Amino acid dipepetide frequency for Acidianus filamentous virus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.417AlaCys: 0.417 ± 0.191
2.254AlaAsp: 2.254 ± 0.428
3.757AlaGlu: 3.757 ± 0.55
1.753AlaPhe: 1.753 ± 0.319
2.755AlaGly: 2.755 ± 0.548
0.751AlaHis: 0.751 ± 0.252
4.007AlaIle: 4.007 ± 0.585
5.009AlaLys: 5.009 ± 0.658
5.259AlaLeu: 5.259 ± 0.692
1.252AlaMet: 1.252 ± 0.455
2.004AlaAsn: 2.004 ± 0.302
1.002AlaPro: 1.002 ± 0.286
1.419AlaGln: 1.419 ± 0.354
2.421AlaArg: 2.421 ± 0.458
3.757AlaSer: 3.757 ± 0.655
3.59AlaThr: 3.59 ± 0.657
3.84AlaVal: 3.84 ± 0.585
0.751AlaTrp: 0.751 ± 0.244
3.256AlaTyr: 3.256 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.263
0.334CysCys: 0.334 ± 0.172
0.501CysAsp: 0.501 ± 0.201
0.751CysGlu: 0.751 ± 0.246
0.584CysPhe: 0.584 ± 0.207
1.002CysGly: 1.002 ± 0.274
0.0CysHis: 0.0 ± 0.0
1.085CysIle: 1.085 ± 0.332
0.584CysLys: 0.584 ± 0.179
0.835CysLeu: 0.835 ± 0.273
0.417CysMet: 0.417 ± 0.203
0.918CysAsn: 0.918 ± 0.257
0.835CysPro: 0.835 ± 0.413
0.501CysGln: 0.501 ± 0.207
0.584CysArg: 0.584 ± 0.197
1.336CysSer: 1.336 ± 0.325
0.668CysThr: 0.668 ± 0.186
1.002CysVal: 1.002 ± 0.225
0.0CysTrp: 0.0 ± 0.0
1.252CysTyr: 1.252 ± 0.367
0.0CysXaa: 0.0 ± 0.0
Asp
2.087AspAla: 2.087 ± 0.534
0.417AspCys: 0.417 ± 0.211
3.59AspAsp: 3.59 ± 0.799
4.341AspGlu: 4.341 ± 0.724
2.087AspPhe: 2.087 ± 0.392
2.671AspGly: 2.671 ± 0.537
0.918AspHis: 0.918 ± 0.234
4.257AspIle: 4.257 ± 0.592
2.838AspLys: 2.838 ± 0.549
4.508AspLeu: 4.508 ± 0.486
1.085AspMet: 1.085 ± 0.336
2.588AspAsn: 2.588 ± 0.415
1.837AspPro: 1.837 ± 0.388
0.668AspGln: 0.668 ± 0.243
1.169AspArg: 1.169 ± 0.276
1.92AspSer: 1.92 ± 0.384
1.67AspThr: 1.67 ± 0.4
4.174AspVal: 4.174 ± 0.641
0.083AspTrp: 0.083 ± 0.081
3.339AspTyr: 3.339 ± 0.642
0.0AspXaa: 0.0 ± 0.0
Glu
2.922GluAla: 2.922 ± 0.555
1.419GluCys: 1.419 ± 0.37
3.673GluAsp: 3.673 ± 0.739
7.179GluGlu: 7.179 ± 1.025
3.256GluPhe: 3.256 ± 0.581
3.59GluGly: 3.59 ± 0.592
0.751GluHis: 0.751 ± 0.276
8.098GluIle: 8.098 ± 0.924
7.931GluLys: 7.931 ± 1.294
7.764GluLeu: 7.764 ± 0.899
3.005GluMet: 3.005 ± 0.474
4.09GluAsn: 4.09 ± 0.683
1.419GluPro: 1.419 ± 0.344
1.336GluGln: 1.336 ± 0.289
2.17GluArg: 2.17 ± 0.52
2.755GluSer: 2.755 ± 0.466
3.673GluThr: 3.673 ± 0.708
5.092GluVal: 5.092 ± 0.63
0.751GluTrp: 0.751 ± 0.283
3.423GluTyr: 3.423 ± 0.594
0.0GluXaa: 0.0 ± 0.0
Phe
2.004PheAla: 2.004 ± 0.371
0.751PheCys: 0.751 ± 0.355
2.17PheAsp: 2.17 ± 0.406
2.922PheGlu: 2.922 ± 0.482
1.753PhePhe: 1.753 ± 0.388
1.586PheGly: 1.586 ± 0.409
0.835PheHis: 0.835 ± 0.261
2.588PheIle: 2.588 ± 0.401
2.755PheLys: 2.755 ± 0.536
4.758PheLeu: 4.758 ± 0.738
1.169PheMet: 1.169 ± 0.396
2.671PheAsn: 2.671 ± 0.516
1.419PhePro: 1.419 ± 0.331
2.087PheGln: 2.087 ± 0.39
1.169PheArg: 1.169 ± 0.265
3.423PheSer: 3.423 ± 0.511
2.922PheThr: 2.922 ± 0.653
4.508PheVal: 4.508 ± 0.833
0.334PheTrp: 0.334 ± 0.171
2.337PheTyr: 2.337 ± 0.386
0.0PheXaa: 0.0 ± 0.0
Gly
2.421GlyAla: 2.421 ± 0.536
1.002GlyCys: 1.002 ± 0.329
2.838GlyAsp: 2.838 ± 0.435
3.84GlyGlu: 3.84 ± 0.603
2.254GlyPhe: 2.254 ± 0.416
1.92GlyGly: 1.92 ± 0.431
0.417GlyHis: 0.417 ± 0.173
5.343GlyIle: 5.343 ± 0.722
5.343GlyLys: 5.343 ± 0.891
3.423GlyLeu: 3.423 ± 0.688
0.918GlyMet: 0.918 ± 0.237
3.256GlyAsn: 3.256 ± 0.569
0.501GlyPro: 0.501 ± 0.198
2.17GlyGln: 2.17 ± 0.419
2.421GlyArg: 2.421 ± 0.704
2.922GlySer: 2.922 ± 0.767
3.506GlyThr: 3.506 ± 0.622
3.673GlyVal: 3.673 ± 0.494
0.668GlyTrp: 0.668 ± 0.248
3.59GlyTyr: 3.59 ± 0.632
0.0GlyXaa: 0.0 ± 0.0
His
0.835HisAla: 0.835 ± 0.247
0.334HisCys: 0.334 ± 0.164
0.918HisAsp: 0.918 ± 0.277
0.835HisGlu: 0.835 ± 0.325
1.085HisPhe: 1.085 ± 0.335
0.751HisGly: 0.751 ± 0.273
0.501HisHis: 0.501 ± 0.179
0.918HisIle: 0.918 ± 0.241
0.25HisLys: 0.25 ± 0.139
1.002HisLeu: 1.002 ± 0.293
0.167HisMet: 0.167 ± 0.114
0.501HisAsn: 0.501 ± 0.201
0.584HisPro: 0.584 ± 0.207
0.334HisGln: 0.334 ± 0.187
0.334HisArg: 0.334 ± 0.159
0.751HisSer: 0.751 ± 0.263
0.501HisThr: 0.501 ± 0.18
1.419HisVal: 1.419 ± 0.292
0.167HisTrp: 0.167 ± 0.122
0.918HisTyr: 0.918 ± 0.243
0.0HisXaa: 0.0 ± 0.0
Ile
5.76IleAla: 5.76 ± 0.827
0.751IleCys: 0.751 ± 0.269
4.675IleAsp: 4.675 ± 0.682
6.261IleGlu: 6.261 ± 0.988
4.09IlePhe: 4.09 ± 0.517
3.089IleGly: 3.089 ± 0.542
1.085IleHis: 1.085 ± 0.301
7.764IleIle: 7.764 ± 1.226
4.925IleLys: 4.925 ± 0.788
7.096IleLeu: 7.096 ± 0.675
1.837IleMet: 1.837 ± 0.473
4.758IleAsn: 4.758 ± 0.782
5.092IlePro: 5.092 ± 0.636
3.172IleGln: 3.172 ± 0.481
3.339IleArg: 3.339 ± 0.644
7.012IleSer: 7.012 ± 0.889
5.927IleThr: 5.927 ± 0.791
6.595IleVal: 6.595 ± 0.834
0.668IleTrp: 0.668 ± 0.26
4.675IleTyr: 4.675 ± 0.599
0.0IleXaa: 0.0 ± 0.0
Lys
2.504LysAla: 2.504 ± 0.528
0.584LysCys: 0.584 ± 0.243
2.755LysAsp: 2.755 ± 0.544
7.68LysGlu: 7.68 ± 1.277
2.671LysPhe: 2.671 ± 0.536
3.924LysGly: 3.924 ± 0.681
0.501LysHis: 0.501 ± 0.215
8.932LysIle: 8.932 ± 1.428
7.513LysLys: 7.513 ± 1.249
8.098LysLeu: 8.098 ± 1.023
2.17LysMet: 2.17 ± 0.497
2.838LysAsn: 2.838 ± 0.524
1.67LysPro: 1.67 ± 0.325
2.254LysGln: 2.254 ± 0.427
3.089LysArg: 3.089 ± 0.685
3.84LysSer: 3.84 ± 0.709
3.172LysThr: 3.172 ± 0.593
4.341LysVal: 4.341 ± 0.816
0.417LysTrp: 0.417 ± 0.164
4.257LysTyr: 4.257 ± 0.723
0.0LysXaa: 0.0 ± 0.0
Leu
4.424LeuAla: 4.424 ± 0.715
1.503LeuCys: 1.503 ± 0.412
3.423LeuAsp: 3.423 ± 0.515
5.677LeuGlu: 5.677 ± 0.744
4.341LeuPhe: 4.341 ± 0.643
4.09LeuGly: 4.09 ± 0.593
1.252LeuHis: 1.252 ± 0.302
5.927LeuIle: 5.927 ± 0.81
7.012LeuLys: 7.012 ± 1.151
8.098LeuLeu: 8.098 ± 1.234
2.421LeuMet: 2.421 ± 0.464
4.09LeuAsn: 4.09 ± 0.688
3.924LeuPro: 3.924 ± 0.548
2.588LeuGln: 2.588 ± 0.429
4.424LeuArg: 4.424 ± 0.914
5.927LeuSer: 5.927 ± 0.852
5.092LeuThr: 5.092 ± 0.763
6.511LeuVal: 6.511 ± 0.691
1.169LeuTrp: 1.169 ± 0.287
4.758LeuTyr: 4.758 ± 0.512
0.0LeuXaa: 0.0 ± 0.0
Met
1.503MetAla: 1.503 ± 0.432
0.25MetCys: 0.25 ± 0.161
0.751MetAsp: 0.751 ± 0.255
2.004MetGlu: 2.004 ± 0.473
1.002MetPhe: 1.002 ± 0.301
1.503MetGly: 1.503 ± 0.421
0.083MetHis: 0.083 ± 0.08
2.421MetIle: 2.421 ± 0.528
2.337MetLys: 2.337 ± 0.49
2.17MetLeu: 2.17 ± 0.425
0.584MetMet: 0.584 ± 0.19
1.67MetAsn: 1.67 ± 0.452
0.668MetPro: 0.668 ± 0.26
0.668MetGln: 0.668 ± 0.191
1.252MetArg: 1.252 ± 0.372
1.837MetSer: 1.837 ± 0.321
0.835MetThr: 0.835 ± 0.282
1.92MetVal: 1.92 ± 0.427
0.501MetTrp: 0.501 ± 0.178
0.668MetTyr: 0.668 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
3.339AsnAla: 3.339 ± 0.441
0.584AsnCys: 0.584 ± 0.212
2.337AsnAsp: 2.337 ± 0.437
4.174AsnGlu: 4.174 ± 0.657
2.922AsnPhe: 2.922 ± 0.461
3.84AsnGly: 3.84 ± 0.549
0.584AsnHis: 0.584 ± 0.216
4.174AsnIle: 4.174 ± 0.622
3.172AsnLys: 3.172 ± 0.734
3.256AsnLeu: 3.256 ± 0.557
1.419AsnMet: 1.419 ± 0.379
2.755AsnAsn: 2.755 ± 0.476
2.17AsnPro: 2.17 ± 0.363
1.753AsnGln: 1.753 ± 0.353
1.169AsnArg: 1.169 ± 0.333
2.504AsnSer: 2.504 ± 0.47
3.423AsnThr: 3.423 ± 0.788
4.758AsnVal: 4.758 ± 0.706
1.002AsnTrp: 1.002 ± 0.243
2.588AsnTyr: 2.588 ± 0.322
0.0AsnXaa: 0.0 ± 0.0
Pro
2.421ProAla: 2.421 ± 0.416
1.169ProCys: 1.169 ± 0.31
1.085ProAsp: 1.085 ± 0.337
2.254ProGlu: 2.254 ± 0.324
2.17ProPhe: 2.17 ± 0.371
1.586ProGly: 1.586 ± 0.361
0.668ProHis: 0.668 ± 0.349
3.339ProIle: 3.339 ± 0.576
1.92ProLys: 1.92 ± 0.455
1.753ProLeu: 1.753 ± 0.344
0.501ProMet: 0.501 ± 0.208
2.004ProAsn: 2.004 ± 0.402
3.172ProPro: 3.172 ± 0.907
1.169ProGln: 1.169 ± 0.335
1.419ProArg: 1.419 ± 0.472
4.508ProSer: 4.508 ± 0.987
2.922ProThr: 2.922 ± 1.007
3.673ProVal: 3.673 ± 0.641
0.417ProTrp: 0.417 ± 0.164
1.586ProTyr: 1.586 ± 0.362
0.0ProXaa: 0.0 ± 0.0
Gln
1.336GlnAla: 1.336 ± 0.429
0.751GlnCys: 0.751 ± 0.261
0.835GlnAsp: 0.835 ± 0.293
2.922GlnGlu: 2.922 ± 0.443
1.419GlnPhe: 1.419 ± 0.387
2.254GlnGly: 2.254 ± 0.433
0.0GlnHis: 0.0 ± 0.0
3.172GlnIle: 3.172 ± 0.527
2.254GlnLys: 2.254 ± 0.498
2.337GlnLeu: 2.337 ± 0.541
1.252GlnMet: 1.252 ± 0.359
1.169GlnAsn: 1.169 ± 0.276
1.252GlnPro: 1.252 ± 0.258
1.753GlnGln: 1.753 ± 0.387
1.085GlnArg: 1.085 ± 0.368
1.67GlnSer: 1.67 ± 0.672
1.92GlnThr: 1.92 ± 0.432
2.421GlnVal: 2.421 ± 0.532
0.584GlnTrp: 0.584 ± 0.192
1.419GlnTyr: 1.419 ± 0.361
0.0GlnXaa: 0.0 ± 0.0
Arg
1.92ArgAla: 1.92 ± 0.495
0.083ArgCys: 0.083 ± 0.09
1.503ArgAsp: 1.503 ± 0.37
3.59ArgGlu: 3.59 ± 0.715
1.336ArgPhe: 1.336 ± 0.355
2.087ArgGly: 2.087 ± 0.452
0.668ArgHis: 0.668 ± 0.272
3.339ArgIle: 3.339 ± 0.828
4.341ArgLys: 4.341 ± 0.799
3.506ArgLeu: 3.506 ± 0.64
0.835ArgMet: 0.835 ± 0.257
1.419ArgAsn: 1.419 ± 0.385
1.169ArgPro: 1.169 ± 0.314
1.336ArgGln: 1.336 ± 0.391
2.087ArgArg: 2.087 ± 0.474
1.336ArgSer: 1.336 ± 0.31
1.586ArgThr: 1.586 ± 0.388
2.755ArgVal: 2.755 ± 0.501
0.083ArgTrp: 0.083 ± 0.088
1.837ArgTyr: 1.837 ± 0.37
0.0ArgXaa: 0.0 ± 0.0
Ser
3.089SerAla: 3.089 ± 0.612
0.918SerCys: 0.918 ± 0.426
3.339SerAsp: 3.339 ± 0.518
3.59SerGlu: 3.59 ± 0.561
2.504SerPhe: 2.504 ± 0.473
5.092SerGly: 5.092 ± 0.966
1.085SerHis: 1.085 ± 0.261
5.593SerIle: 5.593 ± 0.908
2.922SerLys: 2.922 ± 0.461
7.68SerLeu: 7.68 ± 0.924
1.085SerMet: 1.085 ± 0.237
2.337SerAsn: 2.337 ± 0.422
2.504SerPro: 2.504 ± 0.485
2.922SerGln: 2.922 ± 0.572
2.004SerArg: 2.004 ± 0.43
6.428SerSer: 6.428 ± 2.18
3.256SerThr: 3.256 ± 0.541
5.092SerVal: 5.092 ± 0.921
0.584SerTrp: 0.584 ± 0.185
4.174SerTyr: 4.174 ± 0.78
0.0SerXaa: 0.0 ± 0.0
Thr
3.506ThrAla: 3.506 ± 0.644
0.167ThrCys: 0.167 ± 0.1
2.004ThrAsp: 2.004 ± 0.382
2.922ThrGlu: 2.922 ± 0.573
3.423ThrPhe: 3.423 ± 0.627
3.506ThrGly: 3.506 ± 0.767
0.584ThrHis: 0.584 ± 0.225
5.176ThrIle: 5.176 ± 0.821
3.256ThrLys: 3.256 ± 0.698
4.842ThrLeu: 4.842 ± 0.692
1.336ThrMet: 1.336 ± 0.368
2.922ThrAsn: 2.922 ± 0.459
4.007ThrPro: 4.007 ± 0.636
1.252ThrGln: 1.252 ± 0.368
1.67ThrArg: 1.67 ± 0.402
5.092ThrSer: 5.092 ± 0.891
4.842ThrThr: 4.842 ± 0.884
4.925ThrVal: 4.925 ± 0.716
0.417ThrTrp: 0.417 ± 0.162
4.007ThrTyr: 4.007 ± 0.654
0.0ThrXaa: 0.0 ± 0.0
Val
5.092ValAla: 5.092 ± 0.762
1.002ValCys: 1.002 ± 0.276
4.007ValAsp: 4.007 ± 0.588
5.343ValGlu: 5.343 ± 0.688
2.755ValPhe: 2.755 ± 0.422
4.174ValGly: 4.174 ± 0.657
1.002ValHis: 1.002 ± 0.384
6.678ValIle: 6.678 ± 0.769
4.925ValLys: 4.925 ± 0.7
5.343ValLeu: 5.343 ± 0.705
1.67ValMet: 1.67 ± 0.291
5.176ValAsn: 5.176 ± 0.606
3.757ValPro: 3.757 ± 0.497
2.421ValGln: 2.421 ± 0.528
3.005ValArg: 3.005 ± 0.505
4.925ValSer: 4.925 ± 1.202
6.177ValThr: 6.177 ± 0.998
6.762ValVal: 6.762 ± 1.113
0.668ValTrp: 0.668 ± 0.272
4.925ValTyr: 4.925 ± 0.619
0.0ValXaa: 0.0 ± 0.0
Trp
0.417TrpAla: 0.417 ± 0.189
0.334TrpCys: 0.334 ± 0.151
0.501TrpAsp: 0.501 ± 0.171
1.002TrpGlu: 1.002 ± 0.272
0.25TrpPhe: 0.25 ± 0.152
0.25TrpGly: 0.25 ± 0.132
0.167TrpHis: 0.167 ± 0.095
1.002TrpIle: 1.002 ± 0.223
0.751TrpLys: 0.751 ± 0.23
0.918TrpLeu: 0.918 ± 0.274
0.083TrpMet: 0.083 ± 0.082
0.584TrpAsn: 0.584 ± 0.208
0.0TrpPro: 0.0 ± 0.0
0.334TrpGln: 0.334 ± 0.149
0.334TrpArg: 0.334 ± 0.161
0.751TrpSer: 0.751 ± 0.247
0.668TrpThr: 0.668 ± 0.192
1.002TrpVal: 1.002 ± 0.302
0.25TrpTrp: 0.25 ± 0.197
0.584TrpTyr: 0.584 ± 0.242
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.089TyrAla: 3.089 ± 0.547
1.002TyrCys: 1.002 ± 0.267
3.089TyrAsp: 3.089 ± 0.46
3.256TyrGlu: 3.256 ± 0.547
2.504TyrPhe: 2.504 ± 0.375
2.755TyrGly: 2.755 ± 0.612
1.252TyrHis: 1.252 ± 0.283
4.842TyrIle: 4.842 ± 0.53
3.172TyrLys: 3.172 ± 0.52
4.007TyrLeu: 4.007 ± 0.49
1.336TyrMet: 1.336 ± 0.318
4.174TyrAsn: 4.174 ± 0.714
2.755TyrPro: 2.755 ± 0.589
1.67TyrGln: 1.67 ± 0.364
1.67TyrArg: 1.67 ± 0.339
3.506TyrSer: 3.506 ± 0.712
3.506TyrThr: 3.506 ± 0.521
5.343TyrVal: 5.343 ± 0.645
0.668TyrTrp: 0.668 ± 0.201
3.757TyrTyr: 3.757 ± 0.821
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (11980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski