Amino acid dipepetide frequency for Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.181AlaAla: 6.181 ± 0.118	0.956AlaCys: 0.956 ± 0.03	5.018AlaAsp: 5.018 ± 0.075	4.996AlaGlu: 4.996 ± 0.081	3.144AlaPhe: 3.144 ± 0.054	5.477AlaGly: 5.477 ± 0.069	1.036AlaHis: 1.036 ± 0.028	5.392AlaIle: 5.392 ± 0.073	4.463AlaLys: 4.463 ± 0.074	6.415AlaLeu: 6.415 ± 0.082	2.177AlaMet: 2.177 ± 0.041	2.919AlaAsn: 2.919 ± 0.052	1.942AlaPro: 1.942 ± 0.047	2.176AlaGln: 2.176 ± 0.046	2.871AlaArg: 2.871 ± 0.052	4.427AlaSer: 4.427 ± 0.068	3.666AlaThr: 3.666 ± 0.073	5.337AlaVal: 5.337 ± 0.066	0.566AlaTrp: 0.566 ± 0.021	2.838AlaTyr: 2.838 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.913CysAla: 0.913 ± 0.028	0.245CysCys: 0.245 ± 0.015	0.937CysAsp: 0.937 ± 0.028	0.817CysGlu: 0.817 ± 0.025	0.606CysPhe: 0.606 ± 0.021	1.338CysGly: 1.338 ± 0.031	0.263CysHis: 0.263 ± 0.013	1.072CysIle: 1.072 ± 0.028	0.877CysLys: 0.877 ± 0.027	1.068CysLeu: 1.068 ± 0.032	0.395CysMet: 0.395 ± 0.018	0.627CysAsn: 0.627 ± 0.027	0.555CysPro: 0.555 ± 0.025	0.346CysGln: 0.346 ± 0.019	0.587CysArg: 0.587 ± 0.022	0.823CysSer: 0.823 ± 0.023	0.648CysThr: 0.648 ± 0.025	0.909CysVal: 0.909 ± 0.026	0.118CysTrp: 0.118 ± 0.009	0.585CysTyr: 0.585 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.486AspAla: 4.486 ± 0.073	0.789AspCys: 0.789 ± 0.025	4.186AspAsp: 4.186 ± 0.065	5.716AspGlu: 5.716 ± 0.076	3.046AspPhe: 3.046 ± 0.049	4.819AspGly: 4.819 ± 0.085	0.994AspHis: 0.994 ± 0.031	5.442AspIle: 5.442 ± 0.063	5.161AspLys: 5.161 ± 0.068	4.719AspLeu: 4.719 ± 0.064	1.98AspMet: 1.98 ± 0.044	3.407AspAsn: 3.407 ± 0.055	2.034AspPro: 2.034 ± 0.052	1.407AspGln: 1.407 ± 0.035	2.646AspArg: 2.646 ± 0.048	3.825AspSer: 3.825 ± 0.055	3.247AspThr: 3.247 ± 0.056	4.254AspVal: 4.254 ± 0.061	0.601AspTrp: 0.601 ± 0.025	3.54AspTyr: 3.54 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.332GluAla: 5.332 ± 0.075	0.824GluCys: 0.824 ± 0.026	4.722GluAsp: 4.722 ± 0.073	6.024GluGlu: 6.024 ± 0.097	2.755GluPhe: 2.755 ± 0.054	4.156GluGly: 4.156 ± 0.06	1.307GluHis: 1.307 ± 0.04	5.637GluIle: 5.637 ± 0.073	6.273GluLys: 6.273 ± 0.09	6.415GluLeu: 6.415 ± 0.077	2.283GluMet: 2.283 ± 0.041	4.234GluAsn: 4.234 ± 0.057	1.778GluPro: 1.778 ± 0.049	2.26GluGln: 2.26 ± 0.045	2.767GluArg: 2.767 ± 0.05	3.666GluSer: 3.666 ± 0.058	3.467GluThr: 3.467 ± 0.053	4.282GluVal: 4.282 ± 0.061	0.691GluTrp: 0.691 ± 0.028	3.557GluTyr: 3.557 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.056PheAla: 3.056 ± 0.047	0.695PheCys: 0.695 ± 0.027	3.144PheAsp: 3.144 ± 0.049	2.808PheGlu: 2.808 ± 0.053	2.079PhePhe: 2.079 ± 0.046	3.069PheGly: 3.069 ± 0.048	0.687PheHis: 0.687 ± 0.024	3.263PheIle: 3.263 ± 0.061	2.463PheLys: 2.463 ± 0.04	3.722PheLeu: 3.722 ± 0.069	1.331PheMet: 1.331 ± 0.032	1.895PheAsn: 1.895 ± 0.036	1.272PhePro: 1.272 ± 0.031	0.954PheGln: 0.954 ± 0.031	1.615PheArg: 1.615 ± 0.039	2.92PheSer: 2.92 ± 0.053	2.453PheThr: 2.453 ± 0.05	3.228PheVal: 3.228 ± 0.054	0.499PheTrp: 0.499 ± 0.021	2.022PheTyr: 2.022 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.679GlyAla: 4.679 ± 0.073	1.121GlyCys: 1.121 ± 0.03	4.08GlyAsp: 4.08 ± 0.068	4.332GlyGlu: 4.332 ± 0.064	3.195GlyPhe: 3.195 ± 0.051	4.291GlyGly: 4.291 ± 0.074	1.255GlyHis: 1.255 ± 0.032	5.942GlyIle: 5.942 ± 0.083	5.365GlyLys: 5.365 ± 0.067	5.387GlyLeu: 5.387 ± 0.069	2.133GlyMet: 2.133 ± 0.042	3.554GlyAsn: 3.554 ± 0.069	1.257GlyPro: 1.257 ± 0.034	1.914GlyGln: 1.914 ± 0.04	2.763GlyArg: 2.763 ± 0.052	4.206GlySer: 4.206 ± 0.063	4.014GlyThr: 4.014 ± 0.073	4.551GlyVal: 4.551 ± 0.059	0.697GlyTrp: 0.697 ± 0.03	3.45GlyTyr: 3.45 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.966HisAla: 0.966 ± 0.027	0.248HisCys: 0.248 ± 0.014	1.069HisAsp: 1.069 ± 0.03	1.07HisGlu: 1.07 ± 0.03	0.797HisPhe: 0.797 ± 0.027	1.165HisGly: 1.165 ± 0.033	0.393HisHis: 0.393 ± 0.035	1.333HisIle: 1.333 ± 0.034	1.014HisLys: 1.014 ± 0.029	1.3HisLeu: 1.3 ± 0.032	0.54HisMet: 0.54 ± 0.021	0.812HisAsn: 0.812 ± 0.029	0.707HisPro: 0.707 ± 0.024	0.439HisGln: 0.439 ± 0.019	0.711HisArg: 0.711 ± 0.025	0.956HisSer: 0.956 ± 0.031	0.807HisThr: 0.807 ± 0.023	1.083HisVal: 1.083 ± 0.026	0.166HisTrp: 0.166 ± 0.012	0.778HisTyr: 0.778 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.796IleAla: 5.796 ± 0.071	1.296IleCys: 1.296 ± 0.032	5.15IleAsp: 5.15 ± 0.065	5.011IleGlu: 5.011 ± 0.062	3.002IlePhe: 3.002 ± 0.055	5.027IleGly: 5.027 ± 0.076	1.219IleHis: 1.219 ± 0.03	5.776IleIle: 5.776 ± 0.086	5.038IleLys: 5.038 ± 0.055	6.369IleLeu: 6.369 ± 0.084	2.133IleMet: 2.133 ± 0.048	3.556IleAsn: 3.556 ± 0.051	3.077IlePro: 3.077 ± 0.056	1.911IleGln: 1.911 ± 0.042	3.467IleArg: 3.467 ± 0.05	5.531IleSer: 5.531 ± 0.075	4.533IleThr: 4.533 ± 0.063	5.254IleVal: 5.254 ± 0.08	0.668IleTrp: 0.668 ± 0.026	3.146IleTyr: 3.146 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.385LysAla: 5.385 ± 0.107	0.824LysCys: 0.824 ± 0.029	4.578LysAsp: 4.578 ± 0.061	6.54LysGlu: 6.54 ± 0.087	2.261LysPhe: 2.261 ± 0.042	4.2LysGly: 4.2 ± 0.056	1.055LysHis: 1.055 ± 0.026	4.775LysIle: 4.775 ± 0.064	6.168LysLys: 6.168 ± 0.101	5.606LysLeu: 5.606 ± 0.073	2.158LysMet: 2.158 ± 0.042	3.755LysAsn: 3.755 ± 0.058	1.966LysPro: 1.966 ± 0.041	1.915LysGln: 1.915 ± 0.043	3.046LysArg: 3.046 ± 0.056	3.759LysSer: 3.759 ± 0.057	3.642LysThr: 3.642 ± 0.05	4.461LysVal: 4.461 ± 0.066	0.714LysTrp: 0.714 ± 0.022	3.394LysTyr: 3.394 ± 0.058	0.002LysXaa: 0.002 ± 0.001
Leu	5.979LeuAla: 5.979 ± 0.078	1.275LeuCys: 1.275 ± 0.032	5.218LeuAsp: 5.218 ± 0.073	5.505LeuGlu: 5.505 ± 0.081	3.961LeuPhe: 3.961 ± 0.077	5.621LeuGly: 5.621 ± 0.069	1.35LeuHis: 1.35 ± 0.032	6.069LeuIle: 6.069 ± 0.089	5.571LeuLys: 5.571 ± 0.071	7.287LeuLeu: 7.287 ± 0.115	2.574LeuMet: 2.574 ± 0.045	3.793LeuAsn: 3.793 ± 0.047	2.947LeuPro: 2.947 ± 0.044	2.334LeuGln: 2.334 ± 0.046	3.348LeuArg: 3.348 ± 0.057	6.317LeuSer: 6.317 ± 0.079	4.6LeuThr: 4.6 ± 0.061	5.322LeuVal: 5.322 ± 0.073	0.721LeuTrp: 0.721 ± 0.025	3.504LeuTyr: 3.504 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.352MetAla: 2.352 ± 0.044	0.385MetCys: 0.385 ± 0.02	1.983MetAsp: 1.983 ± 0.04	1.999MetGlu: 1.999 ± 0.037	1.092MetPhe: 1.092 ± 0.033	1.935MetGly: 1.935 ± 0.043	0.529MetHis: 0.529 ± 0.02	2.195MetIle: 2.195 ± 0.051	2.183MetLys: 2.183 ± 0.043	2.648MetLeu: 2.648 ± 0.053	0.949MetMet: 0.949 ± 0.03	1.638MetAsn: 1.638 ± 0.036	1.118MetPro: 1.118 ± 0.029	1.013MetGln: 1.013 ± 0.031	1.215MetArg: 1.215 ± 0.032	1.91MetSer: 1.91 ± 0.039	1.66MetThr: 1.66 ± 0.034	1.822MetVal: 1.822 ± 0.035	0.225MetTrp: 0.225 ± 0.014	1.076MetTyr: 1.076 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.479AsnAla: 3.479 ± 0.054	0.636AsnCys: 0.636 ± 0.022	2.934AsnAsp: 2.934 ± 0.045	3.186AsnGlu: 3.186 ± 0.052	1.787AsnPhe: 1.787 ± 0.036	3.943AsnGly: 3.943 ± 0.064	0.789AsnHis: 0.789 ± 0.026	3.991AsnIle: 3.991 ± 0.057	3.385AsnLys: 3.385 ± 0.049	3.84AsnLeu: 3.84 ± 0.058	1.549AsnMet: 1.549 ± 0.034	2.456AsnAsn: 2.456 ± 0.06	1.962AsnPro: 1.962 ± 0.042	1.266AsnGln: 1.266 ± 0.036	2.017AsnArg: 2.017 ± 0.04	3.022AsnSer: 3.022 ± 0.059	2.666AsnThr: 2.666 ± 0.049	3.383AsnVal: 3.383 ± 0.057	0.506AsnTrp: 0.506 ± 0.021	2.251AsnTyr: 2.251 ± 0.047	0.001AsnXaa: 0.001 ± 0.001
Pro	2.223ProAla: 2.223 ± 0.048	0.363ProCys: 0.363 ± 0.018	2.565ProAsp: 2.565 ± 0.05	3.074ProGlu: 3.074 ± 0.059	1.442ProPhe: 1.442 ± 0.037	2.074ProGly: 2.074 ± 0.043	0.477ProHis: 0.477 ± 0.02	2.052ProIle: 2.052 ± 0.047	1.764ProLys: 1.764 ± 0.041	2.383ProLeu: 2.383 ± 0.044	0.86ProMet: 0.86 ± 0.029	1.268ProAsn: 1.268 ± 0.03	0.554ProPro: 0.554 ± 0.024	0.954ProGln: 0.954 ± 0.026	0.945ProArg: 0.945 ± 0.026	1.856ProSer: 1.856 ± 0.046	1.502ProThr: 1.502 ± 0.043	2.655ProVal: 2.655 ± 0.066	0.31ProTrp: 0.31 ± 0.014	1.475ProTyr: 1.475 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.977GlnAla: 1.977 ± 0.047	0.273GlnCys: 0.273 ± 0.015	1.651GlnAsp: 1.651 ± 0.037	2.112GlnGlu: 2.112 ± 0.042	1.07GlnPhe: 1.07 ± 0.03	1.668GlnGly: 1.668 ± 0.038	0.414GlnHis: 0.414 ± 0.016	2.339GlnIle: 2.339 ± 0.048	2.297GlnLys: 2.297 ± 0.044	2.309GlnLeu: 2.309 ± 0.047	0.969GlnMet: 0.969 ± 0.031	1.515GlnAsn: 1.515 ± 0.033	0.722GlnPro: 0.722 ± 0.027	0.915GlnGln: 0.915 ± 0.034	1.134GlnArg: 1.134 ± 0.032	1.463GlnSer: 1.463 ± 0.039	1.474GlnThr: 1.474 ± 0.034	1.695GlnVal: 1.695 ± 0.037	0.241GlnTrp: 0.241 ± 0.015	1.358GlnTyr: 1.358 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.656ArgAla: 2.656 ± 0.047	0.519ArgCys: 0.519 ± 0.021	2.576ArgAsp: 2.576 ± 0.05	3.103ArgGlu: 3.103 ± 0.059	1.859ArgPhe: 1.859 ± 0.041	2.272ArgGly: 2.272 ± 0.045	0.687ArgHis: 0.687 ± 0.023	3.413ArgIle: 3.413 ± 0.059	3.221ArgLys: 3.221 ± 0.05	3.511ArgLeu: 3.511 ± 0.052	1.256ArgMet: 1.256 ± 0.031	2.251ArgAsn: 2.251 ± 0.046	1.173ArgPro: 1.173 ± 0.033	1.326ArgGln: 1.326 ± 0.038	1.86ArgArg: 1.86 ± 0.044	2.086ArgSer: 2.086 ± 0.044	2.045ArgThr: 2.045 ± 0.041	2.541ArgVal: 2.541 ± 0.043	0.356ArgTrp: 0.356 ± 0.017	1.931ArgTyr: 1.931 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.355SerAla: 4.355 ± 0.066	0.777SerCys: 0.777 ± 0.027	4.514SerAsp: 4.514 ± 0.067	4.481SerGlu: 4.481 ± 0.067	3.304SerPhe: 3.304 ± 0.052	4.962SerGly: 4.962 ± 0.077	1.002SerHis: 1.002 ± 0.027	4.595SerIle: 4.595 ± 0.072	3.996SerLys: 3.996 ± 0.058	5.249SerLeu: 5.249 ± 0.065	1.721SerMet: 1.721 ± 0.038	2.829SerAsn: 2.829 ± 0.055	1.611SerPro: 1.611 ± 0.034	1.75SerGln: 1.75 ± 0.039	2.52SerArg: 2.52 ± 0.045	4.318SerSer: 4.318 ± 0.08	3.013SerThr: 3.013 ± 0.053	4.413SerVal: 4.413 ± 0.062	0.586SerTrp: 0.586 ± 0.023	2.795SerTyr: 2.795 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.931ThrAla: 3.931 ± 0.073	0.635ThrCys: 0.635 ± 0.023	3.669ThrAsp: 3.669 ± 0.06	3.597ThrGlu: 3.597 ± 0.052	2.234ThrPhe: 2.234 ± 0.045	4.312ThrGly: 4.312 ± 0.069	0.787ThrHis: 0.787 ± 0.024	4.216ThrIle: 4.216 ± 0.057	3.076ThrLys: 3.076 ± 0.059	4.444ThrLeu: 4.444 ± 0.05	1.38ThrMet: 1.38 ± 0.032	2.327ThrAsn: 2.327 ± 0.048	2.016ThrPro: 2.016 ± 0.05	1.482ThrGln: 1.482 ± 0.045	2.023ThrArg: 2.023 ± 0.041	3.281ThrSer: 3.281 ± 0.061	2.967ThrThr: 2.967 ± 0.063	4.118ThrVal: 4.118 ± 0.061	0.518ThrTrp: 0.518 ± 0.021	2.44ThrTyr: 2.44 ± 0.053	0.001ThrXaa: 0.001 ± 0.001
Val	4.784ValAla: 4.784 ± 0.07	1.097ValCys: 1.097 ± 0.029	4.338ValAsp: 4.338 ± 0.062	4.166ValGlu: 4.166 ± 0.065	3.125ValPhe: 3.125 ± 0.059	3.993ValGly: 3.993 ± 0.066	1.071ValHis: 1.071 ± 0.027	5.481ValIle: 5.481 ± 0.063	4.361ValLys: 4.361 ± 0.063	5.996ValLeu: 5.996 ± 0.086	1.983ValMet: 1.983 ± 0.044	3.235ValAsn: 3.235 ± 0.055	2.347ValPro: 2.347 ± 0.043	1.625ValGln: 1.625 ± 0.04	2.709ValArg: 2.709 ± 0.048	4.868ValSer: 4.868 ± 0.063	4.106ValThr: 4.106 ± 0.07	4.955ValVal: 4.955 ± 0.072	0.615ValTrp: 0.615 ± 0.023	2.917ValTyr: 2.917 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.585TrpAla: 0.585 ± 0.025	0.137TrpCys: 0.137 ± 0.01	0.64TrpAsp: 0.64 ± 0.024	0.619TrpGlu: 0.619 ± 0.023	0.419TrpPhe: 0.419 ± 0.02	0.715TrpGly: 0.715 ± 0.029	0.208TrpHis: 0.208 ± 0.014	0.7TrpIle: 0.7 ± 0.025	0.644TrpLys: 0.644 ± 0.025	0.818TrpLeu: 0.818 ± 0.028	0.267TrpMet: 0.267 ± 0.014	0.626TrpAsn: 0.626 ± 0.023	0.245TrpPro: 0.245 ± 0.016	0.319TrpGln: 0.319 ± 0.017	0.35TrpArg: 0.35 ± 0.016	0.518TrpSer: 0.518 ± 0.024	0.482TrpThr: 0.482 ± 0.024	0.483TrpVal: 0.483 ± 0.019	0.149TrpTrp: 0.149 ± 0.014	0.453TrpTyr: 0.453 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.882TyrAla: 2.882 ± 0.047	0.636TyrCys: 0.636 ± 0.023	3.327TyrAsp: 3.327 ± 0.06	3.271TyrGlu: 3.271 ± 0.057	1.997TyrPhe: 1.997 ± 0.048	3.148TyrGly: 3.148 ± 0.052	0.83TyrHis: 0.83 ± 0.026	3.282TyrIle: 3.282 ± 0.062	2.882TyrLys: 2.882 ± 0.046	3.811TyrLeu: 3.811 ± 0.061	1.288TyrMet: 1.288 ± 0.039	2.35TyrAsn: 2.35 ± 0.045	1.511TyrPro: 1.511 ± 0.038	1.294TyrGln: 1.294 ± 0.036	2.049TyrArg: 2.049 ± 0.039	3.04TyrSer: 3.04 ± 0.053	2.462TyrThr: 2.462 ± 0.056	3.025TyrVal: 3.025 ± 0.048	0.428TyrTrp: 0.428 ± 0.021	2.454TyrTyr: 2.454 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3799 proteins (1301855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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