Amino acid dipepetide frequency for Microviridae sp. ctQch27

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.521AlaAla: 11.521 ± 2.725
0.768AlaCys: 0.768 ± 0.666
3.84AlaAsp: 3.84 ± 1.833
3.072AlaGlu: 3.072 ± 1.85
1.536AlaPhe: 1.536 ± 0.853
10.753AlaGly: 10.753 ± 2.917
2.304AlaHis: 2.304 ± 0.507
3.84AlaIle: 3.84 ± 1.038
3.84AlaLys: 3.84 ± 0.744
6.144AlaLeu: 6.144 ± 2.201
1.536AlaMet: 1.536 ± 1.25
3.84AlaAsn: 3.84 ± 1.643
6.144AlaPro: 6.144 ± 2.195
3.84AlaGln: 3.84 ± 2.721
9.217AlaArg: 9.217 ± 1.725
9.217AlaSer: 9.217 ± 2.969
2.304AlaThr: 2.304 ± 0.507
7.68AlaVal: 7.68 ± 1.919
1.536AlaTrp: 1.536 ± 1.451
1.536AlaTyr: 1.536 ± 0.601
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.768CysCys: 0.768 ± 0.666
0.0CysAsp: 0.0 ± 0.0
0.768CysGlu: 0.768 ± 0.666
0.0CysPhe: 0.0 ± 0.0
0.768CysGly: 0.768 ± 0.666
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
2.304CysMet: 2.304 ± 1.457
0.0CysAsn: 0.0 ± 0.0
0.768CysPro: 0.768 ± 0.666
0.768CysGln: 0.768 ± 0.666
2.304CysArg: 2.304 ± 1.997
0.768CysSer: 0.768 ± 0.494
0.0CysThr: 0.0 ± 0.0
1.536CysVal: 1.536 ± 0.982
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.536AspAla: 1.536 ± 0.709
0.0AspCys: 0.0 ± 0.0
0.768AspAsp: 0.768 ± 0.666
1.536AspGlu: 1.536 ± 0.601
1.536AspPhe: 1.536 ± 0.988
5.376AspGly: 5.376 ± 1.26
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
0.0AspLys: 0.0 ± 0.0
1.536AspLeu: 1.536 ± 0.988
1.536AspMet: 1.536 ± 0.709
0.768AspAsn: 0.768 ± 1.048
0.0AspPro: 0.0 ± 0.0
0.768AspGln: 0.768 ± 0.494
3.84AspArg: 3.84 ± 1.217
1.536AspSer: 1.536 ± 0.601
1.536AspThr: 1.536 ± 0.988
6.144AspVal: 6.144 ± 0.81
0.768AspTrp: 0.768 ± 0.666
2.304AspTyr: 2.304 ± 0.876
0.0AspXaa: 0.0 ± 0.0
Glu
3.072GluAla: 3.072 ± 1.354
0.768GluCys: 0.768 ± 0.666
3.84GluAsp: 3.84 ± 1.556
3.072GluGlu: 3.072 ± 0.629
3.84GluPhe: 3.84 ± 0.843
0.768GluGly: 0.768 ± 0.725
2.304GluHis: 2.304 ± 1.168
2.304GluIle: 2.304 ± 1.168
2.304GluLys: 2.304 ± 0.876
6.912GluLeu: 6.912 ± 1.167
1.536GluMet: 1.536 ± 1.331
0.768GluAsn: 0.768 ± 0.725
2.304GluPro: 2.304 ± 1.231
1.536GluGln: 1.536 ± 0.709
4.608GluArg: 4.608 ± 2.502
0.768GluSer: 0.768 ± 0.494
2.304GluThr: 2.304 ± 0.876
2.304GluVal: 2.304 ± 0.978
0.768GluTrp: 0.768 ± 0.666
3.84GluTyr: 3.84 ± 1.226
0.0GluXaa: 0.0 ± 0.0
Phe
6.912PheAla: 6.912 ± 0.819
0.0PheCys: 0.0 ± 0.0
1.536PheAsp: 1.536 ± 0.601
1.536PheGlu: 1.536 ± 0.988
1.536PhePhe: 1.536 ± 0.601
4.608PheGly: 4.608 ± 1.752
0.0PheHis: 0.0 ± 0.0
1.536PheIle: 1.536 ± 0.988
0.0PheLys: 0.0 ± 0.0
1.536PheLeu: 1.536 ± 1.737
1.536PheMet: 1.536 ± 1.375
0.768PheAsn: 0.768 ± 0.725
3.072PhePro: 3.072 ± 1.189
1.536PheGln: 1.536 ± 0.709
5.376PheArg: 5.376 ± 2.079
1.536PheSer: 1.536 ± 0.988
0.768PheThr: 0.768 ± 0.494
4.608PheVal: 4.608 ± 1.725
1.536PheTrp: 1.536 ± 0.988
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
6.912GlyAla: 6.912 ± 4.662
0.0GlyCys: 0.0 ± 0.0
1.536GlyAsp: 1.536 ± 0.709
5.376GlyGlu: 5.376 ± 0.891
4.608GlyPhe: 4.608 ± 1.305
5.376GlyGly: 5.376 ± 1.524
0.768GlyHis: 0.768 ± 0.494
3.84GlyIle: 3.84 ± 1.08
0.768GlyLys: 0.768 ± 0.666
4.608GlyLeu: 4.608 ± 1.701
3.072GlyMet: 3.072 ± 1.471
2.304GlyAsn: 2.304 ± 0.96
2.304GlyPro: 2.304 ± 1.09
6.144GlyGln: 6.144 ± 2.018
6.912GlyArg: 6.912 ± 1.997
6.912GlySer: 6.912 ± 1.997
6.144GlyThr: 6.144 ± 3.257
8.449GlyVal: 8.449 ± 1.552
2.304GlyTrp: 2.304 ± 1.253
4.608GlyTyr: 4.608 ± 1.014
0.0GlyXaa: 0.0 ± 0.0
His
1.536HisAla: 1.536 ± 0.601
0.768HisCys: 0.768 ± 1.048
0.0HisAsp: 0.0 ± 0.0
0.768HisGlu: 0.768 ± 0.666
0.768HisPhe: 0.768 ± 0.494
1.536HisGly: 1.536 ± 0.988
1.536HisHis: 1.536 ± 0.988
0.0HisIle: 0.0 ± 0.0
0.768HisLys: 0.768 ± 0.494
1.536HisLeu: 1.536 ± 1.331
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.536HisPro: 1.536 ± 0.709
0.0HisGln: 0.0 ± 0.0
2.304HisArg: 2.304 ± 1.168
2.304HisSer: 2.304 ± 0.829
0.768HisThr: 0.768 ± 0.725
0.0HisVal: 0.0 ± 0.0
0.768HisTrp: 0.768 ± 0.494
0.768HisTyr: 0.768 ± 0.666
0.0HisXaa: 0.0 ± 0.0
Ile
2.304IleAla: 2.304 ± 0.507
0.0IleCys: 0.0 ± 0.0
1.536IleAsp: 1.536 ± 0.778
1.536IleGlu: 1.536 ± 0.709
0.768IlePhe: 0.768 ± 0.666
4.608IleGly: 4.608 ± 0.881
2.304IleHis: 2.304 ± 1.079
0.0IleIle: 0.0 ± 0.0
0.768IleLys: 0.768 ± 0.494
4.608IleLeu: 4.608 ± 1.755
0.768IleMet: 0.768 ± 0.666
0.0IleAsn: 0.0 ± 0.0
1.536IlePro: 1.536 ± 0.709
1.536IleGln: 1.536 ± 0.988
2.304IleArg: 2.304 ± 1.253
0.768IleSer: 0.768 ± 0.869
3.072IleThr: 3.072 ± 1.386
0.0IleVal: 0.0 ± 0.0
1.536IleTrp: 1.536 ± 0.601
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
5.376LysAla: 5.376 ± 2.41
0.0LysCys: 0.0 ± 0.0
1.536LysAsp: 1.536 ± 0.601
4.608LysGlu: 4.608 ± 1.006
0.768LysPhe: 0.768 ± 0.494
2.304LysGly: 2.304 ± 0.829
0.768LysHis: 0.768 ± 0.494
0.0LysIle: 0.0 ± 0.0
2.304LysLys: 2.304 ± 1.066
5.376LysLeu: 5.376 ± 2.165
0.768LysMet: 0.768 ± 0.666
1.536LysAsn: 1.536 ± 0.709
3.072LysPro: 3.072 ± 1.415
1.536LysGln: 1.536 ± 1.451
3.84LysArg: 3.84 ± 1.928
4.608LysSer: 4.608 ± 1.858
1.536LysThr: 1.536 ± 0.988
3.84LysVal: 3.84 ± 1.74
0.768LysTrp: 0.768 ± 0.725
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
5.376LeuAla: 5.376 ± 1.934
0.768LeuCys: 0.768 ± 0.869
3.072LeuAsp: 3.072 ± 1.304
5.376LeuGlu: 5.376 ± 2.165
2.304LeuPhe: 2.304 ± 1.52
10.753LeuGly: 10.753 ± 1.384
0.0LeuHis: 0.0 ± 0.0
3.072LeuIle: 3.072 ± 1.098
6.144LeuLys: 6.144 ± 3.361
6.912LeuLeu: 6.912 ± 2.982
0.768LeuMet: 0.768 ± 0.869
2.304LeuAsn: 2.304 ± 1.149
4.608LeuPro: 4.608 ± 1.014
5.376LeuGln: 5.376 ± 1.373
8.449LeuArg: 8.449 ± 3.42
3.84LeuSer: 3.84 ± 1.24
4.608LeuThr: 4.608 ± 1.92
6.144LeuVal: 6.144 ± 1.152
2.304LeuTrp: 2.304 ± 0.507
1.536LeuTyr: 1.536 ± 0.709
0.0LeuXaa: 0.0 ± 0.0
Met
3.072MetAla: 3.072 ± 1.419
0.0MetCys: 0.0 ± 0.0
0.768MetAsp: 0.768 ± 0.494
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
3.072MetGly: 3.072 ± 1.386
0.768MetHis: 0.768 ± 0.494
0.768MetIle: 0.768 ± 0.494
3.072MetLys: 3.072 ± 1.258
2.304MetLeu: 2.304 ± 0.507
0.768MetMet: 0.768 ± 0.666
1.536MetAsn: 1.536 ± 1.451
1.536MetPro: 1.536 ± 0.601
1.536MetGln: 1.536 ± 0.988
5.376MetArg: 5.376 ± 1.375
3.072MetSer: 3.072 ± 0.719
3.072MetThr: 3.072 ± 0.629
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
2.304MetTyr: 2.304 ± 0.978
0.0MetXaa: 0.0 ± 0.0
Asn
3.072AsnAla: 3.072 ± 0.939
0.0AsnCys: 0.0 ± 0.0
1.536AsnAsp: 1.536 ± 0.988
1.536AsnGlu: 1.536 ± 0.709
1.536AsnPhe: 1.536 ± 0.709
0.768AsnGly: 0.768 ± 0.494
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
0.768AsnLys: 0.768 ± 0.494
2.304AsnLeu: 2.304 ± 0.984
0.768AsnMet: 0.768 ± 0.725
1.536AsnAsn: 1.536 ± 0.988
4.608AsnPro: 4.608 ± 2.067
0.0AsnGln: 0.0 ± 0.0
3.84AsnArg: 3.84 ± 1.931
0.0AsnSer: 0.0 ± 0.0
3.84AsnThr: 3.84 ± 1.744
0.768AsnVal: 0.768 ± 0.725
0.768AsnTrp: 0.768 ± 0.494
1.536AsnTyr: 1.536 ± 1.451
0.0AsnXaa: 0.0 ± 0.0
Pro
3.072ProAla: 3.072 ± 0.939
0.0ProCys: 0.0 ± 0.0
1.536ProAsp: 1.536 ± 0.988
2.304ProGlu: 2.304 ± 1.168
2.304ProPhe: 2.304 ± 1.079
5.376ProGly: 5.376 ± 1.829
1.536ProHis: 1.536 ± 0.601
0.768ProIle: 0.768 ± 0.494
2.304ProLys: 2.304 ± 0.507
7.68ProLeu: 7.68 ± 1.794
0.0ProMet: 0.0 ± 0.0
0.768ProAsn: 0.768 ± 0.725
3.072ProPro: 3.072 ± 1.554
1.536ProGln: 1.536 ± 0.778
3.84ProArg: 3.84 ± 2.937
9.217ProSer: 9.217 ± 3.01
2.304ProThr: 2.304 ± 1.481
5.376ProVal: 5.376 ± 1.934
1.536ProTrp: 1.536 ± 0.988
1.536ProTyr: 1.536 ± 1.451
0.0ProXaa: 0.0 ± 0.0
Gln
7.68GlnAla: 7.68 ± 2.076
1.536GlnCys: 1.536 ± 1.331
2.304GlnAsp: 2.304 ± 0.984
0.768GlnGlu: 0.768 ± 0.666
1.536GlnPhe: 1.536 ± 0.988
2.304GlnGly: 2.304 ± 0.507
0.768GlnHis: 0.768 ± 0.666
1.536GlnIle: 1.536 ± 1.25
3.072GlnLys: 3.072 ± 0.629
2.304GlnLeu: 2.304 ± 1.997
0.768GlnMet: 0.768 ± 0.494
0.0GlnAsn: 0.0 ± 0.0
1.536GlnPro: 1.536 ± 1.451
2.304GlnGln: 2.304 ± 0.984
1.536GlnArg: 1.536 ± 0.709
1.536GlnSer: 1.536 ± 1.451
3.072GlnThr: 3.072 ± 1.419
1.536GlnVal: 1.536 ± 0.982
0.768GlnTrp: 0.768 ± 0.725
0.768GlnTyr: 0.768 ± 0.666
0.0GlnXaa: 0.0 ± 0.0
Arg
9.217ArgAla: 9.217 ± 2.686
1.536ArgCys: 1.536 ± 1.331
3.072ArgAsp: 3.072 ± 0.993
2.304ArgGlu: 2.304 ± 0.978
3.84ArgPhe: 3.84 ± 1.24
3.84ArgGly: 3.84 ± 3.011
0.0ArgHis: 0.0 ± 0.0
6.912ArgIle: 6.912 ± 3.282
7.68ArgLys: 7.68 ± 4.076
7.68ArgLeu: 7.68 ± 4.94
2.304ArgMet: 2.304 ± 0.974
2.304ArgAsn: 2.304 ± 2.176
4.608ArgPro: 4.608 ± 1.79
2.304ArgGln: 2.304 ± 0.876
16.897ArgArg: 16.897 ± 7.461
9.985ArgSer: 9.985 ± 3.037
6.144ArgThr: 6.144 ± 1.622
3.84ArgVal: 3.84 ± 1.057
3.072ArgTrp: 3.072 ± 2.377
4.608ArgTyr: 4.608 ± 2.216
0.0ArgXaa: 0.0 ± 0.0
Ser
7.68SerAla: 7.68 ± 0.928
2.304SerCys: 2.304 ± 0.876
1.536SerAsp: 1.536 ± 0.601
3.84SerGlu: 3.84 ± 0.744
2.304SerPhe: 2.304 ± 0.507
7.68SerGly: 7.68 ± 3.691
0.768SerHis: 0.768 ± 0.494
1.536SerIle: 1.536 ± 0.853
2.304SerLys: 2.304 ± 1.253
8.449SerLeu: 8.449 ± 3.579
1.536SerMet: 1.536 ± 0.626
0.768SerAsn: 0.768 ± 0.494
4.608SerPro: 4.608 ± 1.791
3.072SerGln: 3.072 ± 0.889
5.376SerArg: 5.376 ± 3.349
6.144SerSer: 6.144 ± 2.259
3.84SerThr: 3.84 ± 1.296
6.144SerVal: 6.144 ± 1.664
3.84SerTrp: 3.84 ± 1.111
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
3.84ThrAla: 3.84 ± 1.833
0.0ThrCys: 0.0 ± 0.0
0.768ThrAsp: 0.768 ± 0.666
3.072ThrGlu: 3.072 ± 0.993
6.144ThrPhe: 6.144 ± 2.042
3.84ThrGly: 3.84 ± 1.276
1.536ThrHis: 1.536 ± 0.778
1.536ThrIle: 1.536 ± 0.988
2.304ThrLys: 2.304 ± 1.168
3.072ThrLeu: 3.072 ± 1.804
3.84ThrMet: 3.84 ± 2.469
4.608ThrAsn: 4.608 ± 2.963
3.072ThrPro: 3.072 ± 1.419
1.536ThrGln: 1.536 ± 1.451
1.536ThrArg: 1.536 ± 1.384
1.536ThrSer: 1.536 ± 0.853
4.608ThrThr: 4.608 ± 2.216
6.144ThrVal: 6.144 ± 3.95
1.536ThrTrp: 1.536 ± 0.709
0.768ThrTyr: 0.768 ± 0.666
0.0ThrXaa: 0.0 ± 0.0
Val
6.912ValAla: 6.912 ± 1.564
0.768ValCys: 0.768 ± 1.048
1.536ValAsp: 1.536 ± 0.982
0.0ValGlu: 0.0 ± 0.0
2.304ValPhe: 2.304 ± 1.481
6.912ValGly: 6.912 ± 2.175
0.768ValHis: 0.768 ± 0.869
0.0ValIle: 0.0 ± 0.0
4.608ValLys: 4.608 ± 1.199
5.376ValLeu: 5.376 ± 1.909
6.144ValMet: 6.144 ± 2.415
3.072ValAsn: 3.072 ± 1.119
6.912ValPro: 6.912 ± 1.609
0.768ValGln: 0.768 ± 0.666
8.449ValArg: 8.449 ± 1.552
7.68ValSer: 7.68 ± 1.141
3.84ValThr: 3.84 ± 1.419
6.144ValVal: 6.144 ± 5.402
1.536ValTrp: 1.536 ± 0.853
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
3.072TrpAla: 3.072 ± 0.947
0.768TrpCys: 0.768 ± 0.666
0.0TrpAsp: 0.0 ± 0.0
4.608TrpGlu: 4.608 ± 1.083
1.536TrpPhe: 1.536 ± 0.853
0.768TrpGly: 0.768 ± 0.666
0.768TrpHis: 0.768 ± 0.494
0.0TrpIle: 0.0 ± 0.0
1.536TrpLys: 1.536 ± 1.451
0.768TrpLeu: 0.768 ± 0.666
1.536TrpMet: 1.536 ± 0.709
1.536TrpAsn: 1.536 ± 0.988
0.768TrpPro: 0.768 ± 0.725
0.768TrpGln: 0.768 ± 0.494
3.072TrpArg: 3.072 ± 1.432
0.0TrpSer: 0.0 ± 0.0
1.536TrpThr: 1.536 ± 0.778
1.536TrpVal: 1.536 ± 0.709
1.536TrpTrp: 1.536 ± 0.709
0.768TrpTyr: 0.768 ± 0.494
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.304TyrAla: 2.304 ± 0.507
0.0TyrCys: 0.0 ± 0.0
0.768TyrAsp: 0.768 ± 0.494
3.84TyrGlu: 3.84 ± 1.217
1.536TyrPhe: 1.536 ± 0.982
1.536TyrGly: 1.536 ± 1.331
0.768TyrHis: 0.768 ± 0.666
2.304TyrIle: 2.304 ± 0.507
0.0TyrLys: 0.0 ± 0.0
4.608TyrLeu: 4.608 ± 1.462
0.768TyrMet: 0.768 ± 0.494
0.768TyrAsn: 0.768 ± 0.494
0.0TyrPro: 0.0 ± 0.0
0.768TyrGln: 0.768 ± 0.494
3.072TyrArg: 3.072 ± 1.386
2.304TyrSer: 2.304 ± 1.231
0.0TyrThr: 0.0 ± 0.0
1.536TyrVal: 1.536 ± 0.601
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1303 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski