Amino acid dipepetide frequency for Ostreococcus lucimarinus virus OlV4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.15AlaAla: 4.15 ± 0.399
1.202AlaCys: 1.202 ± 0.19
3.475AlaAsp: 3.475 ± 0.242
3.014AlaGlu: 3.014 ± 0.26
2.273AlaPhe: 2.273 ± 0.198
3.475AlaGly: 3.475 ± 0.31
1.136AlaHis: 1.136 ± 0.134
4.002AlaIle: 4.002 ± 0.235
4.051AlaLys: 4.051 ± 0.268
4.644AlaLeu: 4.644 ± 0.3
1.482AlaMet: 1.482 ± 0.152
3.392AlaAsn: 3.392 ± 0.447
1.647AlaPro: 1.647 ± 0.216
2.388AlaGln: 2.388 ± 0.215
2.882AlaArg: 2.882 ± 0.275
3.014AlaSer: 3.014 ± 0.281
3.689AlaThr: 3.689 ± 0.37
3.195AlaVal: 3.195 ± 0.216
0.428AlaTrp: 0.428 ± 0.114
2.19AlaTyr: 2.19 ± 0.223
0.0AlaXaa: 0.0 ± 0.0
Cys
0.84CysAla: 0.84 ± 0.122
0.445CysCys: 0.445 ± 0.093
1.202CysAsp: 1.202 ± 0.146
1.63CysGlu: 1.63 ± 0.198
0.725CysPhe: 0.725 ± 0.12
1.383CysGly: 1.383 ± 0.225
0.296CysHis: 0.296 ± 0.072
0.659CysIle: 0.659 ± 0.117
1.268CysLys: 1.268 ± 0.199
1.252CysLeu: 1.252 ± 0.164
0.576CysMet: 0.576 ± 0.102
0.774CysAsn: 0.774 ± 0.149
1.367CysPro: 1.367 ± 0.243
0.461CysGln: 0.461 ± 0.083
1.021CysArg: 1.021 ± 0.13
1.021CysSer: 1.021 ± 0.128
0.873CysThr: 0.873 ± 0.115
0.889CysVal: 0.889 ± 0.128
0.148CysTrp: 0.148 ± 0.049
0.807CysTyr: 0.807 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
3.573AspAla: 3.573 ± 0.272
0.758AspCys: 0.758 ± 0.139
3.903AspAsp: 3.903 ± 0.337
4.891AspGlu: 4.891 ± 0.339
2.783AspPhe: 2.783 ± 0.205
3.557AspGly: 3.557 ± 0.292
1.268AspHis: 1.268 ± 0.194
4.776AspIle: 4.776 ± 0.263
3.886AspLys: 3.886 ± 0.252
5.023AspLeu: 5.023 ± 0.384
1.581AspMet: 1.581 ± 0.143
2.487AspAsn: 2.487 ± 0.234
2.256AspPro: 2.256 ± 0.23
1.499AspGln: 1.499 ± 0.171
2.767AspArg: 2.767 ± 0.189
2.865AspSer: 2.865 ± 0.238
3.359AspThr: 3.359 ± 0.263
3.656AspVal: 3.656 ± 0.234
0.741AspTrp: 0.741 ± 0.132
3.03AspTyr: 3.03 ± 0.252
0.0AspXaa: 0.0 ± 0.0
Glu
4.15GluAla: 4.15 ± 0.318
1.202GluCys: 1.202 ± 0.15
4.067GluAsp: 4.067 ± 0.329
6.109GluGlu: 6.109 ± 0.471
2.767GluPhe: 2.767 ± 0.238
3.359GluGly: 3.359 ± 0.244
1.416GluHis: 1.416 ± 0.159
4.808GluIle: 4.808 ± 0.294
5.731GluLys: 5.731 ± 0.403
6.044GluLeu: 6.044 ± 0.433
1.762GluMet: 1.762 ± 0.203
3.639GluAsn: 3.639 ± 0.236
2.305GluPro: 2.305 ± 0.305
1.91GluGln: 1.91 ± 0.222
3.59GluArg: 3.59 ± 0.313
3.442GluSer: 3.442 ± 0.197
3.705GluThr: 3.705 ± 0.305
4.1GluVal: 4.1 ± 0.27
0.725GluTrp: 0.725 ± 0.107
2.783GluTyr: 2.783 ± 0.226
0.0GluXaa: 0.0 ± 0.0
Phe
2.305PheAla: 2.305 ± 0.242
0.873PheCys: 0.873 ± 0.15
2.849PheAsp: 2.849 ± 0.237
2.684PheGlu: 2.684 ± 0.239
1.597PhePhe: 1.597 ± 0.194
2.042PheGly: 2.042 ± 0.221
0.856PheHis: 0.856 ± 0.122
2.338PheIle: 2.338 ± 0.232
3.178PheLys: 3.178 ± 0.295
3.524PheLeu: 3.524 ± 0.303
1.614PheMet: 1.614 ± 0.191
2.157PheAsn: 2.157 ± 0.185
1.433PhePro: 1.433 ± 0.176
1.037PheGln: 1.037 ± 0.145
2.058PheArg: 2.058 ± 0.201
2.552PheSer: 2.552 ± 0.263
2.289PheThr: 2.289 ± 0.189
3.162PheVal: 3.162 ± 0.242
0.329PheTrp: 0.329 ± 0.076
1.811PheTyr: 1.811 ± 0.19
0.0PheXaa: 0.0 ± 0.0
Gly
3.623GlyAla: 3.623 ± 0.362
1.186GlyCys: 1.186 ± 0.154
3.326GlyAsp: 3.326 ± 0.304
3.293GlyGlu: 3.293 ± 0.27
2.651GlyPhe: 2.651 ± 0.179
4.479GlyGly: 4.479 ± 0.47
1.252GlyHis: 1.252 ± 0.152
4.002GlyIle: 4.002 ± 0.364
4.397GlyLys: 4.397 ± 0.274
4.594GlyLeu: 4.594 ± 0.235
1.614GlyMet: 1.614 ± 0.188
3.738GlyAsn: 3.738 ± 0.704
2.24GlyPro: 2.24 ± 0.222
2.157GlyGln: 2.157 ± 0.21
2.536GlyArg: 2.536 ± 0.246
3.475GlySer: 3.475 ± 0.274
3.689GlyThr: 3.689 ± 0.46
3.82GlyVal: 3.82 ± 0.35
0.758GlyTrp: 0.758 ± 0.103
2.388GlyTyr: 2.388 ± 0.223
0.0GlyXaa: 0.0 ± 0.0
His
0.856HisAla: 0.856 ± 0.134
0.527HisCys: 0.527 ± 0.1
1.07HisAsp: 1.07 ± 0.138
1.186HisGlu: 1.186 ± 0.134
0.758HisPhe: 0.758 ± 0.123
1.367HisGly: 1.367 ± 0.154
0.609HisHis: 0.609 ± 0.104
1.663HisIle: 1.663 ± 0.159
1.301HisLys: 1.301 ± 0.152
1.746HisLeu: 1.746 ± 0.159
0.642HisMet: 0.642 ± 0.12
1.219HisAsn: 1.219 ± 0.158
0.823HisPro: 0.823 ± 0.146
0.692HisGln: 0.692 ± 0.121
1.153HisArg: 1.153 ± 0.122
1.07HisSer: 1.07 ± 0.12
1.383HisThr: 1.383 ± 0.166
1.466HisVal: 1.466 ± 0.162
0.296HisTrp: 0.296 ± 0.081
0.823HisTyr: 0.823 ± 0.118
0.0HisXaa: 0.0 ± 0.0
Ile
3.343IleAla: 3.343 ± 0.252
1.021IleCys: 1.021 ± 0.166
4.43IleAsp: 4.43 ± 0.32
4.545IleGlu: 4.545 ± 0.32
2.273IlePhe: 2.273 ± 0.239
3.524IleGly: 3.524 ± 0.268
1.894IleHis: 1.894 ± 0.183
3.623IleIle: 3.623 ± 0.246
5.237IleLys: 5.237 ± 0.378
5.368IleLeu: 5.368 ± 0.332
1.795IleMet: 1.795 ± 0.195
4.1IleAsn: 4.1 ± 0.33
2.981IlePro: 2.981 ± 0.233
2.783IleGln: 2.783 ± 0.232
3.079IleArg: 3.079 ± 0.241
3.557IleSer: 3.557 ± 0.266
3.54IleThr: 3.54 ± 0.311
4.249IleVal: 4.249 ± 0.313
0.527IleTrp: 0.527 ± 0.098
2.536IleTyr: 2.536 ± 0.202
0.0IleXaa: 0.0 ± 0.0
Lys
3.656LysAla: 3.656 ± 0.319
1.581LysCys: 1.581 ± 0.209
4.331LysAsp: 4.331 ± 0.323
5.039LysGlu: 5.039 ± 0.393
3.326LysPhe: 3.326 ± 0.276
3.689LysGly: 3.689 ± 0.242
1.531LysHis: 1.531 ± 0.167
5.023LysIle: 5.023 ± 0.369
7.509LysLys: 7.509 ± 0.526
6.818LysLeu: 6.818 ± 0.415
2.799LysMet: 2.799 ± 0.236
5.27LysAsn: 5.27 ± 0.469
2.799LysPro: 2.799 ± 0.26
2.931LysGln: 2.931 ± 0.264
4.693LysArg: 4.693 ± 0.379
4.874LysSer: 4.874 ± 0.314
5.023LysThr: 5.023 ± 0.299
4.71LysVal: 4.71 ± 0.293
0.906LysTrp: 0.906 ± 0.118
3.491LysTyr: 3.491 ± 0.286
0.0LysXaa: 0.0 ± 0.0
Leu
4.561LeuAla: 4.561 ± 0.266
1.136LeuCys: 1.136 ± 0.154
4.743LeuAsp: 4.743 ± 0.278
5.401LeuGlu: 5.401 ± 0.289
2.832LeuPhe: 2.832 ± 0.212
4.43LeuGly: 4.43 ± 0.27
1.383LeuHis: 1.383 ± 0.155
4.561LeuIle: 4.561 ± 0.258
7.41LeuLys: 7.41 ± 0.497
6.505LeuLeu: 6.505 ± 0.368
2.141LeuMet: 2.141 ± 0.19
5.747LeuAsn: 5.747 ± 0.66
3.129LeuPro: 3.129 ± 0.272
2.816LeuGln: 2.816 ± 0.244
4.99LeuArg: 4.99 ± 0.33
5.533LeuSer: 5.533 ± 0.278
5.385LeuThr: 5.385 ± 0.335
5.286LeuVal: 5.286 ± 0.283
0.758LeuTrp: 0.758 ± 0.132
2.816LeuTyr: 2.816 ± 0.221
0.0LeuXaa: 0.0 ± 0.0
Met
1.449MetAla: 1.449 ± 0.16
0.708MetCys: 0.708 ± 0.12
1.548MetAsp: 1.548 ± 0.174
1.828MetGlu: 1.828 ± 0.256
1.367MetPhe: 1.367 ± 0.159
1.729MetGly: 1.729 ± 0.157
0.609MetHis: 0.609 ± 0.111
1.597MetIle: 1.597 ± 0.164
2.816MetLys: 2.816 ± 0.249
1.844MetLeu: 1.844 ± 0.211
1.136MetMet: 1.136 ± 0.155
1.894MetAsn: 1.894 ± 0.266
0.955MetPro: 0.955 ± 0.126
0.939MetGln: 0.939 ± 0.135
1.35MetArg: 1.35 ± 0.143
2.404MetSer: 2.404 ± 0.188
1.581MetThr: 1.581 ± 0.166
1.663MetVal: 1.663 ± 0.183
0.379MetTrp: 0.379 ± 0.09
1.4MetTyr: 1.4 ± 0.142
0.0MetXaa: 0.0 ± 0.0
Asn
4.216AsnAla: 4.216 ± 0.509
0.823AsnCys: 0.823 ± 0.135
3.129AsnAsp: 3.129 ± 0.227
3.59AsnGlu: 3.59 ± 0.315
2.635AsnPhe: 2.635 ± 0.214
3.458AsnGly: 3.458 ± 0.256
1.054AsnHis: 1.054 ± 0.119
4.133AsnIle: 4.133 ± 0.314
4.924AsnLys: 4.924 ± 0.586
4.907AsnLeu: 4.907 ± 0.369
1.795AsnMet: 1.795 ± 0.194
3.458AsnAsn: 3.458 ± 0.353
2.009AsnPro: 2.009 ± 0.232
1.927AsnGln: 1.927 ± 0.249
3.54AsnArg: 3.54 ± 0.512
3.573AsnSer: 3.573 ± 0.255
4.496AsnThr: 4.496 ± 0.529
5.517AsnVal: 5.517 ± 0.867
0.576AsnTrp: 0.576 ± 0.111
2.404AsnTyr: 2.404 ± 0.26
0.0AsnXaa: 0.0 ± 0.0
Pro
1.713ProAla: 1.713 ± 0.248
0.807ProCys: 0.807 ± 0.14
2.338ProAsp: 2.338 ± 0.206
3.293ProGlu: 3.293 ± 0.324
1.778ProPhe: 1.778 ± 0.192
2.24ProGly: 2.24 ± 0.228
0.725ProHis: 0.725 ± 0.133
2.058ProIle: 2.058 ± 0.209
2.981ProLys: 2.981 ± 0.286
2.849ProLeu: 2.849 ± 0.232
1.037ProMet: 1.037 ± 0.148
2.388ProAsn: 2.388 ± 0.216
2.157ProPro: 2.157 ± 0.29
1.795ProGln: 1.795 ± 0.178
1.68ProArg: 1.68 ± 0.191
2.799ProSer: 2.799 ± 0.36
2.915ProThr: 2.915 ± 0.235
2.503ProVal: 2.503 ± 0.201
0.296ProTrp: 0.296 ± 0.069
1.334ProTyr: 1.334 ± 0.148
0.0ProXaa: 0.0 ± 0.0
Gln
1.482GlnAla: 1.482 ± 0.163
0.626GlnCys: 0.626 ± 0.11
2.009GlnAsp: 2.009 ± 0.225
2.371GlnGlu: 2.371 ± 0.253
1.317GlnPhe: 1.317 ± 0.204
1.433GlnGly: 1.433 ± 0.141
0.593GlnHis: 0.593 ± 0.111
2.437GlnIle: 2.437 ± 0.172
2.849GlnLys: 2.849 ± 0.258
2.997GlnLeu: 2.997 ± 0.245
1.07GlnMet: 1.07 ± 0.134
2.141GlnAsn: 2.141 ± 0.215
1.597GlnPro: 1.597 ± 0.174
1.416GlnGln: 1.416 ± 0.179
2.141GlnArg: 2.141 ± 0.21
2.24GlnSer: 2.24 ± 0.19
2.322GlnThr: 2.322 ± 0.216
1.976GlnVal: 1.976 ± 0.208
0.395GlnTrp: 0.395 ± 0.082
1.153GlnTyr: 1.153 ± 0.156
0.0GlnXaa: 0.0 ± 0.0
Arg
2.816ArgAla: 2.816 ± 0.203
0.889ArgCys: 0.889 ± 0.111
3.079ArgAsp: 3.079 ± 0.247
3.969ArgGlu: 3.969 ± 0.379
2.075ArgPhe: 2.075 ± 0.178
2.799ArgGly: 2.799 ± 0.243
1.169ArgHis: 1.169 ± 0.147
3.195ArgIle: 3.195 ± 0.215
4.249ArgLys: 4.249 ± 0.442
3.886ArgLeu: 3.886 ± 0.302
1.647ArgMet: 1.647 ± 0.195
3.112ArgAsn: 3.112 ± 0.36
1.96ArgPro: 1.96 ± 0.199
2.19ArgGln: 2.19 ± 0.218
3.046ArgArg: 3.046 ± 0.395
2.487ArgSer: 2.487 ± 0.201
2.404ArgThr: 2.404 ± 0.201
3.985ArgVal: 3.985 ± 0.333
0.725ArgTrp: 0.725 ± 0.109
1.91ArgTyr: 1.91 ± 0.19
0.0ArgXaa: 0.0 ± 0.0
Ser
3.343SerAla: 3.343 ± 0.266
0.79SerCys: 0.79 ± 0.113
3.162SerAsp: 3.162 ± 0.217
4.413SerGlu: 4.413 ± 0.274
2.552SerPhe: 2.552 ± 0.228
4.874SerGly: 4.874 ± 0.587
1.021SerHis: 1.021 ± 0.146
4.051SerIle: 4.051 ± 0.316
4.561SerLys: 4.561 ± 0.305
5.006SerLeu: 5.006 ± 0.341
1.367SerMet: 1.367 ± 0.15
4.347SerAsn: 4.347 ± 0.444
2.223SerPro: 2.223 ± 0.216
2.305SerGln: 2.305 ± 0.221
2.931SerArg: 2.931 ± 0.232
3.919SerSer: 3.919 ± 0.297
3.606SerThr: 3.606 ± 0.29
3.82SerVal: 3.82 ± 0.31
0.626SerTrp: 0.626 ± 0.119
2.091SerTyr: 2.091 ± 0.179
0.0SerXaa: 0.0 ± 0.0
Thr
2.915ThrAla: 2.915 ± 0.237
0.84ThrCys: 0.84 ± 0.141
3.508ThrAsp: 3.508 ± 0.328
2.981ThrGlu: 2.981 ± 0.216
2.305ThrPhe: 2.305 ± 0.198
4.1ThrGly: 4.1 ± 0.541
1.499ThrHis: 1.499 ± 0.173
3.771ThrIle: 3.771 ± 0.203
4.94ThrLys: 4.94 ± 0.27
5.22ThrLeu: 5.22 ± 0.332
1.762ThrMet: 1.762 ± 0.138
4.973ThrAsn: 4.973 ± 0.583
3.277ThrPro: 3.277 ± 0.327
1.96ThrGln: 1.96 ± 0.204
2.569ThrArg: 2.569 ± 0.213
4.446ThrSer: 4.446 ± 0.429
3.853ThrThr: 3.853 ± 0.483
3.277ThrVal: 3.277 ± 0.247
0.56ThrTrp: 0.56 ± 0.105
2.305ThrTyr: 2.305 ± 0.226
0.0ThrXaa: 0.0 ± 0.0
Val
3.936ValAla: 3.936 ± 0.343
1.416ValCys: 1.416 ± 0.151
3.705ValAsp: 3.705 ± 0.278
4.183ValGlu: 4.183 ± 0.274
2.52ValPhe: 2.52 ± 0.205
4.15ValGly: 4.15 ± 0.539
1.35ValHis: 1.35 ± 0.173
4.166ValIle: 4.166 ± 0.297
4.825ValLys: 4.825 ± 0.305
4.611ValLeu: 4.611 ± 0.303
1.68ValMet: 1.68 ± 0.169
3.936ValAsn: 3.936 ± 0.613
2.865ValPro: 2.865 ± 0.208
2.174ValGln: 2.174 ± 0.183
3.096ValArg: 3.096 ± 0.212
4.364ValSer: 4.364 ± 0.336
4.298ValThr: 4.298 ± 0.527
4.117ValVal: 4.117 ± 0.44
0.675ValTrp: 0.675 ± 0.136
2.618ValTyr: 2.618 ± 0.371
0.0ValXaa: 0.0 ± 0.0
Trp
0.379TrpAla: 0.379 ± 0.085
0.296TrpCys: 0.296 ± 0.08
0.478TrpAsp: 0.478 ± 0.095
0.692TrpGlu: 0.692 ± 0.118
0.445TrpPhe: 0.445 ± 0.085
0.675TrpGly: 0.675 ± 0.112
0.181TrpHis: 0.181 ± 0.056
0.906TrpIle: 0.906 ± 0.144
0.873TrpLys: 0.873 ± 0.171
0.84TrpLeu: 0.84 ± 0.101
0.263TrpMet: 0.263 ± 0.073
0.725TrpAsn: 0.725 ± 0.115
0.379TrpPro: 0.379 ± 0.083
0.214TrpGln: 0.214 ± 0.07
0.461TrpArg: 0.461 ± 0.083
0.873TrpSer: 0.873 ± 0.127
0.51TrpThr: 0.51 ± 0.108
0.675TrpVal: 0.675 ± 0.123
0.181TrpTrp: 0.181 ± 0.057
0.329TrpTyr: 0.329 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.421TyrAla: 2.421 ± 0.251
0.51TyrCys: 0.51 ± 0.108
2.305TyrAsp: 2.305 ± 0.205
2.503TyrGlu: 2.503 ± 0.234
1.729TyrPhe: 1.729 ± 0.235
2.454TyrGly: 2.454 ± 0.226
0.807TyrHis: 0.807 ± 0.11
2.635TyrIle: 2.635 ± 0.238
3.014TyrLys: 3.014 ± 0.292
3.886TyrLeu: 3.886 ± 0.26
1.416TyrMet: 1.416 ± 0.171
2.668TyrAsn: 2.668 ± 0.214
1.284TyrPro: 1.284 ± 0.145
0.972TyrGln: 0.972 ± 0.122
2.009TyrArg: 2.009 ± 0.196
2.503TyrSer: 2.503 ± 0.23
2.141TyrThr: 2.141 ± 0.229
2.618TyrVal: 2.618 ± 0.302
0.346TyrTrp: 0.346 ± 0.07
1.284TyrTyr: 1.284 ± 0.15
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 294 proteins (60727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski