Amino acid dipepetide frequency for Pelosinus fermentans B4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.596AlaAla: 8.596 ± 0.111
0.945AlaCys: 0.945 ± 0.027
4.064AlaAsp: 4.064 ± 0.06
5.018AlaGlu: 5.018 ± 0.063
3.155AlaPhe: 3.155 ± 0.057
6.622AlaGly: 6.622 ± 0.083
1.319AlaHis: 1.319 ± 0.032
6.617AlaIle: 6.617 ± 0.07
5.181AlaLys: 5.181 ± 0.067
7.964AlaLeu: 7.964 ± 0.094
2.482AlaMet: 2.482 ± 0.047
3.159AlaAsn: 3.159 ± 0.051
2.272AlaPro: 2.272 ± 0.038
2.956AlaGln: 2.956 ± 0.049
3.138AlaArg: 3.138 ± 0.047
4.431AlaSer: 4.431 ± 0.06
3.974AlaThr: 3.974 ± 0.101
6.666AlaVal: 6.666 ± 0.07
0.676AlaTrp: 0.676 ± 0.022
2.485AlaTyr: 2.485 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.794CysAla: 0.794 ± 0.026
0.231CysCys: 0.231 ± 0.013
0.541CysAsp: 0.541 ± 0.021
0.587CysGlu: 0.587 ± 0.021
0.445CysPhe: 0.445 ± 0.017
1.118CysGly: 1.118 ± 0.033
0.27CysHis: 0.27 ± 0.016
0.913CysIle: 0.913 ± 0.028
0.601CysLys: 0.601 ± 0.02
1.061CysLeu: 1.061 ± 0.033
0.346CysMet: 0.346 ± 0.016
0.501CysAsn: 0.501 ± 0.021
0.57CysPro: 0.57 ± 0.022
0.458CysGln: 0.458 ± 0.018
0.525CysArg: 0.525 ± 0.022
0.831CysSer: 0.831 ± 0.024
0.61CysThr: 0.61 ± 0.024
0.649CysVal: 0.649 ± 0.022
0.113CysTrp: 0.113 ± 0.014
0.36CysTyr: 0.36 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.675AspAla: 3.675 ± 0.062
0.577AspCys: 0.577 ± 0.022
2.179AspAsp: 2.179 ± 0.043
3.32AspGlu: 3.32 ± 0.053
2.261AspPhe: 2.261 ± 0.045
3.336AspGly: 3.336 ± 0.049
1.031AspHis: 1.031 ± 0.025
4.478AspIle: 4.478 ± 0.057
3.235AspLys: 3.235 ± 0.058
4.502AspLeu: 4.502 ± 0.056
1.389AspMet: 1.389 ± 0.034
1.951AspAsn: 1.951 ± 0.04
1.782AspPro: 1.782 ± 0.043
1.58AspGln: 1.58 ± 0.033
2.063AspArg: 2.063 ± 0.041
2.681AspSer: 2.681 ± 0.045
2.684AspThr: 2.684 ± 0.048
3.682AspVal: 3.682 ± 0.057
0.559AspTrp: 0.559 ± 0.021
1.906AspTyr: 1.906 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.936GluAla: 4.936 ± 0.061
0.63GluCys: 0.63 ± 0.02
2.844GluAsp: 2.844 ± 0.04
5.072GluGlu: 5.072 ± 0.072
2.398GluPhe: 2.398 ± 0.044
3.647GluGly: 3.647 ± 0.058
1.274GluHis: 1.274 ± 0.033
5.536GluIle: 5.536 ± 0.072
5.439GluLys: 5.439 ± 0.064
6.349GluLeu: 6.349 ± 0.072
2.046GluMet: 2.046 ± 0.039
3.215GluAsn: 3.215 ± 0.049
1.674GluPro: 1.674 ± 0.036
2.99GluGln: 2.99 ± 0.054
3.146GluArg: 3.146 ± 0.056
3.007GluSer: 3.007 ± 0.043
2.954GluThr: 2.954 ± 0.041
4.51GluVal: 4.51 ± 0.065
0.61GluTrp: 0.61 ± 0.021
2.267GluTyr: 2.267 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.175PheAla: 3.175 ± 0.055
0.515PheCys: 0.515 ± 0.017
2.186PheAsp: 2.186 ± 0.041
1.997PheGlu: 1.997 ± 0.039
1.907PhePhe: 1.907 ± 0.04
3.175PheGly: 3.175 ± 0.051
0.806PheHis: 0.806 ± 0.023
3.42PheIle: 3.42 ± 0.053
2.059PheLys: 2.059 ± 0.043
3.945PheLeu: 3.945 ± 0.063
1.118PheMet: 1.118 ± 0.029
1.711PheAsn: 1.711 ± 0.031
1.425PhePro: 1.425 ± 0.032
1.263PheGln: 1.263 ± 0.029
1.497PheArg: 1.497 ± 0.037
2.948PheSer: 2.948 ± 0.049
2.407PheThr: 2.407 ± 0.039
2.649PheVal: 2.649 ± 0.05
0.411PheTrp: 0.411 ± 0.018
1.343PheTyr: 1.343 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
5.815GlyAla: 5.815 ± 0.116
1.027GlyCys: 1.027 ± 0.031
3.221GlyAsp: 3.221 ± 0.058
4.132GlyGlu: 4.132 ± 0.057
3.193GlyPhe: 3.193 ± 0.045
5.322GlyGly: 5.322 ± 0.08
1.443GlyHis: 1.443 ± 0.034
6.881GlyIle: 6.881 ± 0.081
5.114GlyLys: 5.114 ± 0.063
6.814GlyLeu: 6.814 ± 0.077
2.351GlyMet: 2.351 ± 0.047
3.026GlyAsn: 3.026 ± 0.079
1.818GlyPro: 1.818 ± 0.041
2.61GlyGln: 2.61 ± 0.047
3.095GlyArg: 3.095 ± 0.046
4.189GlySer: 4.189 ± 0.062
4.205GlyThr: 4.205 ± 0.069
5.466GlyVal: 5.466 ± 0.069
0.754GlyTrp: 0.754 ± 0.025
2.786GlyTyr: 2.786 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.347HisAla: 1.347 ± 0.03
0.308HisCys: 0.308 ± 0.014
0.968HisAsp: 0.968 ± 0.025
1.137HisGlu: 1.137 ± 0.027
0.869HisPhe: 0.869 ± 0.028
1.476HisGly: 1.476 ± 0.036
0.539HisHis: 0.539 ± 0.021
1.564HisIle: 1.564 ± 0.038
1.061HisLys: 1.061 ± 0.027
1.927HisLeu: 1.927 ± 0.04
0.51HisMet: 0.51 ± 0.02
0.852HisAsn: 0.852 ± 0.024
1.019HisPro: 1.019 ± 0.026
0.74HisGln: 0.74 ± 0.021
0.871HisArg: 0.871 ± 0.024
1.257HisSer: 1.257 ± 0.03
1.097HisThr: 1.097 ± 0.028
1.336HisVal: 1.336 ± 0.033
0.215HisTrp: 0.215 ± 0.012
0.73HisTyr: 0.73 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.305IleAla: 7.305 ± 0.083
0.948IleCys: 0.948 ± 0.026
4.335IleAsp: 4.335 ± 0.065
5.115IleGlu: 5.115 ± 0.061
3.1IlePhe: 3.1 ± 0.055
6.454IleGly: 6.454 ± 0.081
1.732IleHis: 1.732 ± 0.039
6.606IleIle: 6.606 ± 0.089
4.854IleLys: 4.854 ± 0.061
7.602IleLeu: 7.602 ± 0.086
2.163IleMet: 2.163 ± 0.041
3.516IleAsn: 3.516 ± 0.054
3.557IlePro: 3.557 ± 0.059
2.726IleGln: 2.726 ± 0.048
3.26IleArg: 3.26 ± 0.049
5.254IleSer: 5.254 ± 0.065
4.884IleThr: 4.884 ± 0.065
5.983IleVal: 5.983 ± 0.062
0.62IleTrp: 0.62 ± 0.023
2.273IleTyr: 2.273 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.875LysAla: 4.875 ± 0.071
0.504LysCys: 0.504 ± 0.023
3.309LysAsp: 3.309 ± 0.053
5.284LysGlu: 5.284 ± 0.065
1.891LysPhe: 1.891 ± 0.04
3.88LysGly: 3.88 ± 0.057
1.095LysHis: 1.095 ± 0.028
5.354LysIle: 5.354 ± 0.068
4.746LysLys: 4.746 ± 0.067
5.466LysLeu: 5.466 ± 0.065
2.139LysMet: 2.139 ± 0.04
3.276LysAsn: 3.276 ± 0.055
2.095LysPro: 2.095 ± 0.035
2.678LysGln: 2.678 ± 0.048
2.736LysArg: 2.736 ± 0.047
3.319LysSer: 3.319 ± 0.048
3.363LysThr: 3.363 ± 0.056
4.603LysVal: 4.603 ± 0.057
0.57LysTrp: 0.57 ± 0.023
2.02LysTyr: 2.02 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
8.697LeuAla: 8.697 ± 0.083
1.101LeuCys: 1.101 ± 0.026
4.672LeuAsp: 4.672 ± 0.057
6.111LeuGlu: 6.111 ± 0.084
4.041LeuPhe: 4.041 ± 0.067
7.157LeuGly: 7.157 ± 0.088
1.941LeuHis: 1.941 ± 0.036
6.796LeuIle: 6.796 ± 0.08
5.875LeuLys: 5.875 ± 0.076
10.091LeuLeu: 10.091 ± 0.114
2.535LeuMet: 2.535 ± 0.042
3.871LeuAsn: 3.871 ± 0.05
4.219LeuPro: 4.219 ± 0.063
3.751LeuGln: 3.751 ± 0.056
4.059LeuArg: 4.059 ± 0.064
6.645LeuSer: 6.645 ± 0.073
5.629LeuThr: 5.629 ± 0.063
6.626LeuVal: 6.626 ± 0.076
0.875LeuTrp: 0.875 ± 0.026
2.838LeuTyr: 2.838 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.535MetAla: 2.535 ± 0.046
0.234MetCys: 0.234 ± 0.012
1.479MetAsp: 1.479 ± 0.033
1.885MetGlu: 1.885 ± 0.035
0.934MetPhe: 0.934 ± 0.025
2.172MetGly: 2.172 ± 0.041
0.486MetHis: 0.486 ± 0.02
2.238MetIle: 2.238 ± 0.04
1.956MetLys: 1.956 ± 0.039
2.843MetLeu: 2.843 ± 0.046
0.817MetMet: 0.817 ± 0.027
1.398MetAsn: 1.398 ± 0.029
1.148MetPro: 1.148 ± 0.03
1.14MetGln: 1.14 ± 0.029
1.188MetArg: 1.188 ± 0.032
1.749MetSer: 1.749 ± 0.039
1.565MetThr: 1.565 ± 0.036
2.072MetVal: 2.072 ± 0.039
0.203MetTrp: 0.203 ± 0.012
0.754MetTyr: 0.754 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.041AsnAla: 3.041 ± 0.051
0.524AsnCys: 0.524 ± 0.021
2.009AsnAsp: 2.009 ± 0.043
2.566AsnGlu: 2.566 ± 0.051
1.644AsnPhe: 1.644 ± 0.038
2.889AsnGly: 2.889 ± 0.053
0.969AsnHis: 0.969 ± 0.025
3.856AsnIle: 3.856 ± 0.061
2.692AsnLys: 2.692 ± 0.047
4.258AsnLeu: 4.258 ± 0.058
1.25AsnMet: 1.25 ± 0.029
1.937AsnAsn: 1.937 ± 0.051
2.024AsnPro: 2.024 ± 0.035
1.815AsnGln: 1.815 ± 0.046
1.823AsnArg: 1.823 ± 0.037
2.512AsnSer: 2.512 ± 0.049
2.361AsnThr: 2.361 ± 0.055
3.092AsnVal: 3.092 ± 0.056
0.464AsnTrp: 0.464 ± 0.018
1.544AsnTyr: 1.544 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
2.741ProAla: 2.741 ± 0.05
0.398ProCys: 0.398 ± 0.018
1.982ProAsp: 1.982 ± 0.035
2.853ProGlu: 2.853 ± 0.046
1.598ProPhe: 1.598 ± 0.033
2.748ProGly: 2.748 ± 0.047
0.79ProHis: 0.79 ± 0.022
2.956ProIle: 2.956 ± 0.048
1.928ProLys: 1.928 ± 0.037
3.649ProLeu: 3.649 ± 0.058
0.91ProMet: 0.91 ± 0.023
1.512ProAsn: 1.512 ± 0.03
1.128ProPro: 1.128 ± 0.032
1.333ProGln: 1.333 ± 0.034
1.296ProArg: 1.296 ± 0.029
2.011ProSer: 2.011 ± 0.036
1.889ProThr: 1.889 ± 0.043
2.907ProVal: 2.907 ± 0.042
0.398ProTrp: 0.398 ± 0.015
1.336ProTyr: 1.336 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.234GlnAla: 3.234 ± 0.049
0.428GlnCys: 0.428 ± 0.019
1.885GlnAsp: 1.885 ± 0.039
3.077GlnGlu: 3.077 ± 0.056
1.245GlnPhe: 1.245 ± 0.029
2.619GlnGly: 2.619 ± 0.045
0.773GlnHis: 0.773 ± 0.025
2.856GlnIle: 2.856 ± 0.046
2.391GlnLys: 2.391 ± 0.042
3.786GlnLeu: 3.786 ± 0.055
1.092GlnMet: 1.092 ± 0.026
1.631GlnAsn: 1.631 ± 0.033
1.213GlnPro: 1.213 ± 0.028
1.958GlnGln: 1.958 ± 0.053
1.676GlnArg: 1.676 ± 0.038
2.207GlnSer: 2.207 ± 0.046
1.804GlnThr: 1.804 ± 0.029
2.714GlnVal: 2.714 ± 0.044
0.388GlnTrp: 0.388 ± 0.015
1.371GlnTyr: 1.371 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.611ArgAla: 2.611 ± 0.041
0.451ArgCys: 0.451 ± 0.019
1.968ArgAsp: 1.968 ± 0.039
3.148ArgGlu: 3.148 ± 0.054
1.759ArgPhe: 1.759 ± 0.035
2.674ArgGly: 2.674 ± 0.054
0.877ArgHis: 0.877 ± 0.027
3.548ArgIle: 3.548 ± 0.049
2.705ArgLys: 2.705 ± 0.049
4.192ArgLeu: 4.192 ± 0.064
1.335ArgMet: 1.335 ± 0.031
1.928ArgAsn: 1.928 ± 0.034
1.463ArgPro: 1.463 ± 0.037
1.963ArgGln: 1.963 ± 0.04
2.084ArgArg: 2.084 ± 0.046
2.309ArgSer: 2.309 ± 0.044
2.079ArgThr: 2.079 ± 0.04
2.789ArgVal: 2.789 ± 0.045
0.45ArgTrp: 0.45 ± 0.017
1.525ArgTyr: 1.525 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.407SerAla: 4.407 ± 0.065
0.69SerCys: 0.69 ± 0.023
2.679SerAsp: 2.679 ± 0.045
3.319SerGlu: 3.319 ± 0.052
2.644SerPhe: 2.644 ± 0.047
4.778SerGly: 4.778 ± 0.071
1.2SerHis: 1.2 ± 0.029
5.031SerIle: 5.031 ± 0.06
3.499SerLys: 3.499 ± 0.054
6.202SerLeu: 6.202 ± 0.076
1.802SerMet: 1.802 ± 0.038
2.474SerAsn: 2.474 ± 0.044
2.168SerPro: 2.168 ± 0.041
2.397SerGln: 2.397 ± 0.043
2.528SerArg: 2.528 ± 0.042
3.965SerSer: 3.965 ± 0.068
3.086SerThr: 3.086 ± 0.059
4.026SerVal: 4.026 ± 0.054
0.621SerTrp: 0.621 ± 0.019
2.148SerTyr: 2.148 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.825ThrAla: 4.825 ± 0.065
0.568ThrCys: 0.568 ± 0.024
2.469ThrAsp: 2.469 ± 0.045
2.87ThrGlu: 2.87 ± 0.048
2.144ThrPhe: 2.144 ± 0.039
4.813ThrGly: 4.813 ± 0.119
0.953ThrHis: 0.953 ± 0.025
4.585ThrIle: 4.585 ± 0.067
3.005ThrLys: 3.005 ± 0.048
5.466ThrLeu: 5.466 ± 0.067
1.422ThrMet: 1.422 ± 0.035
2.229ThrAsn: 2.229 ± 0.045
2.37ThrPro: 2.37 ± 0.044
1.728ThrGln: 1.728 ± 0.035
1.979ThrArg: 1.979 ± 0.04
3.07ThrSer: 3.07 ± 0.058
3.079ThrThr: 3.079 ± 0.055
4.254ThrVal: 4.254 ± 0.06
0.502ThrTrp: 0.502 ± 0.018
1.735ThrTyr: 1.735 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
6.144ValAla: 6.144 ± 0.078
0.88ValCys: 0.88 ± 0.026
3.793ValAsp: 3.793 ± 0.051
4.553ValGlu: 4.553 ± 0.056
2.841ValPhe: 2.841 ± 0.041
5.169ValGly: 5.169 ± 0.075
1.313ValHis: 1.313 ± 0.031
5.988ValIle: 5.988 ± 0.076
4.409ValLys: 4.409 ± 0.057
7.013ValLeu: 7.013 ± 0.089
2.032ValMet: 2.032 ± 0.039
3.139ValAsn: 3.139 ± 0.052
2.763ValPro: 2.763 ± 0.049
2.297ValGln: 2.297 ± 0.045
2.836ValArg: 2.836 ± 0.056
4.555ValSer: 4.555 ± 0.053
4.166ValThr: 4.166 ± 0.056
5.576ValVal: 5.576 ± 0.081
0.586ValTrp: 0.586 ± 0.019
2.148ValTyr: 2.148 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.64TrpAla: 0.64 ± 0.022
0.106TrpCys: 0.106 ± 0.01
0.495TrpAsp: 0.495 ± 0.02
0.565TrpGlu: 0.565 ± 0.02
0.421TrpPhe: 0.421 ± 0.019
0.689TrpGly: 0.689 ± 0.026
0.225TrpHis: 0.225 ± 0.013
0.655TrpIle: 0.655 ± 0.025
0.573TrpLys: 0.573 ± 0.021
1.073TrpLeu: 1.073 ± 0.027
0.3TrpMet: 0.3 ± 0.015
0.452TrpAsn: 0.452 ± 0.022
0.324TrpPro: 0.324 ± 0.019
0.505TrpGln: 0.505 ± 0.019
0.479TrpArg: 0.479 ± 0.02
0.593TrpSer: 0.593 ± 0.021
0.404TrpThr: 0.404 ± 0.02
0.585TrpVal: 0.585 ± 0.021
0.154TrpTrp: 0.154 ± 0.011
0.316TrpTyr: 0.316 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.328TyrAla: 2.328 ± 0.04
0.46TyrCys: 0.46 ± 0.02
1.79TyrAsp: 1.79 ± 0.048
1.937TyrGlu: 1.937 ± 0.036
1.465TyrPhe: 1.465 ± 0.037
2.523TyrGly: 2.523 ± 0.043
0.788TyrHis: 0.788 ± 0.024
2.413TyrIle: 2.413 ± 0.036
1.877TyrLys: 1.877 ± 0.038
3.326TyrLeu: 3.326 ± 0.057
0.757TyrMet: 0.757 ± 0.026
1.49TyrAsn: 1.49 ± 0.044
1.333TyrPro: 1.333 ± 0.029
1.459TyrGln: 1.459 ± 0.033
1.581TyrArg: 1.581 ± 0.031
2.129TyrSer: 2.129 ± 0.041
1.827TyrThr: 1.827 ± 0.042
2.016TyrVal: 2.016 ± 0.04
0.382TyrTrp: 0.382 ± 0.019
1.28TyrTyr: 1.28 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4690 proteins (1436960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski