Amino acid dipepetide frequency for Streptococcus phage Javan351

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.693AlaAla: 3.693 ± 0.78
0.528AlaCys: 0.528 ± 0.197
4.572AlaAsp: 4.572 ± 0.788
5.803AlaGlu: 5.803 ± 0.841
2.726AlaPhe: 2.726 ± 0.617
4.572AlaGly: 4.572 ± 0.803
0.791AlaHis: 0.791 ± 0.202
5.364AlaIle: 5.364 ± 0.86
5.539AlaLys: 5.539 ± 0.684
6.067AlaLeu: 6.067 ± 1.061
2.11AlaMet: 2.11 ± 0.325
4.045AlaAsn: 4.045 ± 0.528
1.671AlaPro: 1.671 ± 0.376
3.781AlaGln: 3.781 ± 0.623
2.55AlaArg: 2.55 ± 0.392
4.836AlaSer: 4.836 ± 0.672
4.748AlaThr: 4.748 ± 0.766
3.781AlaVal: 3.781 ± 0.654
0.879AlaTrp: 0.879 ± 0.431
2.814AlaTyr: 2.814 ± 0.486
0.0AlaXaa: 0.0 ± 0.0
Cys
0.264CysAla: 0.264 ± 0.191
0.352CysCys: 0.352 ± 0.295
0.088CysAsp: 0.088 ± 0.103
0.088CysGlu: 0.088 ± 0.081
0.352CysPhe: 0.352 ± 0.219
0.528CysGly: 0.528 ± 0.28
0.088CysHis: 0.088 ± 0.095
0.352CysIle: 0.352 ± 0.157
0.528CysLys: 0.528 ± 0.181
0.615CysLeu: 0.615 ± 0.236
0.264CysMet: 0.264 ± 0.144
0.352CysAsn: 0.352 ± 0.15
0.352CysPro: 0.352 ± 0.157
0.176CysGln: 0.176 ± 0.129
0.0CysArg: 0.0 ± 0.0
0.264CysSer: 0.264 ± 0.151
0.264CysThr: 0.264 ± 0.164
0.528CysVal: 0.528 ± 0.196
0.088CysTrp: 0.088 ± 0.087
0.44CysTyr: 0.44 ± 0.193
0.0CysXaa: 0.0 ± 0.0
Asp
3.341AspAla: 3.341 ± 0.496
0.44AspCys: 0.44 ± 0.209
3.517AspAsp: 3.517 ± 0.709
4.133AspGlu: 4.133 ± 0.733
3.693AspPhe: 3.693 ± 0.573
4.836AspGly: 4.836 ± 0.707
0.879AspHis: 0.879 ± 0.315
5.1AspIle: 5.1 ± 0.686
5.276AspLys: 5.276 ± 0.557
4.748AspLeu: 4.748 ± 0.598
1.495AspMet: 1.495 ± 0.338
3.165AspAsn: 3.165 ± 0.472
1.407AspPro: 1.407 ± 0.309
1.495AspGln: 1.495 ± 0.391
2.286AspArg: 2.286 ± 0.586
4.836AspSer: 4.836 ± 0.68
2.726AspThr: 2.726 ± 0.503
4.221AspVal: 4.221 ± 0.425
1.407AspTrp: 1.407 ± 0.255
2.726AspTyr: 2.726 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
5.539GluAla: 5.539 ± 0.776
0.352GluCys: 0.352 ± 0.203
3.341GluAsp: 3.341 ± 0.716
5.627GluGlu: 5.627 ± 1.045
3.077GluPhe: 3.077 ± 0.554
2.99GluGly: 2.99 ± 0.514
0.879GluHis: 0.879 ± 0.324
5.1GluIle: 5.1 ± 0.699
7.298GluLys: 7.298 ± 0.899
6.858GluLeu: 6.858 ± 0.756
3.429GluMet: 3.429 ± 0.5
3.429GluAsn: 3.429 ± 0.603
1.495GluPro: 1.495 ± 0.431
3.605GluGln: 3.605 ± 0.599
3.341GluArg: 3.341 ± 0.595
4.308GluSer: 4.308 ± 0.601
2.814GluThr: 2.814 ± 0.548
4.396GluVal: 4.396 ± 0.658
0.879GluTrp: 0.879 ± 0.289
2.902GluTyr: 2.902 ± 0.607
0.0GluXaa: 0.0 ± 0.0
Phe
2.462PheAla: 2.462 ± 0.533
0.352PheCys: 0.352 ± 0.183
3.253PheAsp: 3.253 ± 0.542
4.308PheGlu: 4.308 ± 0.765
2.462PhePhe: 2.462 ± 0.366
2.55PheGly: 2.55 ± 0.473
0.528PheHis: 0.528 ± 0.21
2.726PheIle: 2.726 ± 0.451
4.221PheLys: 4.221 ± 0.629
2.462PheLeu: 2.462 ± 0.338
1.055PheMet: 1.055 ± 0.275
2.814PheAsn: 2.814 ± 0.564
1.231PhePro: 1.231 ± 0.286
1.671PheGln: 1.671 ± 0.407
1.671PheArg: 1.671 ± 0.399
3.341PheSer: 3.341 ± 0.608
3.605PheThr: 3.605 ± 0.86
3.517PheVal: 3.517 ± 0.58
0.264PheTrp: 0.264 ± 0.149
1.407PheTyr: 1.407 ± 0.346
0.0PheXaa: 0.0 ± 0.0
Gly
4.396GlyAla: 4.396 ± 0.905
0.528GlyCys: 0.528 ± 0.292
4.484GlyAsp: 4.484 ± 0.692
4.308GlyGlu: 4.308 ± 0.582
3.253GlyPhe: 3.253 ± 0.678
4.924GlyGly: 4.924 ± 1.168
0.528GlyHis: 0.528 ± 0.202
5.276GlyIle: 5.276 ± 0.688
5.452GlyLys: 5.452 ± 0.689
5.979GlyLeu: 5.979 ± 1.197
1.143GlyMet: 1.143 ± 0.255
3.165GlyAsn: 3.165 ± 0.817
1.407GlyPro: 1.407 ± 0.356
3.341GlyGln: 3.341 ± 0.514
3.341GlyArg: 3.341 ± 0.543
4.221GlySer: 4.221 ± 1.019
3.517GlyThr: 3.517 ± 0.484
4.924GlyVal: 4.924 ± 0.638
1.407GlyTrp: 1.407 ± 0.565
2.638GlyTyr: 2.638 ± 0.535
0.0GlyXaa: 0.0 ± 0.0
His
0.703HisAla: 0.703 ± 0.251
0.088HisCys: 0.088 ± 0.094
1.055HisAsp: 1.055 ± 0.349
0.791HisGlu: 0.791 ± 0.332
0.703HisPhe: 0.703 ± 0.263
0.791HisGly: 0.791 ± 0.317
0.176HisHis: 0.176 ± 0.114
1.495HisIle: 1.495 ± 0.436
0.703HisLys: 0.703 ± 0.228
0.879HisLeu: 0.879 ± 0.311
0.352HisMet: 0.352 ± 0.17
1.055HisAsn: 1.055 ± 0.268
0.879HisPro: 0.879 ± 0.335
0.615HisGln: 0.615 ± 0.192
0.352HisArg: 0.352 ± 0.171
1.055HisSer: 1.055 ± 0.342
0.967HisThr: 0.967 ± 0.347
0.791HisVal: 0.791 ± 0.227
0.264HisTrp: 0.264 ± 0.119
0.352HisTyr: 0.352 ± 0.158
0.0HisXaa: 0.0 ± 0.0
Ile
5.539IleAla: 5.539 ± 0.847
0.528IleCys: 0.528 ± 0.204
4.748IleAsp: 4.748 ± 0.604
5.891IleGlu: 5.891 ± 0.785
2.99IlePhe: 2.99 ± 0.441
4.572IleGly: 4.572 ± 0.92
0.879IleHis: 0.879 ± 0.278
4.045IleIle: 4.045 ± 0.791
6.682IleLys: 6.682 ± 0.792
4.045IleLeu: 4.045 ± 0.668
1.671IleMet: 1.671 ± 0.332
3.957IleAsn: 3.957 ± 0.743
2.022IlePro: 2.022 ± 0.347
2.814IleGln: 2.814 ± 0.485
2.638IleArg: 2.638 ± 0.497
4.045IleSer: 4.045 ± 0.474
4.221IleThr: 4.221 ± 0.782
4.572IleVal: 4.572 ± 0.605
0.615IleTrp: 0.615 ± 0.234
1.934IleTyr: 1.934 ± 0.486
0.0IleXaa: 0.0 ± 0.0
Lys
6.507LysAla: 6.507 ± 0.956
0.44LysCys: 0.44 ± 0.209
4.836LysAsp: 4.836 ± 0.628
6.243LysGlu: 6.243 ± 0.97
3.869LysPhe: 3.869 ± 0.553
4.836LysGly: 4.836 ± 0.711
1.055LysHis: 1.055 ± 0.394
5.891LysIle: 5.891 ± 0.739
7.562LysLys: 7.562 ± 0.975
6.858LysLeu: 6.858 ± 0.747
1.319LysMet: 1.319 ± 0.339
4.133LysAsn: 4.133 ± 0.586
2.902LysPro: 2.902 ± 0.546
4.396LysGln: 4.396 ± 0.623
3.693LysArg: 3.693 ± 0.744
4.484LysSer: 4.484 ± 0.416
6.243LysThr: 6.243 ± 0.727
5.452LysVal: 5.452 ± 0.83
1.231LysTrp: 1.231 ± 0.318
3.605LysTyr: 3.605 ± 0.665
0.0LysXaa: 0.0 ± 0.0
Leu
6.243LeuAla: 6.243 ± 0.653
0.615LeuCys: 0.615 ± 0.261
6.067LeuAsp: 6.067 ± 0.492
5.276LeuGlu: 5.276 ± 0.585
2.814LeuPhe: 2.814 ± 0.518
4.308LeuGly: 4.308 ± 0.883
1.143LeuHis: 1.143 ± 0.334
3.693LeuIle: 3.693 ± 0.561
5.452LeuLys: 5.452 ± 0.674
5.452LeuLeu: 5.452 ± 0.831
1.759LeuMet: 1.759 ± 0.431
3.429LeuAsn: 3.429 ± 0.48
2.814LeuPro: 2.814 ± 0.448
4.66LeuGln: 4.66 ± 0.582
2.374LeuArg: 2.374 ± 0.45
6.595LeuSer: 6.595 ± 0.749
5.1LeuThr: 5.1 ± 0.79
4.924LeuVal: 4.924 ± 0.652
0.352LeuTrp: 0.352 ± 0.152
2.374LeuTyr: 2.374 ± 0.548
0.0LeuXaa: 0.0 ± 0.0
Met
2.638MetAla: 2.638 ± 0.498
0.0MetCys: 0.0 ± 0.0
1.671MetAsp: 1.671 ± 0.333
1.407MetGlu: 1.407 ± 0.329
0.791MetPhe: 0.791 ± 0.235
1.231MetGly: 1.231 ± 0.332
0.088MetHis: 0.088 ± 0.087
1.495MetIle: 1.495 ± 0.384
2.11MetLys: 2.11 ± 0.347
1.759MetLeu: 1.759 ± 0.427
0.264MetMet: 0.264 ± 0.153
1.671MetAsn: 1.671 ± 0.378
1.055MetPro: 1.055 ± 0.388
0.879MetGln: 0.879 ± 0.245
1.143MetArg: 1.143 ± 0.388
1.495MetSer: 1.495 ± 0.375
1.759MetThr: 1.759 ± 0.35
1.846MetVal: 1.846 ± 0.372
0.352MetTrp: 0.352 ± 0.156
0.703MetTyr: 0.703 ± 0.267
0.0MetXaa: 0.0 ± 0.0
Asn
4.836AsnAla: 4.836 ± 0.543
0.352AsnCys: 0.352 ± 0.17
3.077AsnAsp: 3.077 ± 0.55
3.341AsnGlu: 3.341 ± 0.538
2.374AsnPhe: 2.374 ± 0.61
5.1AsnGly: 5.1 ± 0.826
0.879AsnHis: 0.879 ± 0.263
3.429AsnIle: 3.429 ± 0.383
4.221AsnLys: 4.221 ± 0.631
3.605AsnLeu: 3.605 ± 0.445
0.967AsnMet: 0.967 ± 0.285
2.99AsnAsn: 2.99 ± 0.687
2.638AsnPro: 2.638 ± 0.391
2.638AsnGln: 2.638 ± 0.445
2.198AsnArg: 2.198 ± 0.428
3.429AsnSer: 3.429 ± 0.561
2.55AsnThr: 2.55 ± 0.463
3.165AsnVal: 3.165 ± 0.483
0.615AsnTrp: 0.615 ± 0.258
2.286AsnTyr: 2.286 ± 0.571
0.0AsnXaa: 0.0 ± 0.0
Pro
1.846ProAla: 1.846 ± 0.445
0.44ProCys: 0.44 ± 0.259
1.759ProAsp: 1.759 ± 0.367
2.462ProGlu: 2.462 ± 0.418
1.055ProPhe: 1.055 ± 0.319
2.11ProGly: 2.11 ± 0.57
0.528ProHis: 0.528 ± 0.208
1.759ProIle: 1.759 ± 0.39
2.814ProLys: 2.814 ± 0.456
1.759ProLeu: 1.759 ± 0.241
0.528ProMet: 0.528 ± 0.227
1.934ProAsn: 1.934 ± 0.427
0.264ProPro: 0.264 ± 0.159
1.231ProGln: 1.231 ± 0.319
1.319ProArg: 1.319 ± 0.253
1.846ProSer: 1.846 ± 0.516
0.967ProThr: 0.967 ± 0.309
2.198ProVal: 2.198 ± 0.523
0.264ProTrp: 0.264 ± 0.136
1.671ProTyr: 1.671 ± 0.402
0.0ProXaa: 0.0 ± 0.0
Gln
3.693GlnAla: 3.693 ± 0.687
0.088GlnCys: 0.088 ± 0.089
1.407GlnAsp: 1.407 ± 0.24
3.253GlnGlu: 3.253 ± 0.494
2.022GlnPhe: 2.022 ± 0.423
3.517GlnGly: 3.517 ± 0.837
0.791GlnHis: 0.791 ± 0.293
3.429GlnIle: 3.429 ± 0.44
3.957GlnLys: 3.957 ± 0.863
3.693GlnLeu: 3.693 ± 0.54
1.055GlnMet: 1.055 ± 0.325
2.022GlnAsn: 2.022 ± 0.453
0.703GlnPro: 0.703 ± 0.277
2.462GlnGln: 2.462 ± 0.675
2.022GlnArg: 2.022 ± 0.337
2.198GlnSer: 2.198 ± 0.436
2.638GlnThr: 2.638 ± 0.535
2.638GlnVal: 2.638 ± 0.473
0.791GlnTrp: 0.791 ± 0.232
1.583GlnTyr: 1.583 ± 0.366
0.0GlnXaa: 0.0 ± 0.0
Arg
1.846ArgAla: 1.846 ± 0.354
0.0ArgCys: 0.0 ± 0.0
2.022ArgAsp: 2.022 ± 0.477
2.374ArgGlu: 2.374 ± 0.435
1.671ArgPhe: 1.671 ± 0.35
2.638ArgGly: 2.638 ± 0.575
0.879ArgHis: 0.879 ± 0.316
3.253ArgIle: 3.253 ± 0.424
3.429ArgLys: 3.429 ± 0.71
3.429ArgLeu: 3.429 ± 0.523
1.583ArgMet: 1.583 ± 0.327
3.517ArgAsn: 3.517 ± 0.542
0.44ArgPro: 0.44 ± 0.192
1.934ArgGln: 1.934 ± 0.419
2.374ArgArg: 2.374 ± 0.535
2.55ArgSer: 2.55 ± 0.371
2.902ArgThr: 2.902 ± 0.563
2.286ArgVal: 2.286 ± 0.442
0.791ArgTrp: 0.791 ± 0.3
1.846ArgTyr: 1.846 ± 0.375
0.0ArgXaa: 0.0 ± 0.0
Ser
4.484SerAla: 4.484 ± 0.752
0.088SerCys: 0.088 ± 0.081
4.572SerAsp: 4.572 ± 0.55
3.253SerGlu: 3.253 ± 0.484
2.99SerPhe: 2.99 ± 0.659
5.891SerGly: 5.891 ± 1.109
1.407SerHis: 1.407 ± 0.407
3.341SerIle: 3.341 ± 0.615
5.452SerLys: 5.452 ± 0.702
4.924SerLeu: 4.924 ± 0.607
1.407SerMet: 1.407 ± 0.376
3.869SerAsn: 3.869 ± 0.531
1.407SerPro: 1.407 ± 0.313
2.99SerGln: 2.99 ± 0.477
2.814SerArg: 2.814 ± 0.555
3.429SerSer: 3.429 ± 0.729
3.693SerThr: 3.693 ± 0.597
3.957SerVal: 3.957 ± 0.654
0.791SerTrp: 0.791 ± 0.271
2.198SerTyr: 2.198 ± 0.387
0.0SerXaa: 0.0 ± 0.0
Thr
4.308ThrAla: 4.308 ± 0.671
0.264ThrCys: 0.264 ± 0.145
3.429ThrAsp: 3.429 ± 0.469
4.748ThrGlu: 4.748 ± 0.668
3.077ThrPhe: 3.077 ± 0.518
5.452ThrGly: 5.452 ± 0.688
0.967ThrHis: 0.967 ± 0.268
4.924ThrIle: 4.924 ± 0.614
5.188ThrLys: 5.188 ± 0.698
4.748ThrLeu: 4.748 ± 0.777
0.967ThrMet: 0.967 ± 0.291
2.814ThrAsn: 2.814 ± 0.475
2.462ThrPro: 2.462 ± 0.436
1.759ThrGln: 1.759 ± 0.375
1.759ThrArg: 1.759 ± 0.32
2.638ThrSer: 2.638 ± 0.486
3.341ThrThr: 3.341 ± 0.519
3.869ThrVal: 3.869 ± 0.547
0.615ThrTrp: 0.615 ± 0.269
2.726ThrTyr: 2.726 ± 0.514
0.0ThrXaa: 0.0 ± 0.0
Val
5.452ValAla: 5.452 ± 0.657
0.0ValCys: 0.0 ± 0.0
4.484ValAsp: 4.484 ± 0.536
4.748ValGlu: 4.748 ± 0.793
2.462ValPhe: 2.462 ± 0.522
4.572ValGly: 4.572 ± 0.731
0.967ValHis: 0.967 ± 0.319
4.396ValIle: 4.396 ± 0.656
5.012ValLys: 5.012 ± 0.63
3.957ValLeu: 3.957 ± 0.561
2.11ValMet: 2.11 ± 0.372
3.077ValAsn: 3.077 ± 0.489
1.934ValPro: 1.934 ± 0.385
1.671ValGln: 1.671 ± 0.392
2.462ValArg: 2.462 ± 0.379
4.396ValSer: 4.396 ± 0.609
4.748ValThr: 4.748 ± 0.618
3.517ValVal: 3.517 ± 0.67
0.791ValTrp: 0.791 ± 0.276
2.814ValTyr: 2.814 ± 0.456
0.0ValXaa: 0.0 ± 0.0
Trp
0.703TrpAla: 0.703 ± 0.293
0.176TrpCys: 0.176 ± 0.128
0.703TrpAsp: 0.703 ± 0.225
1.407TrpGlu: 1.407 ± 0.326
1.407TrpPhe: 1.407 ± 0.503
0.703TrpGly: 0.703 ± 0.165
0.088TrpHis: 0.088 ± 0.079
0.352TrpIle: 0.352 ± 0.148
1.319TrpLys: 1.319 ± 0.369
0.615TrpLeu: 0.615 ± 0.303
0.264TrpMet: 0.264 ± 0.168
0.615TrpAsn: 0.615 ± 0.232
0.088TrpPro: 0.088 ± 0.082
0.44TrpGln: 0.44 ± 0.192
0.879TrpArg: 0.879 ± 0.262
0.703TrpSer: 0.703 ± 0.23
0.703TrpThr: 0.703 ± 0.239
0.791TrpVal: 0.791 ± 0.284
0.264TrpTrp: 0.264 ± 0.167
0.879TrpTyr: 0.879 ± 0.392
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.374TyrAla: 2.374 ± 0.488
0.352TyrCys: 0.352 ± 0.204
2.638TyrAsp: 2.638 ± 0.369
2.198TyrGlu: 2.198 ± 0.478
2.11TyrPhe: 2.11 ± 0.446
2.11TyrGly: 2.11 ± 0.542
0.528TyrHis: 0.528 ± 0.212
2.99TyrIle: 2.99 ± 0.54
3.429TyrLys: 3.429 ± 0.758
2.99TyrLeu: 2.99 ± 0.505
0.528TyrMet: 0.528 ± 0.177
2.638TyrAsn: 2.638 ± 0.372
1.583TyrPro: 1.583 ± 0.357
1.407TyrGln: 1.407 ± 0.372
2.55TyrArg: 2.55 ± 0.458
2.286TyrSer: 2.286 ± 0.423
2.55TyrThr: 2.55 ± 0.502
2.198TyrVal: 2.198 ± 0.356
0.44TyrTrp: 0.44 ± 0.178
1.055TyrTyr: 1.055 ± 0.256
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski