Amino acid dipepetide frequency for Streptococcus satellite phage Javan260

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.976AlaCys: 0.976 ± 0.547
7.154AlaAsp: 7.154 ± 2.126
5.203AlaGlu: 5.203 ± 1.093
1.626AlaPhe: 1.626 ± 0.75
3.577AlaGly: 3.577 ± 1.244
0.0AlaHis: 0.0 ± 0.0
3.577AlaIle: 3.577 ± 1.104
4.553AlaLys: 4.553 ± 1.325
5.854AlaLeu: 5.854 ± 1.111
1.951AlaMet: 1.951 ± 1.093
4.553AlaAsn: 4.553 ± 0.957
2.602AlaPro: 2.602 ± 0.974
1.951AlaGln: 1.951 ± 0.782
3.252AlaArg: 3.252 ± 1.07
1.951AlaSer: 1.951 ± 0.556
3.902AlaThr: 3.902 ± 1.383
3.902AlaVal: 3.902 ± 0.664
0.0AlaTrp: 0.0 ± 0.0
0.65AlaTyr: 0.65 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.325CysAla: 0.325 ± 0.343
0.0CysCys: 0.0 ± 0.0
1.301CysAsp: 1.301 ± 0.64
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.65CysGly: 0.65 ± 0.699
0.0CysHis: 0.0 ± 0.0
0.65CysIle: 0.65 ± 0.509
0.325CysLys: 0.325 ± 0.396
0.65CysLeu: 0.65 ± 0.435
0.0CysMet: 0.0 ± 0.0
0.325CysAsn: 0.325 ± 0.255
0.325CysPro: 0.325 ± 0.349
0.976CysGln: 0.976 ± 0.779
0.65CysArg: 0.65 ± 0.42
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.325CysTyr: 0.325 ± 0.255
0.0CysXaa: 0.0 ± 0.0
Asp
0.65AspAla: 0.65 ± 0.408
0.65AspCys: 0.65 ± 0.461
5.854AspAsp: 5.854 ± 1.347
4.553AspGlu: 4.553 ± 0.888
3.577AspPhe: 3.577 ± 1.035
1.301AspGly: 1.301 ± 0.56
0.976AspHis: 0.976 ± 0.517
5.854AspIle: 5.854 ± 1.119
7.154AspLys: 7.154 ± 1.059
7.154AspLeu: 7.154 ± 1.514
2.602AspMet: 2.602 ± 1.066
4.553AspAsn: 4.553 ± 0.916
1.301AspPro: 1.301 ± 0.547
1.951AspGln: 1.951 ± 0.689
2.927AspArg: 2.927 ± 0.779
2.927AspSer: 2.927 ± 1.071
2.927AspThr: 2.927 ± 1.263
2.276AspVal: 2.276 ± 0.772
0.65AspTrp: 0.65 ± 0.396
4.228AspTyr: 4.228 ± 1.222
0.0AspXaa: 0.0 ± 0.0
Glu
4.228GluAla: 4.228 ± 1.002
0.0GluCys: 0.0 ± 0.0
3.577GluAsp: 3.577 ± 0.8
4.228GluGlu: 4.228 ± 0.982
2.602GluPhe: 2.602 ± 0.693
1.626GluGly: 1.626 ± 0.596
1.951GluHis: 1.951 ± 0.885
5.528GluIle: 5.528 ± 1.178
5.854GluLys: 5.854 ± 1.232
11.707GluLeu: 11.707 ± 1.773
1.951GluMet: 1.951 ± 0.944
4.878GluAsn: 4.878 ± 1.11
2.602GluPro: 2.602 ± 0.658
3.252GluGln: 3.252 ± 1.645
2.602GluArg: 2.602 ± 1.105
4.228GluSer: 4.228 ± 0.859
4.228GluThr: 4.228 ± 1.099
5.528GluVal: 5.528 ± 1.118
1.301GluTrp: 1.301 ± 0.52
1.951GluTyr: 1.951 ± 0.677
0.0GluXaa: 0.0 ± 0.0
Phe
1.301PheAla: 1.301 ± 0.56
0.325PheCys: 0.325 ± 0.402
2.602PheAsp: 2.602 ± 0.985
3.252PheGlu: 3.252 ± 0.88
1.951PhePhe: 1.951 ± 0.936
1.951PheGly: 1.951 ± 0.732
0.65PheHis: 0.65 ± 0.438
4.228PheIle: 4.228 ± 1.238
2.602PheLys: 2.602 ± 0.815
2.602PheLeu: 2.602 ± 0.854
0.976PheMet: 0.976 ± 0.595
2.602PheAsn: 2.602 ± 1.035
0.65PhePro: 0.65 ± 0.481
1.951PheGln: 1.951 ± 0.625
1.301PheArg: 1.301 ± 0.573
3.577PheSer: 3.577 ± 1.024
2.602PheThr: 2.602 ± 0.943
1.301PheVal: 1.301 ± 0.564
0.0PheTrp: 0.0 ± 0.0
1.301PheTyr: 1.301 ± 0.539
0.0PheXaa: 0.0 ± 0.0
Gly
3.577GlyAla: 3.577 ± 1.686
0.325GlyCys: 0.325 ± 0.264
1.626GlyAsp: 1.626 ± 0.811
3.902GlyGlu: 3.902 ± 1.094
2.602GlyPhe: 2.602 ± 1.01
1.626GlyGly: 1.626 ± 0.809
0.325GlyHis: 0.325 ± 0.264
4.878GlyIle: 4.878 ± 0.65
5.203GlyLys: 5.203 ± 0.954
4.878GlyLeu: 4.878 ± 1.56
0.65GlyMet: 0.65 ± 0.422
2.276GlyAsn: 2.276 ± 0.81
0.0GlyPro: 0.0 ± 0.0
0.325GlyGln: 0.325 ± 0.277
2.602GlyArg: 2.602 ± 0.83
1.301GlySer: 1.301 ± 0.615
3.252GlyThr: 3.252 ± 1.182
3.252GlyVal: 3.252 ± 1.062
1.301GlyTrp: 1.301 ± 0.787
3.252GlyTyr: 3.252 ± 0.864
0.0GlyXaa: 0.0 ± 0.0
His
1.626HisAla: 1.626 ± 1.106
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.976HisGlu: 0.976 ± 0.537
0.0HisPhe: 0.0 ± 0.0
0.976HisGly: 0.976 ± 0.525
0.65HisHis: 0.65 ± 0.561
0.325HisIle: 0.325 ± 0.255
0.325HisLys: 0.325 ± 0.255
2.927HisLeu: 2.927 ± 0.805
0.65HisMet: 0.65 ± 0.549
0.65HisAsn: 0.65 ± 0.481
0.325HisPro: 0.325 ± 0.316
0.976HisGln: 0.976 ± 0.539
0.976HisArg: 0.976 ± 0.574
0.976HisSer: 0.976 ± 0.408
1.951HisThr: 1.951 ± 0.636
0.976HisVal: 0.976 ± 0.489
0.0HisTrp: 0.0 ± 0.0
1.301HisTyr: 1.301 ± 0.568
0.0HisXaa: 0.0 ± 0.0
Ile
5.203IleAla: 5.203 ± 0.912
0.325IleCys: 0.325 ± 0.349
4.878IleAsp: 4.878 ± 1.221
5.203IleGlu: 5.203 ± 1.263
4.228IlePhe: 4.228 ± 0.921
2.602IleGly: 2.602 ± 0.733
0.65IleHis: 0.65 ± 0.669
5.203IleIle: 5.203 ± 1.261
7.805IleLys: 7.805 ± 1.488
4.553IleLeu: 4.553 ± 1.326
0.325IleMet: 0.325 ± 0.382
5.528IleAsn: 5.528 ± 1.527
4.553IlePro: 4.553 ± 1.109
0.976IleGln: 0.976 ± 0.41
2.927IleArg: 2.927 ± 1.108
5.203IleSer: 5.203 ± 1.235
5.854IleThr: 5.854 ± 1.235
4.228IleVal: 4.228 ± 1.474
0.0IleTrp: 0.0 ± 0.0
3.902IleTyr: 3.902 ± 0.959
0.0IleXaa: 0.0 ± 0.0
Lys
5.528LysAla: 5.528 ± 1.884
0.0LysCys: 0.0 ± 0.0
2.927LysAsp: 2.927 ± 1.177
10.081LysGlu: 10.081 ± 1.738
2.276LysPhe: 2.276 ± 0.655
6.829LysGly: 6.829 ± 1.842
1.951LysHis: 1.951 ± 0.572
5.854LysIle: 5.854 ± 1.043
7.48LysLys: 7.48 ± 1.442
7.48LysLeu: 7.48 ± 1.217
1.951LysMet: 1.951 ± 0.663
3.577LysAsn: 3.577 ± 1.068
5.203LysPro: 5.203 ± 1.405
6.829LysGln: 6.829 ± 1.561
4.553LysArg: 4.553 ± 0.946
3.252LysSer: 3.252 ± 0.839
4.553LysThr: 4.553 ± 0.767
3.902LysVal: 3.902 ± 0.839
1.301LysTrp: 1.301 ± 0.493
1.626LysTyr: 1.626 ± 0.542
0.0LysXaa: 0.0 ± 0.0
Leu
8.455LeuAla: 8.455 ± 1.896
1.301LeuCys: 1.301 ± 0.611
8.455LeuAsp: 8.455 ± 1.394
8.455LeuGlu: 8.455 ± 2.075
1.626LeuPhe: 1.626 ± 0.779
5.528LeuGly: 5.528 ± 1.311
1.301LeuHis: 1.301 ± 0.732
6.179LeuIle: 6.179 ± 1.22
8.78LeuLys: 8.78 ± 1.565
13.008LeuLeu: 13.008 ± 2.277
2.276LeuMet: 2.276 ± 0.789
7.154LeuAsn: 7.154 ± 1.354
3.577LeuPro: 3.577 ± 1.137
4.228LeuGln: 4.228 ± 1.198
2.602LeuArg: 2.602 ± 0.585
6.504LeuSer: 6.504 ± 1.043
6.179LeuThr: 6.179 ± 1.063
3.902LeuVal: 3.902 ± 1.259
1.626LeuTrp: 1.626 ± 0.657
3.577LeuTyr: 3.577 ± 0.96
0.0LeuXaa: 0.0 ± 0.0
Met
5.203MetAla: 5.203 ± 1.381
0.0MetCys: 0.0 ± 0.0
0.65MetAsp: 0.65 ± 0.528
0.65MetGlu: 0.65 ± 0.447
0.325MetPhe: 0.325 ± 0.326
0.325MetGly: 0.325 ± 0.288
0.0MetHis: 0.0 ± 0.0
2.276MetIle: 2.276 ± 0.932
0.65MetLys: 0.65 ± 0.306
2.927MetLeu: 2.927 ± 0.843
0.325MetMet: 0.325 ± 0.302
2.927MetAsn: 2.927 ± 0.89
0.325MetPro: 0.325 ± 0.329
0.976MetGln: 0.976 ± 0.464
0.976MetArg: 0.976 ± 0.478
0.325MetSer: 0.325 ± 0.255
3.902MetThr: 3.902 ± 1.03
2.602MetVal: 2.602 ± 1.04
0.0MetTrp: 0.0 ± 0.0
0.325MetTyr: 0.325 ± 0.288
0.0MetXaa: 0.0 ± 0.0
Asn
4.228AsnAla: 4.228 ± 1.039
0.65AsnCys: 0.65 ± 0.443
2.602AsnAsp: 2.602 ± 0.939
2.927AsnGlu: 2.927 ± 0.799
1.951AsnPhe: 1.951 ± 0.72
5.203AsnGly: 5.203 ± 1.461
0.976AsnHis: 0.976 ± 0.517
2.927AsnIle: 2.927 ± 1.272
5.528AsnLys: 5.528 ± 1.025
5.528AsnLeu: 5.528 ± 1.516
1.301AsnMet: 1.301 ± 0.488
2.276AsnAsn: 2.276 ± 0.552
3.902AsnPro: 3.902 ± 1.107
1.951AsnGln: 1.951 ± 0.897
3.902AsnArg: 3.902 ± 0.782
1.951AsnSer: 1.951 ± 0.577
2.276AsnThr: 2.276 ± 1.019
2.276AsnVal: 2.276 ± 0.79
0.325AsnTrp: 0.325 ± 0.288
3.252AsnTyr: 3.252 ± 1.193
0.0AsnXaa: 0.0 ± 0.0
Pro
2.927ProAla: 2.927 ± 0.938
0.0ProCys: 0.0 ± 0.0
1.626ProAsp: 1.626 ± 0.623
1.951ProGlu: 1.951 ± 0.661
2.602ProPhe: 2.602 ± 0.759
0.325ProGly: 0.325 ± 0.349
0.325ProHis: 0.325 ± 0.329
3.252ProIle: 3.252 ± 0.76
4.878ProLys: 4.878 ± 1.258
3.252ProLeu: 3.252 ± 1.015
0.65ProMet: 0.65 ± 0.386
1.951ProAsn: 1.951 ± 0.688
0.976ProPro: 0.976 ± 0.516
1.626ProGln: 1.626 ± 0.735
1.951ProArg: 1.951 ± 0.601
2.927ProSer: 2.927 ± 0.945
2.602ProThr: 2.602 ± 0.721
1.951ProVal: 1.951 ± 0.462
0.0ProTrp: 0.0 ± 0.0
1.951ProTyr: 1.951 ± 0.663
0.0ProXaa: 0.0 ± 0.0
Gln
3.252GlnAla: 3.252 ± 1.349
0.0GlnCys: 0.0 ± 0.0
1.951GlnAsp: 1.951 ± 0.688
3.577GlnGlu: 3.577 ± 0.957
1.301GlnPhe: 1.301 ± 0.565
2.602GlnGly: 2.602 ± 0.778
1.626GlnHis: 1.626 ± 0.749
3.252GlnIle: 3.252 ± 0.835
3.252GlnLys: 3.252 ± 0.95
5.528GlnLeu: 5.528 ± 1.382
0.976GlnMet: 0.976 ± 0.459
1.626GlnAsn: 1.626 ± 0.886
1.626GlnPro: 1.626 ± 0.697
2.276GlnGln: 2.276 ± 1.277
2.276GlnArg: 2.276 ± 0.867
1.626GlnSer: 1.626 ± 0.594
2.927GlnThr: 2.927 ± 0.83
3.252GlnVal: 3.252 ± 0.677
0.325GlnTrp: 0.325 ± 0.255
2.276GlnTyr: 2.276 ± 0.809
0.0GlnXaa: 0.0 ± 0.0
Arg
1.626ArgAla: 1.626 ± 0.76
0.325ArgCys: 0.325 ± 0.349
5.203ArgAsp: 5.203 ± 1.106
2.602ArgGlu: 2.602 ± 1.199
2.276ArgPhe: 2.276 ± 0.964
1.301ArgGly: 1.301 ± 0.726
0.976ArgHis: 0.976 ± 0.53
1.951ArgIle: 1.951 ± 0.81
4.878ArgLys: 4.878 ± 1.029
5.528ArgLeu: 5.528 ± 1.289
1.951ArgMet: 1.951 ± 0.702
2.276ArgAsn: 2.276 ± 0.829
1.301ArgPro: 1.301 ± 0.635
4.228ArgGln: 4.228 ± 1.137
2.602ArgArg: 2.602 ± 0.925
1.626ArgSer: 1.626 ± 0.563
2.927ArgThr: 2.927 ± 0.749
2.276ArgVal: 2.276 ± 0.828
0.65ArgTrp: 0.65 ± 0.445
1.951ArgTyr: 1.951 ± 1.396
0.0ArgXaa: 0.0 ± 0.0
Ser
1.626SerAla: 1.626 ± 0.559
0.325SerCys: 0.325 ± 0.302
4.878SerAsp: 4.878 ± 1.026
2.927SerGlu: 2.927 ± 1.139
1.626SerPhe: 1.626 ± 0.62
1.951SerGly: 1.951 ± 0.745
1.301SerHis: 1.301 ± 0.681
3.902SerIle: 3.902 ± 0.992
3.577SerLys: 3.577 ± 1.024
4.553SerLeu: 4.553 ± 1.211
1.951SerMet: 1.951 ± 0.661
2.276SerAsn: 2.276 ± 0.749
0.976SerPro: 0.976 ± 0.593
3.577SerGln: 3.577 ± 1.009
4.553SerArg: 4.553 ± 1.279
2.602SerSer: 2.602 ± 0.871
1.301SerThr: 1.301 ± 0.962
3.902SerVal: 3.902 ± 0.955
0.0SerTrp: 0.0 ± 0.0
4.553SerTyr: 4.553 ± 1.363
0.0SerXaa: 0.0 ± 0.0
Thr
3.252ThrAla: 3.252 ± 1.136
0.325ThrCys: 0.325 ± 0.349
4.228ThrAsp: 4.228 ± 0.855
5.854ThrGlu: 5.854 ± 1.163
2.276ThrPhe: 2.276 ± 0.617
4.228ThrGly: 4.228 ± 1.163
0.65ThrHis: 0.65 ± 0.398
5.528ThrIle: 5.528 ± 0.995
5.203ThrLys: 5.203 ± 1.475
6.504ThrLeu: 6.504 ± 1.262
1.301ThrMet: 1.301 ± 0.436
1.626ThrAsn: 1.626 ± 0.72
2.927ThrPro: 2.927 ± 0.988
2.927ThrGln: 2.927 ± 1.033
3.252ThrArg: 3.252 ± 0.791
1.951ThrSer: 1.951 ± 0.625
2.602ThrThr: 2.602 ± 0.823
2.602ThrVal: 2.602 ± 0.636
0.65ThrTrp: 0.65 ± 0.376
2.276ThrTyr: 2.276 ± 0.993
0.0ThrXaa: 0.0 ± 0.0
Val
3.577ValAla: 3.577 ± 1.006
0.65ValCys: 0.65 ± 0.358
1.951ValAsp: 1.951 ± 0.727
3.577ValGlu: 3.577 ± 1.092
1.626ValPhe: 1.626 ± 0.862
1.951ValGly: 1.951 ± 0.622
0.976ValHis: 0.976 ± 0.512
3.902ValIle: 3.902 ± 1.218
4.553ValLys: 4.553 ± 1.151
5.203ValLeu: 5.203 ± 1.493
2.276ValMet: 2.276 ± 0.652
2.276ValAsn: 2.276 ± 0.645
2.927ValPro: 2.927 ± 0.936
0.976ValGln: 0.976 ± 0.808
1.951ValArg: 1.951 ± 0.677
4.878ValSer: 4.878 ± 1.029
4.228ValThr: 4.228 ± 1.174
1.951ValVal: 1.951 ± 1.027
0.325ValTrp: 0.325 ± 0.277
1.951ValTyr: 1.951 ± 0.793
0.0ValXaa: 0.0 ± 0.0
Trp
0.65TrpAla: 0.65 ± 0.468
0.0TrpCys: 0.0 ± 0.0
0.325TrpAsp: 0.325 ± 0.288
0.325TrpGlu: 0.325 ± 0.358
0.65TrpPhe: 0.65 ± 0.364
0.325TrpGly: 0.325 ± 0.288
0.65TrpHis: 0.65 ± 0.364
0.0TrpIle: 0.0 ± 0.0
0.325TrpLys: 0.325 ± 0.349
1.951TrpLeu: 1.951 ± 0.634
0.0TrpMet: 0.0 ± 0.0
0.325TrpAsn: 0.325 ± 0.288
0.0TrpPro: 0.0 ± 0.0
0.325TrpGln: 0.325 ± 0.255
0.65TrpArg: 0.65 ± 0.358
0.65TrpSer: 0.65 ± 0.377
0.325TrpThr: 0.325 ± 0.329
0.976TrpVal: 0.976 ± 0.438
0.325TrpTrp: 0.325 ± 0.288
0.65TrpTyr: 0.65 ± 0.377
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.325TyrCys: 0.325 ± 0.316
2.276TyrAsp: 2.276 ± 1.314
3.577TyrGlu: 3.577 ± 0.752
2.602TyrPhe: 2.602 ± 0.826
2.276TyrGly: 2.276 ± 0.707
0.65TyrHis: 0.65 ± 0.509
4.878TyrIle: 4.878 ± 1.046
4.228TyrLys: 4.228 ± 1.19
2.927TyrLeu: 2.927 ± 0.914
1.301TyrMet: 1.301 ± 0.576
2.276TyrAsn: 2.276 ± 0.647
1.626TyrPro: 1.626 ± 0.765
3.252TyrGln: 3.252 ± 0.728
2.276TyrArg: 2.276 ± 0.678
3.902TyrSer: 3.902 ± 1.223
1.626TyrThr: 1.626 ± 0.616
0.65TyrVal: 0.65 ± 0.42
0.65TyrTrp: 0.65 ± 0.699
2.602TyrTyr: 2.602 ± 0.761
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3076 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski