Amino acid dipepetide frequency for Metschnikowia bicuspidata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.993AlaAla: 7.993 ± 0.103
1.092AlaCys: 1.092 ± 0.026
4.374AlaAsp: 4.374 ± 0.056
5.006AlaGlu: 5.006 ± 0.062
3.204AlaPhe: 3.204 ± 0.045
4.423AlaGly: 4.423 ± 0.055
1.945AlaHis: 1.945 ± 0.035
3.855AlaIle: 3.855 ± 0.048
4.69AlaLys: 4.69 ± 0.054
8.837AlaLeu: 8.837 ± 0.078
1.634AlaMet: 1.634 ± 0.029
3.164AlaAsn: 3.164 ± 0.041
3.821AlaPro: 3.821 ± 0.051
3.3AlaGln: 3.3 ± 0.045
4.415AlaArg: 4.415 ± 0.054
6.366AlaSer: 6.366 ± 0.069
4.253AlaThr: 4.253 ± 0.048
5.748AlaVal: 5.748 ± 0.066
0.767AlaTrp: 0.767 ± 0.023
2.252AlaTyr: 2.252 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
1.11CysAla: 1.11 ± 0.024
0.268CysCys: 0.268 ± 0.01
0.848CysAsp: 0.848 ± 0.021
0.757CysGlu: 0.757 ± 0.02
0.71CysPhe: 0.71 ± 0.019
1.027CysGly: 1.027 ± 0.027
0.373CysHis: 0.373 ± 0.015
0.8CysIle: 0.8 ± 0.021
0.691CysLys: 0.691 ± 0.021
1.514CysLeu: 1.514 ± 0.029
0.302CysMet: 0.302 ± 0.012
0.562CysAsn: 0.562 ± 0.017
0.599CysPro: 0.599 ± 0.017
0.429CysGln: 0.429 ± 0.014
0.727CysArg: 0.727 ± 0.019
1.066CysSer: 1.066 ± 0.023
0.758CysThr: 0.758 ± 0.02
1.067CysVal: 1.067 ± 0.022
0.152CysTrp: 0.152 ± 0.008
0.474CysTyr: 0.474 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.274AspAla: 5.274 ± 0.071
0.731AspCys: 0.731 ± 0.021
4.169AspAsp: 4.169 ± 0.064
4.267AspGlu: 4.267 ± 0.053
2.777AspPhe: 2.777 ± 0.037
3.111AspGly: 3.111 ± 0.048
1.238AspHis: 1.238 ± 0.022
3.146AspIle: 3.146 ± 0.04
2.865AspLys: 2.865 ± 0.04
6.211AspLeu: 6.211 ± 0.053
1.22AspMet: 1.22 ± 0.024
2.142AspAsn: 2.142 ± 0.035
2.712AspPro: 2.712 ± 0.038
1.7AspGln: 1.7 ± 0.029
2.516AspArg: 2.516 ± 0.035
4.318AspSer: 4.318 ± 0.059
2.953AspThr: 2.953 ± 0.037
4.038AspVal: 4.038 ± 0.051
0.659AspTrp: 0.659 ± 0.018
2.005AspTyr: 2.005 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
4.363GluAla: 4.363 ± 0.057
0.778GluCys: 0.778 ± 0.02
3.63GluAsp: 3.63 ± 0.056
4.677GluGlu: 4.677 ± 0.073
2.555GluPhe: 2.555 ± 0.035
2.619GluGly: 2.619 ± 0.038
1.512GluHis: 1.512 ± 0.027
3.568GluIle: 3.568 ± 0.046
4.406GluLys: 4.406 ± 0.064
6.884GluLeu: 6.884 ± 0.07
1.371GluMet: 1.371 ± 0.027
3.017GluAsn: 3.017 ± 0.043
2.487GluPro: 2.487 ± 0.038
2.653GluGln: 2.653 ± 0.041
3.423GluArg: 3.423 ± 0.052
4.136GluSer: 4.136 ± 0.052
3.432GluThr: 3.432 ± 0.048
3.728GluVal: 3.728 ± 0.056
0.672GluTrp: 0.672 ± 0.018
2.058GluTyr: 2.058 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.286PheAla: 3.286 ± 0.046
0.728PheCys: 0.728 ± 0.019
2.776PheAsp: 2.776 ± 0.037
2.661PheGlu: 2.661 ± 0.036
2.105PhePhe: 2.105 ± 0.041
2.894PheGly: 2.894 ± 0.052
1.07PheHis: 1.07 ± 0.023
2.105PheIle: 2.105 ± 0.033
2.34PheLys: 2.34 ± 0.038
4.661PheLeu: 4.661 ± 0.051
0.93PheMet: 0.93 ± 0.023
1.94PheAsn: 1.94 ± 0.032
1.799PhePro: 1.799 ± 0.029
1.629PheGln: 1.629 ± 0.028
2.209PheArg: 2.209 ± 0.035
3.589PheSer: 3.589 ± 0.045
2.222PheThr: 2.222 ± 0.038
3.316PheVal: 3.316 ± 0.044
0.522PheTrp: 0.522 ± 0.017
1.487PheTyr: 1.487 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
4.589GlyAla: 4.589 ± 0.062
0.825GlyCys: 0.825 ± 0.024
3.129GlyAsp: 3.129 ± 0.044
2.971GlyGlu: 2.971 ± 0.04
2.538GlyPhe: 2.538 ± 0.039
3.417GlyGly: 3.417 ± 0.059
1.376GlyHis: 1.376 ± 0.03
2.956GlyIle: 2.956 ± 0.045
3.237GlyLys: 3.237 ± 0.042
5.615GlyLeu: 5.615 ± 0.056
1.107GlyMet: 1.107 ± 0.028
2.235GlyAsn: 2.235 ± 0.037
2.108GlyPro: 2.108 ± 0.036
1.763GlyGln: 1.763 ± 0.033
2.764GlyArg: 2.764 ± 0.046
4.263GlySer: 4.263 ± 0.056
3.19GlyThr: 3.19 ± 0.046
3.845GlyVal: 3.845 ± 0.05
0.656GlyTrp: 0.656 ± 0.021
1.845GlyTyr: 1.845 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
1.825HisAla: 1.825 ± 0.033
0.365HisCys: 0.365 ± 0.013
1.343HisAsp: 1.343 ± 0.023
1.436HisGlu: 1.436 ± 0.03
1.146HisPhe: 1.146 ± 0.021
1.406HisGly: 1.406 ± 0.026
0.704HisHis: 0.704 ± 0.021
1.347HisIle: 1.347 ± 0.026
1.343HisLys: 1.343 ± 0.027
2.635HisLeu: 2.635 ± 0.039
0.567HisMet: 0.567 ± 0.018
1.034HisAsn: 1.034 ± 0.022
1.19HisPro: 1.19 ± 0.024
0.89HisGln: 0.89 ± 0.025
1.29HisArg: 1.29 ± 0.027
1.776HisSer: 1.776 ± 0.031
1.259HisThr: 1.259 ± 0.025
1.729HisVal: 1.729 ± 0.03
0.246HisTrp: 0.246 ± 0.011
0.841HisTyr: 0.841 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
3.869IleAla: 3.869 ± 0.046
0.783IleCys: 0.783 ± 0.019
3.241IleAsp: 3.241 ± 0.043
3.222IleGlu: 3.222 ± 0.048
2.267IlePhe: 2.267 ± 0.044
2.75IleGly: 2.75 ± 0.041
1.23IleHis: 1.23 ± 0.026
2.606IleIle: 2.606 ± 0.04
3.042IleLys: 3.042 ± 0.045
5.247IleLeu: 5.247 ± 0.067
1.1IleMet: 1.1 ± 0.024
2.414IleAsn: 2.414 ± 0.038
2.537IlePro: 2.537 ± 0.04
1.749IleGln: 1.749 ± 0.032
2.665IleArg: 2.665 ± 0.036
3.998IleSer: 3.998 ± 0.045
2.721IleThr: 2.721 ± 0.043
3.626IleVal: 3.626 ± 0.044
0.545IleTrp: 0.545 ± 0.018
1.617IleTyr: 1.617 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.078LysAla: 4.078 ± 0.052
0.727LysCys: 0.727 ± 0.024
3.215LysAsp: 3.215 ± 0.041
3.883LysGlu: 3.883 ± 0.058
2.484LysPhe: 2.484 ± 0.039
2.569LysGly: 2.569 ± 0.046
1.485LysHis: 1.485 ± 0.028
3.336LysIle: 3.336 ± 0.047
4.695LysLys: 4.695 ± 0.073
6.485LysLeu: 6.485 ± 0.074
1.295LysMet: 1.295 ± 0.024
2.93LysAsn: 2.93 ± 0.043
2.69LysPro: 2.69 ± 0.041
2.325LysGln: 2.325 ± 0.04
3.469LysArg: 3.469 ± 0.052
4.056LysSer: 4.056 ± 0.053
3.425LysThr: 3.425 ± 0.041
3.559LysVal: 3.559 ± 0.041
0.649LysTrp: 0.649 ± 0.018
2.189LysTyr: 2.189 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
8.98LeuAla: 8.98 ± 0.083
1.654LeuCys: 1.654 ± 0.033
6.034LeuAsp: 6.034 ± 0.051
6.356LeuGlu: 6.356 ± 0.068
4.607LeuPhe: 4.607 ± 0.055
5.727LeuGly: 5.727 ± 0.055
2.66LeuHis: 2.66 ± 0.04
4.903LeuIle: 4.903 ± 0.062
6.347LeuLys: 6.347 ± 0.072
11.675LeuLeu: 11.675 ± 0.109
2.195LeuMet: 2.195 ± 0.033
4.545LeuAsn: 4.545 ± 0.049
5.053LeuPro: 5.053 ± 0.052
4.652LeuGln: 4.652 ± 0.056
6.434LeuArg: 6.434 ± 0.064
8.315LeuSer: 8.315 ± 0.078
5.252LeuThr: 5.252 ± 0.058
7.54LeuVal: 7.54 ± 0.074
1.116LeuTrp: 1.116 ± 0.023
3.248LeuTyr: 3.248 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
1.838MetAla: 1.838 ± 0.033
0.344MetCys: 0.344 ± 0.012
1.244MetAsp: 1.244 ± 0.022
1.207MetGlu: 1.207 ± 0.026
0.891MetPhe: 0.891 ± 0.023
1.199MetGly: 1.199 ± 0.026
0.474MetHis: 0.474 ± 0.015
0.962MetIle: 0.962 ± 0.021
1.221MetLys: 1.221 ± 0.028
2.091MetLeu: 2.091 ± 0.031
0.461MetMet: 0.461 ± 0.015
0.909MetAsn: 0.909 ± 0.02
1.007MetPro: 1.007 ± 0.021
0.758MetGln: 0.758 ± 0.021
1.182MetArg: 1.182 ± 0.026
1.831MetSer: 1.831 ± 0.032
1.08MetThr: 1.08 ± 0.022
1.345MetVal: 1.345 ± 0.025
0.216MetTrp: 0.216 ± 0.011
0.676MetTyr: 0.676 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.382AsnAla: 3.382 ± 0.038
0.617AsnCys: 0.617 ± 0.018
2.492AsnAsp: 2.492 ± 0.035
2.615AsnGlu: 2.615 ± 0.037
2.043AsnPhe: 2.043 ± 0.037
2.607AsnGly: 2.607 ± 0.041
0.918AsnHis: 0.918 ± 0.023
2.418AsnIle: 2.418 ± 0.036
2.388AsnLys: 2.388 ± 0.043
4.349AsnLeu: 4.349 ± 0.048
0.954AsnMet: 0.954 ± 0.024
1.956AsnAsn: 1.956 ± 0.039
2.101AsnPro: 2.101 ± 0.035
1.367AsnGln: 1.367 ± 0.031
1.987AsnArg: 1.987 ± 0.031
3.317AsnSer: 3.317 ± 0.043
2.381AsnThr: 2.381 ± 0.036
2.831AsnVal: 2.831 ± 0.037
0.523AsnTrp: 0.523 ± 0.015
1.634AsnTyr: 1.634 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
4.004ProAla: 4.004 ± 0.054
0.495ProCys: 0.495 ± 0.015
2.557ProAsp: 2.557 ± 0.037
3.405ProGlu: 3.405 ± 0.039
1.897ProPhe: 1.897 ± 0.033
2.471ProGly: 2.471 ± 0.037
1.21ProHis: 1.21 ± 0.025
2.143ProIle: 2.143 ± 0.033
2.683ProLys: 2.683 ± 0.043
4.592ProLeu: 4.592 ± 0.055
0.823ProMet: 0.823 ± 0.02
1.851ProAsn: 1.851 ± 0.029
2.666ProPro: 2.666 ± 0.056
2.013ProGln: 2.013 ± 0.037
2.339ProArg: 2.339 ± 0.038
3.604ProSer: 3.604 ± 0.06
2.531ProThr: 2.531 ± 0.036
3.379ProVal: 3.379 ± 0.044
0.426ProTrp: 0.426 ± 0.014
1.398ProTyr: 1.398 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
2.62GlnAla: 2.62 ± 0.041
0.493GlnCys: 0.493 ± 0.016
1.784GlnAsp: 1.784 ± 0.031
2.333GlnGlu: 2.333 ± 0.038
1.681GlnPhe: 1.681 ± 0.031
1.672GlnGly: 1.672 ± 0.025
0.963GlnHis: 0.963 ± 0.026
2.122GlnIle: 2.122 ± 0.035
2.565GlnLys: 2.565 ± 0.043
4.444GlnLeu: 4.444 ± 0.052
0.943GlnMet: 0.943 ± 0.027
1.792GlnAsn: 1.792 ± 0.03
1.699GlnPro: 1.699 ± 0.039
2.008GlnGln: 2.008 ± 0.053
2.176GlnArg: 2.176 ± 0.035
2.587GlnSer: 2.587 ± 0.04
2.075GlnThr: 2.075 ± 0.033
2.229GlnVal: 2.229 ± 0.034
0.417GlnTrp: 0.417 ± 0.015
1.299GlnTyr: 1.299 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
4.319ArgAla: 4.319 ± 0.057
0.734ArgCys: 0.734 ± 0.02
2.985ArgAsp: 2.985 ± 0.039
3.188ArgGlu: 3.188 ± 0.047
2.414ArgPhe: 2.414 ± 0.032
2.641ArgGly: 2.641 ± 0.038
1.31ArgHis: 1.31 ± 0.027
2.875ArgIle: 2.875 ± 0.035
3.604ArgLys: 3.604 ± 0.053
5.989ArgLeu: 5.989 ± 0.066
1.164ArgMet: 1.164 ± 0.026
2.333ArgAsn: 2.333 ± 0.035
2.246ArgPro: 2.246 ± 0.04
2.041ArgGln: 2.041 ± 0.031
3.521ArgArg: 3.521 ± 0.059
3.71ArgSer: 3.71 ± 0.043
2.81ArgThr: 2.81 ± 0.038
3.569ArgVal: 3.569 ± 0.05
0.566ArgTrp: 0.566 ± 0.015
1.679ArgTyr: 1.679 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.362SerAla: 6.362 ± 0.062
0.966SerCys: 0.966 ± 0.02
4.495SerAsp: 4.495 ± 0.058
4.385SerGlu: 4.385 ± 0.053
3.384SerPhe: 3.384 ± 0.043
4.624SerGly: 4.624 ± 0.049
1.797SerHis: 1.797 ± 0.029
3.887SerIle: 3.887 ± 0.05
4.266SerLys: 4.266 ± 0.06
8.146SerLeu: 8.146 ± 0.072
1.522SerMet: 1.522 ± 0.03
3.073SerAsn: 3.073 ± 0.037
3.602SerPro: 3.602 ± 0.068
2.684SerGln: 2.684 ± 0.041
3.834SerArg: 3.834 ± 0.051
6.791SerSer: 6.791 ± 0.098
4.168SerThr: 4.168 ± 0.056
5.341SerVal: 5.341 ± 0.045
0.774SerTrp: 0.774 ± 0.019
2.238SerTyr: 2.238 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
4.366ThrAla: 4.366 ± 0.055
0.761ThrCys: 0.761 ± 0.021
2.79ThrAsp: 2.79 ± 0.038
3.033ThrGlu: 3.033 ± 0.04
2.291ThrPhe: 2.291 ± 0.034
3.207ThrGly: 3.207 ± 0.046
1.31ThrHis: 1.31 ± 0.025
2.836ThrIle: 2.836 ± 0.041
3.011ThrLys: 3.011 ± 0.04
5.546ThrLeu: 5.546 ± 0.052
1.01ThrMet: 1.01 ± 0.025
2.191ThrAsn: 2.191 ± 0.035
2.901ThrPro: 2.901 ± 0.042
1.934ThrGln: 1.934 ± 0.033
2.887ThrArg: 2.887 ± 0.036
4.136ThrSer: 4.136 ± 0.056
2.988ThrThr: 2.988 ± 0.044
3.758ThrVal: 3.758 ± 0.051
0.561ThrTrp: 0.561 ± 0.018
1.682ThrTyr: 1.682 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
5.771ValAla: 5.771 ± 0.071
1.119ValCys: 1.119 ± 0.023
4.268ValAsp: 4.268 ± 0.051
4.082ValGlu: 4.082 ± 0.057
3.175ValPhe: 3.175 ± 0.042
3.618ValGly: 3.618 ± 0.052
1.731ValHis: 1.731 ± 0.029
3.147ValIle: 3.147 ± 0.043
3.655ValLys: 3.655 ± 0.045
7.593ValLeu: 7.593 ± 0.064
1.358ValMet: 1.358 ± 0.027
2.727ValAsn: 2.727 ± 0.035
3.559ValPro: 3.559 ± 0.042
2.454ValGln: 2.454 ± 0.035
3.592ValArg: 3.592 ± 0.049
5.388ValSer: 5.388 ± 0.053
3.425ValThr: 3.425 ± 0.04
5.387ValVal: 5.387 ± 0.059
0.738ValTrp: 0.738 ± 0.022
2.168ValTyr: 2.168 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.759TrpAla: 0.759 ± 0.02
0.231TrpCys: 0.231 ± 0.011
0.69TrpAsp: 0.69 ± 0.021
0.554TrpGlu: 0.554 ± 0.016
0.501TrpPhe: 0.501 ± 0.019
0.581TrpGly: 0.581 ± 0.019
0.263TrpHis: 0.263 ± 0.011
0.536TrpIle: 0.536 ± 0.017
0.707TrpLys: 0.707 ± 0.018
1.194TrpLeu: 1.194 ± 0.028
0.24TrpMet: 0.24 ± 0.011
0.569TrpAsn: 0.569 ± 0.019
0.39TrpPro: 0.39 ± 0.014
0.357TrpGln: 0.357 ± 0.013
0.639TrpArg: 0.639 ± 0.019
0.742TrpSer: 0.742 ± 0.019
0.587TrpThr: 0.587 ± 0.02
0.667TrpVal: 0.667 ± 0.018
0.174TrpTrp: 0.174 ± 0.009
0.37TrpTyr: 0.37 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.351TyrAla: 2.351 ± 0.037
0.524TyrCys: 0.524 ± 0.018
1.988TyrAsp: 1.988 ± 0.03
1.931TyrGlu: 1.931 ± 0.035
1.599TyrPhe: 1.599 ± 0.032
1.865TyrGly: 1.865 ± 0.032
0.8TyrHis: 0.8 ± 0.02
1.683TyrIle: 1.683 ± 0.03
1.79TyrLys: 1.79 ± 0.029
3.584TyrLeu: 3.584 ± 0.048
0.739TyrMet: 0.739 ± 0.02
1.497TyrAsn: 1.497 ± 0.025
1.317TyrPro: 1.317 ± 0.028
1.198TyrGln: 1.198 ± 0.026
1.631TyrArg: 1.631 ± 0.029
2.348TyrSer: 2.348 ± 0.037
1.688TyrThr: 1.688 ± 0.03
2.254TyrVal: 2.254 ± 0.037
0.374TyrTrp: 0.374 ± 0.016
1.169TyrTyr: 1.169 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4707 proteins (2058784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski