Amino acid dipepetide frequency for Podoviridae sp. ctpVR23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.376AlaAla: 11.376 ± 1.639
0.948AlaCys: 0.948 ± 0.2
5.257AlaAsp: 5.257 ± 0.642
6.722AlaGlu: 6.722 ± 0.937
2.93AlaPhe: 2.93 ± 0.513
7.757AlaGly: 7.757 ± 0.853
1.551AlaHis: 1.551 ± 0.429
6.033AlaIle: 6.033 ± 0.747
5.861AlaLys: 5.861 ± 0.848
5.688AlaLeu: 5.688 ± 0.657
3.361AlaMet: 3.361 ± 0.503
3.534AlaAsn: 3.534 ± 0.416
2.499AlaPro: 2.499 ± 0.491
3.964AlaGln: 3.964 ± 0.659
4.568AlaArg: 4.568 ± 0.725
5.602AlaSer: 5.602 ± 0.792
5.171AlaThr: 5.171 ± 0.857
4.74AlaVal: 4.74 ± 0.88
1.379AlaTrp: 1.379 ± 0.347
2.586AlaTyr: 2.586 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.345CysAla: 0.345 ± 0.177
0.345CysCys: 0.345 ± 0.179
0.862CysAsp: 0.862 ± 0.311
0.862CysGlu: 0.862 ± 0.313
0.431CysPhe: 0.431 ± 0.151
1.379CysGly: 1.379 ± 0.358
0.431CysHis: 0.431 ± 0.197
0.517CysIle: 0.517 ± 0.217
0.862CysLys: 0.862 ± 0.299
0.431CysLeu: 0.431 ± 0.21
0.259CysMet: 0.259 ± 0.152
0.517CysAsn: 0.517 ± 0.23
0.603CysPro: 0.603 ± 0.285
0.345CysGln: 0.345 ± 0.204
0.776CysArg: 0.776 ± 0.315
0.603CysSer: 0.603 ± 0.258
0.776CysThr: 0.776 ± 0.276
1.207CysVal: 1.207 ± 0.359
0.259CysTrp: 0.259 ± 0.129
0.172CysTyr: 0.172 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
4.999AspAla: 4.999 ± 0.718
0.862AspCys: 0.862 ± 0.363
3.62AspAsp: 3.62 ± 0.565
3.792AspGlu: 3.792 ± 0.579
2.068AspPhe: 2.068 ± 0.439
5.085AspGly: 5.085 ± 0.849
1.293AspHis: 1.293 ± 0.317
5.171AspIle: 5.171 ± 0.695
3.62AspLys: 3.62 ± 0.604
5.43AspLeu: 5.43 ± 0.601
1.982AspMet: 1.982 ± 0.363
1.982AspAsn: 1.982 ± 0.427
3.534AspPro: 3.534 ± 0.527
1.896AspGln: 1.896 ± 0.313
2.844AspArg: 2.844 ± 0.622
3.706AspSer: 3.706 ± 0.624
3.275AspThr: 3.275 ± 0.467
4.568AspVal: 4.568 ± 0.554
1.293AspTrp: 1.293 ± 0.453
2.586AspTyr: 2.586 ± 0.502
0.0AspXaa: 0.0 ± 0.0
Glu
6.119GluAla: 6.119 ± 0.889
0.517GluCys: 0.517 ± 0.171
3.361GluAsp: 3.361 ± 0.474
4.826GluGlu: 4.826 ± 0.663
2.93GluPhe: 2.93 ± 0.619
3.792GluGly: 3.792 ± 0.66
0.862GluHis: 0.862 ± 0.282
3.706GluIle: 3.706 ± 0.547
3.447GluLys: 3.447 ± 0.648
7.153GluLeu: 7.153 ± 0.737
1.982GluMet: 1.982 ± 0.309
2.327GluAsn: 2.327 ± 0.468
1.465GluPro: 1.465 ± 0.343
2.672GluGln: 2.672 ± 0.68
4.482GluArg: 4.482 ± 0.668
4.137GluSer: 4.137 ± 0.742
2.155GluThr: 2.155 ± 0.384
4.309GluVal: 4.309 ± 0.642
1.465GluTrp: 1.465 ± 0.303
2.93GluTyr: 2.93 ± 0.51
0.0GluXaa: 0.0 ± 0.0
Phe
2.155PheAla: 2.155 ± 0.382
0.517PheCys: 0.517 ± 0.197
2.758PheAsp: 2.758 ± 0.471
2.844PheGlu: 2.844 ± 0.379
0.603PhePhe: 0.603 ± 0.176
2.758PheGly: 2.758 ± 0.456
0.862PheHis: 0.862 ± 0.262
2.155PheIle: 2.155 ± 0.366
2.413PheLys: 2.413 ± 0.503
1.551PheLeu: 1.551 ± 0.347
1.207PheMet: 1.207 ± 0.339
1.638PheAsn: 1.638 ± 0.419
1.293PhePro: 1.293 ± 0.372
1.638PheGln: 1.638 ± 0.389
1.982PheArg: 1.982 ± 0.378
2.327PheSer: 2.327 ± 0.518
2.068PheThr: 2.068 ± 0.447
1.896PheVal: 1.896 ± 0.374
0.259PheTrp: 0.259 ± 0.177
1.638PheTyr: 1.638 ± 0.425
0.0PheXaa: 0.0 ± 0.0
Gly
4.826GlyAla: 4.826 ± 0.757
0.517GlyCys: 0.517 ± 0.314
3.964GlyAsp: 3.964 ± 0.573
3.534GlyGlu: 3.534 ± 0.512
3.103GlyPhe: 3.103 ± 0.499
4.223GlyGly: 4.223 ± 0.771
0.776GlyHis: 0.776 ± 0.342
3.706GlyIle: 3.706 ± 0.41
3.361GlyLys: 3.361 ± 0.702
4.051GlyLeu: 4.051 ± 0.508
1.982GlyMet: 1.982 ± 0.462
3.016GlyAsn: 3.016 ± 0.448
2.155GlyPro: 2.155 ± 0.375
2.413GlyGln: 2.413 ± 0.36
4.223GlyArg: 4.223 ± 0.687
5.343GlySer: 5.343 ± 0.897
6.636GlyThr: 6.636 ± 1.179
5.257GlyVal: 5.257 ± 0.719
1.293GlyTrp: 1.293 ± 0.384
3.447GlyTyr: 3.447 ± 0.656
0.0GlyXaa: 0.0 ± 0.0
His
1.638HisAla: 1.638 ± 0.455
0.172HisCys: 0.172 ± 0.159
1.638HisAsp: 1.638 ± 0.324
0.345HisGlu: 0.345 ± 0.177
0.603HisPhe: 0.603 ± 0.209
1.12HisGly: 1.12 ± 0.274
0.345HisHis: 0.345 ± 0.205
0.948HisIle: 0.948 ± 0.29
0.862HisLys: 0.862 ± 0.392
1.379HisLeu: 1.379 ± 0.366
0.862HisMet: 0.862 ± 0.252
0.862HisAsn: 0.862 ± 0.248
0.948HisPro: 0.948 ± 0.261
0.689HisGln: 0.689 ± 0.279
0.776HisArg: 0.776 ± 0.291
0.689HisSer: 0.689 ± 0.234
1.12HisThr: 1.12 ± 0.281
1.465HisVal: 1.465 ± 0.344
0.431HisTrp: 0.431 ± 0.183
0.776HisTyr: 0.776 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
5.602IleAla: 5.602 ± 0.802
0.948IleCys: 0.948 ± 0.307
4.482IleAsp: 4.482 ± 0.677
4.999IleGlu: 4.999 ± 0.645
1.293IlePhe: 1.293 ± 0.308
3.792IleGly: 3.792 ± 0.595
1.034IleHis: 1.034 ± 0.295
2.155IleIle: 2.155 ± 0.427
4.309IleLys: 4.309 ± 0.525
3.447IleLeu: 3.447 ± 0.438
1.207IleMet: 1.207 ± 0.321
3.447IleAsn: 3.447 ± 0.561
2.413IlePro: 2.413 ± 0.508
2.413IleGln: 2.413 ± 0.494
3.62IleArg: 3.62 ± 0.455
3.103IleSer: 3.103 ± 0.508
2.93IleThr: 2.93 ± 0.538
3.706IleVal: 3.706 ± 0.737
0.948IleTrp: 0.948 ± 0.252
1.379IleTyr: 1.379 ± 0.296
0.0IleXaa: 0.0 ± 0.0
Lys
5.343LysAla: 5.343 ± 0.922
0.603LysCys: 0.603 ± 0.2
3.275LysAsp: 3.275 ± 0.541
4.482LysGlu: 4.482 ± 0.749
1.81LysPhe: 1.81 ± 0.379
3.361LysGly: 3.361 ± 0.731
1.638LysHis: 1.638 ± 0.322
3.706LysIle: 3.706 ± 0.578
2.413LysLys: 2.413 ± 0.46
3.792LysLeu: 3.792 ± 0.637
2.068LysMet: 2.068 ± 0.558
2.413LysAsn: 2.413 ± 0.396
2.327LysPro: 2.327 ± 0.479
2.672LysGln: 2.672 ± 0.384
3.361LysArg: 3.361 ± 0.434
3.964LysSer: 3.964 ± 0.438
2.93LysThr: 2.93 ± 0.355
3.706LysVal: 3.706 ± 0.436
0.776LysTrp: 0.776 ± 0.185
1.896LysTyr: 1.896 ± 0.475
0.0LysXaa: 0.0 ± 0.0
Leu
7.757LeuAla: 7.757 ± 0.872
0.776LeuCys: 0.776 ± 0.255
5.257LeuAsp: 5.257 ± 0.586
4.482LeuGlu: 4.482 ± 0.537
2.068LeuPhe: 2.068 ± 0.439
4.137LeuGly: 4.137 ± 0.563
1.034LeuHis: 1.034 ± 0.289
3.534LeuIle: 3.534 ± 0.503
4.826LeuLys: 4.826 ± 0.635
4.395LeuLeu: 4.395 ± 0.554
2.499LeuMet: 2.499 ± 0.484
3.447LeuAsn: 3.447 ± 0.481
4.223LeuPro: 4.223 ± 0.574
2.672LeuGln: 2.672 ± 0.431
3.878LeuArg: 3.878 ± 0.419
5.257LeuSer: 5.257 ± 0.586
4.395LeuThr: 4.395 ± 0.475
6.636LeuVal: 6.636 ± 0.755
0.948LeuTrp: 0.948 ± 0.266
1.638LeuTyr: 1.638 ± 0.468
0.0LeuXaa: 0.0 ± 0.0
Met
3.706MetAla: 3.706 ± 0.484
0.345MetCys: 0.345 ± 0.192
1.81MetAsp: 1.81 ± 0.427
1.896MetGlu: 1.896 ± 0.338
0.948MetPhe: 0.948 ± 0.257
2.241MetGly: 2.241 ± 0.395
0.603MetHis: 0.603 ± 0.208
1.293MetIle: 1.293 ± 0.364
2.068MetLys: 2.068 ± 0.374
1.724MetLeu: 1.724 ± 0.281
0.862MetMet: 0.862 ± 0.232
1.638MetAsn: 1.638 ± 0.436
1.034MetPro: 1.034 ± 0.277
1.207MetGln: 1.207 ± 0.267
1.465MetArg: 1.465 ± 0.323
2.327MetSer: 2.327 ± 0.534
2.068MetThr: 2.068 ± 0.511
2.413MetVal: 2.413 ± 0.44
0.345MetTrp: 0.345 ± 0.176
1.034MetTyr: 1.034 ± 0.256
0.0MetXaa: 0.0 ± 0.0
Asn
4.051AsnAla: 4.051 ± 0.567
0.603AsnCys: 0.603 ± 0.245
2.586AsnAsp: 2.586 ± 0.637
2.499AsnGlu: 2.499 ± 0.43
1.81AsnPhe: 1.81 ± 0.315
3.878AsnGly: 3.878 ± 0.502
0.689AsnHis: 0.689 ± 0.232
2.327AsnIle: 2.327 ± 0.468
2.586AsnLys: 2.586 ± 0.494
3.189AsnLeu: 3.189 ± 0.508
1.207AsnMet: 1.207 ± 0.22
1.982AsnAsn: 1.982 ± 0.378
1.81AsnPro: 1.81 ± 0.362
1.207AsnGln: 1.207 ± 0.317
2.758AsnArg: 2.758 ± 0.398
2.499AsnSer: 2.499 ± 0.521
3.103AsnThr: 3.103 ± 0.44
3.361AsnVal: 3.361 ± 0.556
0.776AsnTrp: 0.776 ± 0.273
0.689AsnTyr: 0.689 ± 0.216
0.0AsnXaa: 0.0 ± 0.0
Pro
3.361ProAla: 3.361 ± 0.509
0.517ProCys: 0.517 ± 0.178
3.103ProAsp: 3.103 ± 0.516
3.62ProGlu: 3.62 ± 0.481
1.207ProPhe: 1.207 ± 0.381
0.0ProGly: 0.0 ± 0.0
0.603ProHis: 0.603 ± 0.289
1.982ProIle: 1.982 ± 0.434
2.155ProLys: 2.155 ± 0.435
3.103ProLeu: 3.103 ± 0.529
0.689ProMet: 0.689 ± 0.222
2.499ProAsn: 2.499 ± 0.52
2.068ProPro: 2.068 ± 0.532
1.12ProGln: 1.12 ± 0.282
1.982ProArg: 1.982 ± 0.334
3.706ProSer: 3.706 ± 0.538
3.016ProThr: 3.016 ± 0.422
3.103ProVal: 3.103 ± 0.395
1.207ProTrp: 1.207 ± 0.307
1.293ProTyr: 1.293 ± 0.253
0.0ProXaa: 0.0 ± 0.0
Gln
2.93GlnAla: 2.93 ± 0.539
0.172GlnCys: 0.172 ± 0.129
2.068GlnAsp: 2.068 ± 0.347
2.068GlnGlu: 2.068 ± 0.505
1.379GlnPhe: 1.379 ± 0.354
2.155GlnGly: 2.155 ± 0.469
0.948GlnHis: 0.948 ± 0.224
2.241GlnIle: 2.241 ± 0.353
2.327GlnLys: 2.327 ± 0.407
3.534GlnLeu: 3.534 ± 0.432
1.034GlnMet: 1.034 ± 0.279
1.551GlnAsn: 1.551 ± 0.347
1.638GlnPro: 1.638 ± 0.581
2.241GlnGln: 2.241 ± 0.554
2.499GlnArg: 2.499 ± 0.347
3.361GlnSer: 3.361 ± 0.609
2.672GlnThr: 2.672 ± 0.491
2.155GlnVal: 2.155 ± 0.542
0.431GlnTrp: 0.431 ± 0.167
1.379GlnTyr: 1.379 ± 0.484
0.0GlnXaa: 0.0 ± 0.0
Arg
4.654ArgAla: 4.654 ± 0.643
0.948ArgCys: 0.948 ± 0.28
3.447ArgAsp: 3.447 ± 0.435
3.62ArgGlu: 3.62 ± 0.544
2.155ArgPhe: 2.155 ± 0.339
3.275ArgGly: 3.275 ± 0.469
0.948ArgHis: 0.948 ± 0.286
4.223ArgIle: 4.223 ± 0.639
3.016ArgLys: 3.016 ± 0.611
3.792ArgLeu: 3.792 ± 0.643
2.499ArgMet: 2.499 ± 0.433
2.844ArgAsn: 2.844 ± 0.493
2.844ArgPro: 2.844 ± 0.565
2.499ArgGln: 2.499 ± 0.484
4.309ArgArg: 4.309 ± 0.785
2.672ArgSer: 2.672 ± 0.408
3.447ArgThr: 3.447 ± 0.561
4.74ArgVal: 4.74 ± 0.691
0.776ArgTrp: 0.776 ± 0.299
2.155ArgTyr: 2.155 ± 0.416
0.0ArgXaa: 0.0 ± 0.0
Ser
4.826SerAla: 4.826 ± 0.681
0.948SerCys: 0.948 ± 0.26
4.395SerAsp: 4.395 ± 0.665
3.361SerGlu: 3.361 ± 0.557
2.327SerPhe: 2.327 ± 0.454
6.378SerGly: 6.378 ± 0.795
1.207SerHis: 1.207 ± 0.365
3.447SerIle: 3.447 ± 0.4
4.482SerLys: 4.482 ± 0.537
5.343SerLeu: 5.343 ± 0.523
1.81SerMet: 1.81 ± 0.573
2.844SerAsn: 2.844 ± 0.483
2.844SerPro: 2.844 ± 0.674
2.068SerGln: 2.068 ± 0.431
3.706SerArg: 3.706 ± 0.503
4.568SerSer: 4.568 ± 0.803
5.171SerThr: 5.171 ± 1.026
3.878SerVal: 3.878 ± 0.691
1.551SerTrp: 1.551 ± 0.339
1.896SerTyr: 1.896 ± 0.359
0.0SerXaa: 0.0 ± 0.0
Thr
6.033ThrAla: 6.033 ± 1.084
0.431ThrCys: 0.431 ± 0.187
2.413ThrAsp: 2.413 ± 0.535
3.878ThrGlu: 3.878 ± 0.701
1.896ThrPhe: 1.896 ± 0.338
4.826ThrGly: 4.826 ± 0.693
1.12ThrHis: 1.12 ± 0.268
3.361ThrIle: 3.361 ± 0.463
3.103ThrLys: 3.103 ± 0.533
4.913ThrLeu: 4.913 ± 0.696
1.12ThrMet: 1.12 ± 0.331
2.155ThrAsn: 2.155 ± 0.441
3.103ThrPro: 3.103 ± 0.426
2.413ThrGln: 2.413 ± 0.4
3.361ThrArg: 3.361 ± 0.577
4.137ThrSer: 4.137 ± 0.61
2.844ThrThr: 2.844 ± 0.561
5.861ThrVal: 5.861 ± 0.66
0.862ThrTrp: 0.862 ± 0.275
2.068ThrTyr: 2.068 ± 0.41
0.0ThrXaa: 0.0 ± 0.0
Val
6.809ValAla: 6.809 ± 0.773
0.603ValCys: 0.603 ± 0.252
4.74ValAsp: 4.74 ± 0.722
4.223ValGlu: 4.223 ± 0.498
2.499ValPhe: 2.499 ± 0.52
4.826ValGly: 4.826 ± 0.759
0.603ValHis: 0.603 ± 0.248
4.137ValIle: 4.137 ± 0.735
2.844ValLys: 2.844 ± 0.589
6.722ValLeu: 6.722 ± 0.856
2.327ValMet: 2.327 ± 0.495
3.361ValAsn: 3.361 ± 0.522
1.982ValPro: 1.982 ± 0.327
2.413ValGln: 2.413 ± 0.515
5.171ValArg: 5.171 ± 0.632
5.602ValSer: 5.602 ± 0.996
3.792ValThr: 3.792 ± 0.944
5.171ValVal: 5.171 ± 0.672
1.12ValTrp: 1.12 ± 0.299
2.241ValTyr: 2.241 ± 0.301
0.0ValXaa: 0.0 ± 0.0
Trp
1.293TrpAla: 1.293 ± 0.306
0.345TrpCys: 0.345 ± 0.148
1.896TrpAsp: 1.896 ± 0.5
0.517TrpGlu: 0.517 ± 0.186
0.948TrpPhe: 0.948 ± 0.427
0.776TrpGly: 0.776 ± 0.235
0.345TrpHis: 0.345 ± 0.184
0.689TrpIle: 0.689 ± 0.195
0.431TrpLys: 0.431 ± 0.215
1.465TrpLeu: 1.465 ± 0.381
0.948TrpMet: 0.948 ± 0.237
0.603TrpAsn: 0.603 ± 0.204
0.431TrpPro: 0.431 ± 0.209
0.689TrpGln: 0.689 ± 0.242
1.12TrpArg: 1.12 ± 0.349
1.12TrpSer: 1.12 ± 0.324
1.034TrpThr: 1.034 ± 0.358
1.551TrpVal: 1.551 ± 0.391
0.431TrpTrp: 0.431 ± 0.146
0.345TrpTyr: 0.345 ± 0.162
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.706TyrAla: 3.706 ± 0.475
0.862TyrCys: 0.862 ± 0.304
2.672TyrAsp: 2.672 ± 0.41
2.068TyrGlu: 2.068 ± 0.363
1.638TyrPhe: 1.638 ± 0.404
2.068TyrGly: 2.068 ± 0.411
0.776TyrHis: 0.776 ± 0.238
1.896TyrIle: 1.896 ± 0.467
1.551TyrLys: 1.551 ± 0.285
2.758TyrLeu: 2.758 ± 0.362
1.034TyrMet: 1.034 ± 0.386
0.948TyrAsn: 0.948 ± 0.277
1.12TyrPro: 1.12 ± 0.282
1.551TyrGln: 1.551 ± 0.337
1.982TyrArg: 1.982 ± 0.452
2.327TyrSer: 2.327 ± 0.491
1.293TyrThr: 1.293 ± 0.252
1.465TyrVal: 1.465 ± 0.314
0.431TyrTrp: 0.431 ± 0.17
0.689TyrTyr: 0.689 ± 0.224
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski