Amino acid dipepetide frequency for Auraticoccus cholistanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.221AlaAla: 20.221 ± 0.214	0.987AlaCys: 0.987 ± 0.032	8.109AlaAsp: 8.109 ± 0.109	9.565AlaGlu: 9.565 ± 0.112	3.029AlaPhe: 3.029 ± 0.056	13.466AlaGly: 13.466 ± 0.12	2.275AlaHis: 2.275 ± 0.055	2.918AlaIle: 2.918 ± 0.062	1.554AlaLys: 1.554 ± 0.049	13.851AlaLeu: 13.851 ± 0.145	2.421AlaMet: 2.421 ± 0.044	1.685AlaAsn: 1.685 ± 0.043	6.723AlaPro: 6.723 ± 0.1	3.54AlaGln: 3.54 ± 0.061	10.453AlaArg: 10.453 ± 0.112	6.095AlaSer: 6.095 ± 0.077	7.112AlaThr: 7.112 ± 0.08	13.163AlaVal: 13.163 ± 0.154	1.932AlaTrp: 1.932 ± 0.046	2.019AlaTyr: 2.019 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.855CysAla: 0.855 ± 0.025	0.086CysCys: 0.086 ± 0.009	0.447CysAsp: 0.447 ± 0.019	0.401CysGlu: 0.401 ± 0.02	0.218CysPhe: 0.218 ± 0.014	0.836CysGly: 0.836 ± 0.026	0.177CysHis: 0.177 ± 0.012	0.156CysIle: 0.156 ± 0.012	0.061CysLys: 0.061 ± 0.007	0.677CysLeu: 0.677 ± 0.024	0.091CysMet: 0.091 ± 0.009	0.104CysAsn: 0.104 ± 0.01	0.48CysPro: 0.48 ± 0.025	0.199CysGln: 0.199 ± 0.014	0.638CysArg: 0.638 ± 0.027	0.445CysSer: 0.445 ± 0.018	0.503CysThr: 0.503 ± 0.023	0.584CysVal: 0.584 ± 0.024	0.126CysTrp: 0.126 ± 0.011	0.158CysTyr: 0.158 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.342AspAla: 7.342 ± 0.093	0.343AspCys: 0.343 ± 0.018	3.944AspAsp: 3.944 ± 0.071	4.104AspGlu: 4.104 ± 0.071	1.492AspPhe: 1.492 ± 0.041	6.239AspGly: 6.239 ± 0.094	1.4AspHis: 1.4 ± 0.038	1.412AspIle: 1.412 ± 0.037	0.687AspLys: 0.687 ± 0.03	6.689AspLeu: 6.689 ± 0.078	0.677AspMet: 0.677 ± 0.025	0.777AspAsn: 0.777 ± 0.029	5.114AspPro: 5.114 ± 0.074	1.739AspGln: 1.739 ± 0.042	4.877AspArg: 4.877 ± 0.07	2.189AspSer: 2.189 ± 0.044	2.783AspThr: 2.783 ± 0.052	5.989AspVal: 5.989 ± 0.085	1.001AspTrp: 1.001 ± 0.034	1.127AspTyr: 1.127 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.284GluAla: 7.284 ± 0.104	0.274GluCys: 0.274 ± 0.016	3.125GluAsp: 3.125 ± 0.065	3.747GluGlu: 3.747 ± 0.065	1.308GluPhe: 1.308 ± 0.035	4.394GluGly: 4.394 ± 0.074	1.728GluHis: 1.728 ± 0.043	1.788GluIle: 1.788 ± 0.045	0.854GluLys: 0.854 ± 0.032	7.768GluLeu: 7.768 ± 0.097	0.878GluMet: 0.878 ± 0.029	0.831GluAsn: 0.831 ± 0.025	3.791GluPro: 3.791 ± 0.069	3.132GluGln: 3.132 ± 0.051	5.486GluArg: 5.486 ± 0.085	2.278GluSer: 2.278 ± 0.047	2.579GluThr: 2.579 ± 0.049	6.094GluVal: 6.094 ± 0.078	0.799GluTrp: 0.799 ± 0.024	0.945GluTyr: 0.945 ± 0.029	0.002GluXaa: 0.002 ± 0.001
Phe	3.473PheAla: 3.473 ± 0.059	0.242PheCys: 0.242 ± 0.015	1.922PheAsp: 1.922 ± 0.045	1.393PheGlu: 1.393 ± 0.038	0.873PhePhe: 0.873 ± 0.035	2.808PheGly: 2.808 ± 0.06	0.489PheHis: 0.489 ± 0.02	0.632PheIle: 0.632 ± 0.028	0.349PheLys: 0.349 ± 0.02	2.524PheLeu: 2.524 ± 0.06	0.359PheMet: 0.359 ± 0.019	0.515PheAsn: 0.515 ± 0.024	1.222PhePro: 1.222 ± 0.034	0.617PheGln: 0.617 ± 0.025	1.658PheArg: 1.658 ± 0.04	1.546PheSer: 1.546 ± 0.041	1.841PheThr: 1.841 ± 0.04	2.48PheVal: 2.48 ± 0.049	0.464PheTrp: 0.464 ± 0.02	0.564PheTyr: 0.564 ± 0.023	0.001PheXaa: 0.001 ± 0.001
Gly	10.325GlyAla: 10.325 ± 0.099	0.856GlyCys: 0.856 ± 0.024	5.015GlyAsp: 5.015 ± 0.076	5.545GlyGlu: 5.545 ± 0.082	2.798GlyPhe: 2.798 ± 0.045	8.303GlyGly: 8.303 ± 0.122	2.114GlyHis: 2.114 ± 0.048	2.944GlyIle: 2.944 ± 0.06	1.388GlyLys: 1.388 ± 0.042	9.908GlyLeu: 9.908 ± 0.118	1.956GlyMet: 1.956 ± 0.047	1.406GlyAsn: 1.406 ± 0.04	5.352GlyPro: 5.352 ± 0.078	2.943GlyGln: 2.943 ± 0.06	8.401GlyArg: 8.401 ± 0.102	5.643GlySer: 5.643 ± 0.082	5.909GlyThr: 5.909 ± 0.073	8.438GlyVal: 8.438 ± 0.092	2.16GlyTrp: 2.16 ± 0.05	2.312GlyTyr: 2.312 ± 0.051	0.001GlyXaa: 0.001 ± 0.001
His	2.361HisAla: 2.361 ± 0.051	0.187HisCys: 0.187 ± 0.013	1.32HisAsp: 1.32 ± 0.039	1.153HisGlu: 1.153 ± 0.033	0.485HisPhe: 0.485 ± 0.019	2.181HisGly: 2.181 ± 0.05	0.692HisHis: 0.692 ± 0.025	0.473HisIle: 0.473 ± 0.021	0.194HisLys: 0.194 ± 0.013	2.517HisLeu: 2.517 ± 0.049	0.238HisMet: 0.238 ± 0.015	0.335HisAsn: 0.335 ± 0.019	1.984HisPro: 1.984 ± 0.045	0.686HisGln: 0.686 ± 0.026	2.215HisArg: 2.215 ± 0.047	0.896HisSer: 0.896 ± 0.029	1.073HisThr: 1.073 ± 0.032	1.846HisVal: 1.846 ± 0.043	0.363HisTrp: 0.363 ± 0.02	0.406HisTyr: 0.406 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.567IleAla: 3.567 ± 0.066	0.23IleCys: 0.23 ± 0.014	1.9IleAsp: 1.9 ± 0.043	1.701IleGlu: 1.701 ± 0.042	0.678IlePhe: 0.678 ± 0.03	3.031IleGly: 3.031 ± 0.064	0.444IleHis: 0.444 ± 0.019	0.799IleIle: 0.799 ± 0.036	0.461IleLys: 0.461 ± 0.023	1.73IleLeu: 1.73 ± 0.048	0.357IleMet: 0.357 ± 0.018	0.601IleAsn: 0.601 ± 0.026	1.412IlePro: 1.412 ± 0.044	0.658IleGln: 0.658 ± 0.026	1.866IleArg: 1.866 ± 0.037	1.674IleSer: 1.674 ± 0.043	2.133IleThr: 2.133 ± 0.048	2.017IleVal: 2.017 ± 0.054	0.363IleTrp: 0.363 ± 0.018	0.561IleTyr: 0.561 ± 0.026	0.001IleXaa: 0.001 ± 0.001
Lys	1.58LysAla: 1.58 ± 0.049	0.066LysCys: 0.066 ± 0.007	0.704LysAsp: 0.704 ± 0.025	0.628LysGlu: 0.628 ± 0.027	0.313LysPhe: 0.313 ± 0.018	1.119LysGly: 1.119 ± 0.035	0.293LysHis: 0.293 ± 0.017	0.54LysIle: 0.54 ± 0.025	0.425LysLys: 0.425 ± 0.026	1.182LysLeu: 1.182 ± 0.033	0.255LysMet: 0.255 ± 0.015	0.267LysAsn: 0.267 ± 0.016	0.76LysPro: 0.76 ± 0.031	0.473LysGln: 0.473 ± 0.025	0.85LysArg: 0.85 ± 0.031	0.648LysSer: 0.648 ± 0.026	0.789LysThr: 0.789 ± 0.03	1.336LysVal: 1.336 ± 0.042	0.131LysTrp: 0.131 ± 0.011	0.255LysTyr: 0.255 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.28LeuAla: 16.28 ± 0.172	0.738LeuCys: 0.738 ± 0.026	7.045LeuAsp: 7.045 ± 0.096	5.484LeuGlu: 5.484 ± 0.075	2.491LeuPhe: 2.491 ± 0.062	9.905LeuGly: 9.905 ± 0.108	2.275LeuHis: 2.275 ± 0.046	2.322LeuIle: 2.322 ± 0.062	1.152LeuLys: 1.152 ± 0.032	12.505LeuLeu: 12.505 ± 0.179	1.54LeuMet: 1.54 ± 0.041	1.475LeuAsn: 1.475 ± 0.034	6.445LeuPro: 6.445 ± 0.069	3.231LeuGln: 3.231 ± 0.056	8.675LeuArg: 8.675 ± 0.095	5.526LeuSer: 5.526 ± 0.072	6.739LeuThr: 6.739 ± 0.069	11.678LeuVal: 11.678 ± 0.126	1.369LeuTrp: 1.369 ± 0.041	1.576LeuTyr: 1.576 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	2.275MetAla: 2.275 ± 0.042	0.098MetCys: 0.098 ± 0.009	0.8MetAsp: 0.8 ± 0.028	0.687MetGlu: 0.687 ± 0.023	0.396MetPhe: 0.396 ± 0.018	1.254MetGly: 1.254 ± 0.038	0.309MetHis: 0.309 ± 0.017	0.573MetIle: 0.573 ± 0.024	0.28MetLys: 0.28 ± 0.018	1.597MetLeu: 1.597 ± 0.04	0.293MetMet: 0.293 ± 0.016	0.353MetAsn: 0.353 ± 0.019	1.017MetPro: 1.017 ± 0.029	0.458MetGln: 0.458 ± 0.02	1.26MetArg: 1.26 ± 0.032	1.419MetSer: 1.419 ± 0.038	1.451MetThr: 1.451 ± 0.034	1.601MetVal: 1.601 ± 0.039	0.183MetTrp: 0.183 ± 0.014	0.269MetTyr: 0.269 ± 0.014	0.001MetXaa: 0.001 ± 0.001
Asn	1.801AsnAla: 1.801 ± 0.041	0.113AsnCys: 0.113 ± 0.009	0.804AsnAsp: 0.804 ± 0.03	0.716AsnGlu: 0.716 ± 0.027	0.468AsnPhe: 0.468 ± 0.02	1.407AsnGly: 1.407 ± 0.043	0.325AsnHis: 0.325 ± 0.018	0.511AsnIle: 0.511 ± 0.025	0.238AsnLys: 0.238 ± 0.017	1.628AsnLeu: 1.628 ± 0.037	0.22AsnMet: 0.22 ± 0.015	0.353AsnAsn: 0.353 ± 0.018	1.357AsnPro: 1.357 ± 0.04	0.506AsnGln: 0.506 ± 0.023	1.168AsnArg: 1.168 ± 0.035	0.701AsnSer: 0.701 ± 0.026	0.96AsnThr: 0.96 ± 0.042	1.299AsnVal: 1.299 ± 0.04	0.231AsnTrp: 0.231 ± 0.014	0.397AsnTyr: 0.397 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.696ProAla: 8.696 ± 0.121	0.324ProCys: 0.324 ± 0.018	4.541ProAsp: 4.541 ± 0.069	4.469ProGlu: 4.469 ± 0.067	1.445ProPhe: 1.445 ± 0.046	7.086ProGly: 7.086 ± 0.088	1.257ProHis: 1.257 ± 0.036	1.147ProIle: 1.147 ± 0.035	0.618ProLys: 0.618 ± 0.03	5.498ProLeu: 5.498 ± 0.077	0.886ProMet: 0.886 ± 0.028	0.775ProAsn: 0.775 ± 0.028	3.625ProPro: 3.625 ± 0.075	1.889ProGln: 1.889 ± 0.045	4.582ProArg: 4.582 ± 0.066	3.249ProSer: 3.249 ± 0.06	3.687ProThr: 3.687 ± 0.069	6.02ProVal: 6.02 ± 0.078	1.037ProTrp: 1.037 ± 0.032	1.102ProTyr: 1.102 ± 0.032	0.004ProXaa: 0.004 ± 0.002
Gln	3.927GlnAla: 3.927 ± 0.064	0.152GlnCys: 0.152 ± 0.01	1.338GlnAsp: 1.338 ± 0.033	1.439GlnGlu: 1.439 ± 0.039	0.773GlnPhe: 0.773 ± 0.027	2.353GlnGly: 2.353 ± 0.049	0.861GlnHis: 0.861 ± 0.031	1.025GlnIle: 1.025 ± 0.033	0.418GlnLys: 0.418 ± 0.023	4.032GlnLeu: 4.032 ± 0.064	0.534GlnMet: 0.534 ± 0.023	0.488GlnAsn: 0.488 ± 0.02	2.166GlnPro: 2.166 ± 0.051	1.761GlnGln: 1.761 ± 0.042	2.853GlnArg: 2.853 ± 0.047	1.248GlnSer: 1.248 ± 0.036	1.596GlnThr: 1.596 ± 0.039	3.312GlnVal: 3.312 ± 0.056	0.472GlnTrp: 0.472 ± 0.021	0.569GlnTyr: 0.569 ± 0.025	0.001GlnXaa: 0.001 ± 0.001
Arg	9.772ArgAla: 9.772 ± 0.111	0.613ArgCys: 0.613 ± 0.024	4.287ArgAsp: 4.287 ± 0.059	4.55ArgGlu: 4.55 ± 0.07	2.32ArgPhe: 2.32 ± 0.047	6.37ArgGly: 6.37 ± 0.095	2.101ArgHis: 2.101 ± 0.042	2.71ArgIle: 2.71 ± 0.054	0.958ArgLys: 0.958 ± 0.034	9.374ArgLeu: 9.374 ± 0.11	1.768ArgMet: 1.768 ± 0.041	1.178ArgAsn: 1.178 ± 0.033	5.371ArgPro: 5.371 ± 0.083	2.574ArgGln: 2.574 ± 0.045	9.196ArgArg: 9.196 ± 0.124	4.723ArgSer: 4.723 ± 0.065	4.982ArgThr: 4.982 ± 0.076	6.996ArgVal: 6.996 ± 0.081	1.788ArgTrp: 1.788 ± 0.043	1.741ArgTyr: 1.741 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.317SerAla: 6.317 ± 0.077	0.429SerCys: 0.429 ± 0.022	2.696SerAsp: 2.696 ± 0.053	2.588SerGlu: 2.588 ± 0.045	1.536SerPhe: 1.536 ± 0.039	5.65SerGly: 5.65 ± 0.082	0.967SerHis: 0.967 ± 0.026	1.433SerIle: 1.433 ± 0.041	0.678SerLys: 0.678 ± 0.027	4.933SerLeu: 4.933 ± 0.063	1.109SerMet: 1.109 ± 0.033	0.844SerAsn: 0.844 ± 0.028	3.266SerPro: 3.266 ± 0.061	1.487SerGln: 1.487 ± 0.038	4.251SerArg: 4.251 ± 0.06	3.293SerSer: 3.293 ± 0.06	3.511SerThr: 3.511 ± 0.061	4.49SerVal: 4.49 ± 0.075	1.227SerTrp: 1.227 ± 0.035	1.195SerTyr: 1.195 ± 0.035	0.001SerXaa: 0.001 ± 0.001
Thr	7.946ThrAla: 7.946 ± 0.106	0.424ThrCys: 0.424 ± 0.022	3.451ThrAsp: 3.451 ± 0.065	3.079ThrGlu: 3.079 ± 0.054	1.753ThrPhe: 1.753 ± 0.048	6.32ThrGly: 6.32 ± 0.082	1.031ThrHis: 1.031 ± 0.032	1.693ThrIle: 1.693 ± 0.044	0.759ThrLys: 0.759 ± 0.029	5.917ThrLeu: 5.917 ± 0.081	0.967ThrMet: 0.967 ± 0.034	0.961ThrAsn: 0.961 ± 0.036	4.105ThrPro: 4.105 ± 0.078	1.385ThrGln: 1.385 ± 0.036	4.14ThrArg: 4.14 ± 0.065	3.52ThrSer: 3.52 ± 0.052	4.088ThrThr: 4.088 ± 0.072	6.294ThrVal: 6.294 ± 0.093	0.945ThrTrp: 0.945 ± 0.031	1.162ThrTyr: 1.162 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	13.143ValAla: 13.143 ± 0.123	0.742ValCys: 0.742 ± 0.024	6.38ValAsp: 6.38 ± 0.083	6.138ValGlu: 6.138 ± 0.074	2.447ValPhe: 2.447 ± 0.047	8.094ValGly: 8.094 ± 0.085	2.09ValHis: 2.09 ± 0.047	2.241ValIle: 2.241 ± 0.049	1.082ValLys: 1.082 ± 0.034	11.903ValLeu: 11.903 ± 0.142	1.539ValMet: 1.539 ± 0.041	1.526ValAsn: 1.526 ± 0.04	5.785ValPro: 5.785 ± 0.083	2.665ValGln: 2.665 ± 0.046	7.522ValArg: 7.522 ± 0.088	4.705ValSer: 4.705 ± 0.062	5.968ValThr: 5.968 ± 0.094	12.062ValVal: 12.062 ± 0.129	1.245ValTrp: 1.245 ± 0.036	1.435ValTyr: 1.435 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.72TrpAla: 1.72 ± 0.04	0.16TrpCys: 0.16 ± 0.012	0.851TrpAsp: 0.851 ± 0.034	0.72TrpGlu: 0.72 ± 0.026	0.558TrpPhe: 0.558 ± 0.024	1.11TrpGly: 1.11 ± 0.032	0.38TrpHis: 0.38 ± 0.019	0.457TrpIle: 0.457 ± 0.019	0.21TrpLys: 0.21 ± 0.013	2.08TrpLeu: 2.08 ± 0.049	0.293TrpMet: 0.293 ± 0.016	0.372TrpAsn: 0.372 ± 0.018	0.924TrpPro: 0.924 ± 0.028	0.755TrpGln: 0.755 ± 0.026	1.573TrpArg: 1.573 ± 0.041	1.155TrpSer: 1.155 ± 0.032	1.082TrpThr: 1.082 ± 0.033	1.466TrpVal: 1.466 ± 0.04	0.405TrpTrp: 0.405 ± 0.021	0.304TrpTyr: 0.304 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.231TyrAla: 2.231 ± 0.048	0.178TyrCys: 0.178 ± 0.012	1.246TyrAsp: 1.246 ± 0.033	0.974TyrGlu: 0.974 ± 0.033	0.591TyrPhe: 0.591 ± 0.022	1.793TyrGly: 1.793 ± 0.04	0.394TyrHis: 0.394 ± 0.023	0.409TyrIle: 0.409 ± 0.021	0.248TyrLys: 0.248 ± 0.015	2.137TyrLeu: 2.137 ± 0.049	0.196TyrMet: 0.196 ± 0.013	0.361TyrAsn: 0.361 ± 0.02	1.033TyrPro: 1.033 ± 0.032	0.618TyrGln: 0.618 ± 0.024	1.702TyrArg: 1.702 ± 0.036	0.946TyrSer: 0.946 ± 0.028	1.154TyrThr: 1.154 ± 0.042	1.55TyrVal: 1.55 ± 0.034	0.335TyrTrp: 0.335 ± 0.018	0.434TyrTyr: 0.434 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.004

Statistics based on 3358 proteins (1128129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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