Amino acid dipepetide frequency for Sulfuricurvum sp. MLSB

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.463AlaAla: 7.463 ± 0.154
0.815AlaCys: 0.815 ± 0.04
4.317AlaAsp: 4.317 ± 0.094
5.057AlaGlu: 5.057 ± 0.088
3.65AlaPhe: 3.65 ± 0.098
5.246AlaGly: 5.246 ± 0.105
1.961AlaHis: 1.961 ± 0.061
6.25AlaIle: 6.25 ± 0.11
5.722AlaLys: 5.722 ± 0.113
10.175AlaLeu: 10.175 ± 0.137
2.698AlaMet: 2.698 ± 0.076
3.048AlaAsn: 3.048 ± 0.075
2.723AlaPro: 2.723 ± 0.071
3.192AlaGln: 3.192 ± 0.083
3.649AlaArg: 3.649 ± 0.095
5.059AlaSer: 5.059 ± 0.092
3.927AlaThr: 3.927 ± 0.091
5.717AlaVal: 5.717 ± 0.124
0.597AlaTrp: 0.597 ± 0.034
2.993AlaTyr: 2.993 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.044
0.106CysCys: 0.106 ± 0.015
0.803CysAsp: 0.803 ± 0.041
0.779CysGlu: 0.779 ± 0.038
0.32CysPhe: 0.32 ± 0.023
0.926CysGly: 0.926 ± 0.047
0.282CysHis: 0.282 ± 0.023
0.533CysIle: 0.533 ± 0.027
0.45CysLys: 0.45 ± 0.031
0.639CysLeu: 0.639 ± 0.032
0.216CysMet: 0.216 ± 0.021
0.381CysAsn: 0.381 ± 0.027
0.44CysPro: 0.44 ± 0.031
0.206CysGln: 0.206 ± 0.017
0.526CysArg: 0.526 ± 0.031
0.659CysSer: 0.659 ± 0.033
0.569CysThr: 0.569 ± 0.03
0.633CysVal: 0.633 ± 0.036
0.055CysTrp: 0.055 ± 0.01
0.367CysTyr: 0.367 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
5.128AspAla: 5.128 ± 0.094
0.455AspCys: 0.455 ± 0.03
2.837AspAsp: 2.837 ± 0.073
5.05AspGlu: 5.05 ± 0.107
2.78AspPhe: 2.78 ± 0.067
3.394AspGly: 3.394 ± 0.083
1.073AspHis: 1.073 ± 0.045
4.315AspIle: 4.315 ± 0.09
3.153AspLys: 3.153 ± 0.078
5.054AspLeu: 5.054 ± 0.104
1.558AspMet: 1.558 ± 0.049
2.138AspAsn: 2.138 ± 0.061
2.298AspPro: 2.298 ± 0.066
1.553AspGln: 1.553 ± 0.054
2.428AspArg: 2.428 ± 0.074
2.679AspSer: 2.679 ± 0.065
3.122AspThr: 3.122 ± 0.075
3.714AspVal: 3.714 ± 0.082
0.424AspTrp: 0.424 ± 0.031
2.136AspTyr: 2.136 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
6.444GluAla: 6.444 ± 0.126
0.807GluCys: 0.807 ± 0.04
2.928GluAsp: 2.928 ± 0.074
5.371GluGlu: 5.371 ± 0.129
2.674GluPhe: 2.674 ± 0.071
4.855GluGly: 4.855 ± 0.096
1.956GluHis: 1.956 ± 0.055
5.409GluIle: 5.409 ± 0.116
5.185GluLys: 5.185 ± 0.113
6.904GluLeu: 6.904 ± 0.124
2.127GluMet: 2.127 ± 0.056
3.205GluAsn: 3.205 ± 0.078
2.065GluPro: 2.065 ± 0.056
2.465GluGln: 2.465 ± 0.062
4.216GluArg: 4.216 ± 0.104
4.131GluSer: 4.131 ± 0.091
3.619GluThr: 3.619 ± 0.073
4.277GluVal: 4.277 ± 0.093
0.668GluTrp: 0.668 ± 0.034
2.504GluTyr: 2.504 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
3.607PheAla: 3.607 ± 0.069
0.485PheCys: 0.485 ± 0.028
3.302PheAsp: 3.302 ± 0.072
3.552PheGlu: 3.552 ± 0.082
2.342PhePhe: 2.342 ± 0.07
3.588PheGly: 3.588 ± 0.083
0.874PheHis: 0.874 ± 0.042
3.015PheIle: 3.015 ± 0.076
2.544PheLys: 2.544 ± 0.07
3.993PheLeu: 3.993 ± 0.102
1.115PheMet: 1.115 ± 0.045
1.857PheAsn: 1.857 ± 0.057
1.367PhePro: 1.367 ± 0.048
1.006PheGln: 1.006 ± 0.047
1.797PheArg: 1.797 ± 0.059
3.119PheSer: 3.119 ± 0.08
2.499PheThr: 2.499 ± 0.067
2.987PheVal: 2.987 ± 0.081
0.462PheTrp: 0.462 ± 0.032
1.622PheTyr: 1.622 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.284GlyAla: 5.284 ± 0.113
0.879GlyCys: 0.879 ± 0.039
3.636GlyAsp: 3.636 ± 0.08
4.682GlyGlu: 4.682 ± 0.098
3.496GlyPhe: 3.496 ± 0.078
4.896GlyGly: 4.896 ± 0.113
1.36GlyHis: 1.36 ± 0.053
5.551GlyIle: 5.551 ± 0.113
4.543GlyLys: 4.543 ± 0.084
5.609GlyLeu: 5.609 ± 0.116
2.129GlyMet: 2.129 ± 0.059
2.593GlyAsn: 2.593 ± 0.07
1.224GlyPro: 1.224 ± 0.051
1.644GlyGln: 1.644 ± 0.052
2.968GlyArg: 2.968 ± 0.082
4.197GlySer: 4.197 ± 0.094
3.434GlyThr: 3.434 ± 0.08
5.04GlyVal: 5.04 ± 0.093
0.833GlyTrp: 0.833 ± 0.041
2.982GlyTyr: 2.982 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.778HisAla: 1.778 ± 0.048
0.27HisCys: 0.27 ± 0.02
1.236HisAsp: 1.236 ± 0.049
1.532HisGlu: 1.532 ± 0.054
1.234HisPhe: 1.234 ± 0.039
1.514HisGly: 1.514 ± 0.055
0.727HisHis: 0.727 ± 0.04
1.696HisIle: 1.696 ± 0.051
1.154HisLys: 1.154 ± 0.042
2.219HisLeu: 2.219 ± 0.061
0.578HisMet: 0.578 ± 0.032
0.974HisAsn: 0.974 ± 0.044
1.246HisPro: 1.246 ± 0.05
0.76HisGln: 0.76 ± 0.037
1.127HisArg: 1.127 ± 0.044
1.27HisSer: 1.27 ± 0.043
1.3HisThr: 1.3 ± 0.049
1.284HisVal: 1.284 ± 0.046
0.19HisTrp: 0.19 ± 0.018
0.983HisTyr: 0.983 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
7.439IleAla: 7.439 ± 0.12
0.665IleCys: 0.665 ± 0.035
5.577IleAsp: 5.577 ± 0.107
6.023IleGlu: 6.023 ± 0.12
2.655IlePhe: 2.655 ± 0.084
5.615IleGly: 5.615 ± 0.113
1.502IleHis: 1.502 ± 0.045
4.848IleIle: 4.848 ± 0.11
4.176IleLys: 4.176 ± 0.099
6.395IleLeu: 6.395 ± 0.123
1.565IleMet: 1.565 ± 0.047
3.051IleAsn: 3.051 ± 0.073
2.693IlePro: 2.693 ± 0.063
2.02IleGln: 2.02 ± 0.062
3.69IleArg: 3.69 ± 0.079
4.386IleSer: 4.386 ± 0.089
4.085IleThr: 4.085 ± 0.086
5.376IleVal: 5.376 ± 0.111
0.457IleTrp: 0.457 ± 0.028
2.139IleTyr: 2.139 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.27LysAla: 5.27 ± 0.091
0.452LysCys: 0.452 ± 0.029
2.712LysAsp: 2.712 ± 0.065
5.691LysGlu: 5.691 ± 0.111
1.904LysPhe: 1.904 ± 0.055
3.65LysGly: 3.65 ± 0.078
1.376LysHis: 1.376 ± 0.054
4.926LysIle: 4.926 ± 0.094
4.523LysLys: 4.523 ± 0.104
5.539LysLeu: 5.539 ± 0.099
1.977LysMet: 1.977 ± 0.06
3.174LysAsn: 3.174 ± 0.076
2.196LysPro: 2.196 ± 0.056
1.98LysGln: 1.98 ± 0.07
3.235LysArg: 3.235 ± 0.073
3.761LysSer: 3.761 ± 0.088
3.835LysThr: 3.835 ± 0.083
3.572LysVal: 3.572 ± 0.079
0.44LysTrp: 0.44 ± 0.031
1.893LysTyr: 1.893 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
7.382LeuAla: 7.382 ± 0.133
0.987LeuCys: 0.987 ± 0.043
5.251LeuAsp: 5.251 ± 0.108
6.804LeuGlu: 6.804 ± 0.122
4.799LeuPhe: 4.799 ± 0.111
6.428LeuGly: 6.428 ± 0.115
2.279LeuHis: 2.279 ± 0.076
7.089LeuIle: 7.089 ± 0.122
6.56LeuLys: 6.56 ± 0.129
9.194LeuLeu: 9.194 ± 0.151
2.586LeuMet: 2.586 ± 0.069
4.235LeuAsn: 4.235 ± 0.099
3.816LeuPro: 3.816 ± 0.084
2.984LeuGln: 2.984 ± 0.085
4.947LeuArg: 4.947 ± 0.101
7.828LeuSer: 7.828 ± 0.114
4.633LeuThr: 4.633 ± 0.098
5.435LeuVal: 5.435 ± 0.102
0.834LeuTrp: 0.834 ± 0.039
3.515LeuTyr: 3.515 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
2.414MetAla: 2.414 ± 0.077
0.208MetCys: 0.208 ± 0.02
1.379MetAsp: 1.379 ± 0.045
1.769MetGlu: 1.769 ± 0.057
1.049MetPhe: 1.049 ± 0.044
1.994MetGly: 1.994 ± 0.061
0.625MetHis: 0.625 ± 0.032
2.26MetIle: 2.26 ± 0.06
1.911MetLys: 1.911 ± 0.057
2.638MetLeu: 2.638 ± 0.065
1.019MetMet: 1.019 ± 0.043
1.402MetAsn: 1.402 ± 0.047
1.006MetPro: 1.006 ± 0.036
1.068MetGln: 1.068 ± 0.046
1.435MetArg: 1.435 ± 0.053
1.848MetSer: 1.848 ± 0.055
1.404MetThr: 1.404 ± 0.05
1.848MetVal: 1.848 ± 0.062
0.18MetTrp: 0.18 ± 0.019
0.673MetTyr: 0.673 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.891AsnAla: 3.891 ± 0.074
0.374AsnCys: 0.374 ± 0.025
2.537AsnAsp: 2.537 ± 0.076
2.939AsnGlu: 2.939 ± 0.081
1.791AsnPhe: 1.791 ± 0.06
2.93AsnGly: 2.93 ± 0.081
0.86AsnHis: 0.86 ± 0.037
3.022AsnIle: 3.022 ± 0.078
2.091AsnLys: 2.091 ± 0.071
3.811AsnLeu: 3.811 ± 0.096
0.857AsnMet: 0.857 ± 0.043
1.646AsnAsn: 1.646 ± 0.056
2.241AsnPro: 2.241 ± 0.057
1.158AsnGln: 1.158 ± 0.049
2.186AsnArg: 2.186 ± 0.06
2.118AsnSer: 2.118 ± 0.068
2.357AsnThr: 2.357 ± 0.078
2.93AsnVal: 2.93 ± 0.079
0.254AsnTrp: 0.254 ± 0.021
1.466AsnTyr: 1.466 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.534ProAla: 2.534 ± 0.078
0.336ProCys: 0.336 ± 0.027
2.009ProAsp: 2.009 ± 0.061
2.556ProGlu: 2.556 ± 0.061
1.907ProPhe: 1.907 ± 0.05
1.743ProGly: 1.743 ± 0.056
0.917ProHis: 0.917 ± 0.044
2.679ProIle: 2.679 ± 0.066
2.489ProLys: 2.489 ± 0.067
3.787ProLeu: 3.787 ± 0.069
0.992ProMet: 0.992 ± 0.041
1.405ProAsn: 1.405 ± 0.057
1.106ProPro: 1.106 ± 0.053
1.146ProGln: 1.146 ± 0.044
1.338ProArg: 1.338 ± 0.055
2.496ProSer: 2.496 ± 0.068
2.001ProThr: 2.001 ± 0.068
2.349ProVal: 2.349 ± 0.07
0.334ProTrp: 0.334 ± 0.024
1.691ProTyr: 1.691 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.12GlnAla: 2.12 ± 0.063
0.284GlnCys: 0.284 ± 0.023
1.239GlnAsp: 1.239 ± 0.049
2.238GlnGlu: 2.238 ± 0.073
1.22GlnPhe: 1.22 ± 0.045
1.842GlnGly: 1.842 ± 0.062
0.649GlnHis: 0.649 ± 0.032
2.603GlnIle: 2.603 ± 0.069
2.472GlnLys: 2.472 ± 0.068
2.683GlnLeu: 2.683 ± 0.082
1.073GlnMet: 1.073 ± 0.041
1.779GlnAsn: 1.779 ± 0.05
0.917GlnPro: 0.917 ± 0.037
0.968GlnGln: 0.968 ± 0.043
1.533GlnArg: 1.533 ± 0.056
2.193GlnSer: 2.193 ± 0.063
1.887GlnThr: 1.887 ± 0.053
1.705GlnVal: 1.705 ± 0.051
0.313GlnTrp: 0.313 ± 0.025
1.045GlnTyr: 1.045 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.46ArgAla: 3.46 ± 0.08
0.447ArgCys: 0.447 ± 0.029
2.517ArgAsp: 2.517 ± 0.066
3.588ArgGlu: 3.588 ± 0.095
2.844ArgPhe: 2.844 ± 0.076
2.75ArgGly: 2.75 ± 0.067
1.295ArgHis: 1.295 ± 0.044
3.754ArgIle: 3.754 ± 0.086
2.437ArgLys: 2.437 ± 0.063
5.078ArgLeu: 5.078 ± 0.1
1.362ArgMet: 1.362 ± 0.047
2.015ArgAsn: 2.015 ± 0.061
1.523ArgPro: 1.523 ± 0.056
1.426ArgGln: 1.426 ± 0.051
2.465ArgArg: 2.465 ± 0.065
3.188ArgSer: 3.188 ± 0.081
2.163ArgThr: 2.163 ± 0.065
3.024ArgVal: 3.024 ± 0.068
0.415ArgTrp: 0.415 ± 0.03
2.375ArgTyr: 2.375 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
5.393SerAla: 5.393 ± 0.114
0.623SerCys: 0.623 ± 0.039
3.681SerAsp: 3.681 ± 0.088
4.052SerGlu: 4.052 ± 0.074
3.044SerPhe: 3.044 ± 0.082
4.779SerGly: 4.779 ± 0.093
1.528SerHis: 1.528 ± 0.047
4.616SerIle: 4.616 ± 0.093
3.441SerLys: 3.441 ± 0.077
6.454SerLeu: 6.454 ± 0.119
1.784SerMet: 1.784 ± 0.05
2.297SerAsn: 2.297 ± 0.065
2.165SerPro: 2.165 ± 0.062
1.821SerGln: 1.821 ± 0.057
2.866SerArg: 2.866 ± 0.074
3.811SerSer: 3.811 ± 0.091
3.129SerThr: 3.129 ± 0.069
4.436SerVal: 4.436 ± 0.089
0.479SerTrp: 0.479 ± 0.029
2.257SerTyr: 2.257 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
4.374ThrAla: 4.374 ± 0.092
0.408ThrCys: 0.408 ± 0.028
2.768ThrAsp: 2.768 ± 0.077
2.607ThrGlu: 2.607 ± 0.067
2.477ThrPhe: 2.477 ± 0.074
3.385ThrGly: 3.385 ± 0.069
1.257ThrHis: 1.257 ± 0.044
4.01ThrIle: 4.01 ± 0.077
2.944ThrLys: 2.944 ± 0.071
6.53ThrLeu: 6.53 ± 0.108
1.352ThrMet: 1.352 ± 0.051
1.819ThrAsn: 1.819 ± 0.061
2.804ThrPro: 2.804 ± 0.072
1.902ThrGln: 1.902 ± 0.067
2.179ThrArg: 2.179 ± 0.056
2.87ThrSer: 2.87 ± 0.076
2.797ThrThr: 2.797 ± 0.075
3.73ThrVal: 3.73 ± 0.093
0.338ThrTrp: 0.338 ± 0.025
1.843ThrTyr: 1.843 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
5.58ValAla: 5.58 ± 0.115
0.767ValCys: 0.767 ± 0.035
3.678ValAsp: 3.678 ± 0.079
4.49ValGlu: 4.49 ± 0.083
2.75ValPhe: 2.75 ± 0.069
4.304ValGly: 4.304 ± 0.101
1.431ValHis: 1.431 ± 0.048
5.059ValIle: 5.059 ± 0.1
3.82ValLys: 3.82 ± 0.092
6.207ValLeu: 6.207 ± 0.11
2.011ValMet: 2.011 ± 0.062
2.584ValAsn: 2.584 ± 0.073
2.323ValPro: 2.323 ± 0.061
1.949ValGln: 1.949 ± 0.056
3.055ValArg: 3.055 ± 0.073
4.554ValSer: 4.554 ± 0.088
3.365ValThr: 3.365 ± 0.084
4.763ValVal: 4.763 ± 0.104
0.542ValTrp: 0.542 ± 0.034
2.262ValTyr: 2.262 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.531TrpAla: 0.531 ± 0.033
0.113TrpCys: 0.113 ± 0.014
0.478TrpAsp: 0.478 ± 0.033
0.514TrpGlu: 0.514 ± 0.034
0.426TrpPhe: 0.426 ± 0.028
0.59TrpGly: 0.59 ± 0.036
0.23TrpHis: 0.23 ± 0.021
0.71TrpIle: 0.71 ± 0.041
0.426TrpLys: 0.426 ± 0.028
0.95TrpLeu: 0.95 ± 0.042
0.332TrpMet: 0.332 ± 0.021
0.369TrpAsn: 0.369 ± 0.024
0.211TrpPro: 0.211 ± 0.017
0.284TrpGln: 0.284 ± 0.022
0.336TrpArg: 0.336 ± 0.025
0.447TrpSer: 0.447 ± 0.028
0.299TrpThr: 0.299 ± 0.022
0.604TrpVal: 0.604 ± 0.037
0.111TrpTrp: 0.111 ± 0.016
0.336TrpTyr: 0.336 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.256TyrAla: 3.256 ± 0.081
0.325TyrCys: 0.325 ± 0.024
2.404TyrAsp: 2.404 ± 0.075
2.518TyrGlu: 2.518 ± 0.084
1.769TyrPhe: 1.769 ± 0.057
2.551TyrGly: 2.551 ± 0.075
0.89TyrHis: 0.89 ± 0.037
2.011TyrIle: 2.011 ± 0.055
2.065TyrLys: 2.065 ± 0.064
3.728TyrLeu: 3.728 ± 0.085
0.798TyrMet: 0.798 ± 0.037
1.488TyrAsn: 1.488 ± 0.057
1.45TyrPro: 1.45 ± 0.049
1.234TyrGln: 1.234 ± 0.043
2.15TyrArg: 2.15 ± 0.064
2.042TyrSer: 2.042 ± 0.061
1.966TyrThr: 1.966 ± 0.07
2.068TyrVal: 2.068 ± 0.061
0.369TyrTrp: 0.369 ± 0.029
1.385TyrTyr: 1.385 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2005 proteins (577772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski