Amino acid dipepetide frequency for Deinococcus yavapaiensis KR-236

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.381AlaAla: 14.381 ± 0.157	0.939AlaCys: 0.939 ± 0.031	5.593AlaAsp: 5.593 ± 0.069	6.174AlaGlu: 6.174 ± 0.095	4.912AlaPhe: 4.912 ± 0.066	8.214AlaGly: 8.214 ± 0.074	2.751AlaHis: 2.751 ± 0.048	3.687AlaIle: 3.687 ± 0.061	3.323AlaLys: 3.323 ± 0.062	15.916AlaLeu: 15.916 ± 0.167	2.28AlaMet: 2.28 ± 0.037	3.095AlaAsn: 3.095 ± 0.067	5.785AlaPro: 5.785 ± 0.081	3.848AlaGln: 3.848 ± 0.055	11.272AlaArg: 11.272 ± 0.136	7.831AlaSer: 7.831 ± 0.078	6.439AlaThr: 6.439 ± 0.078	8.832AlaVal: 8.832 ± 0.084	2.216AlaTrp: 2.216 ± 0.041	2.924AlaTyr: 2.924 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.688CysAla: 0.688 ± 0.027	0.072CysCys: 0.072 ± 0.007	0.393CysAsp: 0.393 ± 0.017	0.351CysGlu: 0.351 ± 0.017	0.187CysPhe: 0.187 ± 0.012	0.6CysGly: 0.6 ± 0.021	0.131CysHis: 0.131 ± 0.009	0.157CysIle: 0.157 ± 0.011	0.12CysLys: 0.12 ± 0.01	0.566CysLeu: 0.566 ± 0.021	0.09CysMet: 0.09 ± 0.009	0.127CysAsn: 0.127 ± 0.01	0.351CysPro: 0.351 ± 0.02	0.165CysGln: 0.165 ± 0.011	0.411CysArg: 0.411 ± 0.016	0.34CysSer: 0.34 ± 0.015	0.389CysThr: 0.389 ± 0.017	0.528CysVal: 0.528 ± 0.019	0.075CysTrp: 0.075 ± 0.008	0.115CysTyr: 0.115 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.793AspAla: 7.793 ± 0.092	0.235AspCys: 0.235 ± 0.014	3.177AspAsp: 3.177 ± 0.063	3.932AspGlu: 3.932 ± 0.062	2.362AspPhe: 2.362 ± 0.04	4.68AspGly: 4.68 ± 0.069	0.977AspHis: 0.977 ± 0.024	1.764AspIle: 1.764 ± 0.04	1.231AspLys: 1.231 ± 0.033	6.963AspLeu: 6.963 ± 0.075	0.9AspMet: 0.9 ± 0.025	0.979AspAsn: 0.979 ± 0.022	2.971AspPro: 2.971 ± 0.046	1.083AspGln: 1.083 ± 0.028	3.504AspArg: 3.504 ± 0.055	2.021AspSer: 2.021 ± 0.037	2.716AspThr: 2.716 ± 0.045	6.667AspVal: 6.667 ± 0.075	0.755AspTrp: 0.755 ± 0.029	0.996AspTyr: 0.996 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.915GluAla: 7.915 ± 0.093	0.246GluCys: 0.246 ± 0.014	3.026GluAsp: 3.026 ± 0.05	3.291GluGlu: 3.291 ± 0.061	1.83GluPhe: 1.83 ± 0.039	4.639GluGly: 4.639 ± 0.056	1.519GluHis: 1.519 ± 0.036	1.953GluIle: 1.953 ± 0.047	1.52GluLys: 1.52 ± 0.037	6.219GluLeu: 6.219 ± 0.083	0.931GluMet: 0.931 ± 0.024	1.33GluAsn: 1.33 ± 0.034	2.39GluPro: 2.39 ± 0.051	2.096GluGln: 2.096 ± 0.045	6.764GluArg: 6.764 ± 0.099	2.497GluSer: 2.497 ± 0.04	3.011GluThr: 3.011 ± 0.048	4.828GluVal: 4.828 ± 0.067	0.8GluTrp: 0.8 ± 0.025	1.19GluTyr: 1.19 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.412PheAla: 4.412 ± 0.06	0.203PheCys: 0.203 ± 0.012	2.768PheAsp: 2.768 ± 0.049	2.709PheGlu: 2.709 ± 0.046	1.207PhePhe: 1.207 ± 0.031	3.481PheGly: 3.481 ± 0.063	0.713PheHis: 0.713 ± 0.023	1.052PheIle: 1.052 ± 0.029	0.975PheLys: 0.975 ± 0.031	3.489PheLeu: 3.489 ± 0.055	0.588PheMet: 0.588 ± 0.02	0.892PheAsn: 0.892 ± 0.034	1.642PhePro: 1.642 ± 0.038	0.986PheGln: 0.986 ± 0.027	1.981PheArg: 1.981 ± 0.039	2.051PheSer: 2.051 ± 0.044	2.526PheThr: 2.526 ± 0.055	3.466PheVal: 3.466 ± 0.06	0.502PheTrp: 0.502 ± 0.021	0.813PheTyr: 0.813 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.215GlyAla: 9.215 ± 0.092	0.541GlyCys: 0.541 ± 0.021	4.345GlyAsp: 4.345 ± 0.062	5.186GlyGlu: 5.186 ± 0.066	3.124GlyPhe: 3.124 ± 0.052	7.294GlyGly: 7.294 ± 0.098	1.772GlyHis: 1.772 ± 0.036	2.843GlyIle: 2.843 ± 0.05	2.838GlyLys: 2.838 ± 0.055	8.514GlyLeu: 8.514 ± 0.098	1.628GlyMet: 1.628 ± 0.042	2.023GlyAsn: 2.023 ± 0.046	3.036GlyPro: 3.036 ± 0.058	2.614GlyGln: 2.614 ± 0.045	6.44GlyArg: 6.44 ± 0.082	4.489GlySer: 4.489 ± 0.081	5.129GlyThr: 5.129 ± 0.087	7.802GlyVal: 7.802 ± 0.079	1.29GlyTrp: 1.29 ± 0.032	2.127GlyTyr: 2.127 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	3.055HisAla: 3.055 ± 0.062	0.135HisCys: 0.135 ± 0.01	1.581HisAsp: 1.581 ± 0.04	1.444HisGlu: 1.444 ± 0.036	0.807HisPhe: 0.807 ± 0.026	1.958HisGly: 1.958 ± 0.045	0.622HisHis: 0.622 ± 0.022	0.596HisIle: 0.596 ± 0.021	0.446HisLys: 0.446 ± 0.017	2.788HisLeu: 2.788 ± 0.056	0.295HisMet: 0.295 ± 0.016	0.415HisAsn: 0.415 ± 0.018	1.462HisPro: 1.462 ± 0.037	0.441HisGln: 0.441 ± 0.017	1.37HisArg: 1.37 ± 0.036	0.85HisSer: 0.85 ± 0.027	1.021HisThr: 1.021 ± 0.029	2.151HisVal: 2.151 ± 0.044	0.262HisTrp: 0.262 ± 0.013	0.439HisTyr: 0.439 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.185IleAla: 4.185 ± 0.063	0.187IleCys: 0.187 ± 0.011	2.177IleAsp: 2.177 ± 0.041	2.304IleGlu: 2.304 ± 0.043	1.088IlePhe: 1.088 ± 0.033	3.268IleGly: 3.268 ± 0.052	0.625IleHis: 0.625 ± 0.02	1.1IleIle: 1.1 ± 0.037	0.81IleLys: 0.81 ± 0.027	3.393IleLeu: 3.393 ± 0.055	0.487IleMet: 0.487 ± 0.017	0.825IleAsn: 0.825 ± 0.026	1.6IlePro: 1.6 ± 0.032	0.828IleGln: 0.828 ± 0.025	2.122IleArg: 2.122 ± 0.046	1.794IleSer: 1.794 ± 0.041	2.054IleThr: 2.054 ± 0.049	3.442IleVal: 3.442 ± 0.061	0.298IleTrp: 0.298 ± 0.016	0.651IleTyr: 0.651 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.191LysAla: 3.191 ± 0.056	0.127LysCys: 0.127 ± 0.011	1.413LysAsp: 1.413 ± 0.034	1.259LysGlu: 1.259 ± 0.03	0.887LysPhe: 0.887 ± 0.027	2.075LysGly: 2.075 ± 0.045	0.556LysHis: 0.556 ± 0.019	1.132LysIle: 1.132 ± 0.034	0.949LysLys: 0.949 ± 0.033	3.199LysLeu: 3.199 ± 0.058	0.573LysMet: 0.573 ± 0.02	0.887LysAsn: 0.887 ± 0.029	1.521LysPro: 1.521 ± 0.034	0.75LysGln: 0.75 ± 0.026	2.187LysArg: 2.187 ± 0.041	1.443LysSer: 1.443 ± 0.039	1.841LysThr: 1.841 ± 0.04	2.331LysVal: 2.331 ± 0.047	0.308LysTrp: 0.308 ± 0.016	0.667LysTyr: 0.667 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.827LeuAla: 14.827 ± 0.129	0.632LeuCys: 0.632 ± 0.021	6.807LeuAsp: 6.807 ± 0.077	6.677LeuGlu: 6.677 ± 0.095	3.14LeuPhe: 3.14 ± 0.053	10.049LeuGly: 10.049 ± 0.117	2.593LeuHis: 2.593 ± 0.054	3.417LeuIle: 3.417 ± 0.057	3.163LeuLys: 3.163 ± 0.055	12.5LeuLeu: 12.5 ± 0.148	1.715LeuMet: 1.715 ± 0.036	2.687LeuAsn: 2.687 ± 0.046	6.444LeuPro: 6.444 ± 0.077	3.372LeuGln: 3.372 ± 0.05	9.147LeuArg: 9.147 ± 0.095	6.926LeuSer: 6.926 ± 0.083	7.058LeuThr: 7.058 ± 0.087	9.062LeuVal: 9.062 ± 0.086	1.318LeuTrp: 1.318 ± 0.036	2.293LeuTyr: 2.293 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.533MetAla: 1.533 ± 0.032	0.078MetCys: 0.078 ± 0.009	0.751MetAsp: 0.751 ± 0.023	0.764MetGlu: 0.764 ± 0.025	0.52MetPhe: 0.52 ± 0.019	1.194MetGly: 1.194 ± 0.031	0.403MetHis: 0.403 ± 0.017	0.778MetIle: 0.778 ± 0.027	0.782MetLys: 0.782 ± 0.023	2.01MetLeu: 2.01 ± 0.039	0.343MetMet: 0.343 ± 0.017	0.777MetAsn: 0.777 ± 0.023	1.033MetPro: 1.033 ± 0.028	0.585MetGln: 0.585 ± 0.019	1.437MetArg: 1.437 ± 0.029	1.207MetSer: 1.207 ± 0.035	1.739MetThr: 1.739 ± 0.035	0.978MetVal: 0.978 ± 0.027	0.18MetTrp: 0.18 ± 0.012	0.377MetTyr: 0.377 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.605AsnAla: 3.605 ± 0.052	0.153AsnCys: 0.153 ± 0.011	1.443AsnAsp: 1.443 ± 0.038	1.288AsnGlu: 1.288 ± 0.03	1.082AsnPhe: 1.082 ± 0.032	2.403AsnGly: 2.403 ± 0.066	0.44AsnHis: 0.44 ± 0.016	0.947AsnIle: 0.947 ± 0.029	0.578AsnLys: 0.578 ± 0.024	2.991AsnLeu: 2.991 ± 0.054	0.4AsnMet: 0.4 ± 0.017	0.695AsnAsn: 0.695 ± 0.029	1.608AsnPro: 1.608 ± 0.035	0.587AsnGln: 0.587 ± 0.021	1.462AsnArg: 1.462 ± 0.035	1.21AsnSer: 1.21 ± 0.035	1.44AsnThr: 1.44 ± 0.04	2.922AsnVal: 2.922 ± 0.056	0.342AsnTrp: 0.342 ± 0.016	0.597AsnTyr: 0.597 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.2ProAla: 5.2 ± 0.077	0.255ProCys: 0.255 ± 0.014	3.557ProAsp: 3.557 ± 0.06	3.336ProGlu: 3.336 ± 0.061	1.86ProPhe: 1.86 ± 0.038	3.941ProGly: 3.941 ± 0.06	1.31ProHis: 1.31 ± 0.029	1.92ProIle: 1.92 ± 0.038	1.445ProLys: 1.445 ± 0.038	5.413ProLeu: 5.413 ± 0.066	0.963ProMet: 0.963 ± 0.029	1.759ProAsn: 1.759 ± 0.035	2.662ProPro: 2.662 ± 0.05	1.524ProGln: 1.524 ± 0.037	3.533ProArg: 3.533 ± 0.056	3.885ProSer: 3.885 ± 0.058	3.313ProThr: 3.313 ± 0.059	3.676ProVal: 3.676 ± 0.053	0.756ProTrp: 0.756 ± 0.026	1.186ProTyr: 1.186 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.839GlnAla: 3.839 ± 0.062	0.134GlnCys: 0.134 ± 0.01	1.652GlnAsp: 1.652 ± 0.032	1.7GlnGlu: 1.7 ± 0.034	0.942GlnPhe: 0.942 ± 0.029	2.711GlnGly: 2.711 ± 0.049	0.68GlnHis: 0.68 ± 0.022	1.041GlnIle: 1.041 ± 0.028	0.809GlnLys: 0.809 ± 0.026	3.012GlnLeu: 3.012 ± 0.05	0.477GlnMet: 0.477 ± 0.02	0.867GlnAsn: 0.867 ± 0.027	1.549GlnPro: 1.549 ± 0.034	1.236GlnGln: 1.236 ± 0.04	2.433GlnArg: 2.433 ± 0.049	1.471GlnSer: 1.471 ± 0.029	1.538GlnThr: 1.538 ± 0.031	2.215GlnVal: 2.215 ± 0.041	0.349GlnTrp: 0.349 ± 0.015	0.697GlnTyr: 0.697 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.184ArgAla: 10.184 ± 0.115	0.391ArgCys: 0.391 ± 0.017	4.867ArgAsp: 4.867 ± 0.067	5.513ArgGlu: 5.513 ± 0.09	3.208ArgPhe: 3.208 ± 0.048	6.035ArgGly: 6.035 ± 0.089	1.9ArgHis: 1.9 ± 0.046	2.476ArgIle: 2.476 ± 0.044	1.789ArgLys: 1.789 ± 0.037	8.995ArgLeu: 8.995 ± 0.096	1.49ArgMet: 1.49 ± 0.034	1.647ArgAsn: 1.647 ± 0.04	3.687ArgPro: 3.687 ± 0.061	2.314ArgGln: 2.314 ± 0.047	6.512ArgArg: 6.512 ± 0.081	4.221ArgSer: 4.221 ± 0.057	4.347ArgThr: 4.347 ± 0.061	7.253ArgVal: 7.253 ± 0.085	1.082ArgTrp: 1.082 ± 0.03	1.803ArgTyr: 1.803 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.618SerAla: 6.618 ± 0.075	0.352SerCys: 0.352 ± 0.018	3.061SerAsp: 3.061 ± 0.049	2.969SerGlu: 2.969 ± 0.046	2.289SerPhe: 2.289 ± 0.042	5.878SerGly: 5.878 ± 0.099	1.152SerHis: 1.152 ± 0.033	1.869SerIle: 1.869 ± 0.042	1.555SerLys: 1.555 ± 0.035	6.026SerLeu: 6.026 ± 0.07	1.126SerMet: 1.126 ± 0.028	1.692SerAsn: 1.692 ± 0.046	2.931SerPro: 2.931 ± 0.047	1.442SerGln: 1.442 ± 0.034	3.865SerArg: 3.865 ± 0.056	3.697SerSer: 3.697 ± 0.064	3.422SerThr: 3.422 ± 0.066	4.916SerVal: 4.916 ± 0.06	0.809SerTrp: 0.809 ± 0.026	1.231SerTyr: 1.231 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.473ThrAla: 6.473 ± 0.08	0.373ThrCys: 0.373 ± 0.017	2.761ThrAsp: 2.761 ± 0.05	2.279ThrGlu: 2.279 ± 0.047	2.829ThrPhe: 2.829 ± 0.058	4.374ThrGly: 4.374 ± 0.069	1.231ThrHis: 1.231 ± 0.031	2.325ThrIle: 2.325 ± 0.052	1.358ThrLys: 1.358 ± 0.034	8.154ThrLeu: 8.154 ± 0.096	0.948ThrMet: 0.948 ± 0.027	1.803ThrAsn: 1.803 ± 0.047	4.435ThrPro: 4.435 ± 0.061	1.466ThrGln: 1.466 ± 0.033	4.476ThrArg: 4.476 ± 0.061	4.142ThrSer: 4.142 ± 0.068	3.955ThrThr: 3.955 ± 0.088	5.125ThrVal: 5.125 ± 0.084	0.945ThrTrp: 0.945 ± 0.03	1.586ThrTyr: 1.586 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.376ValAla: 9.376 ± 0.099	0.538ValCys: 0.538 ± 0.021	4.263ValAsp: 4.263 ± 0.057	4.867ValGlu: 4.867 ± 0.063	2.837ValPhe: 2.837 ± 0.048	6.466ValGly: 6.466 ± 0.067	1.85ValHis: 1.85 ± 0.034	3.091ValIle: 3.091 ± 0.064	2.62ValLys: 2.62 ± 0.044	9.623ValLeu: 9.623 ± 0.105	1.613ValMet: 1.613 ± 0.038	2.553ValAsn: 2.553 ± 0.047	4.572ValPro: 4.572 ± 0.066	2.692ValGln: 2.692 ± 0.042	7.428ValArg: 7.428 ± 0.084	4.786ValSer: 4.786 ± 0.065	6.659ValThr: 6.659 ± 0.102	7.278ValVal: 7.278 ± 0.09	1.113ValTrp: 1.113 ± 0.027	1.896ValTyr: 1.896 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.273TrpAla: 1.273 ± 0.035	0.1TrpCys: 0.1 ± 0.008	0.618TrpAsp: 0.618 ± 0.022	0.61TrpGlu: 0.61 ± 0.02	0.443TrpPhe: 0.443 ± 0.019	0.905TrpGly: 0.905 ± 0.028	0.39TrpHis: 0.39 ± 0.017	0.509TrpIle: 0.509 ± 0.023	0.401TrpLys: 0.401 ± 0.016	1.62TrpLeu: 1.62 ± 0.042	0.318TrpMet: 0.318 ± 0.014	0.562TrpAsn: 0.562 ± 0.018	0.675TrpPro: 0.675 ± 0.024	0.622TrpGln: 0.622 ± 0.022	1.472TrpArg: 1.472 ± 0.034	0.964TrpSer: 0.964 ± 0.028	1.042TrpThr: 1.042 ± 0.029	0.874TrpVal: 0.874 ± 0.025	0.282TrpTrp: 0.282 ± 0.014	0.331TrpTyr: 0.331 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.647TyrAla: 2.647 ± 0.045	0.167TyrCys: 0.167 ± 0.01	1.455TyrAsp: 1.455 ± 0.036	1.342TyrGlu: 1.342 ± 0.033	0.903TyrPhe: 0.903 ± 0.026	2.085TyrGly: 2.085 ± 0.041	0.524TyrHis: 0.524 ± 0.02	0.58TyrIle: 0.58 ± 0.021	0.584TyrLys: 0.584 ± 0.025	2.434TyrLeu: 2.434 ± 0.042	0.301TyrMet: 0.301 ± 0.016	0.578TyrAsn: 0.578 ± 0.026	1.138TyrPro: 1.138 ± 0.029	0.704TyrGln: 0.704 ± 0.025	1.898TyrArg: 1.898 ± 0.035	1.077TyrSer: 1.077 ± 0.028	1.4TyrThr: 1.4 ± 0.042	1.773TyrVal: 1.773 ± 0.039	0.329TyrTrp: 0.329 ± 0.016	0.613TyrTyr: 0.613 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4447 proteins (1404029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---