Amino acid dipepetide frequency for Paraglaciecola arctica BSs20135

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.016AlaAla: 7.016 ± 0.082	0.867AlaCys: 0.867 ± 0.022	4.754AlaAsp: 4.754 ± 0.058	5.015AlaGlu: 5.015 ± 0.068	3.457AlaPhe: 3.457 ± 0.047	5.504AlaGly: 5.504 ± 0.064	1.473AlaHis: 1.473 ± 0.03	6.024AlaIle: 6.024 ± 0.058	5.101AlaLys: 5.101 ± 0.056	8.937AlaLeu: 8.937 ± 0.075	2.306AlaMet: 2.306 ± 0.039	3.956AlaAsn: 3.956 ± 0.055	2.622AlaPro: 2.622 ± 0.048	3.692AlaGln: 3.692 ± 0.056	2.989AlaArg: 2.989 ± 0.045	5.292AlaSer: 5.292 ± 0.057	4.44AlaThr: 4.44 ± 0.054	5.362AlaVal: 5.362 ± 0.062	0.912AlaTrp: 0.912 ± 0.023	2.398AlaTyr: 2.398 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.824CysAla: 0.824 ± 0.024	0.169CysCys: 0.169 ± 0.009	0.553CysAsp: 0.553 ± 0.018	0.544CysGlu: 0.544 ± 0.017	0.45CysPhe: 0.45 ± 0.017	0.775CysGly: 0.775 ± 0.023	0.31CysHis: 0.31 ± 0.014	0.665CysIle: 0.665 ± 0.021	0.444CysLys: 0.444 ± 0.019	1.042CysLeu: 1.042 ± 0.026	0.2CysMet: 0.2 ± 0.01	0.391CysAsn: 0.391 ± 0.016	0.394CysPro: 0.394 ± 0.015	0.463CysGln: 0.463 ± 0.02	0.38CysArg: 0.38 ± 0.015	0.735CysSer: 0.735 ± 0.02	0.431CysThr: 0.431 ± 0.015	0.596CysVal: 0.596 ± 0.02	0.11CysTrp: 0.11 ± 0.008	0.298CysTyr: 0.298 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.132AspAla: 4.132 ± 0.065	0.533AspCys: 0.533 ± 0.018	3.296AspAsp: 3.296 ± 0.064	3.611AspGlu: 3.611 ± 0.048	2.725AspPhe: 2.725 ± 0.043	3.825AspGly: 3.825 ± 0.076	1.027AspHis: 1.027 ± 0.022	4.39AspIle: 4.39 ± 0.055	3.563AspLys: 3.563 ± 0.049	5.383AspLeu: 5.383 ± 0.057	1.499AspMet: 1.499 ± 0.029	2.917AspAsn: 2.917 ± 0.048	2.19AspPro: 2.19 ± 0.037	1.941AspGln: 1.941 ± 0.034	1.936AspArg: 1.936 ± 0.038	3.468AspSer: 3.468 ± 0.054	2.926AspThr: 2.926 ± 0.046	3.822AspVal: 3.822 ± 0.057	0.892AspTrp: 0.892 ± 0.024	2.129AspTyr: 2.129 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.352GluAla: 4.352 ± 0.058	0.447GluCys: 0.447 ± 0.017	2.911GluAsp: 2.911 ± 0.045	3.114GluGlu: 3.114 ± 0.062	2.609GluPhe: 2.609 ± 0.041	3.169GluGly: 3.169 ± 0.046	1.496GluHis: 1.496 ± 0.031	3.923GluIle: 3.923 ± 0.051	3.679GluLys: 3.679 ± 0.059	6.832GluLeu: 6.832 ± 0.065	1.501GluMet: 1.501 ± 0.031	3.017GluAsn: 3.017 ± 0.042	1.799GluPro: 1.799 ± 0.041	4.051GluGln: 4.051 ± 0.061	2.527GluArg: 2.527 ± 0.042	3.447GluSer: 3.447 ± 0.051	2.977GluThr: 2.977 ± 0.043	3.929GluVal: 3.929 ± 0.053	0.68GluTrp: 0.68 ± 0.021	1.909GluTyr: 1.909 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.748PheAla: 3.748 ± 0.05	0.52PheCys: 0.52 ± 0.015	2.962PheAsp: 2.962 ± 0.049	2.741PheGlu: 2.741 ± 0.037	1.85PhePhe: 1.85 ± 0.047	3.229PheGly: 3.229 ± 0.054	0.788PheHis: 0.788 ± 0.02	3.06PheIle: 3.06 ± 0.05	2.273PheLys: 2.273 ± 0.04	3.653PheLeu: 3.653 ± 0.052	1.094PheMet: 1.094 ± 0.025	2.391PheAsn: 2.391 ± 0.044	1.492PhePro: 1.492 ± 0.031	1.268PheGln: 1.268 ± 0.028	1.468PheArg: 1.468 ± 0.029	3.905PheSer: 3.905 ± 0.047	2.488PheThr: 2.488 ± 0.039	2.959PheVal: 2.959 ± 0.045	0.547PheTrp: 0.547 ± 0.022	1.499PheTyr: 1.499 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	4.977GlyAla: 4.977 ± 0.063	0.777GlyCys: 0.777 ± 0.023	3.622GlyAsp: 3.622 ± 0.055	3.887GlyGlu: 3.887 ± 0.055	3.424GlyPhe: 3.424 ± 0.053	4.557GlyGly: 4.557 ± 0.061	1.437GlyHis: 1.437 ± 0.029	4.822GlyIle: 4.822 ± 0.071	3.98GlyLys: 3.98 ± 0.055	7.117GlyLeu: 7.117 ± 0.079	1.819GlyMet: 1.819 ± 0.033	2.909GlyAsn: 2.909 ± 0.051	1.607GlyPro: 1.607 ± 0.039	2.778GlyGln: 2.778 ± 0.044	2.653GlyArg: 2.653 ± 0.046	4.28GlySer: 4.28 ± 0.059	3.358GlyThr: 3.358 ± 0.053	4.753GlyVal: 4.753 ± 0.06	0.963GlyTrp: 0.963 ± 0.025	2.473GlyTyr: 2.473 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.433HisAla: 1.433 ± 0.035	0.329HisCys: 0.329 ± 0.014	1.057HisAsp: 1.057 ± 0.027	1.013HisGlu: 1.013 ± 0.027	1.159HisPhe: 1.159 ± 0.03	1.429HisGly: 1.429 ± 0.031	0.63HisHis: 0.63 ± 0.022	1.461HisIle: 1.461 ± 0.032	1.165HisLys: 1.165 ± 0.026	2.204HisLeu: 2.204 ± 0.038	0.498HisMet: 0.498 ± 0.016	1.031HisAsn: 1.031 ± 0.028	1.082HisPro: 1.082 ± 0.027	1.175HisGln: 1.175 ± 0.027	0.859HisArg: 0.859 ± 0.022	1.449HisSer: 1.449 ± 0.03	1.006HisThr: 1.006 ± 0.023	1.179HisVal: 1.179 ± 0.025	0.331HisTrp: 0.331 ± 0.013	0.889HisTyr: 0.889 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.302IleAla: 6.302 ± 0.062	0.732IleCys: 0.732 ± 0.023	4.438IleAsp: 4.438 ± 0.054	4.871IleGlu: 4.871 ± 0.049	2.603IlePhe: 2.603 ± 0.039	4.805IleGly: 4.805 ± 0.062	1.303IleHis: 1.303 ± 0.029	4.108IleIle: 4.108 ± 0.067	4.029IleLys: 4.029 ± 0.057	5.806IleLeu: 5.806 ± 0.073	1.438IleMet: 1.438 ± 0.032	3.613IleAsn: 3.613 ± 0.05	2.709IlePro: 2.709 ± 0.038	2.729IleGln: 2.729 ± 0.044	2.705IleArg: 2.705 ± 0.043	5.195IleSer: 5.195 ± 0.062	3.941IleThr: 3.941 ± 0.05	4.264IleVal: 4.264 ± 0.054	0.726IleTrp: 0.726 ± 0.021	1.893IleTyr: 1.893 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.627LysAla: 4.627 ± 0.061	0.343LysCys: 0.343 ± 0.015	2.866LysAsp: 2.866 ± 0.035	3.07LysGlu: 3.07 ± 0.056	1.893LysPhe: 1.893 ± 0.029	3.303LysGly: 3.303 ± 0.043	1.389LysHis: 1.389 ± 0.03	3.722LysIle: 3.722 ± 0.055	3.227LysLys: 3.227 ± 0.055	5.848LysLeu: 5.848 ± 0.061	1.47LysMet: 1.47 ± 0.032	2.9LysAsn: 2.9 ± 0.051	2.319LysPro: 2.319 ± 0.042	3.387LysGln: 3.387 ± 0.057	2.583LysArg: 2.583 ± 0.043	3.578LysSer: 3.578 ± 0.055	3.405LysThr: 3.405 ± 0.046	4.024LysVal: 4.024 ± 0.055	0.654LysTrp: 0.654 ± 0.022	1.605LysTyr: 1.605 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.526LeuAla: 9.526 ± 0.075	1.041LeuCys: 1.041 ± 0.027	5.826LeuAsp: 5.826 ± 0.059	5.697LeuGlu: 5.697 ± 0.065	4.453LeuPhe: 4.453 ± 0.064	7.005LeuGly: 7.005 ± 0.068	2.009LeuHis: 2.009 ± 0.037	6.728LeuIle: 6.728 ± 0.074	5.605LeuLys: 5.605 ± 0.062	10.781LeuLeu: 10.781 ± 0.106	2.496LeuMet: 2.496 ± 0.038	5.051LeuAsn: 5.051 ± 0.053	4.515LeuPro: 4.515 ± 0.052	4.172LeuGln: 4.172 ± 0.056	4.0LeuArg: 4.0 ± 0.052	8.25LeuSer: 8.25 ± 0.074	6.13LeuThr: 6.13 ± 0.065	6.967LeuVal: 6.967 ± 0.07	1.042LeuTrp: 1.042 ± 0.028	2.741LeuTyr: 2.741 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.3MetAla: 2.3 ± 0.038	0.219MetCys: 0.219 ± 0.011	1.183MetAsp: 1.183 ± 0.027	1.07MetGlu: 1.07 ± 0.026	1.041MetPhe: 1.041 ± 0.026	1.699MetGly: 1.699 ± 0.035	0.51MetHis: 0.51 ± 0.017	1.301MetIle: 1.301 ± 0.028	1.289MetLys: 1.289 ± 0.024	2.819MetLeu: 2.819 ± 0.045	0.644MetMet: 0.644 ± 0.02	1.067MetAsn: 1.067 ± 0.025	1.227MetPro: 1.227 ± 0.026	1.431MetGln: 1.431 ± 0.032	1.073MetArg: 1.073 ± 0.026	1.907MetSer: 1.907 ± 0.032	1.507MetThr: 1.507 ± 0.031	1.535MetVal: 1.535 ± 0.033	0.229MetTrp: 0.229 ± 0.011	0.544MetTyr: 0.544 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.607AsnAla: 3.607 ± 0.046	0.468AsnCys: 0.468 ± 0.019	2.565AsnAsp: 2.565 ± 0.05	2.614AsnGlu: 2.614 ± 0.041	1.985AsnPhe: 1.985 ± 0.038	3.205AsnGly: 3.205 ± 0.048	1.01AsnHis: 1.01 ± 0.023	3.748AsnIle: 3.748 ± 0.047	2.979AsnLys: 2.979 ± 0.048	4.706AsnLeu: 4.706 ± 0.056	1.191AsnMet: 1.191 ± 0.028	2.734AsnAsn: 2.734 ± 0.05	2.037AsnPro: 2.037 ± 0.035	2.507AsnGln: 2.507 ± 0.042	1.902AsnArg: 1.902 ± 0.033	3.215AsnSer: 3.215 ± 0.043	2.702AsnThr: 2.702 ± 0.048	3.013AsnVal: 3.013 ± 0.053	0.731AsnTrp: 0.731 ± 0.023	1.599AsnTyr: 1.599 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.854ProAla: 2.854 ± 0.049	0.285ProCys: 0.285 ± 0.014	2.296ProAsp: 2.296 ± 0.042	2.945ProGlu: 2.945 ± 0.05	1.718ProPhe: 1.718 ± 0.03	2.156ProGly: 2.156 ± 0.042	0.735ProHis: 0.735 ± 0.023	2.709ProIle: 2.709 ± 0.037	2.174ProLys: 2.174 ± 0.041	3.847ProLeu: 3.847 ± 0.047	0.943ProMet: 0.943 ± 0.027	1.923ProAsn: 1.923 ± 0.032	1.124ProPro: 1.124 ± 0.027	1.655ProGln: 1.655 ± 0.031	1.182ProArg: 1.182 ± 0.028	2.561ProSer: 2.561 ± 0.037	1.962ProThr: 1.962 ± 0.045	2.748ProVal: 2.748 ± 0.042	0.498ProTrp: 0.498 ± 0.018	1.142ProTyr: 1.142 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.342GlnAla: 4.342 ± 0.056	0.356GlnCys: 0.356 ± 0.014	2.255GlnAsp: 2.255 ± 0.037	2.274GlnGlu: 2.274 ± 0.038	1.872GlnPhe: 1.872 ± 0.037	3.09GlnGly: 3.09 ± 0.044	1.27GlnHis: 1.27 ± 0.03	3.038GlnIle: 3.038 ± 0.043	2.568GlnLys: 2.568 ± 0.042	5.293GlnLeu: 5.293 ± 0.072	1.03GlnMet: 1.03 ± 0.026	2.179GlnAsn: 2.179 ± 0.035	1.68GlnPro: 1.68 ± 0.031	3.862GlnGln: 3.862 ± 0.091	2.151GlnArg: 2.151 ± 0.041	3.205GlnSer: 3.205 ± 0.042	2.615GlnThr: 2.615 ± 0.041	3.184GlnVal: 3.184 ± 0.044	0.65GlnTrp: 0.65 ± 0.019	1.51GlnTyr: 1.51 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.971ArgAla: 2.971 ± 0.041	0.37ArgCys: 0.37 ± 0.013	2.163ArgAsp: 2.163 ± 0.036	2.389ArgGlu: 2.389 ± 0.038	2.05ArgPhe: 2.05 ± 0.036	2.25ArgGly: 2.25 ± 0.037	0.907ArgHis: 0.907 ± 0.026	2.797ArgIle: 2.797 ± 0.044	2.206ArgLys: 2.206 ± 0.037	4.439ArgLeu: 4.439 ± 0.054	0.997ArgMet: 0.997 ± 0.026	1.774ArgAsn: 1.774 ± 0.031	1.397ArgPro: 1.397 ± 0.03	1.945ArgGln: 1.945 ± 0.036	1.824ArgArg: 1.824 ± 0.033	2.422ArgSer: 2.422 ± 0.039	1.952ArgThr: 1.952 ± 0.034	2.726ArgVal: 2.726 ± 0.043	0.545ArgTrp: 0.545 ± 0.017	1.524ArgTyr: 1.524 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.661SerAla: 5.661 ± 0.064	0.702SerCys: 0.702 ± 0.018	3.896SerAsp: 3.896 ± 0.058	4.11SerGlu: 4.11 ± 0.057	3.105SerPhe: 3.105 ± 0.049	5.062SerGly: 5.062 ± 0.054	1.566SerHis: 1.566 ± 0.032	4.829SerIle: 4.829 ± 0.068	3.59SerLys: 3.59 ± 0.047	7.41SerLeu: 7.41 ± 0.067	1.655SerMet: 1.655 ± 0.034	3.187SerAsn: 3.187 ± 0.052	2.445SerPro: 2.445 ± 0.044	3.319SerGln: 3.319 ± 0.051	2.781SerArg: 2.781 ± 0.041	4.896SerSer: 4.896 ± 0.063	3.594SerThr: 3.594 ± 0.051	4.72SerVal: 4.72 ± 0.063	0.908SerTrp: 0.908 ± 0.022	2.252SerTyr: 2.252 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.468ThrAla: 4.468 ± 0.063	0.442ThrCys: 0.442 ± 0.016	3.265ThrAsp: 3.265 ± 0.058	3.227ThrGlu: 3.227 ± 0.049	2.321ThrPhe: 2.321 ± 0.043	3.981ThrGly: 3.981 ± 0.054	1.201ThrHis: 1.201 ± 0.03	3.535ThrIle: 3.535 ± 0.047	2.609ThrLys: 2.609 ± 0.037	6.117ThrLeu: 6.117 ± 0.061	1.114ThrMet: 1.114 ± 0.027	2.443ThrAsn: 2.443 ± 0.04	2.575ThrPro: 2.575 ± 0.051	2.608ThrGln: 2.608 ± 0.036	1.971ThrArg: 1.971 ± 0.04	3.737ThrSer: 3.737 ± 0.053	2.948ThrThr: 2.948 ± 0.051	3.684ThrVal: 3.684 ± 0.054	0.626ThrTrp: 0.626 ± 0.021	1.57ThrTyr: 1.57 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	5.838ValAla: 5.838 ± 0.058	0.671ValCys: 0.671 ± 0.023	3.996ValAsp: 3.996 ± 0.05	4.116ValGlu: 4.116 ± 0.055	3.007ValPhe: 3.007 ± 0.044	4.366ValGly: 4.366 ± 0.058	1.205ValHis: 1.205 ± 0.027	4.802ValIle: 4.802 ± 0.055	3.663ValLys: 3.663 ± 0.054	6.7ValLeu: 6.7 ± 0.066	1.752ValMet: 1.752 ± 0.036	3.292ValAsn: 3.292 ± 0.045	2.471ValPro: 2.471 ± 0.045	2.282ValGln: 2.282 ± 0.039	2.489ValArg: 2.489 ± 0.041	5.022ValSer: 5.022 ± 0.063	3.995ValThr: 3.995 ± 0.056	4.918ValVal: 4.918 ± 0.066	0.711ValTrp: 0.711 ± 0.024	1.788ValTyr: 1.788 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.799TrpAla: 0.799 ± 0.023	0.125TrpCys: 0.125 ± 0.009	0.648TrpAsp: 0.648 ± 0.022	0.52TrpGlu: 0.52 ± 0.019	0.585TrpPhe: 0.585 ± 0.02	0.761TrpGly: 0.761 ± 0.023	0.37TrpHis: 0.37 ± 0.017	0.697TrpIle: 0.697 ± 0.021	0.527TrpLys: 0.527 ± 0.018	1.735TrpLeu: 1.735 ± 0.038	0.306TrpMet: 0.306 ± 0.015	0.494TrpAsn: 0.494 ± 0.016	0.456TrpPro: 0.456 ± 0.017	1.07TrpGln: 1.07 ± 0.028	0.61TrpArg: 0.61 ± 0.019	0.792TrpSer: 0.792 ± 0.024	0.534TrpThr: 0.534 ± 0.019	0.838TrpVal: 0.838 ± 0.028	0.188TrpTrp: 0.188 ± 0.013	0.394TrpTyr: 0.394 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.338TyrAla: 2.338 ± 0.032	0.378TyrCys: 0.378 ± 0.012	1.654TyrAsp: 1.654 ± 0.037	1.541TyrGlu: 1.541 ± 0.029	1.629TyrPhe: 1.629 ± 0.031	2.021TyrGly: 2.021 ± 0.041	0.744TyrHis: 0.744 ± 0.021	1.85TyrIle: 1.85 ± 0.033	1.542TyrLys: 1.542 ± 0.031	3.366TyrLeu: 3.366 ± 0.048	0.645TyrMet: 0.645 ± 0.019	1.248TyrAsn: 1.248 ± 0.029	1.316TyrPro: 1.316 ± 0.03	2.086TyrGln: 2.086 ± 0.037	1.564TyrArg: 1.564 ± 0.033	2.332TyrSer: 2.332 ± 0.043	1.531TyrThr: 1.531 ± 0.033	1.864TyrVal: 1.864 ± 0.034	0.506TyrTrp: 0.506 ± 0.019	1.108TyrTyr: 1.108 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5330 proteins (1724099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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