Amino acid dipepetide frequency for Lake Sarah-associated circular virus-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.657AlaAla: 7.657 ± 0.568
0.0AlaCys: 0.0 ± 0.0
6.126AlaAsp: 6.126 ± 2.665
3.063AlaGlu: 3.063 ± 0.218
1.531AlaPhe: 1.531 ± 1.005
3.063AlaGly: 3.063 ± 0.218
3.063AlaHis: 3.063 ± 2.01
3.063AlaIle: 3.063 ± 2.01
3.063AlaLys: 3.063 ± 2.01
6.126AlaLeu: 6.126 ± 0.437
0.0AlaMet: 0.0 ± 0.0
3.063AlaAsn: 3.063 ± 0.218
0.0AlaPro: 0.0 ± 0.0
4.594AlaGln: 4.594 ± 3.015
3.063AlaArg: 3.063 ± 0.218
6.126AlaSer: 6.126 ± 0.437
6.126AlaThr: 6.126 ± 0.437
4.594AlaVal: 4.594 ± 1.442
4.594AlaTrp: 4.594 ± 0.787
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.531CysGly: 1.531 ± 1.005
0.0CysHis: 0.0 ± 0.0
1.531CysIle: 1.531 ± 1.005
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.531CysPro: 1.531 ± 1.005
1.531CysGln: 1.531 ± 1.223
1.531CysArg: 1.531 ± 1.005
0.0CysSer: 0.0 ± 0.0
1.531CysThr: 1.531 ± 1.005
1.531CysVal: 1.531 ± 1.005
1.531CysTrp: 1.531 ± 1.223
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.531AspAla: 1.531 ± 1.223
0.0AspCys: 0.0 ± 0.0
3.063AspAsp: 3.063 ± 2.01
1.531AspGlu: 1.531 ± 1.005
3.063AspPhe: 3.063 ± 2.01
6.126AspGly: 6.126 ± 1.792
3.063AspHis: 3.063 ± 2.447
3.063AspIle: 3.063 ± 0.218
3.063AspLys: 3.063 ± 2.01
7.657AspLeu: 7.657 ± 0.568
0.0AspMet: 0.0 ± 0.0
1.531AspAsn: 1.531 ± 1.223
3.063AspPro: 3.063 ± 2.01
0.0AspGln: 0.0 ± 0.0
0.0AspArg: 0.0 ± 0.0
3.063AspSer: 3.063 ± 2.01
0.0AspThr: 0.0 ± 0.0
4.594AspVal: 4.594 ± 1.442
0.0AspTrp: 0.0 ± 0.0
4.594AspTyr: 4.594 ± 1.442
0.0AspXaa: 0.0 ± 0.0
Glu
3.063GluAla: 3.063 ± 2.01
1.531GluCys: 1.531 ± 1.005
3.063GluAsp: 3.063 ± 2.01
3.063GluGlu: 3.063 ± 2.01
1.531GluPhe: 1.531 ± 1.005
0.0GluGly: 0.0 ± 0.0
0.0GluHis: 0.0 ± 0.0
3.063GluIle: 3.063 ± 2.01
4.594GluLys: 4.594 ± 0.787
1.531GluLeu: 1.531 ± 1.223
0.0GluMet: 0.0 ± 0.0
4.594GluAsn: 4.594 ± 0.787
6.126GluPro: 6.126 ± 2.665
6.126GluGln: 6.126 ± 0.437
0.0GluArg: 0.0 ± 0.0
0.0GluSer: 0.0 ± 0.0
1.531GluThr: 1.531 ± 1.223
1.531GluVal: 1.531 ± 1.223
0.0GluTrp: 0.0 ± 0.0
3.063GluTyr: 3.063 ± 2.01
0.0GluXaa: 0.0 ± 0.0
Phe
3.063PheAla: 3.063 ± 2.01
1.531PheCys: 1.531 ± 1.005
1.531PheAsp: 1.531 ± 1.005
1.531PheGlu: 1.531 ± 1.223
1.531PhePhe: 1.531 ± 1.005
1.531PheGly: 1.531 ± 1.005
1.531PheHis: 1.531 ± 1.005
1.531PheIle: 1.531 ± 1.005
4.594PheLys: 4.594 ± 1.442
4.594PheLeu: 4.594 ± 0.787
0.0PheMet: 0.0 ± 0.0
1.531PheAsn: 1.531 ± 1.223
1.531PhePro: 1.531 ± 1.005
0.0PheGln: 0.0 ± 0.0
1.531PheArg: 1.531 ± 1.223
4.594PheSer: 4.594 ± 0.787
1.531PheThr: 1.531 ± 1.223
1.531PheVal: 1.531 ± 1.005
0.0PheTrp: 0.0 ± 0.0
4.594PheTyr: 4.594 ± 3.015
0.0PheXaa: 0.0 ± 0.0
Gly
3.063GlyAla: 3.063 ± 0.218
0.0GlyCys: 0.0 ± 0.0
0.0GlyAsp: 0.0 ± 0.0
0.0GlyGlu: 0.0 ± 0.0
3.063GlyPhe: 3.063 ± 0.218
4.594GlyGly: 4.594 ± 1.442
1.531GlyHis: 1.531 ± 1.223
1.531GlyIle: 1.531 ± 1.223
4.594GlyLys: 4.594 ± 3.015
1.531GlyLeu: 1.531 ± 1.223
0.0GlyMet: 0.0 ± 0.0
3.063GlyAsn: 3.063 ± 0.218
7.657GlyPro: 7.657 ± 0.568
6.126GlyGln: 6.126 ± 1.792
6.126GlyArg: 6.126 ± 4.894
6.126GlySer: 6.126 ± 2.665
1.531GlyThr: 1.531 ± 1.223
1.531GlyVal: 1.531 ± 1.223
1.531GlyTrp: 1.531 ± 1.223
1.531GlyTyr: 1.531 ± 1.223
0.0GlyXaa: 0.0 ± 0.0
His
1.531HisAla: 1.531 ± 1.005
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
3.063HisGlu: 3.063 ± 2.01
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
4.594HisIle: 4.594 ± 1.442
1.531HisLys: 1.531 ± 1.005
3.063HisLeu: 3.063 ± 0.218
1.531HisMet: 1.531 ± 1.005
1.531HisAsn: 1.531 ± 1.005
3.063HisPro: 3.063 ± 0.218
3.063HisGln: 3.063 ± 2.01
0.0HisArg: 0.0 ± 0.0
1.531HisSer: 1.531 ± 1.223
0.0HisThr: 0.0 ± 0.0
1.531HisVal: 1.531 ± 1.223
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.126IleAla: 6.126 ± 1.792
0.0IleCys: 0.0 ± 0.0
1.531IleAsp: 1.531 ± 1.005
3.063IleGlu: 3.063 ± 0.218
0.0IlePhe: 0.0 ± 0.0
3.063IleGly: 3.063 ± 0.218
0.0IleHis: 0.0 ± 0.0
3.063IleIle: 3.063 ± 2.01
3.063IleLys: 3.063 ± 2.01
4.594IleLeu: 4.594 ± 1.442
1.531IleMet: 1.531 ± 1.223
6.126IleAsn: 6.126 ± 0.437
3.063IlePro: 3.063 ± 2.447
4.594IleGln: 4.594 ± 0.787
1.531IleArg: 1.531 ± 1.223
1.531IleSer: 1.531 ± 1.005
9.188IleThr: 9.188 ± 1.573
6.126IleVal: 6.126 ± 1.792
1.531IleTrp: 1.531 ± 1.223
4.594IleTyr: 4.594 ± 0.787
0.0IleXaa: 0.0 ± 0.0
Lys
4.594LysAla: 4.594 ± 0.787
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
7.657LysGlu: 7.657 ± 0.568
4.594LysPhe: 4.594 ± 3.015
6.126LysGly: 6.126 ± 0.437
1.531LysHis: 1.531 ± 1.005
1.531LysIle: 1.531 ± 1.223
3.063LysLys: 3.063 ± 0.218
1.531LysLeu: 1.531 ± 1.005
3.063LysMet: 3.063 ± 2.447
3.063LysAsn: 3.063 ± 0.218
3.063LysPro: 3.063 ± 0.218
1.531LysGln: 1.531 ± 1.005
7.657LysArg: 7.657 ± 0.568
7.657LysSer: 7.657 ± 0.568
7.657LysThr: 7.657 ± 0.568
6.126LysVal: 6.126 ± 4.894
0.0LysTrp: 0.0 ± 0.0
3.063LysTyr: 3.063 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
6.126LeuAla: 6.126 ± 0.437
0.0LeuCys: 0.0 ± 0.0
3.063LeuAsp: 3.063 ± 0.218
6.126LeuGlu: 6.126 ± 4.02
6.126LeuPhe: 6.126 ± 0.437
3.063LeuGly: 3.063 ± 0.218
1.531LeuHis: 1.531 ± 1.005
3.063LeuIle: 3.063 ± 2.01
1.531LeuLys: 1.531 ± 1.005
4.594LeuLeu: 4.594 ± 3.015
0.0LeuMet: 0.0 ± 0.0
6.126LeuAsn: 6.126 ± 0.437
4.594LeuPro: 4.594 ± 1.442
3.063LeuGln: 3.063 ± 2.01
6.126LeuArg: 6.126 ± 2.665
9.188LeuSer: 9.188 ± 0.655
4.594LeuThr: 4.594 ± 3.015
3.063LeuVal: 3.063 ± 0.218
1.531LeuTrp: 1.531 ± 1.005
3.063LeuTyr: 3.063 ± 0.218
0.0LeuXaa: 0.0 ± 0.0
Met
1.531MetAla: 1.531 ± 1.005
0.0MetCys: 0.0 ± 0.0
3.063MetAsp: 3.063 ± 2.01
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.531MetGly: 1.531 ± 1.223
1.531MetHis: 1.531 ± 1.223
0.0MetIle: 0.0 ± 0.0
4.594MetLys: 4.594 ± 0.787
1.531MetLeu: 1.531 ± 1.223
0.0MetMet: 0.0 ± 0.0
1.531MetAsn: 1.531 ± 1.223
1.531MetPro: 1.531 ± 1.005
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
3.063MetVal: 3.063 ± 2.447
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.063AsnAla: 3.063 ± 0.218
1.531AsnCys: 1.531 ± 1.005
4.594AsnAsp: 4.594 ± 0.787
3.063AsnGlu: 3.063 ± 2.447
0.0AsnPhe: 0.0 ± 0.0
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
6.126AsnIle: 6.126 ± 0.437
6.126AsnLys: 6.126 ± 1.792
4.594AsnLeu: 4.594 ± 0.787
1.531AsnMet: 1.531 ± 1.22
3.063AsnAsn: 3.063 ± 0.218
3.063AsnPro: 3.063 ± 2.454
3.063AsnGln: 3.063 ± 0.218
3.063AsnArg: 3.063 ± 2.447
0.0AsnSer: 0.0 ± 0.0
3.063AsnThr: 3.063 ± 2.447
3.063AsnVal: 3.063 ± 0.218
3.063AsnTrp: 3.063 ± 0.218
1.531AsnTyr: 1.531 ± 1.005
0.0AsnXaa: 0.0 ± 0.0
Pro
7.657ProAla: 7.657 ± 0.568
4.594ProCys: 4.594 ± 0.787
3.063ProAsp: 3.063 ± 0.218
6.126ProGlu: 6.126 ± 1.792
1.531ProPhe: 1.531 ± 1.223
3.063ProGly: 3.063 ± 0.218
1.531ProHis: 1.531 ± 1.005
1.531ProIle: 1.531 ± 1.223
0.0ProLys: 0.0 ± 0.0
4.594ProLeu: 4.594 ± 0.787
1.531ProMet: 1.531 ± 1.005
4.594ProAsn: 4.594 ± 0.787
1.531ProPro: 1.531 ± 1.005
1.531ProGln: 1.531 ± 1.005
3.063ProArg: 3.063 ± 2.01
1.531ProSer: 1.531 ± 1.223
3.063ProThr: 3.063 ± 0.218
4.594ProVal: 4.594 ± 3.015
0.0ProTrp: 0.0 ± 0.0
1.531ProTyr: 1.531 ± 1.223
0.0ProXaa: 0.0 ± 0.0
Gln
4.594GlnAla: 4.594 ± 3.015
1.531GlnCys: 1.531 ± 1.005
0.0GlnAsp: 0.0 ± 0.0
0.0GlnGlu: 0.0 ± 0.0
1.531GlnPhe: 1.531 ± 1.005
1.531GlnGly: 1.531 ± 1.223
4.594GlnHis: 4.594 ± 3.015
3.063GlnIle: 3.063 ± 0.218
1.531GlnLys: 1.531 ± 1.005
4.594GlnLeu: 4.594 ± 0.787
1.531GlnMet: 1.531 ± 1.223
1.531GlnAsn: 1.531 ± 1.005
3.063GlnPro: 3.063 ± 2.01
0.0GlnGln: 0.0 ± 0.0
6.126GlnArg: 6.126 ± 2.665
0.0GlnSer: 0.0 ± 0.0
1.531GlnThr: 1.531 ± 1.005
4.594GlnVal: 4.594 ± 0.787
3.063GlnTrp: 3.063 ± 0.218
1.531GlnTyr: 1.531 ± 1.223
0.0GlnXaa: 0.0 ± 0.0
Arg
1.531ArgAla: 1.531 ± 1.223
0.0ArgCys: 0.0 ± 0.0
1.531ArgAsp: 1.531 ± 1.005
0.0ArgGlu: 0.0 ± 0.0
7.657ArgPhe: 7.657 ± 1.66
1.531ArgGly: 1.531 ± 1.223
3.063ArgHis: 3.063 ± 2.447
15.314ArgIle: 15.314 ± 1.092
6.126ArgLys: 6.126 ± 2.665
4.594ArgLeu: 4.594 ± 0.787
1.531ArgMet: 1.531 ± 1.223
3.063ArgAsn: 3.063 ± 2.01
0.0ArgPro: 0.0 ± 0.0
3.063ArgGln: 3.063 ± 2.447
9.188ArgArg: 9.188 ± 5.112
1.531ArgSer: 1.531 ± 1.223
1.531ArgThr: 1.531 ± 1.223
3.063ArgVal: 3.063 ± 2.447
0.0ArgTrp: 0.0 ± 0.0
1.531ArgTyr: 1.531 ± 1.223
0.0ArgXaa: 0.0 ± 0.0
Ser
7.657SerAla: 7.657 ± 3.889
0.0SerCys: 0.0 ± 0.0
1.531SerAsp: 1.531 ± 1.005
0.0SerGlu: 0.0 ± 0.0
0.0SerPhe: 0.0 ± 0.0
3.063SerGly: 3.063 ± 0.218
1.531SerHis: 1.531 ± 1.005
3.063SerIle: 3.063 ± 2.447
10.72SerLys: 10.72 ± 6.336
3.063SerLeu: 3.063 ± 2.01
0.0SerMet: 0.0 ± 0.0
3.063SerAsn: 3.063 ± 0.218
3.063SerPro: 3.063 ± 2.01
1.531SerGln: 1.531 ± 1.005
4.594SerArg: 4.594 ± 1.442
6.126SerSer: 6.126 ± 2.665
6.126SerThr: 6.126 ± 2.665
1.531SerVal: 1.531 ± 1.005
3.063SerTrp: 3.063 ± 2.447
3.063SerTyr: 3.063 ± 0.218
0.0SerXaa: 0.0 ± 0.0
Thr
3.063ThrAla: 3.063 ± 2.447
0.0ThrCys: 0.0 ± 0.0
7.657ThrAsp: 7.657 ± 3.889
0.0ThrGlu: 0.0 ± 0.0
3.063ThrPhe: 3.063 ± 2.01
7.657ThrGly: 7.657 ± 3.889
1.531ThrHis: 1.531 ± 1.005
0.0ThrIle: 0.0 ± 0.0
3.063ThrLys: 3.063 ± 0.218
3.063ThrLeu: 3.063 ± 0.218
0.0ThrMet: 0.0 ± 0.0
1.531ThrAsn: 1.531 ± 1.005
3.063ThrPro: 3.063 ± 0.218
0.0ThrGln: 0.0 ± 0.0
1.531ThrArg: 1.531 ± 1.005
3.063ThrSer: 3.063 ± 2.447
1.531ThrThr: 1.531 ± 1.005
6.126ThrVal: 6.126 ± 1.792
6.126ThrTrp: 6.126 ± 0.437
1.531ThrTyr: 1.531 ± 1.005
0.0ThrXaa: 0.0 ± 0.0
Val
1.531ValAla: 1.531 ± 1.005
0.0ValCys: 0.0 ± 0.0
0.0ValAsp: 0.0 ± 0.0
1.531ValGlu: 1.531 ± 1.005
3.063ValPhe: 3.063 ± 0.218
4.594ValGly: 4.594 ± 3.67
0.0ValHis: 0.0 ± 0.0
6.126ValIle: 6.126 ± 1.792
9.188ValLys: 9.188 ± 2.884
4.594ValLeu: 4.594 ± 0.787
4.594ValMet: 4.594 ± 0.383
3.063ValAsn: 3.063 ± 2.01
6.126ValPro: 6.126 ± 1.133
1.531ValGln: 1.531 ± 1.223
7.657ValArg: 7.657 ± 3.889
3.063ValSer: 3.063 ± 2.447
1.531ValThr: 1.531 ± 1.223
3.063ValVal: 3.063 ± 0.218
1.531ValTrp: 1.531 ± 1.005
1.531ValTyr: 1.531 ± 1.005
0.0ValXaa: 0.0 ± 0.0
Trp
1.531TrpAla: 1.531 ± 1.005
0.0TrpCys: 0.0 ± 0.0
3.063TrpAsp: 3.063 ± 2.447
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.531TrpGly: 1.531 ± 1.223
0.0TrpHis: 0.0 ± 0.0
1.531TrpIle: 1.531 ± 1.005
3.063TrpLys: 3.063 ± 2.447
6.126TrpLeu: 6.126 ± 4.02
0.0TrpMet: 0.0 ± 0.0
3.063TrpAsn: 3.063 ± 2.447
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
3.063TrpSer: 3.063 ± 2.447
1.531TrpThr: 1.531 ± 1.223
1.531TrpVal: 1.531 ± 1.005
0.0TrpTrp: 0.0 ± 0.0
1.531TrpTyr: 1.531 ± 1.005
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.531TyrCys: 1.531 ± 1.223
6.126TyrAsp: 6.126 ± 4.02
4.594TyrGlu: 4.594 ± 1.442
1.531TyrPhe: 1.531 ± 1.005
1.531TyrGly: 1.531 ± 1.223
0.0TyrHis: 0.0 ± 0.0
1.531TyrIle: 1.531 ± 1.005
0.0TyrLys: 0.0 ± 0.0
4.594TyrLeu: 4.594 ± 0.787
1.531TyrMet: 1.531 ± 1.005
0.0TyrAsn: 0.0 ± 0.0
1.531TyrPro: 1.531 ± 1.005
4.594TyrGln: 4.594 ± 0.787
3.063TyrArg: 3.063 ± 0.218
4.594TyrSer: 4.594 ± 1.442
0.0TyrThr: 0.0 ± 0.0
1.531TyrVal: 1.531 ± 1.223
0.0TyrTrp: 0.0 ± 0.0
1.531TyrTyr: 1.531 ± 1.005
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski