Amino acid dipepetide frequency for Geobacter sp. Red88

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.161AlaAla: 12.161 ± 0.159
1.447AlaCys: 1.447 ± 0.042
5.086AlaAsp: 5.086 ± 0.08
6.441AlaGlu: 6.441 ± 0.1
3.731AlaPhe: 3.731 ± 0.075
8.698AlaGly: 8.698 ± 0.113
1.78AlaHis: 1.78 ± 0.04
5.66AlaIle: 5.66 ± 0.077
4.23AlaLys: 4.23 ± 0.082
10.608AlaLeu: 10.608 ± 0.122
2.718AlaMet: 2.718 ± 0.062
2.694AlaAsn: 2.694 ± 0.059
4.175AlaPro: 4.175 ± 0.075
3.001AlaGln: 3.001 ± 0.056
5.817AlaArg: 5.817 ± 0.087
5.194AlaSer: 5.194 ± 0.075
5.464AlaThr: 5.464 ± 0.086
7.637AlaVal: 7.637 ± 0.091
1.043AlaTrp: 1.043 ± 0.035
2.381AlaTyr: 2.381 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.131CysAla: 1.131 ± 0.033
0.249CysCys: 0.249 ± 0.016
0.659CysAsp: 0.659 ± 0.025
0.576CysGlu: 0.576 ± 0.025
0.495CysPhe: 0.495 ± 0.02
1.439CysGly: 1.439 ± 0.042
0.73CysHis: 0.73 ± 0.055
0.668CysIle: 0.668 ± 0.027
0.424CysLys: 0.424 ± 0.022
1.21CysLeu: 1.21 ± 0.037
0.31CysMet: 0.31 ± 0.018
0.41CysAsn: 0.41 ± 0.019
0.787CysPro: 0.787 ± 0.035
0.344CysGln: 0.344 ± 0.018
0.949CysArg: 0.949 ± 0.031
0.849CysSer: 0.849 ± 0.03
0.648CysThr: 0.648 ± 0.026
0.773CysVal: 0.773 ± 0.027
0.127CysTrp: 0.127 ± 0.012
0.375CysTyr: 0.375 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.747AspAla: 4.747 ± 0.064
0.687AspCys: 0.687 ± 0.027
2.764AspAsp: 2.764 ± 0.057
3.475AspGlu: 3.475 ± 0.076
2.206AspPhe: 2.206 ± 0.044
4.182AspGly: 4.182 ± 0.07
1.057AspHis: 1.057 ± 0.037
3.547AspIle: 3.547 ± 0.053
2.511AspLys: 2.511 ± 0.057
5.19AspLeu: 5.19 ± 0.082
1.335AspMet: 1.335 ± 0.034
1.669AspAsn: 1.669 ± 0.042
2.431AspPro: 2.431 ± 0.058
1.562AspGln: 1.562 ± 0.037
3.222AspArg: 3.222 ± 0.054
2.656AspSer: 2.656 ± 0.053
2.682AspThr: 2.682 ± 0.056
3.587AspVal: 3.587 ± 0.063
0.545AspTrp: 0.545 ± 0.022
1.704AspTyr: 1.704 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.153GluAla: 6.153 ± 0.096
0.67GluCys: 0.67 ± 0.027
2.538GluAsp: 2.538 ± 0.056
4.482GluGlu: 4.482 ± 0.086
2.182GluPhe: 2.182 ± 0.044
4.209GluGly: 4.209 ± 0.065
1.299GluHis: 1.299 ± 0.033
4.273GluIle: 4.273 ± 0.068
3.728GluLys: 3.728 ± 0.075
6.578GluLeu: 6.578 ± 0.083
1.863GluMet: 1.863 ± 0.045
2.066GluAsn: 2.066 ± 0.045
2.271GluPro: 2.271 ± 0.049
2.806GluGln: 2.806 ± 0.06
4.824GluArg: 4.824 ± 0.082
3.051GluSer: 3.051 ± 0.058
3.161GluThr: 3.161 ± 0.059
4.139GluVal: 4.139 ± 0.061
0.605GluTrp: 0.605 ± 0.024
1.714GluTyr: 1.714 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.519PheAla: 3.519 ± 0.065
0.659PheCys: 0.659 ± 0.025
2.305PheAsp: 2.305 ± 0.047
2.135PheGlu: 2.135 ± 0.047
1.819PhePhe: 1.819 ± 0.055
3.318PheGly: 3.318 ± 0.059
0.783PheHis: 0.783 ± 0.028
2.331PheIle: 2.331 ± 0.049
1.701PheLys: 1.701 ± 0.04
3.915PheLeu: 3.915 ± 0.074
0.99PheMet: 0.99 ± 0.032
1.393PheAsn: 1.393 ± 0.034
1.787PhePro: 1.787 ± 0.044
1.12PheGln: 1.12 ± 0.033
2.343PheArg: 2.343 ± 0.05
2.906PheSer: 2.906 ± 0.054
2.35PheThr: 2.35 ± 0.054
2.705PheVal: 2.705 ± 0.055
0.451PheTrp: 0.451 ± 0.023
1.16PheTyr: 1.16 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
7.148GlyAla: 7.148 ± 0.111
1.331GlyCys: 1.331 ± 0.039
4.046GlyAsp: 4.046 ± 0.054
4.865GlyGlu: 4.865 ± 0.073
3.342GlyPhe: 3.342 ± 0.06
6.566GlyGly: 6.566 ± 0.102
1.67GlyHis: 1.67 ± 0.038
5.591GlyIle: 5.591 ± 0.071
4.529GlyLys: 4.529 ± 0.068
7.621GlyLeu: 7.621 ± 0.092
2.49GlyMet: 2.49 ± 0.048
2.681GlyAsn: 2.681 ± 0.064
2.286GlyPro: 2.286 ± 0.044
2.468GlyGln: 2.468 ± 0.047
4.971GlyArg: 4.971 ± 0.081
4.539GlySer: 4.539 ± 0.075
4.833GlyThr: 4.833 ± 0.076
5.942GlyVal: 5.942 ± 0.086
0.935GlyTrp: 0.935 ± 0.031
2.747GlyTyr: 2.747 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.761HisAla: 1.761 ± 0.04
0.289HisCys: 0.289 ± 0.016
1.308HisAsp: 1.308 ± 0.037
1.282HisGlu: 1.282 ± 0.034
0.925HisPhe: 0.925 ± 0.027
1.814HisGly: 1.814 ± 0.049
0.649HisHis: 0.649 ± 0.027
1.228HisIle: 1.228 ± 0.035
0.86HisLys: 0.86 ± 0.029
2.178HisLeu: 2.178 ± 0.05
0.436HisMet: 0.436 ± 0.021
0.738HisAsn: 0.738 ± 0.028
1.312HisPro: 1.312 ± 0.039
0.671HisGln: 0.671 ± 0.022
1.29HisArg: 1.29 ± 0.037
1.116HisSer: 1.116 ± 0.032
1.046HisThr: 1.046 ± 0.035
1.292HisVal: 1.292 ± 0.034
0.234HisTrp: 0.234 ± 0.014
0.669HisTyr: 0.669 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.133IleAla: 6.133 ± 0.077
0.868IleCys: 0.868 ± 0.031
3.461IleAsp: 3.461 ± 0.059
3.592IleGlu: 3.592 ± 0.07
2.28IlePhe: 2.28 ± 0.049
4.706IleGly: 4.706 ± 0.079
1.225IleHis: 1.225 ± 0.032
3.725IleIle: 3.725 ± 0.065
2.779IleLys: 2.779 ± 0.06
5.496IleLeu: 5.496 ± 0.081
1.489IleMet: 1.489 ± 0.036
2.237IleAsn: 2.237 ± 0.05
3.158IlePro: 3.158 ± 0.049
1.654IleGln: 1.654 ± 0.036
3.575IleArg: 3.575 ± 0.068
3.886IleSer: 3.886 ± 0.069
3.682IleThr: 3.682 ± 0.065
4.369IleVal: 4.369 ± 0.067
0.485IleTrp: 0.485 ± 0.02
1.572IleTyr: 1.572 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.638LysAla: 4.638 ± 0.083
0.447LysCys: 0.447 ± 0.022
2.436LysAsp: 2.436 ± 0.056
3.359LysGlu: 3.359 ± 0.072
1.392LysPhe: 1.392 ± 0.039
3.827LysGly: 3.827 ± 0.065
0.877LysHis: 0.877 ± 0.028
2.848LysIle: 2.848 ± 0.067
3.199LysLys: 3.199 ± 0.08
4.352LysLeu: 4.352 ± 0.068
1.354LysMet: 1.354 ± 0.039
1.927LysAsn: 1.927 ± 0.049
2.226LysPro: 2.226 ± 0.053
1.683LysGln: 1.683 ± 0.044
2.982LysArg: 2.982 ± 0.055
2.67LysSer: 2.67 ± 0.059
2.609LysThr: 2.609 ± 0.053
3.381LysVal: 3.381 ± 0.076
0.405LysTrp: 0.405 ± 0.022
1.218LysTyr: 1.218 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
11.334LeuAla: 11.334 ± 0.136
1.247LeuCys: 1.247 ± 0.036
5.453LeuAsp: 5.453 ± 0.076
6.316LeuGlu: 6.316 ± 0.084
4.275LeuPhe: 4.275 ± 0.071
7.448LeuGly: 7.448 ± 0.096
2.118LeuHis: 2.118 ± 0.045
5.246LeuIle: 5.246 ± 0.076
5.266LeuLys: 5.266 ± 0.081
10.838LeuLeu: 10.838 ± 0.136
2.394LeuMet: 2.394 ± 0.045
3.321LeuAsn: 3.321 ± 0.05
5.031LeuPro: 5.031 ± 0.071
3.021LeuGln: 3.021 ± 0.057
6.009LeuArg: 6.009 ± 0.097
6.157LeuSer: 6.157 ± 0.077
5.553LeuThr: 5.553 ± 0.074
7.196LeuVal: 7.196 ± 0.082
0.866LeuTrp: 0.866 ± 0.031
2.433LeuTyr: 2.433 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.921MetAla: 2.921 ± 0.054
0.195MetCys: 0.195 ± 0.013
1.225MetAsp: 1.225 ± 0.035
1.653MetGlu: 1.653 ± 0.043
0.771MetPhe: 0.771 ± 0.024
2.052MetGly: 2.052 ± 0.047
0.439MetHis: 0.439 ± 0.02
1.42MetIle: 1.42 ± 0.038
1.591MetLys: 1.591 ± 0.041
2.478MetLeu: 2.478 ± 0.051
0.624MetMet: 0.624 ± 0.023
1.035MetAsn: 1.035 ± 0.03
1.357MetPro: 1.357 ± 0.035
0.889MetGln: 0.889 ± 0.028
1.499MetArg: 1.499 ± 0.036
1.508MetSer: 1.508 ± 0.039
1.588MetThr: 1.588 ± 0.034
1.931MetVal: 1.931 ± 0.043
0.143MetTrp: 0.143 ± 0.011
0.453MetTyr: 0.453 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.915AsnAla: 2.915 ± 0.057
0.472AsnCys: 0.472 ± 0.02
1.626AsnAsp: 1.626 ± 0.046
1.735AsnGlu: 1.735 ± 0.037
1.224AsnPhe: 1.224 ± 0.035
2.868AsnGly: 2.868 ± 0.057
0.693AsnHis: 0.693 ± 0.024
2.139AsnIle: 2.139 ± 0.05
1.365AsnLys: 1.365 ± 0.035
3.477AsnLeu: 3.477 ± 0.065
0.804AsnMet: 0.804 ± 0.026
1.225AsnAsn: 1.225 ± 0.044
2.096AsnPro: 2.096 ± 0.049
0.965AsnGln: 0.965 ± 0.032
2.199AsnArg: 2.199 ± 0.044
1.823AsnSer: 1.823 ± 0.048
1.62AsnThr: 1.62 ± 0.041
2.322AsnVal: 2.322 ± 0.051
0.335AsnTrp: 0.335 ± 0.018
1.025AsnTyr: 1.025 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.927ProAla: 4.927 ± 0.082
0.485ProCys: 0.485 ± 0.022
2.862ProAsp: 2.862 ± 0.05
3.475ProGlu: 3.475 ± 0.055
1.998ProPhe: 1.998 ± 0.046
3.846ProGly: 3.846 ± 0.061
1.082ProHis: 1.082 ± 0.034
2.039ProIle: 2.039 ± 0.043
1.725ProLys: 1.725 ± 0.045
4.876ProLeu: 4.876 ± 0.067
1.004ProMet: 1.004 ± 0.029
1.225ProAsn: 1.225 ± 0.036
2.397ProPro: 2.397 ± 0.064
1.649ProGln: 1.649 ± 0.043
2.29ProArg: 2.29 ± 0.044
2.396ProSer: 2.396 ± 0.051
2.243ProThr: 2.243 ± 0.051
3.805ProVal: 3.805 ± 0.063
0.523ProTrp: 0.523 ± 0.025
1.301ProTyr: 1.301 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.499GlnAla: 3.499 ± 0.069
0.317GlnCys: 0.317 ± 0.016
1.399GlnAsp: 1.399 ± 0.041
2.2GlnGlu: 2.2 ± 0.051
1.151GlnPhe: 1.151 ± 0.036
2.554GlnGly: 2.554 ± 0.053
0.691GlnHis: 0.691 ± 0.03
1.935GlnIle: 1.935 ± 0.041
1.754GlnLys: 1.754 ± 0.04
3.018GlnLeu: 3.018 ± 0.054
0.891GlnMet: 0.891 ± 0.026
1.036GlnAsn: 1.036 ± 0.034
1.469GlnPro: 1.469 ± 0.039
1.502GlnGln: 1.502 ± 0.042
2.197GlnArg: 2.197 ± 0.048
1.656GlnSer: 1.656 ± 0.039
1.692GlnThr: 1.692 ± 0.043
2.505GlnVal: 2.505 ± 0.047
0.333GlnTrp: 0.333 ± 0.018
0.771GlnTyr: 0.771 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
4.802ArgAla: 4.802 ± 0.074
0.759ArgCys: 0.759 ± 0.03
3.247ArgAsp: 3.247 ± 0.054
4.871ArgGlu: 4.871 ± 0.075
2.793ArgPhe: 2.793 ± 0.056
4.004ArgGly: 4.004 ± 0.07
1.49ArgHis: 1.49 ± 0.041
4.261ArgIle: 4.261 ± 0.066
2.902ArgLys: 2.902 ± 0.054
6.914ArgLeu: 6.914 ± 0.111
1.786ArgMet: 1.786 ± 0.046
2.03ArgAsn: 2.03 ± 0.049
2.412ArgPro: 2.412 ± 0.057
2.547ArgGln: 2.547 ± 0.058
4.312ArgArg: 4.312 ± 0.086
3.269ArgSer: 3.269 ± 0.061
2.911ArgThr: 2.911 ± 0.059
4.098ArgVal: 4.098 ± 0.06
0.636ArgTrp: 0.636 ± 0.027
1.952ArgTyr: 1.952 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.47SerAla: 5.47 ± 0.082
0.781SerCys: 0.781 ± 0.036
2.974SerAsp: 2.974 ± 0.056
2.971SerGlu: 2.971 ± 0.048
2.473SerPhe: 2.473 ± 0.051
5.577SerGly: 5.577 ± 0.084
1.225SerHis: 1.225 ± 0.035
3.409SerIle: 3.409 ± 0.061
2.082SerLys: 2.082 ± 0.053
6.145SerLeu: 6.145 ± 0.074
1.338SerMet: 1.338 ± 0.037
1.746SerAsn: 1.746 ± 0.046
2.737SerPro: 2.737 ± 0.057
1.812SerGln: 1.812 ± 0.041
3.583SerArg: 3.583 ± 0.067
3.641SerSer: 3.641 ± 0.07
2.967SerThr: 2.967 ± 0.061
3.82SerVal: 3.82 ± 0.059
0.624SerTrp: 0.624 ± 0.024
1.678SerTyr: 1.678 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.915ThrAla: 5.915 ± 0.083
0.738ThrCys: 0.738 ± 0.029
2.547ThrAsp: 2.547 ± 0.054
2.67ThrGlu: 2.67 ± 0.048
2.201ThrPhe: 2.201 ± 0.049
5.058ThrGly: 5.058 ± 0.074
1.005ThrHis: 1.005 ± 0.031
3.683ThrIle: 3.683 ± 0.06
2.193ThrLys: 2.193 ± 0.048
5.54ThrLeu: 5.54 ± 0.075
1.27ThrMet: 1.27 ± 0.034
1.614ThrAsn: 1.614 ± 0.047
3.238ThrPro: 3.238 ± 0.062
1.347ThrGln: 1.347 ± 0.042
2.773ThrArg: 2.773 ± 0.051
3.215ThrSer: 3.215 ± 0.066
3.46ThrThr: 3.46 ± 0.072
4.56ThrVal: 4.56 ± 0.083
0.582ThrTrp: 0.582 ± 0.021
1.355ThrTyr: 1.355 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
7.754ValAla: 7.754 ± 0.098
1.003ValCys: 1.003 ± 0.035
3.668ValAsp: 3.668 ± 0.061
4.536ValGlu: 4.536 ± 0.062
2.724ValPhe: 2.724 ± 0.064
5.267ValGly: 5.267 ± 0.075
1.321ValHis: 1.321 ± 0.033
4.556ValIle: 4.556 ± 0.07
3.43ValLys: 3.43 ± 0.06
6.757ValLeu: 6.757 ± 0.083
1.951ValMet: 1.951 ± 0.051
2.521ValAsn: 2.521 ± 0.047
3.2ValPro: 3.2 ± 0.062
2.114ValGln: 2.114 ± 0.039
4.266ValArg: 4.266 ± 0.072
4.382ValSer: 4.382 ± 0.062
4.531ValThr: 4.531 ± 0.078
6.04ValVal: 6.04 ± 0.08
0.658ValTrp: 0.658 ± 0.026
1.768ValTyr: 1.768 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.689TrpAla: 0.689 ± 0.029
0.126TrpCys: 0.126 ± 0.011
0.564TrpAsp: 0.564 ± 0.022
0.553TrpGlu: 0.553 ± 0.019
0.465TrpPhe: 0.465 ± 0.021
0.778TrpGly: 0.778 ± 0.028
0.272TrpHis: 0.272 ± 0.014
0.519TrpIle: 0.519 ± 0.024
0.515TrpLys: 0.515 ± 0.021
1.194TrpLeu: 1.194 ± 0.039
0.239TrpMet: 0.239 ± 0.015
0.386TrpAsn: 0.386 ± 0.021
0.435TrpPro: 0.435 ± 0.022
0.479TrpGln: 0.479 ± 0.021
0.7TrpArg: 0.7 ± 0.03
0.563TrpSer: 0.563 ± 0.025
0.471TrpThr: 0.471 ± 0.025
0.624TrpVal: 0.624 ± 0.023
0.127TrpTrp: 0.127 ± 0.012
0.302TrpTyr: 0.302 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.349TyrAla: 2.349 ± 0.051
0.382TyrCys: 0.382 ± 0.019
1.592TyrAsp: 1.592 ± 0.041
1.423TyrGlu: 1.423 ± 0.039
1.244TyrPhe: 1.244 ± 0.033
2.39TyrGly: 2.39 ± 0.054
0.691TyrHis: 0.691 ± 0.027
1.294TyrIle: 1.294 ± 0.032
1.045TyrLys: 1.045 ± 0.032
3.138TyrLeu: 3.138 ± 0.064
0.484TyrMet: 0.484 ± 0.022
0.973TyrAsn: 0.973 ± 0.037
1.344TyrPro: 1.344 ± 0.035
0.937TyrGln: 0.937 ± 0.025
2.196TyrArg: 2.196 ± 0.046
1.576TyrSer: 1.576 ± 0.042
1.456TyrThr: 1.456 ± 0.044
1.721TyrVal: 1.721 ± 0.039
0.341TyrTrp: 0.341 ± 0.017
0.94TyrTyr: 0.94 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3510 proteins (1106654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski