Amino acid dipepetide frequency for Acetilactobacillus jinshanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.964AlaAla: 4.964 ± 0.356
0.471AlaCys: 0.471 ± 0.033
3.553AlaAsp: 3.553 ± 0.139
2.618AlaGlu: 2.618 ± 0.093
2.907AlaPhe: 2.907 ± 0.083
4.572AlaGly: 4.572 ± 0.112
1.916AlaHis: 1.916 ± 0.066
5.441AlaIle: 5.441 ± 0.146
6.7AlaLys: 6.7 ± 0.165
6.46AlaLeu: 6.46 ± 0.128
2.147AlaMet: 2.147 ± 0.077
4.273AlaAsn: 4.273 ± 0.238
2.046AlaPro: 2.046 ± 0.082
2.697AlaGln: 2.697 ± 0.106
2.684AlaArg: 2.684 ± 0.081
5.529AlaSer: 5.529 ± 0.731
3.679AlaThr: 3.679 ± 0.11
4.539AlaVal: 4.539 ± 0.125
0.592AlaTrp: 0.592 ± 0.038
2.638AlaTyr: 2.638 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.431CysAla: 0.431 ± 0.035
0.057CysCys: 0.057 ± 0.012
0.376CysAsp: 0.376 ± 0.03
0.229CysGlu: 0.229 ± 0.026
0.343CysPhe: 0.343 ± 0.027
0.647CysGly: 0.647 ± 0.036
0.315CysHis: 0.315 ± 0.029
0.418CysIle: 0.418 ± 0.036
0.374CysLys: 0.374 ± 0.034
0.623CysLeu: 0.623 ± 0.042
0.145CysMet: 0.145 ± 0.018
0.304CysAsn: 0.304 ± 0.025
0.312CysPro: 0.312 ± 0.03
0.323CysGln: 0.323 ± 0.028
0.293CysArg: 0.293 ± 0.03
0.403CysSer: 0.403 ± 0.029
0.356CysThr: 0.356 ± 0.029
0.422CysVal: 0.422 ± 0.037
0.097CysTrp: 0.097 ± 0.015
0.295CysTyr: 0.295 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.736AspAla: 3.736 ± 0.182
0.319AspCys: 0.319 ± 0.03
2.907AspAsp: 2.907 ± 0.09
2.262AspGlu: 2.262 ± 0.075
2.222AspPhe: 2.222 ± 0.074
2.966AspGly: 2.966 ± 0.1
2.053AspHis: 2.053 ± 0.077
3.316AspIle: 3.316 ± 0.116
3.857AspLys: 3.857 ± 0.109
4.909AspLeu: 4.909 ± 0.116
1.38AspMet: 1.38 ± 0.054
2.814AspAsn: 2.814 ± 0.082
2.535AspPro: 2.535 ± 0.091
2.829AspGln: 2.829 ± 0.089
2.165AspArg: 2.165 ± 0.073
2.992AspSer: 2.992 ± 0.18
2.625AspThr: 2.625 ± 0.081
4.079AspVal: 4.079 ± 0.115
0.616AspTrp: 0.616 ± 0.039
2.376AspTyr: 2.376 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
2.814GluAla: 2.814 ± 0.091
0.216GluCys: 0.216 ± 0.022
1.674GluAsp: 1.674 ± 0.066
1.124GluGlu: 1.124 ± 0.056
1.492GluPhe: 1.492 ± 0.063
1.776GluGly: 1.776 ± 0.07
1.186GluHis: 1.186 ± 0.052
2.605GluIle: 2.605 ± 0.071
2.645GluLys: 2.645 ± 0.091
3.292GluLeu: 3.292 ± 0.102
1.197GluMet: 1.197 ± 0.052
1.982GluAsn: 1.982 ± 0.065
1.419GluPro: 1.419 ± 0.059
1.351GluGln: 1.351 ± 0.061
1.509GluArg: 1.509 ± 0.064
2.009GluSer: 2.009 ± 0.067
1.811GluThr: 1.811 ± 0.065
2.277GluVal: 2.277 ± 0.073
0.378GluTrp: 0.378 ± 0.027
1.358GluTyr: 1.358 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
2.722PheAla: 2.722 ± 0.082
0.352PheCys: 0.352 ± 0.025
2.284PheAsp: 2.284 ± 0.09
1.283PheGlu: 1.283 ± 0.048
1.699PhePhe: 1.699 ± 0.073
3.107PheGly: 3.107 ± 0.106
1.212PheHis: 1.212 ± 0.053
3.124PheIle: 3.124 ± 0.117
3.336PheLys: 3.336 ± 0.099
3.553PheLeu: 3.553 ± 0.116
1.296PheMet: 1.296 ± 0.061
2.814PheAsn: 2.814 ± 0.082
1.56PhePro: 1.56 ± 0.069
1.226PheGln: 1.226 ± 0.053
1.481PheArg: 1.481 ± 0.065
2.711PheSer: 2.711 ± 0.08
2.205PheThr: 2.205 ± 0.066
2.752PheVal: 2.752 ± 0.089
0.565PheTrp: 0.565 ± 0.04
1.769PheTyr: 1.769 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.15GlyAla: 4.15 ± 0.117
0.521GlyCys: 0.521 ± 0.039
3.017GlyAsp: 3.017 ± 0.09
2.2GlyGlu: 2.2 ± 0.077
2.953GlyPhe: 2.953 ± 0.107
3.925GlyGly: 3.925 ± 0.113
2.15GlyHis: 2.15 ± 0.078
5.232GlyIle: 5.232 ± 0.123
5.069GlyLys: 5.069 ± 0.137
6.103GlyLeu: 6.103 ± 0.148
1.989GlyMet: 1.989 ± 0.079
3.267GlyAsn: 3.267 ± 0.099
1.701GlyPro: 1.701 ± 0.076
2.376GlyGln: 2.376 ± 0.07
2.466GlyArg: 2.466 ± 0.099
4.064GlySer: 4.064 ± 0.121
3.857GlyThr: 3.857 ± 0.101
4.411GlyVal: 4.411 ± 0.096
0.719GlyTrp: 0.719 ± 0.04
2.891GlyTyr: 2.891 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.879HisAla: 1.879 ± 0.063
0.233HisCys: 0.233 ± 0.024
1.789HisAsp: 1.789 ± 0.067
1.287HisGlu: 1.287 ± 0.07
1.487HisPhe: 1.487 ± 0.061
2.337HisGly: 2.337 ± 0.089
1.793HisHis: 1.793 ± 0.076
1.905HisIle: 1.905 ± 0.07
2.189HisLys: 2.189 ± 0.076
3.21HisLeu: 3.21 ± 0.099
0.843HisMet: 0.843 ± 0.044
1.655HisAsn: 1.655 ± 0.059
1.6HisPro: 1.6 ± 0.062
1.936HisGln: 1.936 ± 0.073
1.875HisArg: 1.875 ± 0.075
1.655HisSer: 1.655 ± 0.065
1.375HisThr: 1.375 ± 0.056
2.264HisVal: 2.264 ± 0.078
0.35HisTrp: 0.35 ± 0.031
1.736HisTyr: 1.736 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
5.518IleAla: 5.518 ± 0.127
0.68IleCys: 0.68 ± 0.039
3.965IleAsp: 3.965 ± 0.115
2.447IleGlu: 2.447 ± 0.081
3.083IlePhe: 3.083 ± 0.115
5.133IleGly: 5.133 ± 0.143
2.123IleHis: 2.123 ± 0.077
6.165IleIle: 6.165 ± 0.192
6.209IleLys: 6.209 ± 0.167
6.222IleLeu: 6.222 ± 0.173
2.07IleMet: 2.07 ± 0.069
5.052IleAsn: 5.052 ± 0.128
3.199IlePro: 3.199 ± 0.101
2.574IleGln: 2.574 ± 0.086
2.922IleArg: 2.922 ± 0.084
5.105IleSer: 5.105 ± 0.163
4.374IleThr: 4.374 ± 0.097
5.094IleVal: 5.094 ± 0.125
0.623IleTrp: 0.623 ± 0.036
2.515IleTyr: 2.515 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
5.562LysAla: 5.562 ± 0.143
0.414LysCys: 0.414 ± 0.033
4.323LysAsp: 4.323 ± 0.101
2.73LysGlu: 2.73 ± 0.097
2.774LysPhe: 2.774 ± 0.086
4.084LysGly: 4.084 ± 0.119
3.069LysHis: 3.069 ± 0.096
5.507LysIle: 5.507 ± 0.116
7.083LysLys: 7.083 ± 0.17
7.16LysLeu: 7.16 ± 0.17
2.948LysMet: 2.948 ± 0.087
4.691LysAsn: 4.691 ± 0.115
3.406LysPro: 3.406 ± 0.1
3.96LysGln: 3.96 ± 0.116
4.139LysArg: 4.139 ± 0.11
4.922LysSer: 4.922 ± 0.112
4.222LysThr: 4.222 ± 0.102
5.131LysVal: 5.131 ± 0.113
0.814LysTrp: 0.814 ± 0.056
3.784LysTyr: 3.784 ± 0.103
0.0LysXaa: 0.0 ± 0.0
Leu
6.59LeuAla: 6.59 ± 0.138
0.609LeuCys: 0.609 ± 0.04
4.669LeuAsp: 4.669 ± 0.098
2.579LeuGlu: 2.579 ± 0.073
3.538LeuPhe: 3.538 ± 0.105
6.15LeuGly: 6.15 ± 0.145
2.464LeuHis: 2.464 ± 0.08
7.637LeuIle: 7.637 ± 0.205
7.716LeuLys: 7.716 ± 0.177
7.802LeuLeu: 7.802 ± 0.199
2.592LeuMet: 2.592 ± 0.08
5.404LeuAsn: 5.404 ± 0.127
3.701LeuPro: 3.701 ± 0.097
2.907LeuGln: 2.907 ± 0.101
3.624LeuArg: 3.624 ± 0.107
6.695LeuSer: 6.695 ± 0.169
5.531LeuThr: 5.531 ± 0.122
6.033LeuVal: 6.033 ± 0.144
0.827LeuTrp: 0.827 ± 0.048
2.88LeuTyr: 2.88 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
2.081MetAla: 2.081 ± 0.064
0.183MetCys: 0.183 ± 0.02
1.483MetAsp: 1.483 ± 0.056
0.818MetGlu: 0.818 ± 0.049
1.074MetPhe: 1.074 ± 0.061
1.804MetGly: 1.804 ± 0.071
0.805MetHis: 0.805 ± 0.039
2.519MetIle: 2.519 ± 0.091
2.601MetLys: 2.601 ± 0.087
2.323MetLeu: 2.323 ± 0.086
0.922MetMet: 0.922 ± 0.057
1.916MetAsn: 1.916 ± 0.077
1.232MetPro: 1.232 ± 0.054
0.966MetGln: 0.966 ± 0.051
1.153MetArg: 1.153 ± 0.052
2.051MetSer: 2.051 ± 0.073
1.789MetThr: 1.789 ± 0.064
1.729MetVal: 1.729 ± 0.075
0.244MetTrp: 0.244 ± 0.025
0.898MetTyr: 0.898 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
4.299AsnAla: 4.299 ± 0.232
0.312AsnCys: 0.312 ± 0.027
3.415AsnAsp: 3.415 ± 0.11
2.169AsnGlu: 2.169 ± 0.07
2.158AsnPhe: 2.158 ± 0.08
3.956AsnGly: 3.956 ± 0.12
2.46AsnHis: 2.46 ± 0.082
3.439AsnIle: 3.439 ± 0.119
3.903AsnLys: 3.903 ± 0.107
4.964AsnLeu: 4.964 ± 0.11
1.45AsnMet: 1.45 ± 0.057
3.982AsnAsn: 3.982 ± 0.164
2.726AsnPro: 2.726 ± 0.091
3.252AsnGln: 3.252 ± 0.117
2.737AsnArg: 2.737 ± 0.094
4.222AsnSer: 4.222 ± 0.362
2.689AsnThr: 2.689 ± 0.104
4.326AsnVal: 4.326 ± 0.128
0.708AsnTrp: 0.708 ± 0.045
2.708AsnTyr: 2.708 ± 0.102
0.0AsnXaa: 0.0 ± 0.0
Pro
2.374ProAla: 2.374 ± 0.073
0.216ProCys: 0.216 ± 0.02
2.356ProAsp: 2.356 ± 0.078
1.864ProGlu: 1.864 ± 0.06
1.756ProPhe: 1.756 ± 0.072
2.264ProGly: 2.264 ± 0.085
1.085ProHis: 1.085 ± 0.049
2.878ProIle: 2.878 ± 0.093
4.075ProLys: 4.075 ± 0.115
3.311ProLeu: 3.311 ± 0.088
0.909ProMet: 0.909 ± 0.042
2.44ProAsn: 2.44 ± 0.079
0.647ProPro: 0.647 ± 0.038
1.551ProGln: 1.551 ± 0.06
1.474ProArg: 1.474 ± 0.058
2.493ProSer: 2.493 ± 0.09
2.273ProThr: 2.273 ± 0.08
2.981ProVal: 2.981 ± 0.093
0.383ProTrp: 0.383 ± 0.03
1.681ProTyr: 1.681 ± 0.073
0.0ProXaa: 0.0 ± 0.0
Gln
3.085GlnAla: 3.085 ± 0.084
0.205GlnCys: 0.205 ± 0.021
1.91GlnAsp: 1.91 ± 0.08
1.239GlnGlu: 1.239 ± 0.052
1.817GlnPhe: 1.817 ± 0.063
2.009GlnGly: 2.009 ± 0.081
1.333GlnHis: 1.333 ± 0.066
3.525GlnIle: 3.525 ± 0.11
3.259GlnLys: 3.259 ± 0.121
4.363GlnLeu: 4.363 ± 0.146
1.219GlnMet: 1.219 ± 0.049
2.279GlnAsn: 2.279 ± 0.081
1.586GlnPro: 1.586 ± 0.073
2.073GlnGln: 2.073 ± 0.091
1.965GlnArg: 1.965 ± 0.079
2.618GlnSer: 2.618 ± 0.096
2.174GlnThr: 2.174 ± 0.075
2.814GlnVal: 2.814 ± 0.082
0.486GlnTrp: 0.486 ± 0.036
1.663GlnTyr: 1.663 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
2.73ArgAla: 2.73 ± 0.082
0.268ArgCys: 0.268 ± 0.026
2.24ArgAsp: 2.24 ± 0.069
1.582ArgGlu: 1.582 ± 0.066
1.892ArgPhe: 1.892 ± 0.06
2.271ArgGly: 2.271 ± 0.084
1.771ArgHis: 1.771 ± 0.068
3.439ArgIle: 3.439 ± 0.103
3.624ArgLys: 3.624 ± 0.118
3.912ArgLeu: 3.912 ± 0.104
1.278ArgMet: 1.278 ± 0.057
2.502ArgAsn: 2.502 ± 0.086
1.65ArgPro: 1.65 ± 0.068
2.103ArgGln: 2.103 ± 0.074
2.517ArgArg: 2.517 ± 0.094
2.242ArgSer: 2.242 ± 0.079
2.004ArgThr: 2.004 ± 0.073
2.631ArgVal: 2.631 ± 0.08
0.433ArgTrp: 0.433 ± 0.035
2.04ArgTyr: 2.04 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
5.461SerAla: 5.461 ± 0.602
0.341SerCys: 0.341 ± 0.031
3.868SerAsp: 3.868 ± 0.194
2.211SerGlu: 2.211 ± 0.1
2.774SerPhe: 2.774 ± 0.088
4.246SerGly: 4.246 ± 0.13
2.07SerHis: 2.07 ± 0.071
4.616SerIle: 4.616 ± 0.149
5.043SerLys: 5.043 ± 0.105
5.978SerLeu: 5.978 ± 0.182
1.556SerMet: 1.556 ± 0.059
4.178SerAsn: 4.178 ± 0.313
2.147SerPro: 2.147 ± 0.068
2.702SerGln: 2.702 ± 0.091
2.713SerArg: 2.713 ± 0.094
5.364SerSer: 5.364 ± 0.564
3.866SerThr: 3.866 ± 0.198
4.392SerVal: 4.392 ± 0.21
0.686SerTrp: 0.686 ± 0.053
2.601SerTyr: 2.601 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
3.721ThrAla: 3.721 ± 0.131
0.363ThrCys: 0.363 ± 0.033
2.913ThrAsp: 2.913 ± 0.087
1.69ThrGlu: 1.69 ± 0.055
2.246ThrPhe: 2.246 ± 0.079
4.004ThrGly: 4.004 ± 0.092
1.591ThrHis: 1.591 ± 0.068
4.051ThrIle: 4.051 ± 0.101
4.304ThrLys: 4.304 ± 0.103
5.083ThrLeu: 5.083 ± 0.103
1.234ThrMet: 1.234 ± 0.053
3.135ThrAsn: 3.135 ± 0.142
2.702ThrPro: 2.702 ± 0.091
1.89ThrGln: 1.89 ± 0.074
2.066ThrArg: 2.066 ± 0.067
3.846ThrSer: 3.846 ± 0.222
3.025ThrThr: 3.025 ± 0.105
3.822ThrVal: 3.822 ± 0.088
0.623ThrTrp: 0.623 ± 0.041
2.189ThrTyr: 2.189 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
5.12ValAla: 5.12 ± 0.163
0.535ValCys: 0.535 ± 0.034
3.487ValAsp: 3.487 ± 0.082
2.189ValGlu: 2.189 ± 0.083
2.469ValPhe: 2.469 ± 0.075
4.484ValGly: 4.484 ± 0.119
1.776ValHis: 1.776 ± 0.06
5.857ValIle: 5.857 ± 0.141
5.727ValLys: 5.727 ± 0.131
5.501ValLeu: 5.501 ± 0.132
1.96ValMet: 1.96 ± 0.073
4.363ValAsn: 4.363 ± 0.116
2.807ValPro: 2.807 ± 0.081
2.216ValGln: 2.216 ± 0.074
2.642ValArg: 2.642 ± 0.086
4.7ValSer: 4.7 ± 0.172
4.242ValThr: 4.242 ± 0.106
4.689ValVal: 4.689 ± 0.138
0.563ValTrp: 0.563 ± 0.037
2.414ValTyr: 2.414 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.618TrpAla: 0.618 ± 0.037
0.103TrpCys: 0.103 ± 0.016
0.442TrpAsp: 0.442 ± 0.034
0.262TrpGlu: 0.262 ± 0.022
0.532TrpPhe: 0.532 ± 0.035
0.664TrpGly: 0.664 ± 0.039
0.383TrpHis: 0.383 ± 0.03
0.992TrpIle: 0.992 ± 0.062
0.574TrpLys: 0.574 ± 0.039
1.153TrpLeu: 1.153 ± 0.062
0.356TrpMet: 0.356 ± 0.029
0.563TrpAsn: 0.563 ± 0.039
0.339TrpPro: 0.339 ± 0.026
0.447TrpGln: 0.447 ± 0.032
0.469TrpArg: 0.469 ± 0.033
0.596TrpSer: 0.596 ± 0.039
0.51TrpThr: 0.51 ± 0.033
0.748TrpVal: 0.748 ± 0.057
0.143TrpTrp: 0.143 ± 0.017
0.447TrpTyr: 0.447 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.572TyrAla: 2.572 ± 0.097
0.365TyrCys: 0.365 ± 0.031
2.288TyrAsp: 2.288 ± 0.077
1.331TyrGlu: 1.331 ± 0.051
1.833TyrPhe: 1.833 ± 0.074
2.664TyrGly: 2.664 ± 0.09
1.842TyrHis: 1.842 ± 0.07
2.405TyrIle: 2.405 ± 0.087
2.438TyrLys: 2.438 ± 0.072
4.026TyrLeu: 4.026 ± 0.109
1.098TyrMet: 1.098 ± 0.049
2.262TyrAsn: 2.262 ± 0.084
1.694TyrPro: 1.694 ± 0.07
2.242TyrGln: 2.242 ± 0.086
2.238TyrArg: 2.238 ± 0.071
2.598TyrSer: 2.598 ± 0.09
1.89TyrThr: 1.89 ± 0.071
2.605TyrVal: 2.605 ± 0.088
0.491TyrTrp: 0.491 ± 0.043
1.974TyrTyr: 1.974 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1450 proteins (454499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski