Amino acid dipepetide frequency for Novosphingobium guangzhouense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.08AlaAla: 18.08 ± 0.153	1.124AlaCys: 1.124 ± 0.025	7.387AlaAsp: 7.387 ± 0.071	7.291AlaGlu: 7.291 ± 0.077	4.35AlaPhe: 4.35 ± 0.055	11.316AlaGly: 11.316 ± 0.079	2.467AlaHis: 2.467 ± 0.042	6.559AlaIle: 6.559 ± 0.066	4.053AlaLys: 4.053 ± 0.059	13.644AlaLeu: 13.644 ± 0.113	3.985AlaMet: 3.985 ± 0.045	3.133AlaAsn: 3.133 ± 0.051	6.234AlaPro: 6.234 ± 0.072	4.912AlaGln: 4.912 ± 0.061	9.218AlaArg: 9.218 ± 0.095	6.826AlaSer: 6.826 ± 0.069	6.286AlaThr: 6.286 ± 0.06	8.62AlaVal: 8.62 ± 0.088	1.724AlaTrp: 1.724 ± 0.036	2.686AlaTyr: 2.686 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.074CysAla: 1.074 ± 0.026	0.101CysCys: 0.101 ± 0.008	0.534CysAsp: 0.534 ± 0.019	0.463CysGlu: 0.463 ± 0.017	0.288CysPhe: 0.288 ± 0.014	0.924CysGly: 0.924 ± 0.027	0.221CysHis: 0.221 ± 0.01	0.399CysIle: 0.399 ± 0.013	0.171CysLys: 0.171 ± 0.01	0.729CysLeu: 0.729 ± 0.021	0.185CysMet: 0.185 ± 0.01	0.229CysAsn: 0.229 ± 0.011	0.433CysPro: 0.433 ± 0.017	0.206CysGln: 0.206 ± 0.012	0.614CysArg: 0.614 ± 0.021	0.482CysSer: 0.482 ± 0.018	0.42CysThr: 0.42 ± 0.016	0.592CysVal: 0.592 ± 0.019	0.124CysTrp: 0.124 ± 0.009	0.187CysTyr: 0.187 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.788AspAla: 7.788 ± 0.071	0.481AspCys: 0.481 ± 0.016	3.337AspAsp: 3.337 ± 0.048	3.329AspGlu: 3.329 ± 0.047	2.307AspPhe: 2.307 ± 0.04	5.689AspGly: 5.689 ± 0.07	1.352AspHis: 1.352 ± 0.03	2.822AspIle: 2.822 ± 0.042	1.826AspLys: 1.826 ± 0.033	5.854AspLeu: 5.854 ± 0.061	1.45AspMet: 1.45 ± 0.028	1.415AspAsn: 1.415 ± 0.034	3.612AspPro: 3.612 ± 0.05	1.686AspGln: 1.686 ± 0.033	4.532AspArg: 4.532 ± 0.056	2.271AspSer: 2.271 ± 0.04	2.816AspThr: 2.816 ± 0.037	4.18AspVal: 4.18 ± 0.042	1.1AspTrp: 1.1 ± 0.027	1.685AspTyr: 1.685 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.547GluAla: 7.547 ± 0.068	0.363GluCys: 0.363 ± 0.015	2.906GluAsp: 2.906 ± 0.044	2.942GluGlu: 2.942 ± 0.049	1.628GluPhe: 1.628 ± 0.035	4.662GluGly: 4.662 ± 0.059	1.277GluHis: 1.277 ± 0.028	2.896GluIle: 2.896 ± 0.045	1.956GluLys: 1.956 ± 0.035	4.926GluLeu: 4.926 ± 0.055	1.432GluMet: 1.432 ± 0.03	1.462GluAsn: 1.462 ± 0.032	2.582GluPro: 2.582 ± 0.037	2.055GluGln: 2.055 ± 0.041	4.72GluArg: 4.72 ± 0.056	2.091GluSer: 2.091 ± 0.034	3.135GluThr: 3.135 ± 0.039	3.732GluVal: 3.732 ± 0.043	0.857GluTrp: 0.857 ± 0.023	1.072GluTyr: 1.072 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.844PheAla: 4.844 ± 0.055	0.341PheCys: 0.341 ± 0.015	2.815PheAsp: 2.815 ± 0.042	1.993PheGlu: 1.993 ± 0.038	1.235PhePhe: 1.235 ± 0.027	3.673PheGly: 3.673 ± 0.046	0.716PheHis: 0.716 ± 0.02	1.387PheIle: 1.387 ± 0.028	0.885PheLys: 0.885 ± 0.023	3.054PheLeu: 3.054 ± 0.045	0.802PheMet: 0.802 ± 0.022	1.062PheAsn: 1.062 ± 0.031	1.491PhePro: 1.491 ± 0.027	0.917PheGln: 0.917 ± 0.023	2.169PheArg: 2.169 ± 0.038	2.103PheSer: 2.103 ± 0.039	2.158PheThr: 2.158 ± 0.034	2.674PheVal: 2.674 ± 0.044	0.516PheTrp: 0.516 ± 0.018	0.945PheTyr: 0.945 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.96GlyAla: 9.96 ± 0.084	0.837GlyCys: 0.837 ± 0.021	4.705GlyAsp: 4.705 ± 0.056	4.801GlyGlu: 4.801 ± 0.052	3.629GlyPhe: 3.629 ± 0.045	8.046GlyGly: 8.046 ± 0.087	1.822GlyHis: 1.822 ± 0.041	4.508GlyIle: 4.508 ± 0.054	3.555GlyLys: 3.555 ± 0.049	8.679GlyLeu: 8.679 ± 0.082	2.527GlyMet: 2.527 ± 0.037	2.479GlyAsn: 2.479 ± 0.045	3.631GlyPro: 3.631 ± 0.044	3.063GlyGln: 3.063 ± 0.045	6.328GlyArg: 6.328 ± 0.066	5.148GlySer: 5.148 ± 0.063	5.113GlyThr: 5.113 ± 0.059	6.382GlyVal: 6.382 ± 0.07	1.613GlyTrp: 1.613 ± 0.032	2.52GlyTyr: 2.52 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.486HisAla: 2.486 ± 0.042	0.235HisCys: 0.235 ± 0.013	1.317HisAsp: 1.317 ± 0.029	1.055HisGlu: 1.055 ± 0.025	0.87HisPhe: 0.87 ± 0.024	1.942HisGly: 1.942 ± 0.037	0.528HisHis: 0.528 ± 0.023	0.873HisIle: 0.873 ± 0.023	0.469HisLys: 0.469 ± 0.018	1.939HisLeu: 1.939 ± 0.035	0.473HisMet: 0.473 ± 0.017	0.464HisAsn: 0.464 ± 0.017	1.306HisPro: 1.306 ± 0.029	0.563HisGln: 0.563 ± 0.017	1.409HisArg: 1.409 ± 0.029	0.969HisSer: 0.969 ± 0.024	0.807HisThr: 0.807 ± 0.019	1.504HisVal: 1.504 ± 0.034	0.347HisTrp: 0.347 ± 0.015	0.58HisTyr: 0.58 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.505IleAla: 7.505 ± 0.076	0.451IleCys: 0.451 ± 0.017	3.887IleAsp: 3.887 ± 0.042	3.467IleGlu: 3.467 ± 0.05	1.381IlePhe: 1.381 ± 0.033	4.838IleGly: 4.838 ± 0.054	0.916IleHis: 0.916 ± 0.026	1.784IleIle: 1.784 ± 0.034	1.154IleLys: 1.154 ± 0.028	3.603IleLeu: 3.603 ± 0.05	0.888IleMet: 0.888 ± 0.023	1.316IleAsn: 1.316 ± 0.027	2.273IlePro: 2.273 ± 0.033	1.098IleGln: 1.098 ± 0.025	3.085IleArg: 3.085 ± 0.042	2.706IleSer: 2.706 ± 0.04	2.594IleThr: 2.594 ± 0.049	4.07IleVal: 4.07 ± 0.055	0.583IleTrp: 0.583 ± 0.019	1.054IleTyr: 1.054 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.15LysAla: 4.15 ± 0.054	0.166LysCys: 0.166 ± 0.009	1.637LysAsp: 1.637 ± 0.035	1.287LysGlu: 1.287 ± 0.03	0.891LysPhe: 0.891 ± 0.024	2.839LysGly: 2.839 ± 0.049	0.563LysHis: 0.563 ± 0.02	1.413LysIle: 1.413 ± 0.031	0.96LysLys: 0.96 ± 0.03	3.132LysLeu: 3.132 ± 0.036	0.704LysMet: 0.704 ± 0.023	0.736LysAsn: 0.736 ± 0.022	1.977LysPro: 1.977 ± 0.034	0.941LysGln: 0.941 ± 0.025	2.129LysArg: 2.129 ± 0.039	1.624LysSer: 1.624 ± 0.031	1.632LysThr: 1.632 ± 0.036	2.464LysVal: 2.464 ± 0.039	0.419LysTrp: 0.419 ± 0.016	0.627LysTyr: 0.627 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.664LeuAla: 13.664 ± 0.117	0.869LeuCys: 0.869 ± 0.025	6.18LeuAsp: 6.18 ± 0.073	4.993LeuGlu: 4.993 ± 0.057	3.425LeuPhe: 3.425 ± 0.05	8.452LeuGly: 8.452 ± 0.077	1.875LeuHis: 1.875 ± 0.032	4.303LeuIle: 4.303 ± 0.062	2.934LeuLys: 2.934 ± 0.043	8.924LeuLeu: 8.924 ± 0.099	2.136LeuMet: 2.136 ± 0.04	2.397LeuAsn: 2.397 ± 0.036	5.584LeuPro: 5.584 ± 0.064	2.646LeuGln: 2.646 ± 0.046	6.953LeuArg: 6.953 ± 0.073	6.117LeuSer: 6.117 ± 0.056	5.554LeuThr: 5.554 ± 0.052	7.148LeuVal: 7.148 ± 0.073	1.22LeuTrp: 1.22 ± 0.029	1.979LeuTyr: 1.979 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	3.4MetAla: 3.4 ± 0.049	0.16MetCys: 0.16 ± 0.009	1.206MetAsp: 1.206 ± 0.029	1.13MetGlu: 1.13 ± 0.029	0.719MetPhe: 0.719 ± 0.022	1.96MetGly: 1.96 ± 0.034	0.459MetHis: 0.459 ± 0.016	1.328MetIle: 1.328 ± 0.029	0.906MetLys: 0.906 ± 0.021	2.692MetLeu: 2.692 ± 0.044	0.662MetMet: 0.662 ± 0.024	0.723MetAsn: 0.723 ± 0.02	1.574MetPro: 1.574 ± 0.024	0.788MetGln: 0.788 ± 0.022	1.851MetArg: 1.851 ± 0.031	1.495MetSer: 1.495 ± 0.029	1.803MetThr: 1.803 ± 0.031	1.721MetVal: 1.721 ± 0.034	0.231MetTrp: 0.231 ± 0.01	0.258MetTyr: 0.258 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.38AsnAla: 3.38 ± 0.046	0.253AsnCys: 0.253 ± 0.012	1.494AsnAsp: 1.494 ± 0.03	1.148AsnGlu: 1.148 ± 0.026	1.022AsnPhe: 1.022 ± 0.029	2.553AsnGly: 2.553 ± 0.049	0.485AsnHis: 0.485 ± 0.018	1.255AsnIle: 1.255 ± 0.027	0.605AsnLys: 0.605 ± 0.02	2.646AsnLeu: 2.646 ± 0.044	0.584AsnMet: 0.584 ± 0.02	0.721AsnAsn: 0.721 ± 0.021	1.781AsnPro: 1.781 ± 0.036	0.728AsnGln: 0.728 ± 0.02	1.84AsnArg: 1.84 ± 0.033	1.32AsnSer: 1.32 ± 0.031	1.23AsnThr: 1.23 ± 0.035	1.994AsnVal: 1.994 ± 0.038	0.469AsnTrp: 0.469 ± 0.02	0.763AsnTyr: 0.763 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.847ProAla: 6.847 ± 0.077	0.358ProCys: 0.358 ± 0.016	3.702ProAsp: 3.702 ± 0.043	3.59ProGlu: 3.59 ± 0.043	1.902ProPhe: 1.902 ± 0.037	4.758ProGly: 4.758 ± 0.058	1.003ProHis: 1.003 ± 0.026	2.314ProIle: 2.314 ± 0.037	1.442ProLys: 1.442 ± 0.03	4.858ProLeu: 4.858 ± 0.059	1.241ProMet: 1.241 ± 0.026	1.275ProAsn: 1.275 ± 0.026	2.453ProPro: 2.453 ± 0.049	1.889ProGln: 1.889 ± 0.038	3.085ProArg: 3.085 ± 0.044	2.855ProSer: 2.855 ± 0.035	2.533ProThr: 2.533 ± 0.041	4.359ProVal: 4.359 ± 0.06	0.705ProTrp: 0.705 ± 0.022	1.1ProTyr: 1.1 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.208GlnAla: 4.208 ± 0.056	0.233GlnCys: 0.233 ± 0.012	1.598GlnAsp: 1.598 ± 0.03	1.383GlnGlu: 1.383 ± 0.028	1.146GlnPhe: 1.146 ± 0.03	2.707GlnGly: 2.707 ± 0.041	0.623GlnHis: 0.623 ± 0.018	1.734GlnIle: 1.734 ± 0.034	0.906GlnLys: 0.906 ± 0.023	3.033GlnLeu: 3.033 ± 0.041	0.865GlnMet: 0.865 ± 0.023	0.826GlnAsn: 0.826 ± 0.023	1.781GlnPro: 1.781 ± 0.039	1.248GlnGln: 1.248 ± 0.033	2.454GlnArg: 2.454 ± 0.042	1.79GlnSer: 1.79 ± 0.032	1.745GlnThr: 1.745 ± 0.035	2.51GlnVal: 2.51 ± 0.038	0.503GlnTrp: 0.503 ± 0.017	0.665GlnTyr: 0.665 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.168ArgAla: 8.168 ± 0.085	0.519ArgCys: 0.519 ± 0.016	4.109ArgAsp: 4.109 ± 0.054	4.091ArgGlu: 4.091 ± 0.048	3.036ArgPhe: 3.036 ± 0.042	4.944ArgGly: 4.944 ± 0.058	1.663ArgHis: 1.663 ± 0.034	4.148ArgIle: 4.148 ± 0.056	2.367ArgLys: 2.367 ± 0.039	7.655ArgLeu: 7.655 ± 0.08	1.959ArgMet: 1.959 ± 0.035	1.926ArgAsn: 1.926 ± 0.036	3.484ArgPro: 3.484 ± 0.05	2.506ArgGln: 2.506 ± 0.034	5.587ArgArg: 5.587 ± 0.078	3.756ArgSer: 3.756 ± 0.049	3.646ArgThr: 3.646 ± 0.045	4.739ArgVal: 4.739 ± 0.053	1.192ArgTrp: 1.192 ± 0.031	1.972ArgTyr: 1.972 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.744SerAla: 6.744 ± 0.072	0.444SerCys: 0.444 ± 0.02	3.127SerAsp: 3.127 ± 0.045	2.586SerGlu: 2.586 ± 0.041	2.142SerPhe: 2.142 ± 0.037	5.633SerGly: 5.633 ± 0.066	0.972SerHis: 0.972 ± 0.025	2.678SerIle: 2.678 ± 0.042	1.478SerLys: 1.478 ± 0.035	5.286SerLeu: 5.286 ± 0.06	1.329SerMet: 1.329 ± 0.029	1.443SerAsn: 1.443 ± 0.032	2.859SerPro: 2.859 ± 0.047	1.637SerGln: 1.637 ± 0.029	3.698SerArg: 3.698 ± 0.047	3.035SerSer: 3.035 ± 0.047	2.963SerThr: 2.963 ± 0.048	3.83SerVal: 3.83 ± 0.049	0.816SerTrp: 0.816 ± 0.024	1.473SerTyr: 1.473 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.484ThrAla: 6.484 ± 0.064	0.433ThrCys: 0.433 ± 0.017	2.932ThrAsp: 2.932 ± 0.041	2.405ThrGlu: 2.405 ± 0.041	2.013ThrPhe: 2.013 ± 0.037	5.535ThrGly: 5.535 ± 0.07	0.955ThrHis: 0.955 ± 0.024	2.927ThrIle: 2.927 ± 0.041	1.284ThrLys: 1.284 ± 0.028	5.69ThrLeu: 5.69 ± 0.058	1.269ThrMet: 1.269 ± 0.03	1.344ThrAsn: 1.344 ± 0.033	3.417ThrPro: 3.417 ± 0.051	1.58ThrGln: 1.58 ± 0.034	3.49ThrArg: 3.49 ± 0.047	2.911ThrSer: 2.911 ± 0.046	2.863ThrThr: 2.863 ± 0.049	4.541ThrVal: 4.541 ± 0.057	0.702ThrTrp: 0.702 ± 0.026	1.398ThrTyr: 1.398 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.244ValAla: 9.244 ± 0.096	0.623ValCys: 0.623 ± 0.021	4.293ValAsp: 4.293 ± 0.046	4.448ValGlu: 4.448 ± 0.055	2.365ValPhe: 2.365 ± 0.037	5.593ValGly: 5.593 ± 0.067	1.349ValHis: 1.349 ± 0.032	3.776ValIle: 3.776 ± 0.053	2.154ValLys: 2.154 ± 0.04	7.083ValLeu: 7.083 ± 0.08	1.77ValMet: 1.77 ± 0.031	2.124ValAsn: 2.124 ± 0.041	3.973ValPro: 3.973 ± 0.048	2.12ValGln: 2.12 ± 0.033	5.096ValArg: 5.096 ± 0.057	4.449ValSer: 4.449 ± 0.056	4.747ValThr: 4.747 ± 0.049	5.434ValVal: 5.434 ± 0.066	0.912ValTrp: 0.912 ± 0.026	1.409ValTyr: 1.409 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.428TrpAla: 1.428 ± 0.031	0.136TrpCys: 0.136 ± 0.008	0.761TrpAsp: 0.761 ± 0.023	0.618TrpGlu: 0.618 ± 0.024	0.552TrpPhe: 0.552 ± 0.021	1.014TrpGly: 1.014 ± 0.026	0.38TrpHis: 0.38 ± 0.016	0.685TrpIle: 0.685 ± 0.022	0.541TrpLys: 0.541 ± 0.017	1.786TrpLeu: 1.786 ± 0.032	0.356TrpMet: 0.356 ± 0.014	0.501TrpAsn: 0.501 ± 0.019	0.739TrpPro: 0.739 ± 0.018	0.626TrpGln: 0.626 ± 0.021	1.323TrpArg: 1.323 ± 0.027	0.903TrpSer: 0.903 ± 0.025	0.902TrpThr: 0.902 ± 0.025	0.851TrpVal: 0.851 ± 0.021	0.254TrpTrp: 0.254 ± 0.013	0.323TrpTyr: 0.323 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.895TyrAla: 2.895 ± 0.044	0.252TyrCys: 0.252 ± 0.011	1.609TyrAsp: 1.609 ± 0.034	1.219TyrGlu: 1.219 ± 0.028	0.877TyrPhe: 0.877 ± 0.023	2.265TyrGly: 2.265 ± 0.042	0.51TyrHis: 0.51 ± 0.016	0.864TyrIle: 0.864 ± 0.023	0.641TyrLys: 0.641 ± 0.021	2.14TyrLeu: 2.14 ± 0.039	0.448TyrMet: 0.448 ± 0.017	0.694TyrAsn: 0.694 ± 0.024	1.087TyrPro: 1.087 ± 0.028	0.752TyrGln: 0.752 ± 0.021	1.885TyrArg: 1.885 ± 0.037	1.324TyrSer: 1.324 ± 0.033	1.226TyrThr: 1.226 ± 0.029	1.616TyrVal: 1.616 ± 0.031	0.393TyrTrp: 0.393 ± 0.014	0.692TyrTyr: 0.692 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5282 proteins (1720164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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