192 ± 0.043	2.943LysLeu: 2.943 ± 0.053	0.812LysMet: 0.812 ± 0.024	0.721LysAsn: 0.721 ± 0.025	1.92LysPro: 1.92 ± 0.045	0.816LysGln: 0.816 ± 0.023	2.213LysArg: 2.213 ± 0.048	1.74LysSer: 1.74 ± 0.039	1.87LysThr: 1.87 ± 0.037	2.659LysVal: 2.659 ± 0.052	0.365LysTrp: 0.365 ± 0.017	0.567LysTyr: 0.567 ± 0.02	0.001LysXaa: 0.001 ± 0.001
Leu	15.265LeuAla: 15.265 ± 0.155	0.991LeuCys: 0.991 ± 0.03	6.753LeuAsp: 6.753 ± 0.081	5.368LeuGlu: 5.368 ± 0.08	3.442LeuPhe: 3.442 ± 0.05	8.794LeuGly: 8.794 ± 0.093	2.051LeuHis: 2.051 ± 0.035	4.414LeuIle: 4.414 ± 0.058	3.526LeuLys: 3.526 ± 0.056	9.863LeuLeu: 9.863 ± 0.136	2.398LeuMet: 2.398 ± 0.036	2.333LeuAsn: 2.333 ± 0.044	5.761LeuPro: 5.761 ± 0.078	2.154LeuGln: 2.154 ± 0.04	7.389LeuArg: 7.389 ± 0.097	6.21LeuSer: 6.21 ± 0.077	5.208LeuThr: 5.208 ± 0.092	7.496LeuVal: 7.496 ± 0.093	1.22LeuTrp: 1.22 ± 0.03	1.92LeuTyr: 1.92 ± 0.037	0.001LeuXaa: 0.001 ± 0.001
Met	3.674MetAla: 3.674 ± 0.059	0.18MetCys: 0.18 ± 0.012	1.376MetAsp: 1.376 ± 0.033	1.41MetGlu: 1.41 ± 0.032	0.706MetPhe: 0.706 ± 0.024	2.028MetGly: 2.028 ± 0.045	0.428MetHis: 0.428 ± 0.016	1.287MetIle: 1.287 ± 0.033	0.956MetLys: 0.956 ± 0.026	2.561MetLeu: 2.561 ± 0.046	0.727MetMet: 0.727 ± 0.025	0.697MetAsn: 0.697 ± 0.021	1.511MetPro: 1.511 ± 0.033	0.645MetGln: 0.645 ± 0.019	1.784MetArg: 1.784 ± 0.036	1.562MetSer: 1.562 ± 0.035	1.953MetThr: 1.953 ± 0.041	2.203MetVal: 2.203 ± 0.042	0.206MetTrp: 0.206 ± 0.012	0.299MetTyr: 0.299 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.909AsnAla: 2.909 ± 0.062	0.273AsnCys: 0.273 ± 0.014	1.401AsnAsp: 1.401 ± 0.046	1.036AsnGlu: 1.036 ± 0.029	0.769AsnPhe: 0.769 ± 0.021	2.127AsnGly: 2.127 ± 0.069	0.553AsnHis: 0.553 ± 0.02	1.194AsnIle: 1.194 ± 0.027	0.645AsnLys: 0.645 ± 0.023	2.515AsnLeu: 2.515 ± 0.056	0.556AsnMet: 0.556 ± 0.021	0.61AsnAsn: 0.61 ± 0.023	1.691AsnPro: 1.691 ± 0.035	0.724AsnGln: 0.724 ± 0.026	1.933AsnArg: 1.933 ± 0.038	1.225AsnSer: 1.225 ± 0.036	1.149AsnThr: 1.149 ± 0.043	1.716AsnVal: 1.716 ± 0.038	0.367AsnTrp: 0.367 ± 0.018	0.53AsnTyr: 0.53 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.793ProAla: 6.793 ± 0.073	0.471ProCys: 0.471 ± 0.021	3.969ProAsp: 3.969 ± 0.068	3.505ProGlu: 3.505 ± 0.063	1.871ProPhe: 1.871 ± 0.04	4.7ProGly: 4.7 ± 0.068	1.21ProHis: 1.21 ± 0.032	1.975ProIle: 1.975 ± 0.044	1.51ProLys: 1.51 ± 0.036	5.059ProLeu: 5.059 ± 0.069	1.309ProMet: 1.309 ± 0.031	1.157ProAsn: 1.157 ± 0.031	3.647ProPro: 3.647 ± 0.079	1.388ProGln: 1.388 ± 0.032	3.256ProArg: 3.256 ± 0.057	2.728ProSer: 2.728 ± 0.052	2.194ProThr: 2.194 ± 0.037	4.439ProVal: 4.439 ± 0.063	0.728ProTrp: 0.728 ± 0.027	1.036ProTyr: 1.036 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.155GlnAla: 4.155 ± 0.075	0.25GlnCys: 0.25 ± 0.014	1.431GlnAsp: 1.431 ± 0.039	1.286GlnGlu: 1.286 ± 0.033	0.884GlnPhe: 0.884 ± 0.026	2.471GlnGly: 2.471 ± 0.043	0.593GlnHis: 0.593 ± 0.022	1.443GlnIle: 1.443 ± 0.034	0.903GlnLys: 0.903 ± 0.031	2.551GlnLeu: 2.551 ± 0.039	0.843GlnMet: 0.843 ± 0.022	0.594GlnAsn: 0.594 ± 0.023	1.74GlnPro: 1.74 ± 0.038	0.965GlnGln: 0.965 ± 0.033	2.183GlnArg: 2.183 ± 0.042	1.514GlnSer: 1.514 ± 0.03	1.53GlnThr: 1.53 ± 0.039	2.46GlnVal: 2.46 ± 0.051	0.364GlnTrp: 0.364 ± 0.018	0.598GlnTyr: 0.598 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.957ArgAla: 7.957 ± 0.107	0.666ArgCys: 0.666 ± 0.024	4.645ArgAsp: 4.645 ± 0.071	3.833ArgGlu: 3.833 ± 0.065	2.922ArgPhe: 2.922 ± 0.054	4.938ArgGly: 4.938 ± 0.068	2.361ArgHis: 2.361 ± 0.05	3.994ArgIle: 3.994 ± 0.055	2.609ArgLys: 2.609 ± 0.048	9.584ArgLeu: 9.584 ± 0.117	2.244ArgMet: 2.244 ± 0.041	1.878ArgAsn: 1.878 ± 0.046	4.475ArgPro: 4.475 ± 0.075	2.825ArgGln: 2.825 ± 0.053	7.361ArgArg: 7.361 ± 0.119	3.804ArgSer: 3.804 ± 0.066	3.434ArgThr: 3.434 ± 0.048	5.135ArgVal: 5.135 ± 0.073	1.075ArgTrp: 1.075 ± 0.027	1.579ArgTyr: 1.579 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.899SerAla: 5.899 ± 0.086	0.545SerCys: 0.545 ± 0.02	2.877SerAsp: 2.877 ± 0.054	2.544SerGlu: 2.544 ± 0.046	1.998SerPhe: 1.998 ± 0.044	5.47SerGly: 5.47 ± 0.135	1.219SerHis: 1.219 ± 0.029	2.472SerIle: 2.472 ± 0.044	1.43SerLys: 1.43 ± 0.038	5.508SerLeu: 5.508 ± 0.071	1.376SerMet: 1.376 ± 0.033	1.211SerAsn: 1.211 ± 0.033	3.092SerPro: 3.092 ± 0.051	1.463SerGln: 1.463 ± 0.04	3.93SerArg: 3.93 ± 0.07	2.912SerSer: 2.912 ± 0.064	2.44SerThr: 2.44 ± 0.055	3.944SerVal: 3.944 ± 0.06	0.804SerTrp: 0.804 ± 0.027	1.135SerTyr: 1.135 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.866ThrAla: 5.866 ± 0.124	0.474ThrCys: 0.474 ± 0.02	2.659ThrAsp: 2.659 ± 0.057	2.592ThrGlu: 2.592 ± 0.05	1.826ThrPhe: 1.826 ± 0.054	5.04ThrGly: 5.04 ± 0.108	0.993ThrHis: 0.993 ± 0.026	2.711ThrIle: 2.711 ± 0.075	1.244ThrLys: 1.244 ± 0.034	5.627ThrLeu: 5.627 ± 0.135	1.189ThrMet: 1.189 ± 0.027	1.207ThrAsn: 1.207 ± 0.043	2.987ThrPro: 2.987 ± 0.044	1.296ThrGln: 1.296 ± 0.038	3.283ThrArg: 3.283 ± 0.055	2.478ThrSer: 2.478 ± 0.061	2.497ThrThr: 2.497 ± 0.082	4.471ThrVal: 4.471 ± 0.11	0.642ThrTrp: 0.642 ± 0.025	1.021ThrTyr: 1.021 ± 0.031	0.001ThrXaa: 0.001 ± 0.001
Val	9.823ValAla: 9.823 ± 0.086	0.752ValCys: 0.752 ± 0.027	4.22ValAsp: 4.22 ± 0.055	4.772ValGlu: 4.772 ± 0.072	2.669ValPhe: 2.669 ± 0.042	5.544ValGly: 5.544 ± 0.082	1.438ValHis: 1.438 ± 0.033	3.872ValIle: 3.872 ± 0.056	2.311ValLys: 2.311 ± 0.052	7.725ValLeu: 7.725 ± 0.094	2.087ValMet: 2.087 ± 0.042	2.032ValAsn: 2.032 ± 0.049	3.64ValPro: 3.64 ± 0.059	1.965ValGln: 1.965 ± 0.04	5.33ValArg: 5.33 ± 0.072	4.1ValSer: 4.1 ± 0.051	4.34ValThr: 4.34 ± 0.104	6.626ValVal: 6.626 ± 0.078	0.896ValTrp: 0.896 ± 0.028	1.328ValTyr: 1.328 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.269TrpAla: 1.269 ± 0.033	0.168TrpCys: 0.168 ± 0.011	0.715TrpAsp: 0.715 ± 0.023	0.655TrpGlu: 0.655 ± 0.02	0.485TrpPhe: 0.485 ± 0.022	0.941TrpGly: 0.941 ± 0.029	0.35TrpHis: 0.35 ± 0.017	0.557TrpIle: 0.557 ± 0.021	0.442TrpLys: 0.442 ± 0.02	1.69TrpLeu: 1.69 ± 0.041	0.367TrpMet: 0.367 ± 0.015	0.416TrpAsn: 0.416 ± 0.021	0.675TrpPro: 0.675 ± 0.021	0.546TrpGln: 0.546 ± 0.022	1.441TrpArg: 1.441 ± 0.033	0.744TrpSer: 0.744 ± 0.023	0.72TrpThr: 0.72 ± 0.026	0.859TrpVal: 0.859 ± 0.022	0.214TrpTrp: 0.214 ± 0.013	0.258TrpTyr: 0.258 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.069TyrAla: 2.069 ± 0.04	0.248TyrCys: 0.248 ± 0.015	1.324TyrAsp: 1.324 ± 0.034	0.959TyrGlu: 0.959 ± 0.03	0.795TyrPhe: 0.795 ± 0.027	1.823TyrGly: 1.823 ± 0.039	0.494TyrHis: 0.494 ± 0.018	0.788TyrIle: 0.788 ± 0.028	0.558TyrLys: 0.558 ± 0.022	2.084TyrLeu: 2.084 ± 0.037	0.387TyrMet: 0.387 ± 0.016	0.509TyrAsn: 0.509 ± 0.02	0.959TyrPro: 0.959 ± 0.026	0.643TyrGln: 0.643 ± 0.021	1.827TyrArg: 1.827 ± 0.037	1.118TyrSer: 1.118 ± 0.031	0.899TyrThr: 0.899 ± 0.031	1.449TyrVal: 1.449 ± 0.031	0.32TyrTrp: 0.32 ± 0.015	0.471TyrTyr: 0.471 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4587 proteins (1402263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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