Amino acid dipepetide frequency for Dinothrombium tinctorium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.343AlaAla: 4.343 ± 0.044	1.037AlaCys: 1.037 ± 0.016	2.582AlaAsp: 2.582 ± 0.023	3.441AlaGlu: 3.441 ± 0.025	3.045AlaPhe: 3.045 ± 0.025	2.597AlaGly: 2.597 ± 0.026	1.209AlaHis: 1.209 ± 0.016	4.304AlaIle: 4.304 ± 0.029	4.249AlaLys: 4.249 ± 0.031	5.613AlaLeu: 5.613 ± 0.032	1.269AlaMet: 1.269 ± 0.015	3.34AlaAsn: 3.34 ± 0.027	2.125AlaPro: 2.125 ± 0.024	1.883AlaGln: 1.883 ± 0.02	2.423AlaArg: 2.423 ± 0.022	4.936AlaSer: 4.936 ± 0.038	3.233AlaThr: 3.233 ± 0.027	3.711AlaVal: 3.711 ± 0.027	0.482AlaTrp: 0.482 ± 0.01	1.727AlaTyr: 1.727 ± 0.017	0.002AlaXaa: 0.002 ± 0.001
Cys	1.111CysAla: 1.111 ± 0.015	0.551CysCys: 0.551 ± 0.012	1.365CysAsp: 1.365 ± 0.018	1.527CysGlu: 1.527 ± 0.019	1.081CysPhe: 1.081 ± 0.015	1.365CysGly: 1.365 ± 0.021	0.497CysHis: 0.497 ± 0.01	1.351CysIle: 1.351 ± 0.018	1.433CysLys: 1.433 ± 0.018	2.046CysLeu: 2.046 ± 0.018	0.35CysMet: 0.35 ± 0.008	1.146CysAsn: 1.146 ± 0.017	0.98CysPro: 0.98 ± 0.017	0.735CysGln: 0.735 ± 0.013	1.028CysArg: 1.028 ± 0.016	1.71CysSer: 1.71 ± 0.021	0.934CysThr: 0.934 ± 0.014	1.363CysVal: 1.363 ± 0.018	0.245CysTrp: 0.245 ± 0.008	0.684CysTyr: 0.684 ± 0.011	0.001CysXaa: 0.001 ± 0.0
Asp	2.952AspAla: 2.952 ± 0.025	1.194AspCys: 1.194 ± 0.017	3.339AspAsp: 3.339 ± 0.032	4.693AspGlu: 4.693 ± 0.04	2.729AspPhe: 2.729 ± 0.028	2.865AspGly: 2.865 ± 0.029	1.074AspHis: 1.074 ± 0.014	3.589AspIle: 3.589 ± 0.026	3.216AspLys: 3.216 ± 0.024	4.793AspLeu: 4.793 ± 0.03	0.966AspMet: 0.966 ± 0.015	2.563AspAsn: 2.563 ± 0.02	2.038AspPro: 2.038 ± 0.021	1.567AspGln: 1.567 ± 0.019	2.181AspArg: 2.181 ± 0.022	4.206AspSer: 4.206 ± 0.037	2.257AspThr: 2.257 ± 0.02	3.287AspVal: 3.287 ± 0.024	0.645AspTrp: 0.645 ± 0.011	2.078AspTyr: 2.078 ± 0.021	0.002AspXaa: 0.002 ± 0.001
Glu	3.998GluAla: 3.998 ± 0.03	1.454GluCys: 1.454 ± 0.023	3.591GluAsp: 3.591 ± 0.031	5.969GluGlu: 5.969 ± 0.059	2.755GluPhe: 2.755 ± 0.022	2.603GluGly: 2.603 ± 0.026	1.303GluHis: 1.303 ± 0.017	4.707GluIle: 4.707 ± 0.03	5.892GluLys: 5.892 ± 0.045	5.652GluLeu: 5.652 ± 0.044	1.705GluMet: 1.705 ± 0.018	4.704GluAsn: 4.704 ± 0.035	2.041GluPro: 2.041 ± 0.019	2.541GluGln: 2.541 ± 0.023	3.436GluArg: 3.436 ± 0.025	5.271GluSer: 5.271 ± 0.039	3.817GluThr: 3.817 ± 0.03	3.649GluVal: 3.649 ± 0.025	0.724GluTrp: 0.724 ± 0.012	2.094GluTyr: 2.094 ± 0.02	0.002GluXaa: 0.002 ± 0.001
Phe	2.975PheAla: 2.975 ± 0.026	1.046PheCys: 1.046 ± 0.015	3.002PheAsp: 3.002 ± 0.027	3.15PheGlu: 3.15 ± 0.025	2.195PhePhe: 2.195 ± 0.026	2.853PheGly: 2.853 ± 0.028	1.138PheHis: 1.138 ± 0.015	3.201PheIle: 3.201 ± 0.027	3.003PheLys: 3.003 ± 0.023	4.347PheLeu: 4.347 ± 0.031	0.934PheMet: 0.934 ± 0.014	2.569PheAsn: 2.569 ± 0.022	1.804PhePro: 1.804 ± 0.018	1.582PheGln: 1.582 ± 0.018	2.151PheArg: 2.151 ± 0.023	3.667PheSer: 3.667 ± 0.027	2.585PheThr: 2.585 ± 0.024	3.228PheVal: 3.228 ± 0.028	0.601PheTrp: 0.601 ± 0.012	1.731PheTyr: 1.731 ± 0.02	0.002PheXaa: 0.002 ± 0.001
Gly	2.751GlyAla: 2.751 ± 0.028	1.045GlyCys: 1.045 ± 0.018	2.647GlyAsp: 2.647 ± 0.027	3.015GlyGlu: 3.015 ± 0.029	2.574GlyPhe: 2.574 ± 0.026	3.018GlyGly: 3.018 ± 0.038	1.226GlyHis: 1.226 ± 0.015	3.334GlyIle: 3.334 ± 0.029	3.511GlyLys: 3.511 ± 0.028	4.027GlyLeu: 4.027 ± 0.038	0.935GlyMet: 0.935 ± 0.013	2.664GlyAsn: 2.664 ± 0.021	1.831GlyPro: 1.831 ± 0.032	1.618GlyGln: 1.618 ± 0.019	2.391GlyArg: 2.391 ± 0.024	4.079GlySer: 4.079 ± 0.028	2.587GlyThr: 2.587 ± 0.027	3.098GlyVal: 3.098 ± 0.026	0.577GlyTrp: 0.577 ± 0.01	1.843GlyTyr: 1.843 ± 0.023	0.001GlyXaa: 0.001 ± 0.0
His	0.981HisAla: 0.981 ± 0.015	0.612HisCys: 0.612 ± 0.011	0.929HisAsp: 0.929 ± 0.012	1.362HisGlu: 1.362 ± 0.015	1.315HisPhe: 1.315 ± 0.018	1.128HisGly: 1.128 ± 0.015	0.785HisHis: 0.785 ± 0.019	1.533HisIle: 1.533 ± 0.016	1.43HisLys: 1.43 ± 0.016	2.478HisLeu: 2.478 ± 0.024	0.439HisMet: 0.439 ± 0.008	1.132HisAsn: 1.132 ± 0.015	1.141HisPro: 1.141 ± 0.015	1.007HisGln: 1.007 ± 0.015	1.185HisArg: 1.185 ± 0.016	2.062HisSer: 2.062 ± 0.023	1.033HisThr: 1.033 ± 0.013	1.206HisVal: 1.206 ± 0.015	0.298HisTrp: 0.298 ± 0.007	0.935HisTyr: 0.935 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	4.402IleAla: 4.402 ± 0.03	1.515IleCys: 1.515 ± 0.018	4.116IleAsp: 4.116 ± 0.029	4.847IleGlu: 4.847 ± 0.035	2.956IlePhe: 2.956 ± 0.028	3.469IleGly: 3.469 ± 0.031	1.493IleHis: 1.493 ± 0.016	4.407IleIle: 4.407 ± 0.037	4.49IleLys: 4.49 ± 0.029	5.912IleLeu: 5.912 ± 0.035	1.233IleMet: 1.233 ± 0.014	3.749IleAsn: 3.749 ± 0.026	2.96IlePro: 2.96 ± 0.025	2.224IleGln: 2.224 ± 0.022	3.104IleArg: 3.104 ± 0.023	5.346IleSer: 5.346 ± 0.035	3.652IleThr: 3.652 ± 0.027	4.225IleVal: 4.225 ± 0.033	0.701IleTrp: 0.701 ± 0.012	2.2IleTyr: 2.2 ± 0.019	0.002IleXaa: 0.002 ± 0.0
Lys	4.127LysAla: 4.127 ± 0.03	1.616LysCys: 1.616 ± 0.021	3.453LysAsp: 3.453 ± 0.029	5.226LysGlu: 5.226 ± 0.039	3.001LysPhe: 3.001 ± 0.025	2.939LysGly: 2.939 ± 0.029	1.767LysHis: 1.767 ± 0.018	4.686LysIle: 4.686 ± 0.034	5.355LysLys: 5.355 ± 0.049	6.72LysLeu: 6.72 ± 0.04	1.668LysMet: 1.668 ± 0.016	4.027LysAsn: 4.027 ± 0.031	3.056LysPro: 3.056 ± 0.032	3.143LysGln: 3.143 ± 0.026	4.184LysArg: 4.184 ± 0.036	5.526LysSer: 5.526 ± 0.038	3.781LysThr: 3.781 ± 0.029	3.974LysVal: 3.974 ± 0.024	0.868LysTrp: 0.868 ± 0.011	2.52LysTyr: 2.52 ± 0.021	0.002LysXaa: 0.002 ± 0.001
Leu	5.012LeuAla: 5.012 ± 0.033	1.937LeuCys: 1.937 ± 0.021	4.365LeuAsp: 4.365 ± 0.031	5.428LeuGlu: 5.428 ± 0.036	4.382LeuPhe: 4.382 ± 0.035	3.92LeuGly: 3.92 ± 0.027	2.196LeuHis: 2.196 ± 0.018	6.357LeuIle: 6.357 ± 0.04	7.293LeuLys: 7.293 ± 0.048	9.247LeuLeu: 9.247 ± 0.055	2.154LeuMet: 2.154 ± 0.02	5.607LeuAsn: 5.607 ± 0.039	4.243LeuPro: 4.243 ± 0.033	3.93LeuGln: 3.93 ± 0.033	4.925LeuArg: 4.925 ± 0.033	7.704LeuSer: 7.704 ± 0.047	5.064LeuThr: 5.064 ± 0.034	4.979LeuVal: 4.979 ± 0.036	0.987LeuTrp: 0.987 ± 0.015	2.961LeuTyr: 2.961 ± 0.023	0.002LeuXaa: 0.002 ± 0.001
Met	1.318MetAla: 1.318 ± 0.016	0.405MetCys: 0.405 ± 0.009	1.032MetAsp: 1.032 ± 0.014	1.222MetGlu: 1.222 ± 0.015	0.938MetPhe: 0.938 ± 0.014	0.908MetGly: 0.908 ± 0.016	0.486MetHis: 0.486 ± 0.009	1.356MetIle: 1.356 ± 0.015	1.748MetLys: 1.748 ± 0.019	1.856MetLeu: 1.856 ± 0.019	0.499MetMet: 0.499 ± 0.01	1.243MetAsn: 1.243 ± 0.015	0.942MetPro: 0.942 ± 0.014	0.906MetGln: 0.906 ± 0.014	1.104MetArg: 1.104 ± 0.014	1.795MetSer: 1.795 ± 0.017	1.057MetThr: 1.057 ± 0.012	1.149MetVal: 1.149 ± 0.015	0.218MetTrp: 0.218 ± 0.006	0.603MetTyr: 0.603 ± 0.01	0.001MetXaa: 0.001 ± 0.0
Asn	3.504AsnAla: 3.504 ± 0.027	1.33AsnCys: 1.33 ± 0.016	3.319AsnAsp: 3.319 ± 0.028	4.666AsnGlu: 4.666 ± 0.034	2.678AsnPhe: 2.678 ± 0.02	3.442AsnGly: 3.442 ± 0.032	1.291AsnHis: 1.291 ± 0.016	3.671AsnIle: 3.671 ± 0.028	3.601AsnLys: 3.601 ± 0.028	5.147AsnLeu: 5.147 ± 0.031	1.055AsnMet: 1.055 ± 0.015	3.328AsnAsn: 3.328 ± 0.028	2.342AsnPro: 2.342 ± 0.021	2.116AsnGln: 2.116 ± 0.024	2.561AsnArg: 2.561 ± 0.024	4.909AsnSer: 4.909 ± 0.042	2.613AsnThr: 2.613 ± 0.021	3.692AsnVal: 3.692 ± 0.025	0.62AsnTrp: 0.62 ± 0.009	2.076AsnTyr: 2.076 ± 0.02	0.001AsnXaa: 0.001 ± 0.0
Pro	2.013ProAla: 2.013 ± 0.023	0.701ProCys: 0.701 ± 0.014	2.013ProAsp: 2.013 ± 0.021	2.648ProGlu: 2.648 ± 0.023	2.158ProPhe: 2.158 ± 0.021	1.949ProGly: 1.949 ± 0.044	0.983ProHis: 0.983 ± 0.014	2.807ProIle: 2.807 ± 0.026	2.941ProLys: 2.941 ± 0.028	4.041ProLeu: 4.041 ± 0.029	0.787ProMet: 0.787 ± 0.015	2.479ProAsn: 2.479 ± 0.021	2.991ProPro: 2.991 ± 0.046	1.858ProGln: 1.858 ± 0.026	1.83ProArg: 1.83 ± 0.022	3.962ProSer: 3.962 ± 0.037	2.354ProThr: 2.354 ± 0.021	2.423ProVal: 2.423 ± 0.022	0.432ProTrp: 0.432 ± 0.009	1.48ProTyr: 1.48 ± 0.017	0.002ProXaa: 0.002 ± 0.001
Gln	1.921GlnAla: 1.921 ± 0.02	0.824GlnCys: 0.824 ± 0.015	1.284GlnAsp: 1.284 ± 0.015	2.326GlnGlu: 2.326 ± 0.026	1.675GlnPhe: 1.675 ± 0.021	1.271GlnGly: 1.271 ± 0.018	0.959GlnHis: 0.959 ± 0.016	2.647GlnIle: 2.647 ± 0.023	2.799GlnLys: 2.799 ± 0.026	3.881GlnLeu: 3.881 ± 0.031	1.081GlnMet: 1.081 ± 0.014	2.289GlnAsn: 2.289 ± 0.02	1.594GlnPro: 1.594 ± 0.023	2.652GlnGln: 2.652 ± 0.055	2.208GlnArg: 2.208 ± 0.022	3.098GlnSer: 3.098 ± 0.027	2.225GlnThr: 2.225 ± 0.021	1.974GlnVal: 1.974 ± 0.019	0.464GlnTrp: 0.464 ± 0.009	1.22GlnTyr: 1.22 ± 0.017	0.001GlnXaa: 0.001 ± 0.0
Arg	2.39ArgAla: 2.39 ± 0.022	1.07ArgCys: 1.07 ± 0.017	2.399ArgAsp: 2.399 ± 0.022	3.325ArgGlu: 3.325 ± 0.026	2.283ArgPhe: 2.283 ± 0.019	2.253ArgGly: 2.253 ± 0.026	1.156ArgHis: 1.156 ± 0.015	3.215ArgIle: 3.215 ± 0.022	4.14ArgLys: 4.14 ± 0.032	4.397ArgLeu: 4.397 ± 0.032	1.066ArgMet: 1.066 ± 0.015	2.996ArgAsn: 2.996 ± 0.021	1.895ArgPro: 1.895 ± 0.026	1.939ArgGln: 1.939 ± 0.022	3.176ArgArg: 3.176 ± 0.028	3.676ArgSer: 3.676 ± 0.029	2.326ArgThr: 2.326 ± 0.021	2.797ArgVal: 2.797 ± 0.025	0.513ArgTrp: 0.513 ± 0.01	1.69ArgTyr: 1.69 ± 0.019	0.002ArgXaa: 0.002 ± 0.001
Ser	4.524SerAla: 4.524 ± 0.033	1.568SerCys: 1.568 ± 0.021	4.56SerAsp: 4.56 ± 0.035	5.443SerGlu: 5.443 ± 0.04	3.93SerPhe: 3.93 ± 0.029	4.278SerGly: 4.278 ± 0.036	1.863SerHis: 1.863 ± 0.02	5.097SerIle: 5.097 ± 0.032	5.721SerLys: 5.721 ± 0.039	7.815SerLeu: 7.815 ± 0.047	1.573SerMet: 1.573 ± 0.015	5.152SerAsn: 5.152 ± 0.038	3.856SerPro: 3.856 ± 0.039	3.163SerGln: 3.163 ± 0.028	3.66SerArg: 3.66 ± 0.03	9.072SerSer: 9.072 ± 0.083	4.597SerThr: 4.597 ± 0.037	4.898SerVal: 4.898 ± 0.032	0.774SerTrp: 0.774 ± 0.012	2.392SerTyr: 2.392 ± 0.023	0.003SerXaa: 0.003 ± 0.001
Thr	3.312ThrAla: 3.312 ± 0.025	1.12ThrCys: 1.12 ± 0.017	2.467ThrAsp: 2.467 ± 0.02	3.02ThrGlu: 3.02 ± 0.026	2.58ThrPhe: 2.58 ± 0.023	2.703ThrGly: 2.703 ± 0.027	1.185ThrHis: 1.185 ± 0.016	3.63ThrIle: 3.63 ± 0.027	3.452ThrLys: 3.452 ± 0.027	5.106ThrLeu: 5.106 ± 0.036	0.991ThrMet: 0.991 ± 0.011	2.988ThrAsn: 2.988 ± 0.027	2.703ThrPro: 2.703 ± 0.026	1.915ThrGln: 1.915 ± 0.02	2.28ThrArg: 2.28 ± 0.018	4.764ThrSer: 4.764 ± 0.038	3.329ThrThr: 3.329 ± 0.037	3.466ThrVal: 3.466 ± 0.026	0.5ThrTrp: 0.5 ± 0.009	1.609ThrTyr: 1.609 ± 0.017	0.002ThrXaa: 0.002 ± 0.001
Val	3.58ValAla: 3.58 ± 0.026	1.393ValCys: 1.393 ± 0.017	3.333ValAsp: 3.333 ± 0.027	3.819ValGlu: 3.819 ± 0.028	2.94ValPhe: 2.94 ± 0.021	2.779ValGly: 2.779 ± 0.026	1.313ValHis: 1.313 ± 0.017	4.244ValIle: 4.244 ± 0.03	4.367ValLys: 4.367 ± 0.031	5.18ValLeu: 5.18 ± 0.032	1.159ValMet: 1.159 ± 0.015	3.552ValAsn: 3.552 ± 0.028	2.506ValPro: 2.506 ± 0.022	1.985ValGln: 1.985 ± 0.021	2.609ValArg: 2.609 ± 0.025	4.638ValSer: 4.638 ± 0.031	3.421ValThr: 3.421 ± 0.025	3.868ValVal: 3.868 ± 0.031	0.677ValTrp: 0.677 ± 0.012	2.077ValTyr: 2.077 ± 0.023	0.002ValXaa: 0.002 ± 0.001
Trp	0.513TrpAla: 0.513 ± 0.011	0.228TrpCys: 0.228 ± 0.006	0.556TrpAsp: 0.556 ± 0.01	0.573TrpGlu: 0.573 ± 0.01	0.602TrpPhe: 0.602 ± 0.011	0.477TrpGly: 0.477 ± 0.011	0.257TrpHis: 0.257 ± 0.007	0.814TrpIle: 0.814 ± 0.014	0.882TrpLys: 0.882 ± 0.013	1.093TrpLeu: 1.093 ± 0.016	0.282TrpMet: 0.282 ± 0.008	0.641TrpAsn: 0.641 ± 0.012	0.417TrpPro: 0.417 ± 0.009	0.44TrpGln: 0.44 ± 0.009	0.599TrpArg: 0.599 ± 0.012	0.872TrpSer: 0.872 ± 0.013	0.598TrpThr: 0.598 ± 0.011	0.532TrpVal: 0.532 ± 0.01	0.188TrpTrp: 0.188 ± 0.006	0.374TrpTyr: 0.374 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.825TyrAla: 1.825 ± 0.017	0.854TyrCys: 0.854 ± 0.011	1.879TyrAsp: 1.879 ± 0.018	2.207TyrGlu: 2.207 ± 0.018	1.944TyrPhe: 1.944 ± 0.022	1.954TyrGly: 1.954 ± 0.022	0.813TyrHis: 0.813 ± 0.012	2.053TyrIle: 2.053 ± 0.022	2.114TyrLys: 2.114 ± 0.023	3.338TyrLeu: 3.338 ± 0.027	0.64TyrMet: 0.64 ± 0.01	1.788TyrAsn: 1.788 ± 0.019	1.386TyrPro: 1.386 ± 0.02	1.188TyrGln: 1.188 ± 0.016	1.666TyrArg: 1.666 ± 0.016	2.644TyrSer: 2.644 ± 0.023	1.657TyrThr: 1.657 ± 0.019	1.921TyrVal: 1.921 ± 0.019	0.422TyrTrp: 0.422 ± 0.011	1.371TyrTyr: 1.371 ± 0.02	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.118XaaXaa: 0.118 ± 0.021

Statistics based on 13518 proteins (5891483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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