Amino acid dipepetide frequency for Rhizobium mesoamericanum STM3625

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.044AlaAla: 15.044 ± 0.136	1.023AlaCys: 1.023 ± 0.028	6.305AlaAsp: 6.305 ± 0.063	6.999AlaGlu: 6.999 ± 0.072	4.559AlaPhe: 4.559 ± 0.049	9.377AlaGly: 9.377 ± 0.075	2.179AlaHis: 2.179 ± 0.038	7.034AlaIle: 7.034 ± 0.064	4.541AlaLys: 4.541 ± 0.056	12.031AlaLeu: 12.031 ± 0.092	3.325AlaMet: 3.325 ± 0.046	3.183AlaAsn: 3.183 ± 0.044	4.61AlaPro: 4.61 ± 0.052	3.462AlaGln: 3.462 ± 0.047	7.466AlaArg: 7.466 ± 0.068	6.825AlaSer: 6.825 ± 0.07	5.904AlaThr: 5.904 ± 0.058	8.357AlaVal: 8.357 ± 0.079	1.371AlaTrp: 1.371 ± 0.029	2.547AlaTyr: 2.547 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.902CysAla: 0.902 ± 0.021	0.135CysCys: 0.135 ± 0.009	0.528CysAsp: 0.528 ± 0.017	0.452CysGlu: 0.452 ± 0.018	0.345CysPhe: 0.345 ± 0.015	0.928CysGly: 0.928 ± 0.026	0.261CysHis: 0.261 ± 0.013	0.437CysIle: 0.437 ± 0.017	0.226CysLys: 0.226 ± 0.011	0.896CysLeu: 0.896 ± 0.024	0.19CysMet: 0.19 ± 0.01	0.248CysAsn: 0.248 ± 0.013	0.412CysPro: 0.412 ± 0.015	0.254CysGln: 0.254 ± 0.011	0.622CysArg: 0.622 ± 0.02	0.523CysSer: 0.523 ± 0.016	0.423CysThr: 0.423 ± 0.015	0.64CysVal: 0.64 ± 0.02	0.109CysTrp: 0.109 ± 0.007	0.224CysTyr: 0.224 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.204AspAla: 6.204 ± 0.067	0.523AspCys: 0.523 ± 0.016	3.085AspAsp: 3.085 ± 0.055	3.484AspGlu: 3.484 ± 0.042	2.307AspPhe: 2.307 ± 0.034	4.846AspGly: 4.846 ± 0.054	1.256AspHis: 1.256 ± 0.028	3.345AspIle: 3.345 ± 0.048	1.964AspLys: 1.964 ± 0.037	5.7AspLeu: 5.7 ± 0.062	1.299AspMet: 1.299 ± 0.027	1.494AspAsn: 1.494 ± 0.029	3.15AspPro: 3.15 ± 0.051	1.785AspGln: 1.785 ± 0.032	4.049AspArg: 4.049 ± 0.048	2.245AspSer: 2.245 ± 0.037	2.487AspThr: 2.487 ± 0.041	4.22AspVal: 4.22 ± 0.05	0.962AspTrp: 0.962 ± 0.026	1.523AspTyr: 1.523 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.042GluAla: 7.042 ± 0.065	0.386GluCys: 0.386 ± 0.014	2.676GluAsp: 2.676 ± 0.044	3.427GluGlu: 3.427 ± 0.052	1.933GluPhe: 1.933 ± 0.039	4.027GluGly: 4.027 ± 0.054	1.266GluHis: 1.266 ± 0.027	3.83GluIle: 3.83 ± 0.051	2.699GluLys: 2.699 ± 0.039	5.469GluLeu: 5.469 ± 0.063	1.556GluMet: 1.556 ± 0.029	1.834GluAsn: 1.834 ± 0.035	2.494GluPro: 2.494 ± 0.039	2.124GluGln: 2.124 ± 0.037	4.778GluArg: 4.778 ± 0.061	2.449GluSer: 2.449 ± 0.037	3.485GluThr: 3.485 ± 0.043	3.734GluVal: 3.734 ± 0.051	0.736GluTrp: 0.736 ± 0.018	1.087GluTyr: 1.087 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.665PheAla: 4.665 ± 0.052	0.456PheCys: 0.456 ± 0.014	2.769PheAsp: 2.769 ± 0.036	2.241PheGlu: 2.241 ± 0.037	1.652PhePhe: 1.652 ± 0.032	3.703PheGly: 3.703 ± 0.046	0.845PheHis: 0.845 ± 0.022	1.889PheIle: 1.889 ± 0.032	1.248PheLys: 1.248 ± 0.028	3.618PheLeu: 3.618 ± 0.055	0.892PheMet: 0.892 ± 0.02	1.246PheAsn: 1.246 ± 0.029	1.67PhePro: 1.67 ± 0.036	1.1PheGln: 1.1 ± 0.024	2.341PheArg: 2.341 ± 0.038	2.579PheSer: 2.579 ± 0.036	1.98PheThr: 1.98 ± 0.038	3.065PheVal: 3.065 ± 0.04	0.566PheTrp: 0.566 ± 0.017	1.038PheTyr: 1.038 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.112GlyAla: 8.112 ± 0.072	0.833GlyCys: 0.833 ± 0.023	4.205GlyAsp: 4.205 ± 0.05	4.526GlyGlu: 4.526 ± 0.05	3.62GlyPhe: 3.62 ± 0.047	6.557GlyGly: 6.557 ± 0.071	1.912GlyHis: 1.912 ± 0.034	4.937GlyIle: 4.937 ± 0.055	3.733GlyLys: 3.733 ± 0.056	8.3GlyLeu: 8.3 ± 0.081	2.242GlyMet: 2.242 ± 0.031	2.432GlyAsn: 2.432 ± 0.042	3.059GlyPro: 3.059 ± 0.043	2.664GlyGln: 2.664 ± 0.04	5.597GlyArg: 5.597 ± 0.061	4.769GlySer: 4.769 ± 0.055	4.38GlyThr: 4.38 ± 0.057	5.686GlyVal: 5.686 ± 0.056	1.234GlyTrp: 1.234 ± 0.025	2.317GlyTyr: 2.317 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.115HisAla: 2.115 ± 0.034	0.222HisCys: 0.222 ± 0.011	1.258HisAsp: 1.258 ± 0.026	1.15HisGlu: 1.15 ± 0.027	1.013HisPhe: 1.013 ± 0.025	1.874HisGly: 1.874 ± 0.032	0.631HisHis: 0.631 ± 0.022	1.055HisIle: 1.055 ± 0.025	0.582HisLys: 0.582 ± 0.017	2.185HisLeu: 2.185 ± 0.037	0.58HisMet: 0.58 ± 0.019	0.549HisAsn: 0.549 ± 0.02	1.278HisPro: 1.278 ± 0.03	0.621HisGln: 0.621 ± 0.019	1.466HisArg: 1.466 ± 0.034	1.121HisSer: 1.121 ± 0.026	0.848HisThr: 0.848 ± 0.021	1.57HisVal: 1.57 ± 0.027	0.332HisTrp: 0.332 ± 0.014	0.598HisTyr: 0.598 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.772IleAla: 7.772 ± 0.081	0.599IleCys: 0.599 ± 0.019	3.936IleAsp: 3.936 ± 0.048	3.758IleGlu: 3.758 ± 0.047	2.087IlePhe: 2.087 ± 0.037	5.401IleGly: 5.401 ± 0.061	1.022IleHis: 1.022 ± 0.024	2.836IleIle: 2.836 ± 0.044	1.775IleLys: 1.775 ± 0.036	4.891IleLeu: 4.891 ± 0.054	1.173IleMet: 1.173 ± 0.025	1.688IleAsn: 1.688 ± 0.032	2.557IlePro: 2.557 ± 0.036	1.355IleGln: 1.355 ± 0.03	3.503IleArg: 3.503 ± 0.04	3.606IleSer: 3.606 ± 0.044	2.844IleThr: 2.844 ± 0.041	4.7IleVal: 4.7 ± 0.06	0.668IleTrp: 0.668 ± 0.02	1.314IleTyr: 1.314 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.828LysAla: 4.828 ± 0.063	0.188LysCys: 0.188 ± 0.011	2.01LysAsp: 2.01 ± 0.038	1.96LysGlu: 1.96 ± 0.035	1.093LysPhe: 1.093 ± 0.024	2.913LysGly: 2.913 ± 0.042	0.769LysHis: 0.769 ± 0.018	2.163LysIle: 2.163 ± 0.037	1.643LysLys: 1.643 ± 0.039	3.849LysLeu: 3.849 ± 0.048	0.958LysMet: 0.958 ± 0.024	1.13LysAsn: 1.13 ± 0.024	2.217LysPro: 2.217 ± 0.038	1.252LysGln: 1.252 ± 0.027	2.695LysArg: 2.695 ± 0.042	2.305LysSer: 2.305 ± 0.039	2.325LysThr: 2.325 ± 0.037	2.793LysVal: 2.793 ± 0.046	0.446LysTrp: 0.446 ± 0.016	0.723LysTyr: 0.723 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.308LeuAla: 12.308 ± 0.101	0.899LeuCys: 0.899 ± 0.022	5.621LeuAsp: 5.621 ± 0.061	5.327LeuGlu: 5.327 ± 0.055	3.832LeuPhe: 3.832 ± 0.047	7.774LeuGly: 7.774 ± 0.073	1.9LeuHis: 1.9 ± 0.034	5.331LeuIle: 5.331 ± 0.063	4.196LeuLys: 4.196 ± 0.053	9.465LeuLeu: 9.465 ± 0.089	2.351LeuMet: 2.351 ± 0.035	2.854LeuAsn: 2.854 ± 0.04	5.214LeuPro: 5.214 ± 0.056	3.001LeuGln: 3.001 ± 0.04	6.366LeuArg: 6.366 ± 0.063	6.924LeuSer: 6.924 ± 0.069	5.526LeuThr: 5.526 ± 0.059	7.35LeuVal: 7.35 ± 0.07	1.082LeuTrp: 1.082 ± 0.028	2.149LeuTyr: 2.149 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.987MetAla: 2.987 ± 0.042	0.153MetCys: 0.153 ± 0.008	1.18MetAsp: 1.18 ± 0.029	1.19MetGlu: 1.19 ± 0.023	0.751MetPhe: 0.751 ± 0.022	1.696MetGly: 1.696 ± 0.029	0.462MetHis: 0.462 ± 0.015	1.54MetIle: 1.54 ± 0.032	1.143MetLys: 1.143 ± 0.026	2.532MetLeu: 2.532 ± 0.037	0.685MetMet: 0.685 ± 0.021	0.873MetAsn: 0.873 ± 0.024	1.43MetPro: 1.43 ± 0.03	0.907MetGln: 0.907 ± 0.023	1.805MetArg: 1.805 ± 0.032	1.806MetSer: 1.806 ± 0.032	1.943MetThr: 1.943 ± 0.029	1.702MetVal: 1.702 ± 0.032	0.213MetTrp: 0.213 ± 0.009	0.324MetTyr: 0.324 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.427AsnAla: 3.427 ± 0.042	0.269AsnCys: 0.269 ± 0.01	1.666AsnAsp: 1.666 ± 0.028	1.475AsnGlu: 1.475 ± 0.03	1.182AsnPhe: 1.182 ± 0.029	2.593AsnGly: 2.593 ± 0.045	0.611AsnHis: 0.611 ± 0.02	1.596AsnIle: 1.596 ± 0.031	0.898AsnLys: 0.898 ± 0.019	2.891AsnLeu: 2.891 ± 0.045	0.692AsnMet: 0.692 ± 0.02	0.818AsnAsn: 0.818 ± 0.025	1.901AsnPro: 1.901 ± 0.032	0.87AsnGln: 0.87 ± 0.024	1.953AsnArg: 1.953 ± 0.034	1.626AsnSer: 1.626 ± 0.032	1.426AsnThr: 1.426 ± 0.028	2.182AsnVal: 2.182 ± 0.036	0.489AsnTrp: 0.489 ± 0.016	0.777AsnTyr: 0.777 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.305ProAla: 5.305 ± 0.065	0.312ProCys: 0.312 ± 0.014	3.265ProAsp: 3.265 ± 0.044	3.341ProGlu: 3.341 ± 0.046	1.987ProPhe: 1.987 ± 0.031	3.857ProGly: 3.857 ± 0.049	1.04ProHis: 1.04 ± 0.024	2.507ProIle: 2.507 ± 0.039	1.868ProLys: 1.868 ± 0.032	4.538ProLeu: 4.538 ± 0.05	1.136ProMet: 1.136 ± 0.023	1.455ProAsn: 1.455 ± 0.03	2.23ProPro: 2.23 ± 0.039	1.669ProGln: 1.669 ± 0.028	2.628ProArg: 2.628 ± 0.037	2.991ProSer: 2.991 ± 0.036	2.473ProThr: 2.473 ± 0.041	3.889ProVal: 3.889 ± 0.05	0.642ProTrp: 0.642 ± 0.018	1.238ProTyr: 1.238 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.772GlnAla: 3.772 ± 0.05	0.205GlnCys: 0.205 ± 0.011	1.401GlnAsp: 1.401 ± 0.029	1.593GlnGlu: 1.593 ± 0.034	1.128GlnPhe: 1.128 ± 0.026	2.2GlnGly: 2.2 ± 0.034	0.65GlnHis: 0.65 ± 0.019	2.021GlnIle: 2.021 ± 0.031	1.281GlnLys: 1.281 ± 0.031	3.022GlnLeu: 3.022 ± 0.038	0.933GlnMet: 0.933 ± 0.024	0.991GlnAsn: 0.991 ± 0.022	1.709GlnPro: 1.709 ± 0.031	1.391GlnGln: 1.391 ± 0.038	2.319GlnArg: 2.319 ± 0.038	2.025GlnSer: 2.025 ± 0.039	1.817GlnThr: 1.817 ± 0.034	2.096GlnVal: 2.096 ± 0.036	0.409GlnTrp: 0.409 ± 0.015	0.679GlnTyr: 0.679 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.893ArgAla: 6.893 ± 0.065	0.514ArgCys: 0.514 ± 0.018	3.794ArgAsp: 3.794 ± 0.044	3.917ArgGlu: 3.917 ± 0.049	2.855ArgPhe: 2.855 ± 0.039	4.353ArgGly: 4.353 ± 0.047	1.702ArgHis: 1.702 ± 0.034	4.06ArgIle: 4.06 ± 0.047	2.62ArgLys: 2.62 ± 0.038	7.29ArgLeu: 7.29 ± 0.075	1.889ArgMet: 1.889 ± 0.034	2.07ArgAsn: 2.07 ± 0.035	3.22ArgPro: 3.22 ± 0.046	2.653ArgGln: 2.653 ± 0.037	5.291ArgArg: 5.291 ± 0.07	4.103ArgSer: 4.103 ± 0.053	3.235ArgThr: 3.235 ± 0.04	4.302ArgVal: 4.302 ± 0.05	0.897ArgTrp: 0.897 ± 0.023	1.792ArgTyr: 1.792 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.409SerAla: 6.409 ± 0.06	0.488SerCys: 0.488 ± 0.017	3.274SerAsp: 3.274 ± 0.042	3.241SerGlu: 3.241 ± 0.041	2.566SerPhe: 2.566 ± 0.038	5.721SerGly: 5.721 ± 0.065	1.244SerHis: 1.244 ± 0.027	3.441SerIle: 3.441 ± 0.048	2.122SerLys: 2.122 ± 0.034	6.072SerLeu: 6.072 ± 0.063	1.455SerMet: 1.455 ± 0.03	1.725SerAsn: 1.725 ± 0.03	2.875SerPro: 2.875 ± 0.04	1.78SerGln: 1.78 ± 0.035	3.921SerArg: 3.921 ± 0.051	3.744SerSer: 3.744 ± 0.056	3.05SerThr: 3.05 ± 0.04	4.375SerVal: 4.375 ± 0.05	0.809SerTrp: 0.809 ± 0.024	1.471SerTyr: 1.471 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.045ThrAla: 6.045 ± 0.063	0.47ThrCys: 0.47 ± 0.019	2.816ThrAsp: 2.816 ± 0.04	2.714ThrGlu: 2.714 ± 0.043	2.126ThrPhe: 2.126 ± 0.038	4.837ThrGly: 4.837 ± 0.058	1.03ThrHis: 1.03 ± 0.026	3.348ThrIle: 3.348 ± 0.048	1.836ThrLys: 1.836 ± 0.033	5.537ThrLeu: 5.537 ± 0.054	1.31ThrMet: 1.31 ± 0.026	1.493ThrAsn: 1.493 ± 0.031	2.946ThrPro: 2.946 ± 0.038	1.405ThrGln: 1.405 ± 0.027	3.083ThrArg: 3.083 ± 0.045	3.124ThrSer: 3.124 ± 0.043	2.938ThrThr: 2.938 ± 0.044	4.286ThrVal: 4.286 ± 0.048	0.68ThrTrp: 0.68 ± 0.022	1.262ThrTyr: 1.262 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.664ValAla: 8.664 ± 0.068	0.671ValCys: 0.671 ± 0.021	4.058ValAsp: 4.058 ± 0.046	4.33ValGlu: 4.33 ± 0.053	2.943ValPhe: 2.943 ± 0.05	5.469ValGly: 5.469 ± 0.056	1.391ValHis: 1.391 ± 0.03	4.339ValIle: 4.339 ± 0.055	2.595ValLys: 2.595 ± 0.041	7.255ValLeu: 7.255 ± 0.064	1.795ValMet: 1.795 ± 0.031	2.087ValAsn: 2.087 ± 0.036	3.557ValPro: 3.557 ± 0.039	2.01ValGln: 2.01 ± 0.029	4.735ValArg: 4.735 ± 0.053	4.811ValSer: 4.811 ± 0.047	4.377ValThr: 4.377 ± 0.051	5.908ValVal: 5.908 ± 0.072	0.826ValTrp: 0.826 ± 0.024	1.54ValTyr: 1.54 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.03	0.144TrpCys: 0.144 ± 0.009	0.624TrpAsp: 0.624 ± 0.018	0.587TrpGlu: 0.587 ± 0.018	0.531TrpPhe: 0.531 ± 0.018	0.848TrpGly: 0.848 ± 0.022	0.339TrpHis: 0.339 ± 0.015	0.722TrpIle: 0.722 ± 0.02	0.538TrpLys: 0.538 ± 0.017	1.573TrpLeu: 1.573 ± 0.034	0.376TrpMet: 0.376 ± 0.015	0.501TrpAsn: 0.501 ± 0.018	0.689TrpPro: 0.689 ± 0.022	0.563TrpGln: 0.563 ± 0.021	1.036TrpArg: 1.036 ± 0.024	0.834TrpSer: 0.834 ± 0.024	0.748TrpThr: 0.748 ± 0.022	0.754TrpVal: 0.754 ± 0.02	0.211TrpTrp: 0.211 ± 0.011	0.303TrpTyr: 0.303 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.496TyrAla: 2.496 ± 0.038	0.266TyrCys: 0.266 ± 0.011	1.456TyrAsp: 1.456 ± 0.031	1.323TyrGlu: 1.323 ± 0.026	1.053TyrPhe: 1.053 ± 0.027	2.141TyrGly: 2.141 ± 0.039	0.535TyrHis: 0.535 ± 0.019	1.053TyrIle: 1.053 ± 0.024	0.755TyrLys: 0.755 ± 0.021	2.357TyrLeu: 2.357 ± 0.035	0.489TyrMet: 0.489 ± 0.016	0.673TyrAsn: 0.673 ± 0.017	1.155TyrPro: 1.155 ± 0.027	0.777TyrGln: 0.777 ± 0.02	1.794TyrArg: 1.794 ± 0.036	1.373TyrSer: 1.373 ± 0.031	1.075TyrThr: 1.075 ± 0.027	1.752TyrVal: 1.752 ± 0.03	0.385TyrTrp: 0.385 ± 0.017	0.668TyrTyr: 0.668 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6358 proteins (1835771 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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