Amino acid dipepetide frequency for Acidianus tailed spindle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.335AlaCys: 0.335 ± 0.127
2.106AlaAsp: 2.106 ± 0.39
3.973AlaGlu: 3.973 ± 0.575
1.58AlaPhe: 1.58 ± 0.285
2.202AlaGly: 2.202 ± 0.338
0.527AlaHis: 0.527 ± 0.171
5.074AlaIle: 5.074 ± 0.647
4.213AlaLys: 4.213 ± 0.544
5.457AlaLeu: 5.457 ± 0.557
0.862AlaMet: 0.862 ± 0.216
3.112AlaAsn: 3.112 ± 0.416
1.388AlaPro: 1.388 ± 0.299
1.867AlaGln: 1.867 ± 0.613
1.628AlaArg: 1.628 ± 0.371
3.973AlaSer: 3.973 ± 0.461
2.25AlaThr: 2.25 ± 0.371
4.26AlaVal: 4.26 ± 0.453
0.574AlaTrp: 0.574 ± 0.203
2.824AlaTyr: 2.824 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.287CysAla: 0.287 ± 0.092
0.239CysCys: 0.239 ± 0.092
0.479CysAsp: 0.479 ± 0.135
0.718CysGlu: 0.718 ± 0.212
0.527CysPhe: 0.527 ± 0.189
0.814CysGly: 0.814 ± 0.217
0.191CysHis: 0.191 ± 0.096
1.149CysIle: 1.149 ± 0.261
0.718CysLys: 0.718 ± 0.196
0.862CysLeu: 0.862 ± 0.254
0.191CysMet: 0.191 ± 0.093
0.91CysAsn: 0.91 ± 0.236
0.622CysPro: 0.622 ± 0.201
0.096CysGln: 0.096 ± 0.075
0.335CysArg: 0.335 ± 0.138
0.527CysSer: 0.527 ± 0.158
0.479CysThr: 0.479 ± 0.155
0.574CysVal: 0.574 ± 0.17
0.096CysTrp: 0.096 ± 0.068
0.814CysTyr: 0.814 ± 0.218
0.0CysXaa: 0.0 ± 0.0
Asp
2.968AspAla: 2.968 ± 0.357
0.431AspCys: 0.431 ± 0.184
4.069AspAsp: 4.069 ± 0.537
4.26AspGlu: 4.26 ± 0.596
2.776AspPhe: 2.776 ± 0.389
2.298AspGly: 2.298 ± 0.345
0.383AspHis: 0.383 ± 0.15
5.936AspIle: 5.936 ± 0.575
3.399AspLys: 3.399 ± 0.445
5.457AspLeu: 5.457 ± 0.773
0.766AspMet: 0.766 ± 0.255
2.872AspAsn: 2.872 ± 0.406
1.101AspPro: 1.101 ± 0.208
1.149AspGln: 1.149 ± 0.231
1.771AspArg: 1.771 ± 0.32
2.729AspSer: 2.729 ± 0.418
1.819AspThr: 1.819 ± 0.29
4.213AspVal: 4.213 ± 0.513
0.527AspTrp: 0.527 ± 0.145
3.016AspTyr: 3.016 ± 0.349
0.0AspXaa: 0.0 ± 0.0
Glu
3.494GluAla: 3.494 ± 0.495
0.91GluCys: 0.91 ± 0.219
3.542GluAsp: 3.542 ± 0.55
6.702GluGlu: 6.702 ± 1.016
2.202GluPhe: 2.202 ± 0.339
3.351GluGly: 3.351 ± 0.454
0.766GluHis: 0.766 ± 0.219
7.42GluIle: 7.42 ± 0.573
6.079GluLys: 6.079 ± 0.606
7.468GluLeu: 7.468 ± 0.695
1.101GluMet: 1.101 ± 0.258
4.308GluAsn: 4.308 ± 0.383
1.58GluPro: 1.58 ± 0.275
2.298GluGln: 2.298 ± 0.369
2.681GluArg: 2.681 ± 0.457
2.681GluSer: 2.681 ± 0.413
1.628GluThr: 1.628 ± 0.232
4.452GluVal: 4.452 ± 0.511
0.431GluTrp: 0.431 ± 0.158
2.872GluTyr: 2.872 ± 0.44
0.0GluXaa: 0.0 ± 0.0
Phe
2.393PheAla: 2.393 ± 0.298
0.335PheCys: 0.335 ± 0.146
2.441PheAsp: 2.441 ± 0.337
2.441PheGlu: 2.441 ± 0.327
2.489PhePhe: 2.489 ± 0.581
1.628PheGly: 1.628 ± 0.288
0.622PheHis: 0.622 ± 0.206
3.686PheIle: 3.686 ± 0.466
2.298PheLys: 2.298 ± 0.354
4.404PheLeu: 4.404 ± 0.511
1.053PheMet: 1.053 ± 0.198
2.298PheAsn: 2.298 ± 0.309
1.723PhePro: 1.723 ± 0.421
1.388PheGln: 1.388 ± 0.23
1.675PheArg: 1.675 ± 0.221
3.447PheSer: 3.447 ± 0.458
2.92PheThr: 2.92 ± 0.413
3.782PheVal: 3.782 ± 0.578
0.431PheTrp: 0.431 ± 0.164
3.255PheTyr: 3.255 ± 0.536
0.0PheXaa: 0.0 ± 0.0
Gly
2.011GlyAla: 2.011 ± 0.336
0.383GlyCys: 0.383 ± 0.147
3.686GlyAsp: 3.686 ± 0.399
3.207GlyGlu: 3.207 ± 0.396
3.255GlyPhe: 3.255 ± 0.493
1.963GlyGly: 1.963 ± 0.323
0.335GlyHis: 0.335 ± 0.135
4.787GlyIle: 4.787 ± 0.582
4.308GlyLys: 4.308 ± 0.395
3.399GlyLeu: 3.399 ± 0.345
0.91GlyMet: 0.91 ± 0.17
3.064GlyAsn: 3.064 ± 0.437
0.0GlyPro: 0.0 ± 0.0
1.245GlyGln: 1.245 ± 0.277
1.436GlyArg: 1.436 ± 0.31
2.729GlySer: 2.729 ± 0.498
2.106GlyThr: 2.106 ± 0.357
4.165GlyVal: 4.165 ± 0.434
0.527GlyTrp: 0.527 ± 0.17
2.106GlyTyr: 2.106 ± 0.361
0.0GlyXaa: 0.0 ± 0.0
His
0.479HisAla: 0.479 ± 0.182
0.191HisCys: 0.191 ± 0.079
0.622HisAsp: 0.622 ± 0.19
0.91HisGlu: 0.91 ± 0.239
0.383HisPhe: 0.383 ± 0.162
0.91HisGly: 0.91 ± 0.21
0.383HisHis: 0.383 ± 0.133
1.101HisIle: 1.101 ± 0.236
0.862HisLys: 0.862 ± 0.24
0.957HisLeu: 0.957 ± 0.188
0.431HisMet: 0.431 ± 0.14
0.718HisAsn: 0.718 ± 0.188
0.335HisPro: 0.335 ± 0.141
0.096HisGln: 0.096 ± 0.07
0.766HisArg: 0.766 ± 0.228
0.957HisSer: 0.957 ± 0.213
0.527HisThr: 0.527 ± 0.166
0.957HisVal: 0.957 ± 0.224
0.0HisTrp: 0.0 ± 0.0
0.67HisTyr: 0.67 ± 0.156
0.0HisXaa: 0.0 ± 0.0
Ile
5.218IleAla: 5.218 ± 0.474
0.622IleCys: 0.622 ± 0.206
5.17IleAsp: 5.17 ± 0.6
5.84IleGlu: 5.84 ± 0.478
3.447IlePhe: 3.447 ± 0.468
3.83IleGly: 3.83 ± 0.422
1.628IleHis: 1.628 ± 0.33
8.617IleIle: 8.617 ± 0.868
7.755IleLys: 7.755 ± 0.728
9.718IleLeu: 9.718 ± 0.842
2.25IleMet: 2.25 ± 0.366
6.415IleAsn: 6.415 ± 0.571
3.877IlePro: 3.877 ± 0.593
2.393IleGln: 2.393 ± 0.333
3.877IleArg: 3.877 ± 0.569
6.798IleSer: 6.798 ± 0.67
5.122IleThr: 5.122 ± 0.477
5.266IleVal: 5.266 ± 0.665
0.479IleTrp: 0.479 ± 0.129
4.643IleTyr: 4.643 ± 0.418
0.0IleXaa: 0.0 ± 0.0
Lys
3.399LysAla: 3.399 ± 0.417
0.862LysCys: 0.862 ± 0.254
4.069LysAsp: 4.069 ± 0.482
6.175LysGlu: 6.175 ± 0.689
3.351LysPhe: 3.351 ± 0.411
2.729LysGly: 2.729 ± 0.44
0.766LysHis: 0.766 ± 0.176
7.994LysIle: 7.994 ± 0.573
7.851LysLys: 7.851 ± 1.021
10.962LysLeu: 10.962 ± 1.051
1.819LysMet: 1.819 ± 0.326
4.787LysAsn: 4.787 ± 0.629
2.537LysPro: 2.537 ± 0.382
1.915LysGln: 1.915 ± 0.438
2.633LysArg: 2.633 ± 0.487
3.542LysSer: 3.542 ± 0.467
3.447LysThr: 3.447 ± 0.373
5.744LysVal: 5.744 ± 0.639
0.527LysTrp: 0.527 ± 0.167
5.17LysTyr: 5.17 ± 0.459
0.0LysXaa: 0.0 ± 0.0
Leu
6.175LeuAla: 6.175 ± 0.517
1.197LeuCys: 1.197 ± 0.19
4.5LeuAsp: 4.5 ± 0.583
5.409LeuGlu: 5.409 ± 0.67
4.5LeuPhe: 4.5 ± 0.422
4.165LeuGly: 4.165 ± 0.466
1.34LeuHis: 1.34 ± 0.262
8.234LeuIle: 8.234 ± 0.949
8.425LeuLys: 8.425 ± 0.832
8.712LeuLeu: 8.712 ± 0.845
2.202LeuMet: 2.202 ± 0.288
5.697LeuAsn: 5.697 ± 0.706
4.5LeuPro: 4.5 ± 0.388
3.59LeuGln: 3.59 ± 0.793
4.835LeuArg: 4.835 ± 0.664
7.899LeuSer: 7.899 ± 0.885
5.649LeuThr: 5.649 ± 0.649
6.127LeuVal: 6.127 ± 0.503
0.622LeuTrp: 0.622 ± 0.177
5.314LeuTyr: 5.314 ± 0.526
0.0LeuXaa: 0.0 ± 0.0
Met
0.766MetAla: 0.766 ± 0.199
0.144MetCys: 0.144 ± 0.083
0.91MetAsp: 0.91 ± 0.222
1.532MetGlu: 1.532 ± 0.269
1.053MetPhe: 1.053 ± 0.219
1.005MetGly: 1.005 ± 0.229
0.239MetHis: 0.239 ± 0.089
1.149MetIle: 1.149 ± 0.25
2.058MetLys: 2.058 ± 0.324
2.393MetLeu: 2.393 ± 0.466
0.527MetMet: 0.527 ± 0.164
1.34MetAsn: 1.34 ± 0.253
0.527MetPro: 0.527 ± 0.133
0.814MetGln: 0.814 ± 0.224
0.718MetArg: 0.718 ± 0.192
1.484MetSer: 1.484 ± 0.261
1.292MetThr: 1.292 ± 0.243
1.245MetVal: 1.245 ± 0.255
0.191MetTrp: 0.191 ± 0.079
0.814MetTyr: 0.814 ± 0.209
0.0MetXaa: 0.0 ± 0.0
Asn
3.303AsnAla: 3.303 ± 0.418
0.766AsnCys: 0.766 ± 0.186
3.159AsnAsp: 3.159 ± 0.521
4.452AsnGlu: 4.452 ± 0.502
2.393AsnPhe: 2.393 ± 0.277
3.973AsnGly: 3.973 ± 0.514
0.862AsnHis: 0.862 ± 0.196
5.457AsnIle: 5.457 ± 0.465
5.026AsnLys: 5.026 ± 0.45
5.17AsnLeu: 5.17 ± 0.791
1.053AsnMet: 1.053 ± 0.283
5.409AsnAsn: 5.409 ± 0.892
2.298AsnPro: 2.298 ± 0.487
1.58AsnGln: 1.58 ± 0.255
1.963AsnArg: 1.963 ± 0.329
4.356AsnSer: 4.356 ± 0.632
3.973AsnThr: 3.973 ± 0.463
4.643AsnVal: 4.643 ± 0.411
0.239AsnTrp: 0.239 ± 0.117
2.729AsnTyr: 2.729 ± 0.408
0.0AsnXaa: 0.0 ± 0.0
Pro
1.58ProAla: 1.58 ± 0.311
0.383ProCys: 0.383 ± 0.137
1.867ProAsp: 1.867 ± 0.248
1.915ProGlu: 1.915 ± 0.344
1.819ProPhe: 1.819 ± 0.387
1.963ProGly: 1.963 ± 0.306
0.383ProHis: 0.383 ± 0.155
2.585ProIle: 2.585 ± 0.316
1.963ProLys: 1.963 ± 0.235
3.351ProLeu: 3.351 ± 0.414
0.431ProMet: 0.431 ± 0.14
1.819ProAsn: 1.819 ± 0.388
2.729ProPro: 2.729 ± 0.595
1.484ProGln: 1.484 ± 0.303
1.149ProArg: 1.149 ± 0.277
4.165ProSer: 4.165 ± 0.885
3.016ProThr: 3.016 ± 0.547
2.058ProVal: 2.058 ± 0.391
0.383ProTrp: 0.383 ± 0.172
1.915ProTyr: 1.915 ± 0.442
0.0ProXaa: 0.0 ± 0.0
Gln
2.011GlnAla: 2.011 ± 0.529
0.479GlnCys: 0.479 ± 0.154
0.766GlnAsp: 0.766 ± 0.174
1.484GlnGlu: 1.484 ± 0.334
0.957GlnPhe: 0.957 ± 0.201
1.436GlnGly: 1.436 ± 0.297
0.048GlnHis: 0.048 ± 0.049
2.441GlnIle: 2.441 ± 0.588
2.393GlnLys: 2.393 ± 0.362
3.447GlnLeu: 3.447 ± 0.512
0.527GlnMet: 0.527 ± 0.172
1.771GlnAsn: 1.771 ± 0.401
1.34GlnPro: 1.34 ± 0.314
1.819GlnGln: 1.819 ± 0.465
1.197GlnArg: 1.197 ± 0.247
2.489GlnSer: 2.489 ± 0.596
1.867GlnThr: 1.867 ± 0.254
1.484GlnVal: 1.484 ± 0.277
0.096GlnTrp: 0.096 ± 0.064
2.441GlnTyr: 2.441 ± 0.407
0.0GlnXaa: 0.0 ± 0.0
Arg
1.436ArgAla: 1.436 ± 0.26
0.335ArgCys: 0.335 ± 0.155
1.915ArgAsp: 1.915 ± 0.406
3.159ArgGlu: 3.159 ± 0.546
2.011ArgPhe: 2.011 ± 0.436
1.484ArgGly: 1.484 ± 0.319
0.383ArgHis: 0.383 ± 0.159
3.542ArgIle: 3.542 ± 0.519
3.83ArgLys: 3.83 ± 0.639
3.159ArgLeu: 3.159 ± 0.439
1.149ArgMet: 1.149 ± 0.254
1.915ArgAsn: 1.915 ± 0.321
0.622ArgPro: 0.622 ± 0.249
1.005ArgGln: 1.005 ± 0.216
1.388ArgArg: 1.388 ± 0.355
2.058ArgSer: 2.058 ± 0.374
1.58ArgThr: 1.58 ± 0.33
2.633ArgVal: 2.633 ± 0.436
0.287ArgTrp: 0.287 ± 0.132
2.011ArgTyr: 2.011 ± 0.34
0.0ArgXaa: 0.0 ± 0.0
Ser
3.973SerAla: 3.973 ± 0.489
0.814SerCys: 0.814 ± 0.222
2.489SerAsp: 2.489 ± 0.291
3.59SerGlu: 3.59 ± 0.472
3.686SerPhe: 3.686 ± 0.531
3.159SerGly: 3.159 ± 0.658
1.388SerHis: 1.388 ± 0.267
6.367SerIle: 6.367 ± 0.449
4.548SerLys: 4.548 ± 0.46
7.324SerLeu: 7.324 ± 0.8
1.388SerMet: 1.388 ± 0.337
3.973SerAsn: 3.973 ± 0.494
3.447SerPro: 3.447 ± 0.623
2.25SerGln: 2.25 ± 0.414
2.633SerArg: 2.633 ± 0.449
9.191SerSer: 9.191 ± 2.93
5.792SerThr: 5.792 ± 1.912
4.26SerVal: 4.26 ± 0.582
0.718SerTrp: 0.718 ± 0.235
3.686SerTyr: 3.686 ± 0.468
0.0SerXaa: 0.0 ± 0.0
Thr
2.633ThrAla: 2.633 ± 0.434
0.335ThrCys: 0.335 ± 0.115
2.585ThrAsp: 2.585 ± 0.364
2.585ThrGlu: 2.585 ± 0.354
2.441ThrPhe: 2.441 ± 0.317
2.346ThrGly: 2.346 ± 0.389
0.479ThrHis: 0.479 ± 0.179
5.457ThrIle: 5.457 ± 0.499
4.213ThrLys: 4.213 ± 0.552
5.409ThrLeu: 5.409 ± 0.494
0.91ThrMet: 0.91 ± 0.262
2.968ThrAsn: 2.968 ± 0.331
3.973ThrPro: 3.973 ± 0.942
2.441ThrGln: 2.441 ± 0.702
1.292ThrArg: 1.292 ± 0.293
5.266ThrSer: 5.266 ± 1.182
4.308ThrThr: 4.308 ± 1.182
3.973ThrVal: 3.973 ± 0.777
0.239ThrTrp: 0.239 ± 0.108
1.867ThrTyr: 1.867 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
2.968ValAla: 2.968 ± 0.337
1.053ValCys: 1.053 ± 0.229
3.782ValAsp: 3.782 ± 0.447
3.83ValGlu: 3.83 ± 0.427
2.824ValPhe: 2.824 ± 0.444
3.351ValGly: 3.351 ± 0.399
0.766ValHis: 0.766 ± 0.223
6.654ValIle: 6.654 ± 0.807
5.84ValLys: 5.84 ± 0.632
6.223ValLeu: 6.223 ± 0.518
1.484ValMet: 1.484 ± 0.251
5.218ValAsn: 5.218 ± 0.625
2.202ValPro: 2.202 ± 0.336
1.436ValGln: 1.436 ± 0.237
2.154ValArg: 2.154 ± 0.436
5.888ValSer: 5.888 ± 0.721
4.643ValThr: 4.643 ± 0.58
5.266ValVal: 5.266 ± 0.505
0.335ValTrp: 0.335 ± 0.127
3.973ValTyr: 3.973 ± 0.448
0.0ValXaa: 0.0 ± 0.0
Trp
0.144TrpAla: 0.144 ± 0.092
0.287TrpCys: 0.287 ± 0.144
0.479TrpAsp: 0.479 ± 0.144
0.574TrpGlu: 0.574 ± 0.197
0.527TrpPhe: 0.527 ± 0.132
0.431TrpGly: 0.431 ± 0.162
0.048TrpHis: 0.048 ± 0.04
0.431TrpIle: 0.431 ± 0.155
0.862TrpLys: 0.862 ± 0.241
0.479TrpLeu: 0.479 ± 0.164
0.239TrpMet: 0.239 ± 0.118
0.527TrpAsn: 0.527 ± 0.13
0.0TrpPro: 0.0 ± 0.0
0.144TrpGln: 0.144 ± 0.072
0.431TrpArg: 0.431 ± 0.195
0.527TrpSer: 0.527 ± 0.175
0.287TrpThr: 0.287 ± 0.127
0.527TrpVal: 0.527 ± 0.189
0.048TrpTrp: 0.048 ± 0.047
0.239TrpTyr: 0.239 ± 0.096
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.968TyrAla: 2.968 ± 0.414
0.527TyrCys: 0.527 ± 0.146
3.303TyrAsp: 3.303 ± 0.401
3.207TyrGlu: 3.207 ± 0.419
2.489TyrPhe: 2.489 ± 0.422
2.585TyrGly: 2.585 ± 0.325
0.718TyrHis: 0.718 ± 0.171
4.883TyrIle: 4.883 ± 0.568
3.638TyrLys: 3.638 ± 0.378
4.787TyrLeu: 4.787 ± 0.477
0.862TyrMet: 0.862 ± 0.232
3.686TyrAsn: 3.686 ± 0.463
2.154TyrPro: 2.154 ± 0.415
1.484TyrGln: 1.484 ± 0.34
1.34TyrArg: 1.34 ± 0.302
3.973TyrSer: 3.973 ± 0.632
3.016TyrThr: 3.016 ± 0.395
4.26TyrVal: 4.26 ± 0.687
0.479TyrTrp: 0.479 ± 0.24
4.117TyrTyr: 4.117 ± 0.435
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (20891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski