Amino acid dipepetide frequency for Mycetocola manganoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.622AlaAla: 17.622 ± 0.196	0.616AlaCys: 0.616 ± 0.03	7.618AlaAsp: 7.618 ± 0.111	7.704AlaGlu: 7.704 ± 0.107	3.731AlaPhe: 3.731 ± 0.071	11.308AlaGly: 11.308 ± 0.124	2.177AlaHis: 2.177 ± 0.056	6.226AlaIle: 6.226 ± 0.088	2.957AlaLys: 2.957 ± 0.069	13.031AlaLeu: 13.031 ± 0.164	2.497AlaMet: 2.497 ± 0.062	2.609AlaAsn: 2.609 ± 0.056	5.848AlaPro: 5.848 ± 0.105	3.475AlaGln: 3.475 ± 0.072	7.979AlaArg: 7.979 ± 0.119	7.898AlaSer: 7.898 ± 0.092	7.402AlaThr: 7.402 ± 0.102	10.613AlaVal: 10.613 ± 0.137	1.725AlaTrp: 1.725 ± 0.05	2.157AlaTyr: 2.157 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.591CysAla: 0.591 ± 0.03	0.046CysCys: 0.046 ± 0.007	0.298CysAsp: 0.298 ± 0.018	0.257CysGlu: 0.257 ± 0.016	0.158CysPhe: 0.158 ± 0.013	0.529CysGly: 0.529 ± 0.025	0.121CysHis: 0.121 ± 0.012	0.221CysIle: 0.221 ± 0.014	0.058CysLys: 0.058 ± 0.008	0.421CysLeu: 0.421 ± 0.023	0.06CysMet: 0.06 ± 0.008	0.11CysAsn: 0.11 ± 0.011	0.273CysPro: 0.273 ± 0.016	0.117CysGln: 0.117 ± 0.012	0.322CysArg: 0.322 ± 0.02	0.39CysSer: 0.39 ± 0.023	0.31CysThr: 0.31 ± 0.02	0.415CysVal: 0.415 ± 0.023	0.063CysTrp: 0.063 ± 0.008	0.099CysTyr: 0.099 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.74AspAla: 8.74 ± 0.109	0.239AspCys: 0.239 ± 0.015	4.092AspAsp: 4.092 ± 0.079	4.347AspGlu: 4.347 ± 0.078	1.891AspPhe: 1.891 ± 0.043	5.675AspGly: 5.675 ± 0.096	1.109AspHis: 1.109 ± 0.039	2.756AspIle: 2.756 ± 0.065	1.186AspLys: 1.186 ± 0.044	6.151AspLeu: 6.151 ± 0.096	0.849AspMet: 0.849 ± 0.031	1.225AspAsn: 1.225 ± 0.035	3.836AspPro: 3.836 ± 0.058	1.528AspGln: 1.528 ± 0.045	4.155AspArg: 4.155 ± 0.081	3.338AspSer: 3.338 ± 0.069	3.003AspThr: 3.003 ± 0.057	5.543AspVal: 5.543 ± 0.086	0.955AspTrp: 0.955 ± 0.035	1.363AspTyr: 1.363 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.581GluAla: 6.581 ± 0.089	0.23GluCys: 0.23 ± 0.016	2.778GluAsp: 2.778 ± 0.06	3.102GluGlu: 3.102 ± 0.061	1.785GluPhe: 1.785 ± 0.05	3.72GluGly: 3.72 ± 0.068	1.469GluHis: 1.469 ± 0.044	2.89GluIle: 2.89 ± 0.059	1.798GluLys: 1.798 ± 0.052	6.75GluLeu: 6.75 ± 0.095	0.957GluMet: 0.957 ± 0.035	1.701GluAsn: 1.701 ± 0.044	2.976GluPro: 2.976 ± 0.069	2.249GluGln: 2.249 ± 0.053	4.814GluArg: 4.814 ± 0.088	3.441GluSer: 3.441 ± 0.064	3.239GluThr: 3.239 ± 0.064	4.245GluVal: 4.245 ± 0.072	0.84GluTrp: 0.84 ± 0.035	1.27GluTyr: 1.27 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.267PheAla: 4.267 ± 0.076	0.166PheCys: 0.166 ± 0.014	2.519PheAsp: 2.519 ± 0.059	1.89PheGlu: 1.89 ± 0.046	1.244PhePhe: 1.244 ± 0.041	3.473PheGly: 3.473 ± 0.068	0.563PheHis: 0.563 ± 0.025	1.385PheIle: 1.385 ± 0.042	0.541PheLys: 0.541 ± 0.024	3.041PheLeu: 3.041 ± 0.056	0.457PheMet: 0.457 ± 0.023	0.799PheAsn: 0.799 ± 0.029	1.416PhePro: 1.416 ± 0.04	0.817PheGln: 0.817 ± 0.027	1.818PheArg: 1.818 ± 0.044	2.184PheSer: 2.184 ± 0.052	2.176PheThr: 2.176 ± 0.049	2.978PheVal: 2.978 ± 0.062	0.487PheTrp: 0.487 ± 0.025	0.717PheTyr: 0.717 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.79GlyAla: 9.79 ± 0.111	0.568GlyCys: 0.568 ± 0.029	4.961GlyAsp: 4.961 ± 0.089	4.731GlyGlu: 4.731 ± 0.081	3.235GlyPhe: 3.235 ± 0.068	7.178GlyGly: 7.178 ± 0.108	1.799GlyHis: 1.799 ± 0.052	5.176GlyIle: 5.176 ± 0.079	2.542GlyLys: 2.542 ± 0.069	8.57GlyLeu: 8.57 ± 0.117	1.981GlyMet: 1.981 ± 0.055	2.05GlyAsn: 2.05 ± 0.055	3.501GlyPro: 3.501 ± 0.064	2.58GlyGln: 2.58 ± 0.051	5.708GlyArg: 5.708 ± 0.08	5.806GlySer: 5.806 ± 0.075	5.658GlyThr: 5.658 ± 0.097	7.499GlyVal: 7.499 ± 0.106	1.498GlyTrp: 1.498 ± 0.044	2.344GlyTyr: 2.344 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.103HisAla: 2.103 ± 0.056	0.13HisCys: 0.13 ± 0.012	1.219HisAsp: 1.219 ± 0.038	1.088HisGlu: 1.088 ± 0.036	0.547HisPhe: 0.547 ± 0.027	1.776HisGly: 1.776 ± 0.046	0.51HisHis: 0.51 ± 0.029	0.768HisIle: 0.768 ± 0.027	0.331HisLys: 0.331 ± 0.018	1.941HisLeu: 1.941 ± 0.045	0.32HisMet: 0.32 ± 0.02	0.425HisAsn: 0.425 ± 0.022	1.418HisPro: 1.418 ± 0.04	0.523HisGln: 0.523 ± 0.026	1.416HisArg: 1.416 ± 0.04	1.199HisSer: 1.199 ± 0.041	1.022HisThr: 1.022 ± 0.033	1.553HisVal: 1.553 ± 0.043	0.288HisTrp: 0.288 ± 0.02	0.417HisTyr: 0.417 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.885IleAla: 6.885 ± 0.105	0.253IleCys: 0.253 ± 0.016	3.696IleAsp: 3.696 ± 0.064	3.002IleGlu: 3.002 ± 0.056	1.435IlePhe: 1.435 ± 0.045	4.846IleGly: 4.846 ± 0.076	0.719IleHis: 0.719 ± 0.03	2.085IleIle: 2.085 ± 0.064	0.944IleLys: 0.944 ± 0.033	4.601IleLeu: 4.601 ± 0.084	0.681IleMet: 0.681 ± 0.032	1.066IleAsn: 1.066 ± 0.039	2.664IlePro: 2.664 ± 0.056	1.027IleGln: 1.027 ± 0.034	3.058IleArg: 3.058 ± 0.064	2.814IleSer: 2.814 ± 0.058	3.029IleThr: 3.029 ± 0.065	4.816IleVal: 4.816 ± 0.075	0.593IleTrp: 0.593 ± 0.031	0.856IleTyr: 0.856 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	2.772LysAla: 2.772 ± 0.067	0.075LysCys: 0.075 ± 0.009	1.241LysAsp: 1.241 ± 0.039	1.13LysGlu: 1.13 ± 0.038	0.616LysPhe: 0.616 ± 0.027	1.739LysGly: 1.739 ± 0.056	0.551LysHis: 0.551 ± 0.027	1.174LysIle: 1.174 ± 0.04	1.093LysLys: 1.093 ± 0.049	2.379LysLeu: 2.379 ± 0.051	0.506LysMet: 0.506 ± 0.023	0.749LysAsn: 0.749 ± 0.028	1.462LysPro: 1.462 ± 0.048	0.82LysGln: 0.82 ± 0.033	1.875LysArg: 1.875 ± 0.047	1.463LysSer: 1.463 ± 0.04	1.592LysThr: 1.592 ± 0.05	1.823LysVal: 1.823 ± 0.056	0.292LysTrp: 0.292 ± 0.016	0.544LysTyr: 0.544 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.059LeuAla: 14.059 ± 0.177	0.474LeuCys: 0.474 ± 0.022	6.792LeuAsp: 6.792 ± 0.102	5.432LeuGlu: 5.432 ± 0.076	3.253LeuPhe: 3.253 ± 0.08	9.267LeuGly: 9.267 ± 0.127	1.757LeuHis: 1.757 ± 0.041	4.832LeuIle: 4.832 ± 0.089	2.16LeuLys: 2.16 ± 0.056	10.444LeuLeu: 10.444 ± 0.143	1.595LeuMet: 1.595 ± 0.044	2.185LeuAsn: 2.185 ± 0.055	5.363LeuPro: 5.363 ± 0.08	2.481LeuGln: 2.481 ± 0.048	6.692LeuArg: 6.692 ± 0.09	6.452LeuSer: 6.452 ± 0.088	6.66LeuThr: 6.66 ± 0.072	9.113LeuVal: 9.113 ± 0.113	1.281LeuTrp: 1.281 ± 0.045	1.733LeuTyr: 1.733 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.056MetAla: 2.056 ± 0.056	0.08MetCys: 0.08 ± 0.01	0.816MetAsp: 0.816 ± 0.034	0.684MetGlu: 0.684 ± 0.027	0.601MetPhe: 0.601 ± 0.028	1.284MetGly: 1.284 ± 0.041	0.363MetHis: 0.363 ± 0.02	0.888MetIle: 0.888 ± 0.035	0.545MetLys: 0.545 ± 0.028	1.95MetLeu: 1.95 ± 0.055	0.351MetMet: 0.351 ± 0.022	0.507MetAsn: 0.507 ± 0.026	1.138MetPro: 1.138 ± 0.034	0.51MetGln: 0.51 ± 0.024	1.277MetArg: 1.277 ± 0.031	1.536MetSer: 1.536 ± 0.045	1.655MetThr: 1.655 ± 0.043	1.375MetVal: 1.375 ± 0.045	0.198MetTrp: 0.198 ± 0.015	0.275MetTyr: 0.275 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.782AsnAla: 2.782 ± 0.049	0.129AsnCys: 0.129 ± 0.011	1.482AsnAsp: 1.482 ± 0.043	1.269AsnGlu: 1.269 ± 0.037	0.797AsnPhe: 0.797 ± 0.027	2.283AsnGly: 2.283 ± 0.06	0.382AsnHis: 0.382 ± 0.02	1.077AsnIle: 1.077 ± 0.038	0.537AsnLys: 0.537 ± 0.024	2.247AsnLeu: 2.247 ± 0.052	0.405AsnMet: 0.405 ± 0.022	0.62AsnAsn: 0.62 ± 0.026	1.757AsnPro: 1.757 ± 0.043	0.64AsnGln: 0.64 ± 0.028	1.554AsnArg: 1.554 ± 0.04	1.246AsnSer: 1.246 ± 0.041	1.403AsnThr: 1.403 ± 0.042	1.971AsnVal: 1.971 ± 0.047	0.4AsnTrp: 0.4 ± 0.022	0.603AsnTyr: 0.603 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.607ProAla: 6.607 ± 0.1	0.209ProCys: 0.209 ± 0.016	3.856ProAsp: 3.856 ± 0.077	3.815ProGlu: 3.815 ± 0.063	1.79ProPhe: 1.79 ± 0.041	4.864ProGly: 4.864 ± 0.083	0.988ProHis: 0.988 ± 0.034	2.267ProIle: 2.267 ± 0.055	1.205ProLys: 1.205 ± 0.042	4.756ProLeu: 4.756 ± 0.077	0.828ProMet: 0.828 ± 0.034	1.25ProAsn: 1.25 ± 0.04	2.24ProPro: 2.24 ± 0.072	1.451ProGln: 1.451 ± 0.04	3.03ProArg: 3.03 ± 0.069	3.28ProSer: 3.28 ± 0.062	3.311ProThr: 3.311 ± 0.059	4.893ProVal: 4.893 ± 0.084	0.779ProTrp: 0.779 ± 0.034	1.093ProTyr: 1.093 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.261GlnAla: 3.261 ± 0.056	0.098GlnCys: 0.098 ± 0.01	1.308GlnAsp: 1.308 ± 0.037	1.312GlnGlu: 1.312 ± 0.04	0.982GlnPhe: 0.982 ± 0.028	2.006GlnGly: 2.006 ± 0.052	0.593GlnHis: 0.593 ± 0.023	1.427GlnIle: 1.427 ± 0.038	0.84GlnLys: 0.84 ± 0.031	3.174GlnLeu: 3.174 ± 0.061	0.529GlnMet: 0.529 ± 0.025	0.714GlnAsn: 0.714 ± 0.029	1.586GlnPro: 1.586 ± 0.048	1.135GlnGln: 1.135 ± 0.046	2.236GlnArg: 2.236 ± 0.054	1.693GlnSer: 1.693 ± 0.049	1.527GlnThr: 1.527 ± 0.041	2.41GlnVal: 2.41 ± 0.048	0.414GlnTrp: 0.414 ± 0.021	0.643GlnTyr: 0.643 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.436ArgAla: 7.436 ± 0.105	0.289ArgCys: 0.289 ± 0.014	4.005ArgAsp: 4.005 ± 0.073	4.023ArgGlu: 4.023 ± 0.08	2.425ArgPhe: 2.425 ± 0.052	4.825ArgGly: 4.825 ± 0.081	1.4ArgHis: 1.4 ± 0.041	3.627ArgIle: 3.627 ± 0.062	1.722ArgLys: 1.722 ± 0.047	6.877ArgLeu: 6.877 ± 0.094	1.728ArgMet: 1.728 ± 0.044	1.688ArgAsn: 1.688 ± 0.045	3.335ArgPro: 3.335 ± 0.078	2.047ArgGln: 2.047 ± 0.05	5.448ArgArg: 5.448 ± 0.098	4.461ArgSer: 4.461 ± 0.086	4.074ArgThr: 4.074 ± 0.067	5.584ArgVal: 5.584 ± 0.085	1.077ArgTrp: 1.077 ± 0.035	1.546ArgTyr: 1.546 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.606SerAla: 7.606 ± 0.105	0.32SerCys: 0.32 ± 0.018	3.738SerAsp: 3.738 ± 0.067	3.133SerGlu: 3.133 ± 0.069	2.184SerPhe: 2.184 ± 0.057	6.313SerGly: 6.313 ± 0.096	1.174SerHis: 1.174 ± 0.036	3.232SerIle: 3.232 ± 0.064	1.43SerLys: 1.43 ± 0.044	5.869SerLeu: 5.869 ± 0.087	1.3SerMet: 1.3 ± 0.036	1.397SerAsn: 1.397 ± 0.044	3.418SerPro: 3.418 ± 0.058	1.623SerGln: 1.623 ± 0.044	4.254SerArg: 4.254 ± 0.063	4.062SerSer: 4.062 ± 0.08	4.04SerThr: 4.04 ± 0.075	5.49SerVal: 5.49 ± 0.093	0.968SerTrp: 0.968 ± 0.031	1.29SerTyr: 1.29 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	7.665ThrAla: 7.665 ± 0.097	0.276ThrCys: 0.276 ± 0.019	3.994ThrAsp: 3.994 ± 0.067	3.36ThrGlu: 3.36 ± 0.059	1.999ThrPhe: 1.999 ± 0.05	6.11ThrGly: 6.11 ± 0.085	1.053ThrHis: 1.053 ± 0.033	2.989ThrIle: 2.989 ± 0.054	1.386ThrLys: 1.386 ± 0.047	6.208ThrLeu: 6.208 ± 0.081	0.961ThrMet: 0.961 ± 0.034	1.405ThrAsn: 1.405 ± 0.051	3.888ThrPro: 3.888 ± 0.078	1.523ThrGln: 1.523 ± 0.039	3.732ThrArg: 3.732 ± 0.067	3.699ThrSer: 3.699 ± 0.069	4.005ThrThr: 4.005 ± 0.081	5.881ThrVal: 5.881 ± 0.091	0.926ThrTrp: 0.926 ± 0.037	1.177ThrTyr: 1.177 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.68ValAla: 10.68 ± 0.123	0.457ValCys: 0.457 ± 0.022	5.572ValAsp: 5.572 ± 0.078	4.786ValGlu: 4.786 ± 0.069	2.876ValPhe: 2.876 ± 0.059	7.036ValGly: 7.036 ± 0.088	1.653ValHis: 1.653 ± 0.042	4.557ValIle: 4.557 ± 0.08	1.824ValLys: 1.824 ± 0.048	9.434ValLeu: 9.434 ± 0.14	1.486ValMet: 1.486 ± 0.045	2.068ValAsn: 2.068 ± 0.052	4.562ValPro: 4.562 ± 0.069	2.216ValGln: 2.216 ± 0.042	5.435ValArg: 5.435 ± 0.078	5.538ValSer: 5.538 ± 0.084	5.983ValThr: 5.983 ± 0.095	8.225ValVal: 8.225 ± 0.118	1.138ValTrp: 1.138 ± 0.034	1.593ValTyr: 1.593 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.47TrpAla: 1.47 ± 0.048	0.086TrpCys: 0.086 ± 0.01	0.728TrpAsp: 0.728 ± 0.028	0.675TrpGlu: 0.675 ± 0.028	0.554TrpPhe: 0.554 ± 0.024	0.997TrpGly: 0.997 ± 0.034	0.344TrpHis: 0.344 ± 0.02	0.705TrpIle: 0.705 ± 0.029	0.379TrpLys: 0.379 ± 0.021	1.853TrpLeu: 1.853 ± 0.055	0.321TrpMet: 0.321 ± 0.021	0.461TrpAsn: 0.461 ± 0.024	0.693TrpPro: 0.693 ± 0.028	0.576TrpGln: 0.576 ± 0.027	1.163TrpArg: 1.163 ± 0.043	0.963TrpSer: 0.963 ± 0.031	0.934TrpThr: 0.934 ± 0.032	1.074TrpVal: 1.074 ± 0.036	0.368TrpTrp: 0.368 ± 0.021	0.298TrpTyr: 0.298 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.218TyrAla: 2.218 ± 0.051	0.117TyrCys: 0.117 ± 0.011	1.269TyrAsp: 1.269 ± 0.038	1.097TyrGlu: 1.097 ± 0.035	0.831TyrPhe: 0.831 ± 0.029	1.947TyrGly: 1.947 ± 0.05	0.272TyrHis: 0.272 ± 0.019	0.79TyrIle: 0.79 ± 0.028	0.417TyrLys: 0.417 ± 0.022	2.326TyrLeu: 2.326 ± 0.054	0.276TyrMet: 0.276 ± 0.017	0.558TyrAsn: 0.558 ± 0.027	1.139TyrPro: 1.139 ± 0.034	0.549TyrGln: 0.549 ± 0.025	1.652TyrArg: 1.652 ± 0.046	1.378TyrSer: 1.378 ± 0.034	1.215TyrThr: 1.215 ± 0.037	1.618TyrVal: 1.618 ± 0.049	0.352TyrTrp: 0.352 ± 0.018	0.477TyrTyr: 0.477 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2854 proteins (915423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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