Amino acid dipepetide frequency for Freshwater phage uvFW-CGR-AMD-COM-C203

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.855AlaAla: 4.855 ± 0.797
0.702AlaCys: 0.702 ± 0.256
5.908AlaAsp: 5.908 ± 0.647
7.546AlaGlu: 7.546 ± 0.839
3.744AlaPhe: 3.744 ± 0.462
7.78AlaGly: 7.78 ± 1.126
1.228AlaHis: 1.228 ± 0.264
5.791AlaIle: 5.791 ± 0.558
5.967AlaLys: 5.967 ± 0.65
7.078AlaLeu: 7.078 ± 0.671
2.808AlaMet: 2.808 ± 0.553
3.861AlaAsn: 3.861 ± 0.472
4.095AlaPro: 4.095 ± 0.588
3.568AlaGln: 3.568 ± 0.372
4.387AlaArg: 4.387 ± 0.59
7.312AlaSer: 7.312 ± 0.751
8.365AlaThr: 8.365 ± 0.991
6.318AlaVal: 6.318 ± 0.739
1.579AlaTrp: 1.579 ± 0.411
2.164AlaTyr: 2.164 ± 0.381
0.0AlaXaa: 0.0 ± 0.0
Cys
0.76CysAla: 0.76 ± 0.223
0.0CysCys: 0.0 ± 0.0
0.292CysAsp: 0.292 ± 0.16
0.526CysGlu: 0.526 ± 0.222
0.234CysPhe: 0.234 ± 0.118
0.468CysGly: 0.468 ± 0.175
0.117CysHis: 0.117 ± 0.081
0.117CysIle: 0.117 ± 0.083
0.234CysLys: 0.234 ± 0.12
0.702CysLeu: 0.702 ± 0.178
0.117CysMet: 0.117 ± 0.095
0.234CysAsn: 0.234 ± 0.127
0.526CysPro: 0.526 ± 0.167
0.234CysGln: 0.234 ± 0.131
0.468CysArg: 0.468 ± 0.184
0.409CysSer: 0.409 ± 0.131
0.292CysThr: 0.292 ± 0.121
0.351CysVal: 0.351 ± 0.153
0.058CysTrp: 0.058 ± 0.055
0.175CysTyr: 0.175 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
6.376AspAla: 6.376 ± 0.472
0.292AspCys: 0.292 ± 0.142
3.159AspAsp: 3.159 ± 0.508
3.451AspGlu: 3.451 ± 0.506
2.281AspPhe: 2.281 ± 0.427
5.85AspGly: 5.85 ± 0.672
0.351AspHis: 0.351 ± 0.123
3.978AspIle: 3.978 ± 0.584
3.159AspLys: 3.159 ± 0.421
4.738AspLeu: 4.738 ± 0.523
1.228AspMet: 1.228 ± 0.262
3.042AspAsn: 3.042 ± 0.532
2.808AspPro: 2.808 ± 0.378
1.579AspGln: 1.579 ± 0.3
2.398AspArg: 2.398 ± 0.562
3.334AspSer: 3.334 ± 0.448
3.685AspThr: 3.685 ± 0.437
4.563AspVal: 4.563 ± 0.553
0.877AspTrp: 0.877 ± 0.256
1.872AspTyr: 1.872 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
6.142GluAla: 6.142 ± 0.664
0.585GluCys: 0.585 ± 0.218
2.925GluAsp: 2.925 ± 0.371
6.084GluGlu: 6.084 ± 1.158
3.159GluPhe: 3.159 ± 0.352
4.27GluGly: 4.27 ± 0.529
0.819GluHis: 0.819 ± 0.189
5.148GluIle: 5.148 ± 0.552
4.621GluLys: 4.621 ± 0.824
4.972GluLeu: 4.972 ± 0.59
1.345GluMet: 1.345 ± 0.285
2.457GluAsn: 2.457 ± 0.418
4.036GluPro: 4.036 ± 1.783
2.632GluGln: 2.632 ± 0.396
4.212GluArg: 4.212 ± 0.646
4.036GluSer: 4.036 ± 0.57
3.919GluThr: 3.919 ± 0.423
5.089GluVal: 5.089 ± 0.473
1.579GluTrp: 1.579 ± 0.358
1.228GluTyr: 1.228 ± 0.252
0.0GluXaa: 0.0 ± 0.0
Phe
3.568PheAla: 3.568 ± 0.69
0.234PheCys: 0.234 ± 0.105
2.574PheAsp: 2.574 ± 0.378
2.281PheGlu: 2.281 ± 0.401
1.111PhePhe: 1.111 ± 0.276
2.691PheGly: 2.691 ± 0.472
0.468PheHis: 0.468 ± 0.174
2.574PheIle: 2.574 ± 0.317
1.287PheLys: 1.287 ± 0.257
2.749PheLeu: 2.749 ± 0.389
0.643PheMet: 0.643 ± 0.195
1.872PheAsn: 1.872 ± 0.392
0.994PhePro: 0.994 ± 0.246
0.877PheGln: 0.877 ± 0.202
1.989PheArg: 1.989 ± 0.374
2.808PheSer: 2.808 ± 0.455
3.042PheThr: 3.042 ± 0.437
2.691PheVal: 2.691 ± 0.373
0.819PheTrp: 0.819 ± 0.225
0.819PheTyr: 0.819 ± 0.223
0.0PheXaa: 0.0 ± 0.0
Gly
6.376GlyAla: 6.376 ± 0.83
0.409GlyCys: 0.409 ± 0.167
4.621GlyAsp: 4.621 ± 0.593
4.563GlyGlu: 4.563 ± 0.669
3.276GlyPhe: 3.276 ± 0.576
7.605GlyGly: 7.605 ± 2.943
1.579GlyHis: 1.579 ± 0.36
5.206GlyIle: 5.206 ± 0.692
4.504GlyLys: 4.504 ± 0.575
4.27GlyLeu: 4.27 ± 0.692
1.404GlyMet: 1.404 ± 0.243
3.685GlyAsn: 3.685 ± 0.551
0.877GlyPro: 0.877 ± 0.219
2.925GlyGln: 2.925 ± 0.411
3.861GlyArg: 3.861 ± 0.6
4.914GlySer: 4.914 ± 0.787
5.616GlyThr: 5.616 ± 0.859
6.025GlyVal: 6.025 ± 0.742
1.521GlyTrp: 1.521 ± 0.274
2.866GlyTyr: 2.866 ± 0.325
0.0GlyXaa: 0.0 ± 0.0
His
1.111HisAla: 1.111 ± 0.276
0.117HisCys: 0.117 ± 0.084
1.111HisAsp: 1.111 ± 0.374
1.345HisGlu: 1.345 ± 0.295
0.468HisPhe: 0.468 ± 0.165
1.287HisGly: 1.287 ± 0.334
0.585HisHis: 0.585 ± 0.167
0.994HisIle: 0.994 ± 0.304
0.585HisLys: 0.585 ± 0.175
0.76HisLeu: 0.76 ± 0.225
0.117HisMet: 0.117 ± 0.073
0.76HisAsn: 0.76 ± 0.195
0.994HisPro: 0.994 ± 0.254
0.468HisGln: 0.468 ± 0.16
0.351HisArg: 0.351 ± 0.138
0.643HisSer: 0.643 ± 0.153
1.111HisThr: 1.111 ± 0.323
0.877HisVal: 0.877 ± 0.237
0.234HisTrp: 0.234 ± 0.1
0.643HisTyr: 0.643 ± 0.206
0.0HisXaa: 0.0 ± 0.0
Ile
6.844IleAla: 6.844 ± 0.543
0.585IleCys: 0.585 ± 0.193
3.919IleAsp: 3.919 ± 0.439
5.206IleGlu: 5.206 ± 0.628
1.696IlePhe: 1.696 ± 0.318
4.797IleGly: 4.797 ± 0.71
0.76IleHis: 0.76 ± 0.241
3.159IleIle: 3.159 ± 0.556
3.217IleLys: 3.217 ± 0.533
4.563IleLeu: 4.563 ± 0.582
1.17IleMet: 1.17 ± 0.273
1.872IleAsn: 1.872 ± 0.295
2.749IlePro: 2.749 ± 0.405
2.164IleGln: 2.164 ± 0.351
2.808IleArg: 2.808 ± 0.382
4.153IleSer: 4.153 ± 0.546
5.148IleThr: 5.148 ± 0.549
4.68IleVal: 4.68 ± 0.638
0.643IleTrp: 0.643 ± 0.194
2.164IleTyr: 2.164 ± 0.397
0.0IleXaa: 0.0 ± 0.0
Lys
6.318LysAla: 6.318 ± 0.749
0.292LysCys: 0.292 ± 0.18
2.749LysAsp: 2.749 ± 0.483
4.095LysGlu: 4.095 ± 0.569
2.281LysPhe: 2.281 ± 0.373
3.627LysGly: 3.627 ± 0.58
0.702LysHis: 0.702 ± 0.237
4.27LysIle: 4.27 ± 0.602
4.797LysLys: 4.797 ± 0.614
2.925LysLeu: 2.925 ± 0.461
1.872LysMet: 1.872 ± 0.36
2.632LysAsn: 2.632 ± 0.403
2.398LysPro: 2.398 ± 0.466
1.638LysGln: 1.638 ± 0.294
2.808LysArg: 2.808 ± 0.48
4.621LysSer: 4.621 ± 0.73
3.51LysThr: 3.51 ± 0.469
5.323LysVal: 5.323 ± 0.556
0.585LysTrp: 0.585 ± 0.22
1.696LysTyr: 1.696 ± 0.282
0.0LysXaa: 0.0 ± 0.0
Leu
7.663LeuAla: 7.663 ± 0.812
0.468LeuCys: 0.468 ± 0.204
4.68LeuAsp: 4.68 ± 0.507
4.621LeuGlu: 4.621 ± 0.522
1.521LeuPhe: 1.521 ± 0.318
6.084LeuGly: 6.084 ± 0.732
1.111LeuHis: 1.111 ± 0.263
3.802LeuIle: 3.802 ± 0.451
4.27LeuLys: 4.27 ± 0.681
5.674LeuLeu: 5.674 ± 0.557
1.404LeuMet: 1.404 ± 0.196
2.983LeuAsn: 2.983 ± 0.359
3.451LeuPro: 3.451 ± 0.494
2.866LeuGln: 2.866 ± 0.479
3.451LeuArg: 3.451 ± 0.467
5.382LeuSer: 5.382 ± 0.528
5.791LeuThr: 5.791 ± 0.713
5.323LeuVal: 5.323 ± 0.573
0.409LeuTrp: 0.409 ± 0.157
1.638LeuTyr: 1.638 ± 0.277
0.0LeuXaa: 0.0 ± 0.0
Met
2.457MetAla: 2.457 ± 0.359
0.0MetCys: 0.0 ± 0.0
1.17MetAsp: 1.17 ± 0.324
1.287MetGlu: 1.287 ± 0.307
0.643MetPhe: 0.643 ± 0.197
1.696MetGly: 1.696 ± 0.435
0.175MetHis: 0.175 ± 0.085
1.228MetIle: 1.228 ± 0.256
1.872MetLys: 1.872 ± 0.406
0.994MetLeu: 0.994 ± 0.278
0.409MetMet: 0.409 ± 0.147
0.76MetAsn: 0.76 ± 0.203
0.994MetPro: 0.994 ± 0.331
0.234MetGln: 0.234 ± 0.144
0.936MetArg: 0.936 ± 0.207
1.696MetSer: 1.696 ± 0.316
1.462MetThr: 1.462 ± 0.299
1.053MetVal: 1.053 ± 0.25
0.468MetTrp: 0.468 ± 0.152
0.702MetTyr: 0.702 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
3.627AsnAla: 3.627 ± 0.48
0.351AsnCys: 0.351 ± 0.146
2.925AsnAsp: 2.925 ± 0.461
2.047AsnGlu: 2.047 ± 0.358
1.989AsnPhe: 1.989 ± 0.384
3.568AsnGly: 3.568 ± 0.464
0.877AsnHis: 0.877 ± 0.231
2.457AsnIle: 2.457 ± 0.32
2.691AsnLys: 2.691 ± 0.425
3.217AsnLeu: 3.217 ± 0.423
1.228AsnMet: 1.228 ± 0.268
1.638AsnAsn: 1.638 ± 0.313
2.749AsnPro: 2.749 ± 0.41
1.696AsnGln: 1.696 ± 0.289
2.164AsnArg: 2.164 ± 0.412
2.515AsnSer: 2.515 ± 0.446
2.632AsnThr: 2.632 ± 0.332
2.047AsnVal: 2.047 ± 0.402
0.76AsnTrp: 0.76 ± 0.257
1.053AsnTyr: 1.053 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
3.744ProAla: 3.744 ± 0.767
0.234ProCys: 0.234 ± 0.112
2.515ProAsp: 2.515 ± 0.346
3.334ProGlu: 3.334 ± 0.825
1.287ProPhe: 1.287 ± 0.225
0.936ProGly: 0.936 ± 0.246
0.409ProHis: 0.409 ± 0.148
3.159ProIle: 3.159 ± 0.5
2.047ProLys: 2.047 ± 0.389
3.217ProLeu: 3.217 ± 0.469
0.643ProMet: 0.643 ± 0.212
1.93ProAsn: 1.93 ± 0.39
1.93ProPro: 1.93 ± 0.469
2.106ProGln: 2.106 ± 0.83
0.936ProArg: 0.936 ± 0.291
5.089ProSer: 5.089 ± 1.811
5.908ProThr: 5.908 ± 2.072
3.744ProVal: 3.744 ± 0.939
0.702ProTrp: 0.702 ± 0.202
1.404ProTyr: 1.404 ± 0.359
0.0ProXaa: 0.0 ± 0.0
Gln
3.568GlnAla: 3.568 ± 0.536
0.234GlnCys: 0.234 ± 0.096
1.696GlnAsp: 1.696 ± 0.324
1.696GlnGlu: 1.696 ± 0.281
1.462GlnPhe: 1.462 ± 0.315
2.574GlnGly: 2.574 ± 0.493
0.351GlnHis: 0.351 ± 0.131
2.574GlnIle: 2.574 ± 0.386
2.691GlnLys: 2.691 ± 0.426
2.398GlnLeu: 2.398 ± 0.41
0.526GlnMet: 0.526 ± 0.183
2.047GlnAsn: 2.047 ± 0.33
2.281GlnPro: 2.281 ± 0.95
1.053GlnGln: 1.053 ± 0.289
1.696GlnArg: 1.696 ± 0.308
1.989GlnSer: 1.989 ± 0.325
2.223GlnThr: 2.223 ± 0.293
1.813GlnVal: 1.813 ± 0.343
0.702GlnTrp: 0.702 ± 0.24
0.994GlnTyr: 0.994 ± 0.253
0.0GlnXaa: 0.0 ± 0.0
Arg
3.861ArgAla: 3.861 ± 0.576
0.292ArgCys: 0.292 ± 0.139
2.106ArgAsp: 2.106 ± 0.371
2.691ArgGlu: 2.691 ± 0.384
1.521ArgPhe: 1.521 ± 0.315
3.042ArgGly: 3.042 ± 0.501
0.526ArgHis: 0.526 ± 0.193
3.217ArgIle: 3.217 ± 0.405
2.749ArgLys: 2.749 ± 0.412
4.153ArgLeu: 4.153 ± 0.545
0.994ArgMet: 0.994 ± 0.223
2.515ArgAsn: 2.515 ± 0.362
1.638ArgPro: 1.638 ± 0.351
2.223ArgGln: 2.223 ± 0.443
2.164ArgArg: 2.164 ± 0.4
2.691ArgSer: 2.691 ± 0.365
2.34ArgThr: 2.34 ± 0.359
2.749ArgVal: 2.749 ± 0.381
0.877ArgTrp: 0.877 ± 0.339
1.462ArgTyr: 1.462 ± 0.32
0.0ArgXaa: 0.0 ± 0.0
Ser
7.078SerAla: 7.078 ± 0.96
0.409SerCys: 0.409 ± 0.146
3.685SerAsp: 3.685 ± 0.553
3.51SerGlu: 3.51 ± 0.644
2.749SerPhe: 2.749 ± 0.436
6.084SerGly: 6.084 ± 0.71
1.17SerHis: 1.17 ± 0.284
3.978SerIle: 3.978 ± 0.564
3.861SerLys: 3.861 ± 0.435
5.733SerLeu: 5.733 ± 0.421
1.521SerMet: 1.521 ± 0.353
2.223SerAsn: 2.223 ± 0.349
4.095SerPro: 4.095 ± 1.675
2.398SerGln: 2.398 ± 0.39
2.106SerArg: 2.106 ± 0.429
4.446SerSer: 4.446 ± 0.557
5.265SerThr: 5.265 ± 0.793
5.557SerVal: 5.557 ± 0.637
1.053SerTrp: 1.053 ± 0.234
2.223SerTyr: 2.223 ± 0.363
0.0SerXaa: 0.0 ± 0.0
Thr
9.184ThrAla: 9.184 ± 1.147
0.351ThrCys: 0.351 ± 0.136
4.27ThrAsp: 4.27 ± 0.528
3.861ThrGlu: 3.861 ± 0.565
2.866ThrPhe: 2.866 ± 0.454
4.914ThrGly: 4.914 ± 0.525
1.17ThrHis: 1.17 ± 0.28
4.329ThrIle: 4.329 ± 0.507
3.744ThrLys: 3.744 ± 0.543
5.674ThrLeu: 5.674 ± 0.909
1.053ThrMet: 1.053 ± 0.261
3.042ThrAsn: 3.042 ± 0.614
4.329ThrPro: 4.329 ± 1.839
2.398ThrGln: 2.398 ± 0.37
1.989ThrArg: 1.989 ± 0.309
5.674ThrSer: 5.674 ± 0.742
7.254ThrThr: 7.254 ± 1.013
6.259ThrVal: 6.259 ± 0.673
0.877ThrTrp: 0.877 ± 0.236
2.749ThrTyr: 2.749 ± 0.419
0.0ThrXaa: 0.0 ± 0.0
Val
6.844ValAla: 6.844 ± 0.599
0.468ValCys: 0.468 ± 0.143
4.914ValAsp: 4.914 ± 0.605
7.078ValGlu: 7.078 ± 0.695
2.457ValPhe: 2.457 ± 0.592
5.674ValGly: 5.674 ± 0.718
1.521ValHis: 1.521 ± 0.318
4.095ValIle: 4.095 ± 0.625
4.27ValLys: 4.27 ± 0.57
5.85ValLeu: 5.85 ± 0.692
1.17ValMet: 1.17 ± 0.326
2.574ValAsn: 2.574 ± 0.366
3.042ValPro: 3.042 ± 0.678
2.164ValGln: 2.164 ± 0.329
2.457ValArg: 2.457 ± 0.369
5.031ValSer: 5.031 ± 0.599
5.089ValThr: 5.089 ± 0.699
5.616ValVal: 5.616 ± 0.547
0.76ValTrp: 0.76 ± 0.22
2.281ValTyr: 2.281 ± 0.329
0.0ValXaa: 0.0 ± 0.0
Trp
2.223TrpAla: 2.223 ± 0.518
0.175TrpCys: 0.175 ± 0.137
1.17TrpAsp: 1.17 ± 0.298
1.17TrpGlu: 1.17 ± 0.289
0.643TrpPhe: 0.643 ± 0.221
0.819TrpGly: 0.819 ± 0.265
0.234TrpHis: 0.234 ± 0.126
0.936TrpIle: 0.936 ± 0.236
1.111TrpLys: 1.111 ± 0.329
0.819TrpLeu: 0.819 ± 0.238
0.292TrpMet: 0.292 ± 0.115
0.643TrpAsn: 0.643 ± 0.198
0.0TrpPro: 0.0 ± 0.0
0.351TrpGln: 0.351 ± 0.142
0.936TrpArg: 0.936 ± 0.225
0.877TrpSer: 0.877 ± 0.278
1.228TrpThr: 1.228 ± 0.263
1.053TrpVal: 1.053 ± 0.248
0.351TrpTrp: 0.351 ± 0.136
0.409TrpTyr: 0.409 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.457TyrAla: 2.457 ± 0.345
0.117TyrCys: 0.117 ± 0.091
2.632TyrAsp: 2.632 ± 0.327
2.866TyrGlu: 2.866 ± 0.384
0.702TyrPhe: 0.702 ± 0.191
2.34TyrGly: 2.34 ± 0.363
0.409TyrHis: 0.409 ± 0.146
1.287TyrIle: 1.287 ± 0.307
1.521TyrLys: 1.521 ± 0.281
2.106TyrLeu: 2.106 ± 0.365
0.234TyrMet: 0.234 ± 0.117
1.462TyrAsn: 1.462 ± 0.317
1.287TyrPro: 1.287 ± 0.294
0.994TyrGln: 0.994 ± 0.205
1.696TyrArg: 1.696 ± 0.285
1.521TyrSer: 1.521 ± 0.338
2.106TyrThr: 2.106 ± 0.36
2.223TyrVal: 2.223 ± 0.336
0.585TyrTrp: 0.585 ± 0.199
0.936TyrTyr: 0.936 ± 0.231
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (17096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski