Amino acid dipepetide frequency for Blastocystis hominis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.521AlaAla: 5.521 ± 0.096	1.228AlaCys: 1.228 ± 0.028	3.042AlaAsp: 3.042 ± 0.042	4.694AlaGlu: 4.694 ± 0.086	2.767AlaPhe: 2.767 ± 0.037	3.938AlaGly: 3.938 ± 0.091	1.202AlaHis: 1.202 ± 0.025	3.841AlaIle: 3.841 ± 0.052	3.851AlaLys: 3.851 ± 0.061	6.039AlaLeu: 6.039 ± 0.076	1.931AlaMet: 1.931 ± 0.038	2.53AlaAsn: 2.53 ± 0.046	3.082AlaPro: 3.082 ± 0.081	2.35AlaGln: 2.35 ± 0.042	3.187AlaArg: 3.187 ± 0.057	5.2AlaSer: 5.2 ± 0.068	3.382AlaThr: 3.382 ± 0.05	4.613AlaVal: 4.613 ± 0.054	0.592AlaTrp: 0.592 ± 0.018	1.944AlaTyr: 1.944 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.078CysAla: 1.078 ± 0.027	0.652CysCys: 0.652 ± 0.025	1.175CysAsp: 1.175 ± 0.028	1.227CysGlu: 1.227 ± 0.033	1.115CysPhe: 1.115 ± 0.022	1.504CysGly: 1.504 ± 0.04	0.437CysHis: 0.437 ± 0.016	1.338CysIle: 1.338 ± 0.027	0.969CysLys: 0.969 ± 0.023	1.924CysLeu: 1.924 ± 0.04	0.588CysMet: 0.588 ± 0.016	0.874CysAsn: 0.874 ± 0.021	1.111CysPro: 1.111 ± 0.086	0.611CysGln: 0.611 ± 0.017	1.113CysArg: 1.113 ± 0.026	1.768CysSer: 1.768 ± 0.042	1.071CysThr: 1.071 ± 0.035	1.654CysVal: 1.654 ± 0.03	0.273CysTrp: 0.273 ± 0.011	0.803CysTyr: 0.803 ± 0.035	0.0CysXaa: 0.0 ± 0.0
Asp	3.628AspAla: 3.628 ± 0.05	1.162AspCys: 1.162 ± 0.037	3.274AspAsp: 3.274 ± 0.072	4.097AspGlu: 4.097 ± 0.063	2.51AspPhe: 2.51 ± 0.038	3.188AspGly: 3.188 ± 0.048	1.085AspHis: 1.085 ± 0.024	3.201AspIle: 3.201 ± 0.043	2.556AspLys: 2.556 ± 0.041	4.979AspLeu: 4.979 ± 0.056	1.445AspMet: 1.445 ± 0.028	2.065AspAsn: 2.065 ± 0.037	2.387AspPro: 2.387 ± 0.038	1.51AspGln: 1.51 ± 0.027	2.73AspArg: 2.73 ± 0.042	4.189AspSer: 4.189 ± 0.068	2.162AspThr: 2.162 ± 0.037	3.905AspVal: 3.905 ± 0.054	0.677AspTrp: 0.677 ± 0.019	2.116AspTyr: 2.116 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.057GluAla: 5.057 ± 0.088	1.25GluCys: 1.25 ± 0.038	3.822GluAsp: 3.822 ± 0.059	8.399GluGlu: 8.399 ± 0.224	2.616GluPhe: 2.616 ± 0.041	4.21GluGly: 4.21 ± 0.084	1.216GluHis: 1.216 ± 0.027	3.96GluIle: 3.96 ± 0.05	5.988GluLys: 5.988 ± 0.102	6.219GluLeu: 6.219 ± 0.077	2.207GluMet: 2.207 ± 0.038	3.473GluAsn: 3.473 ± 0.052	2.21GluPro: 2.21 ± 0.049	2.648GluGln: 2.648 ± 0.055	3.912GluArg: 3.912 ± 0.065	5.168GluSer: 5.168 ± 0.078	3.551GluThr: 3.551 ± 0.053	4.529GluVal: 4.529 ± 0.056	0.853GluTrp: 0.853 ± 0.022	2.378GluTyr: 2.378 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.858PheAla: 2.858 ± 0.041	1.065PheCys: 1.065 ± 0.022	2.7PheAsp: 2.7 ± 0.038	2.593PheGlu: 2.593 ± 0.043	2.093PhePhe: 2.093 ± 0.039	2.678PheGly: 2.678 ± 0.048	1.073PheHis: 1.073 ± 0.024	2.502PheIle: 2.502 ± 0.039	1.844PheLys: 1.844 ± 0.034	4.127PheLeu: 4.127 ± 0.054	1.037PheMet: 1.037 ± 0.021	1.849PheAsn: 1.849 ± 0.032	2.072PhePro: 2.072 ± 0.035	1.448PheGln: 1.448 ± 0.026	2.007PheArg: 2.007 ± 0.035	3.721PheSer: 3.721 ± 0.053	2.246PheThr: 2.246 ± 0.048	3.339PheVal: 3.339 ± 0.046	0.461PheTrp: 0.461 ± 0.015	1.798PheTyr: 1.798 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	3.404GlyAla: 3.404 ± 0.064	1.164GlyCys: 1.164 ± 0.025	3.099GlyAsp: 3.099 ± 0.049	4.252GlyGlu: 4.252 ± 0.059	2.471GlyPhe: 2.471 ± 0.037	3.842GlyGly: 3.842 ± 0.069	1.176GlyHis: 1.176 ± 0.028	3.639GlyIle: 3.639 ± 0.05	3.842GlyLys: 3.842 ± 0.057	4.514GlyLeu: 4.514 ± 0.075	1.697GlyMet: 1.697 ± 0.034	2.62GlyAsn: 2.62 ± 0.039	1.562GlyPro: 1.562 ± 0.053	1.642GlyGln: 1.642 ± 0.03	3.15GlyArg: 3.15 ± 0.049	4.569GlySer: 4.569 ± 0.147	3.015GlyThr: 3.015 ± 0.05	4.351GlyVal: 4.351 ± 0.065	0.701GlyTrp: 0.701 ± 0.023	2.262GlyTyr: 2.262 ± 0.056	0.0GlyXaa: 0.0 ± 0.001
His	1.248HisAla: 1.248 ± 0.029	0.553HisCys: 0.553 ± 0.018	1.007HisAsp: 1.007 ± 0.025	1.096HisGlu: 1.096 ± 0.02	1.076HisPhe: 1.076 ± 0.025	1.259HisGly: 1.259 ± 0.029	0.63HisHis: 0.63 ± 0.019	1.365HisIle: 1.365 ± 0.027	0.928HisLys: 0.928 ± 0.02	2.023HisLeu: 2.023 ± 0.036	0.486HisMet: 0.486 ± 0.013	0.852HisAsn: 0.852 ± 0.023	1.259HisPro: 1.259 ± 0.028	0.72HisGln: 0.72 ± 0.019	1.355HisArg: 1.355 ± 0.034	1.702HisSer: 1.702 ± 0.036	1.053HisThr: 1.053 ± 0.026	1.416HisVal: 1.416 ± 0.03	0.216HisTrp: 0.216 ± 0.011	0.867HisTyr: 0.867 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.839IleAla: 3.839 ± 0.048	1.34IleCys: 1.34 ± 0.032	3.575IleAsp: 3.575 ± 0.05	3.917IleGlu: 3.917 ± 0.044	2.131IlePhe: 2.131 ± 0.038	3.184IleGly: 3.184 ± 0.048	1.477IleHis: 1.477 ± 0.033	3.24IleIle: 3.24 ± 0.053	2.721IleLys: 2.721 ± 0.044	5.52IleLeu: 5.52 ± 0.074	1.389IleMet: 1.389 ± 0.024	2.389IleAsn: 2.389 ± 0.038	3.258IlePro: 3.258 ± 0.041	2.52IleGln: 2.52 ± 0.044	3.478IleArg: 3.478 ± 0.041	4.474IleSer: 4.474 ± 0.056	3.132IleThr: 3.132 ± 0.04	4.212IleVal: 4.212 ± 0.051	0.563IleTrp: 0.563 ± 0.017	1.905IleTyr: 1.905 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.7LysAla: 3.7 ± 0.055	0.962LysCys: 0.962 ± 0.027	2.946LysAsp: 2.946 ± 0.048	5.918LysGlu: 5.918 ± 0.114	1.651LysPhe: 1.651 ± 0.038	3.016LysGly: 3.016 ± 0.043	1.162LysHis: 1.162 ± 0.027	2.862LysIle: 2.862 ± 0.038	5.286LysLys: 5.286 ± 0.121	4.86LysLeu: 4.86 ± 0.054	1.651LysMet: 1.651 ± 0.031	2.874LysAsn: 2.874 ± 0.047	2.56LysPro: 2.56 ± 0.06	2.709LysGln: 2.709 ± 0.041	3.841LysArg: 3.841 ± 0.077	3.915LysSer: 3.915 ± 0.055	3.129LysThr: 3.129 ± 0.046	3.562LysVal: 3.562 ± 0.048	0.719LysTrp: 0.719 ± 0.019	2.146LysTyr: 2.146 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	5.659LeuAla: 5.659 ± 0.065	2.12LeuCys: 2.12 ± 0.042	4.814LeuAsp: 4.814 ± 0.06	5.789LeuGlu: 5.789 ± 0.083	4.649LeuPhe: 4.649 ± 0.062	4.473LeuGly: 4.473 ± 0.048	2.212LeuHis: 2.212 ± 0.037	4.85LeuIle: 4.85 ± 0.067	5.28LeuLys: 5.28 ± 0.064	9.939LeuLeu: 9.939 ± 0.134	2.184LeuMet: 2.184 ± 0.038	4.057LeuAsn: 4.057 ± 0.058	4.815LeuPro: 4.815 ± 0.057	4.187LeuGln: 4.187 ± 0.059	5.649LeuArg: 5.649 ± 0.073	7.701LeuSer: 7.701 ± 0.076	4.399LeuThr: 4.399 ± 0.053	5.681LeuVal: 5.681 ± 0.062	0.927LeuTrp: 0.927 ± 0.024	3.189LeuTyr: 3.189 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.542MetAla: 1.542 ± 0.033	0.464MetCys: 0.464 ± 0.014	1.595MetAsp: 1.595 ± 0.028	2.121MetGlu: 2.121 ± 0.031	0.959MetPhe: 0.959 ± 0.022	1.572MetGly: 1.572 ± 0.034	0.514MetHis: 0.514 ± 0.017	1.568MetIle: 1.568 ± 0.026	2.087MetLys: 2.087 ± 0.034	2.188MetLeu: 2.188 ± 0.036	0.904MetMet: 0.904 ± 0.029	1.614MetAsn: 1.614 ± 0.034	0.987MetPro: 0.987 ± 0.03	1.157MetGln: 1.157 ± 0.028	1.348MetArg: 1.348 ± 0.027	1.904MetSer: 1.904 ± 0.032	1.295MetThr: 1.295 ± 0.031	1.531MetVal: 1.531 ± 0.03	0.257MetTrp: 0.257 ± 0.011	0.89MetTyr: 0.89 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.926AsnAla: 2.926 ± 0.039	0.956AsnCys: 0.956 ± 0.027	2.414AsnAsp: 2.414 ± 0.041	3.442AsnGlu: 3.442 ± 0.078	1.482AsnPhe: 1.482 ± 0.028	3.203AsnGly: 3.203 ± 0.056	1.014AsnHis: 1.014 ± 0.022	2.447AsnIle: 2.447 ± 0.035	2.338AsnLys: 2.338 ± 0.037	3.706AsnLeu: 3.706 ± 0.047	1.121AsnMet: 1.121 ± 0.025	2.006AsnAsn: 2.006 ± 0.042	2.295AsnPro: 2.295 ± 0.043	1.811AsnGln: 1.811 ± 0.035	2.591AsnArg: 2.591 ± 0.046	3.236AsnSer: 3.236 ± 0.051	2.302AsnThr: 2.302 ± 0.041	2.998AsnVal: 2.998 ± 0.042	0.564AsnTrp: 0.564 ± 0.018	1.619AsnTyr: 1.619 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.616ProAla: 3.616 ± 0.085	0.704ProCys: 0.704 ± 0.024	2.013ProAsp: 2.013 ± 0.031	3.258ProGlu: 3.258 ± 0.063	2.132ProPhe: 2.132 ± 0.035	2.029ProGly: 2.029 ± 0.038	0.895ProHis: 0.895 ± 0.024	2.605ProIle: 2.605 ± 0.06	2.444ProLys: 2.444 ± 0.049	3.77ProLeu: 3.77 ± 0.046	1.085ProMet: 1.085 ± 0.031	1.843ProAsn: 1.843 ± 0.037	2.37ProPro: 2.37 ± 0.07	1.67ProGln: 1.67 ± 0.06	2.426ProArg: 2.426 ± 0.051	4.309ProSer: 4.309 ± 0.071	3.016ProThr: 3.016 ± 0.167	3.058ProVal: 3.058 ± 0.044	0.385ProTrp: 0.385 ± 0.014	1.42ProTyr: 1.42 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.265GlnAla: 2.265 ± 0.046	0.759GlnCys: 0.759 ± 0.027	1.525GlnAsp: 1.525 ± 0.029	2.487GlnGlu: 2.487 ± 0.043	1.673GlnPhe: 1.673 ± 0.031	1.81GlnGly: 1.81 ± 0.04	0.748GlnHis: 0.748 ± 0.021	2.382GlnIle: 2.382 ± 0.039	2.481GlnLys: 2.481 ± 0.038	3.862GlnLeu: 3.862 ± 0.055	1.059GlnMet: 1.059 ± 0.031	1.799GlnAsn: 1.799 ± 0.033	1.759GlnPro: 1.759 ± 0.066	2.15GlnGln: 2.15 ± 0.078	2.245GlnArg: 2.245 ± 0.039	3.042GlnSer: 3.042 ± 0.04	1.975GlnThr: 1.975 ± 0.041	2.021GlnVal: 2.021 ± 0.033	0.432GlnTrp: 0.432 ± 0.014	1.321GlnTyr: 1.321 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.407ArgAla: 3.407 ± 0.052	1.251ArgCys: 1.251 ± 0.036	2.875ArgAsp: 2.875 ± 0.046	4.227ArgGlu: 4.227 ± 0.062	2.644ArgPhe: 2.644 ± 0.037	3.33ArgGly: 3.33 ± 0.063	1.169ArgHis: 1.169 ± 0.031	3.257ArgIle: 3.257 ± 0.05	3.421ArgLys: 3.421 ± 0.081	4.888ArgLeu: 4.888 ± 0.06	1.476ArgMet: 1.476 ± 0.028	2.471ArgAsn: 2.471 ± 0.038	1.852ArgPro: 1.852 ± 0.039	1.97ArgGln: 1.97 ± 0.036	4.067ArgArg: 4.067 ± 0.084	4.55ArgSer: 4.55 ± 0.072	2.434ArgThr: 2.434 ± 0.039	3.774ArgVal: 3.774 ± 0.053	0.646ArgTrp: 0.646 ± 0.019	1.867ArgTyr: 1.867 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	4.906SerAla: 4.906 ± 0.061	1.527SerCys: 1.527 ± 0.035	4.014SerAsp: 4.014 ± 0.076	5.072SerGlu: 5.072 ± 0.08	4.06SerPhe: 4.06 ± 0.049	4.48SerGly: 4.48 ± 0.091	1.672SerHis: 1.672 ± 0.035	5.014SerIle: 5.014 ± 0.063	4.136SerLys: 4.136 ± 0.061	8.27SerLeu: 8.27 ± 0.09	1.952SerMet: 1.952 ± 0.036	3.527SerAsn: 3.527 ± 0.068	3.539SerPro: 3.539 ± 0.063	2.791SerGln: 2.791 ± 0.043	4.082SerArg: 4.082 ± 0.067	7.562SerSer: 7.562 ± 0.14	4.353SerThr: 4.353 ± 0.071	5.534SerVal: 5.534 ± 0.059	0.754SerTrp: 0.754 ± 0.022	2.673SerTyr: 2.673 ± 0.047	0.0SerXaa: 0.0 ± 0.001
Thr	3.533ThrAla: 3.533 ± 0.057	1.016ThrCys: 1.016 ± 0.028	2.38ThrAsp: 2.38 ± 0.036	3.376ThrGlu: 3.376 ± 0.073	2.223ThrPhe: 2.223 ± 0.046	3.072ThrGly: 3.072 ± 0.06	1.085ThrHis: 1.085 ± 0.025	3.443ThrIle: 3.443 ± 0.048	2.635ThrLys: 2.635 ± 0.043	4.967ThrLeu: 4.967 ± 0.067	1.259ThrMet: 1.259 ± 0.028	2.176ThrAsn: 2.176 ± 0.04	3.013ThrPro: 3.013 ± 0.121	1.948ThrGln: 1.948 ± 0.034	2.44ThrArg: 2.44 ± 0.035	3.868ThrSer: 3.868 ± 0.04	3.277ThrThr: 3.277 ± 0.086	3.679ThrVal: 3.679 ± 0.066	0.532ThrTrp: 0.532 ± 0.015	1.636ThrTyr: 1.636 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	4.228ValAla: 4.228 ± 0.061	1.813ValCys: 1.813 ± 0.032	3.885ValAsp: 3.885 ± 0.058	4.86ValGlu: 4.86 ± 0.063	3.122ValPhe: 3.122 ± 0.04	3.46ValGly: 3.46 ± 0.051	1.335ValHis: 1.335 ± 0.033	4.019ValIle: 4.019 ± 0.052	3.904ValLys: 3.904 ± 0.054	6.58ValLeu: 6.58 ± 0.071	1.839ValMet: 1.839 ± 0.032	3.075ValAsn: 3.075 ± 0.047	3.076ValPro: 3.076 ± 0.052	2.396ValGln: 2.396 ± 0.038	3.367ValArg: 3.367 ± 0.042	5.258ValSer: 5.258 ± 0.072	3.378ValThr: 3.378 ± 0.059	5.115ValVal: 5.115 ± 0.063	0.723ValTrp: 0.723 ± 0.021	2.393ValTyr: 2.393 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.499TrpAla: 0.499 ± 0.017	0.256TrpCys: 0.256 ± 0.012	0.701TrpAsp: 0.701 ± 0.02	0.724TrpGlu: 0.724 ± 0.02	0.461TrpPhe: 0.461 ± 0.017	0.611TrpGly: 0.611 ± 0.019	0.155TrpHis: 0.155 ± 0.009	0.743TrpIle: 0.743 ± 0.017	0.942TrpLys: 0.942 ± 0.021	0.846TrpLeu: 0.846 ± 0.026	0.356TrpMet: 0.356 ± 0.012	0.698TrpAsn: 0.698 ± 0.022	0.296TrpPro: 0.296 ± 0.013	0.262TrpGln: 0.262 ± 0.012	0.647TrpArg: 0.647 ± 0.017	0.907TrpSer: 0.907 ± 0.024	0.603TrpThr: 0.603 ± 0.018	0.63TrpVal: 0.63 ± 0.018	0.141TrpTrp: 0.141 ± 0.009	0.36TrpTyr: 0.36 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.025TyrAla: 2.025 ± 0.033	1.043TyrCys: 1.043 ± 0.07	2.01TyrAsp: 2.01 ± 0.036	2.116TyrGlu: 2.116 ± 0.036	1.674TyrPhe: 1.674 ± 0.033	2.115TyrGly: 2.115 ± 0.047	0.853TyrHis: 0.853 ± 0.019	1.99TyrIle: 1.99 ± 0.038	1.814TyrLys: 1.814 ± 0.035	3.353TyrLeu: 3.353 ± 0.04	0.831TyrMet: 0.831 ± 0.021	1.68TyrAsn: 1.68 ± 0.031	1.546TyrPro: 1.546 ± 0.034	1.293TyrGln: 1.293 ± 0.028	1.939TyrArg: 1.939 ± 0.035	2.875TyrSer: 2.875 ± 0.045	1.785TyrThr: 1.785 ± 0.035	2.221TyrVal: 2.221 ± 0.037	0.423TyrTrp: 0.423 ± 0.016	1.702TyrTyr: 1.702 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.527XaaXaa: 0.527 ± 0.276

Statistics based on 5820 proteins (2100011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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